Lucia De Franceschi

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi request reprint Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Policlinico GB Rossi, Piazzale L Scuro, 10, 37134 Verona, Italy
    Blood 102:1087-96. 2003
  2. ncbi request reprint Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients?
    Cinzia Scambi
    Department of Clinical and Experimental Medicine, University of Verona, Chair of Internal Medicine B, 37134 Verona, Italy
    J Cyst Fibros 5:197-9. 2006
  3. pmc Pathophisiology of sickle cell disease and new drugs for the treatment
    Lucia De Franceschi
    Dept of Clinical and Experimental Medicine, University of Verona, Italy
    Mediterr J Hematol Infect Dis 1:e2009024. 2009
  4. ncbi request reprint Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
    Sara Santos Franco
    Haematologica 99:267-75. 2014
  5. pmc Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    FASEB J 27:750-9. 2013
  6. pmc Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e31015. 2012
  7. pmc Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity
    Lucia De Franceschi
    Department of Medicine, University of Verona, Piazzale Lo Scuro 10, Verona, Italy
    Blood 118:5652-63. 2011
  8. ncbi request reprint K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels
    L de Franceschi
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Am J Physiol Cell Physiol 281:C1385-95. 2001
  9. doi request reprint Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    FASEB J 22:1849-60. 2008
  10. ncbi request reprint Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 10 P le L Scuro, 37134 Verona, Italy
    Pflugers Arch 451:760-8. 2006

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Inhaled nitric oxide protects transgenic SAD mice from sickle cell disease-specific lung injury induced by hypoxia/reoxygenation
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Policlinico GB Rossi, Piazzale L Scuro, 10, 37134 Verona, Italy
    Blood 102:1087-96. 2003
    ....
  2. ncbi request reprint Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients?
    Cinzia Scambi
    Department of Clinical and Experimental Medicine, University of Verona, Chair of Internal Medicine B, 37134 Verona, Italy
    J Cyst Fibros 5:197-9. 2006
    ..We describe a CF child with an unusual clinical course presenting high molar percentage of DHA in plasma and red cells membrane during supplementation with 5-methyltetrahydrofolate and vitamin B12...
  3. pmc Pathophisiology of sickle cell disease and new drugs for the treatment
    Lucia De Franceschi
    Dept of Clinical and Experimental Medicine, University of Verona, Italy
    Mediterr J Hematol Infect Dis 1:e2009024. 2009
    ....
  4. ncbi request reprint Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
    Sara Santos Franco
    Haematologica 99:267-75. 2014
    ....
  5. pmc Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    FASEB J 27:750-9. 2013
    ..BDA-410 prevented hypoxia-induced RBC dehydration and K(+) loss in SAD mice. These data suggest a potential role of BDA-410 as a novel therapeutic agent for treatment of SCD...
  6. pmc Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    PLoS ONE 7:e31015. 2012
    ..The final analysis pointed to a novel, very restricted, signaling module of 14 highly interconnected kinases, whose alteration is possibly involved in generation of acanthocytes in MLS and ChAc...
  7. pmc Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity
    Lucia De Franceschi
    Department of Medicine, University of Verona, Piazzale Lo Scuro 10, Verona, Italy
    Blood 118:5652-63. 2011
    ..We propose this altered association between membrane skeleton and membrane proteins as novel mechanism in the generation of acanthocytes in ChAc...
  8. ncbi request reprint K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels
    L de Franceschi
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Am J Physiol Cell Physiol 281:C1385-95. 2001
    ..These findings suggest that in vivo downregulation of K-Cl cotransport activity by Mg is mediated by enhanced Src family kinase activity, leading to inhibition of the K-Cl cotransport stimulator PP1...
  9. doi request reprint Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    FASEB J 22:1849-60. 2008
    ..This finding supports a possible therapeutic use of PDEs inhibitors in the earlier phases of PAH in SCD...
  10. ncbi request reprint Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 10 P le L Scuro, 37134 Verona, Italy
    Pflugers Arch 451:760-8. 2006
    ..These data suggest up-regulation of KCC in SAD red cells is mainly secondary to oxidative damage, which most likely reduces or removes the tonic KCC inhibition resulting from PP-1alpha activity controlled in turn by Src-family kinases...
  11. pmc PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Proteomics 8:4695-708. 2008
    ....
  12. doi request reprint Thrombosis and sickle cell disease
    Lucia De Franceschi
    Department of Medicine, University of Verona, Verona, Italy
    Semin Thromb Hemost 37:226-36. 2011
    ..We also review the available studies on the therapeutic approaches in clinical management of hypercoagulability in SCD...
  13. pmc Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis
    Lucia De Franceschi
    Department of Medicine, University of Verona, Policlinico GB Rossi, Verona, Italy
    Haematologica 96:1595-604. 2011
    ..thalassemic syndromes are inherited red cell disorders characterized by severe ineffective erythropoiesis and increased levels of reactive oxygen species whose contribution to β-thalassemic anemia is only partially understood...
  14. ncbi request reprint Erythrocyte aging in neurodegenerative disorders
    L de Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, P le L Scuro 10, 37134 Verona, Italy
    Cell Mol Biol (Noisy-le-grand) 50:179-85. 2004
    ..We have reviewed the mechanism(s) of the loss of red cell membrane stability and of the precocious red cell aging in neurodegenerative disorders...
  15. ncbi request reprint Established and experimental treatments for sickle cell disease
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Haematologica 89:348-56. 2004
    ..The second one is based on therapeutic strategies, which may reduce sickle cell-endothelial adhesive events...
  16. ncbi request reprint Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease
    Lucia De Franceschi
    Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy
    Am J Physiol Lung Cell Mol Physiol 291:L457-65. 2006
    ..These effects provide new insights into the possible use of NO-Alb in the treatment of acute lung injury in SCD...
  17. doi request reprint Deoxygenation affects tyrosine phosphoproteome of red cell membrane from patients with sickle cell disease
    Angela Siciliano
    Dept of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Blood Cells Mol Dis 44:233-42. 2010
    ....
  18. pmc Preliminary evidence for cell membrane amelioration in children with cystic fibrosis by 5-MTHF and vitamin B12 supplementation: a single arm trial
    Cinzia Scambi
    Department of Clinical and Experimental Medicine, Section of Rheumatology and Internal Medicine, University of Verona, Verona, Italy
    PLoS ONE 4:e4782. 2009
    ..The objective of this study was to evaluate the efficacy of 5-methyltetrahydrofolate (5-MTHF) and vitamin B12 supplementation for ameliorating cell plasma membrane features in pediatric patients with cystic fibrosis...
  19. pmc Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Blood 106:1454-9. 2005
    ....
  20. pmc Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress
    Alessandro Matte
    Section of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, 37134 Verona, Italy
    Free Radic Biol Med 49:457-66. 2010
    ..Thus, reduced access of Prx2 to the membrane in beta-thal RBCs represents a new factor that could contribute to the oxidative damage characterizing the pathology...
  21. pmc Oxidative stress and β-thalassemic erythroid cells behind the molecular defect
    Lucia De Franceschi
    Department of Medicine, Section of Internal Medicine, University of Verona, Policlinico GB Rossi, 37134 Verona, Italy
    Oxid Med Cell Longev 2013:985210. 2013
    ..Finally, we will discuss the results of the major in vitro and in vivo studies with antioxidants in β -thalassemia...
  22. pmc Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy
    Angela Siciliano
    Dept of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Haematologica 96:24-32. 2011
    ..Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is only partially understood...
  23. pmc Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H
    Cinzia Scambi
    Section of Rheumatology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    PLoS ONE 5:e12162. 2010
    ..Since the first cases, the similarity of ScGVHD to SSc has been reported. However, both diseases could have different etiopathogeneses. The objective of this study was to identify new serum biomarkers involved in SSc and ScGVHD...
  24. doi request reprint Membrane association of peroxiredoxin-2 in red cells is mediated by the N-terminal cytoplasmic domain of band 3
    Alessandro Matte
    Section of Internal Medicine, Department of Medicine, University of Verona, 37134 Verona, Italy
    Free Radic Biol Med 55:27-35. 2013
    ..These findings imply yet another important role for B3 in regulating red cell membrane function...
  25. ncbi request reprint ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice
    Jonathan W Stocker
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Blood 101:2412-8. 2003
    ..0 to 300 +/- 15 g/L [34.0 +/- 0.9 to 30 +/- 1.5 g/dL], P <.05), and a left-shift in RBC density curves. These data indicate that ICA-17043 is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse...
  26. ncbi request reprint Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia
    Lucia De Franceschi
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Medicina Interna Università di Verona, Verona, Italy
    Haematologica 91:1336-42. 2006
    ..Reduction of hepcidin synthesis has been reported both in patients and in animal models. We have measured liver hepcidin and other iron gene transcripts in two different mouse models of beta-thalassemia at different ages...
  27. ncbi request reprint In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Haematologica 89:1287-98. 2004
    ..To assess the extent of oxidant damage of circulating erythrocytes and the effects of antioxidant therapy on erythrocyte characteristics and anemia, we used a mouse model of human beta-thalassemia intermedia (b1/b2 deletion)...
  28. ncbi request reprint Acute hemolytic anemia with acanthocytosis associated with high-dose misoprostol for medical abortion
    Alida Filippini
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Ann Emerg Med 50:289-91. 2007
    ....
  29. ncbi request reprint K-CL co-transport plays an important role in normal and beta thalassemic erythropoiesis
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Haematologica 92:1319-26. 2007
    ..We evaluated the possible role of K-Cl co-transport (KCC) in both normal and beta-thalassemic erythropoiesis in vitro...
  30. doi request reprint Heat-shock protein-27, -70 and peroxiredoxin-II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model
    Andrea Biondani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Proteomics Clin Appl 2:706-19. 2008
    ..Our data indicate that HSP27 and HSP70 play a novel role as RBCs membrane protein protectors and as possibly new markers of severity of RBCs membrane damage during acute VOCs...
  31. doi request reprint Proteome analysis of biological fluids from autoimmune-rheumatological disorders
    Lucia De Franceschi
    Department of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy
    Proteomics Clin Appl 5:78-89. 2011
    ....
  32. ncbi request reprint Abnormal red cell features associated with hereditary neurodegenerative disorders: the neuroacanthocytosis syndromes
    Lucia De Franceschi
    aDepartment of Medicine, Section of Internal Medicine, University of Verona, Verona, Italy bDepartment of Biochemistry, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands cRed Cell Physiology Laboratory, New York Blood Center, New York, New York, USA
    Curr Opin Hematol 21:201-9. 2014
    ....
  33. pmc Two-photon microscopy imaging of thy1GFP-M transgenic mice: a novel animal model to investigate brain dendritic cell subsets in vivo
    Claudia Laperchia
    Department of Neurological Sciences, University of Verona, Verona, Italy
    PLoS ONE 8:e56144. 2013
    ..Information on brain DCs is still very limited and imaging in thy1GFP-M mice has a great potential for analyses of DC-neuron interaction in normal and pathological conditions...
  34. ncbi request reprint Selective intra-arterial terlipressin infusion stops acute lower gastrointestinal bleeding: a case report and review of the literature
    Novella Maria Favalli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Eur J Gastroenterol Hepatol 16:1059-61. 2004
    ..The present case should prompt its consideration for further clinical studies...
  35. ncbi request reprint The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function
    Silverio Perrotta
    Department of Pediatrics, Second University of Naples, Italy
    Blood 106:4359-66. 2005
    ..The identification of a novel band 3 mutant and its structural and functional characterization enabled us to identify pivotal roles for the 11 N-terminal amino acids in several protein functions and, in turn, in red-cell physiology...
  36. ncbi request reprint [Clinical trials of new therapeutic pharmacology for sickle cell disease]
    Carlo Brugnara
    Department of Laboratory Medicine and Pathology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Sante 16:263-8. 2006
    ..It prevents the activation of leucocytes, platelets and endothelial cells in patients with sickle cell disease and vascular remodelling. The L-arginine, the NO precursor, provides could be beneficial in sickle cell patients...
  37. ncbi request reprint Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes
    Alicia Rivera
    Children s Hospital Boston, Dept of Laboratory Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 291:C880-6. 2006
    ..1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes. Upregulation of the Na/H exchange is an important contributor to the elevated cell Na content of 4.1(-/-) erythrocytes...
  38. pmc Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease
    Nathalie Sabaa
    Cardiovascular Research Center Lariboisiere, INSERM U689, Paris, France
    J Clin Invest 118:1924-33. 2008
    ..These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients...
  39. ncbi request reprint Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr
    Cinzia Mallozzi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Free Radic Biol Med 38:1625-36. 2005
    ....
  40. ncbi request reprint A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso-occlusive crises and sickle cell pain
    Lucia De Franceschi
    Haematologica 89:1389-91. 2004
    ..Here we report a pilot study which combined balanced analgesia with tramadol plus ketorolac and erythrocytapheresis. Key words: sickle cell disease, therapeutic erythrocytapheresis, HbS, visual analog scale, vaso-occlusive crisis...
  41. doi request reprint Novel inhibitors of the Gardos channel for the treatment of sickle cell disease
    Grant A McNaughton-Smith
    Icagen, Inc, Post Office Box 14487, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 51:976-82. 2008
    ..Several triarylamides such as 10 and 21 were potent inhibitors of the Gardos channel (IC50 of <10 nM) and active in a mouse model of SCD. Compound 21 (ICA-17043) was advanced into phase 3 clinical trials for SCD...
  42. ncbi request reprint Acrylamide-agarose copolymers: improved resolution of high molecular mass proteins in two-dimensional gel electrophoresis
    Paola Roncada
    Istituto Sperimentale Italiano, L Spallanzani, Milan, Italy
    Proteomics 5:2331-9. 2005
    ..The results demonstrate that the new gel is fully compatible with mass spectrometry protein analysis...
  43. doi request reprint Estimation of glomerular filtration rate by the modification of diet in renal disease (MDRD) equation in patients with sickle cell disease
    Giuseppe Lippi
    Clin Chem Lab Med 46:1200-1. 2008
  44. ncbi request reprint Sickle cell disease and hyperreactive malarial splenomegaly (HMS) in young immigrants from Africa
    Lucia De Franceschi
    Blood 106:4415-7. 2005