Research Topics
| Fabrizio De PontiSummaryAffiliation: University of Bologna Country: Italy Publications
| Collaborators
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Detail Information
Publications
Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in ItalyElisabetta Poluzzi
Department of Pharmacology, University of Bologna, and Ahterosclerosis and Metabolic Diseases Study Centre, G Descovich, Department of Clinical Medicine and Applied Biotechnology D Campanacci, S Orsola Malpighi University Hospital, Bologna, Italy
Eur J Clin Pharmacol 64:425-32. 2008..To evaluate the pattern of use of statins in the Emilia Romagna Region, with a focus on the therapeutic regimens and the patient's risk profile as predictors of adherence to therapy...
QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experienceF De Ponti
Department of Pharmacology, University of Bologna and Interuniversity Research Centre for Pharmacoepidemiology, Italy
Eur J Clin Pharmacol 56:1-18. 2000..g. azole antifungals, macrolide antibacterials and class-I or -III antiarrhythmic agents). Future perspectives for drug research and development are also briefly outlined...- Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonistsFabrizio De Ponti
Department of Pharmacology, University of Bologna, Via Irnerio 48, I 40126 Bologna, Italy
Am J Physiol Gastrointest Liver Physiol 285:G96-104. 2003..In conclusion, 5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus. An exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation... 
Non-antiarrhythmic drugs prolonging the QT interval: considerable use in seven countriesFabrizio De Ponti
Department of Pharmacology, University of Bologna, Bologna, Italy
Br J Clin Pharmacol 54:171-7. 2002..The aim of this study was to assess the relevance and the magnitude of the problem in seven countries by grouping all nonantiarrhythmic drugs according to the type of evidence on QT prolongation and analysing their sales data...- Methylnaltrexone ProgenicsFabrizio De Ponti
Department of Pharmacology, University of Bologna, Italy
Curr Opin Investig Drugs 3:614-20. 2002..These trials were initiated in February 2002 [440995]... - Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overviewFabrizio De Ponti
Department of Pharmacology, University of Bologna, Bologna, Italy
Drug Saf 25:263-86. 2002..Therefore, the use of several models facilitates decision making and is recommended by most experts in the field... - Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colonF De Ponti
Department of Pharmacology, University of Bologna, Bologna, Italy
Neurogastroenterol Motil 13:543-53. 2001..Tachykininergic pathways are not involved in the ML10302-induced prokinesia in the small bowel, but they play an important role in mediating the colonic motor response to ML10302... - [Physiopathology of the enteric nervous system: recent advances and clinical implications]Fabrizio De Ponti
Dipartimento di Farmacologia, Universita, Bologna
Recenti Prog Med 93:40-4. 2002..The role of neurotrophins and the potential therapeutic applications are also briefly discussed... - Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensusF De Ponti
Department of Pharmacology, University of Bologna, Italy
Eur J Clin Pharmacol 57:185-209. 2001..Second, drug-induced Torsades de Pointes are still considered idiosyncratic, totally unpredictable adverse drug reactions, whereas a number of risk factors for their occurrence is now recognised... - Irritable bowel syndrome: new agents targeting serotonin receptor subtypesF De Ponti
Department of Pharmacology, University of Bologna, Italy
Drugs 61:317-32. 2001.... - Adherence to chronic cardiovascular therapies: persistence over the years and dose coverageElisabetta Poluzzi
Department of Pharmacology, University of Bologna, Bologna, Italy
Br J Clin Pharmacol 63:346-55. 2007..To evaluate adherence to chronic cardiovascular drug treatments, in terms of long-term persistence and dose coverage... - Gastro-intestinal problems and concomitant medication in NSAID users: additional findings from a questionnaire-based survey in ItalyMaria Chiara Silvani
Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
Eur J Clin Pharmacol 62:235-41. 2006..Adverse effects and untoward drug interactions should be monitored in patients treated with NSAIDs in order to minimise their occurrence... - An update on the first decade of the European centralized procedure: how many innovative drugs?Domenico Motola
Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
Br J Clin Pharmacol 62:610-6. 2006..nonbiotechnological agents in the first decade of European Medicines Agency activity, also studying a possible time trend... - QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug developmentMaurizio Recanatini
Department of Pharmaceutical Sciences, Via Belmeloro 6, University of Bologna, I 40126 Bologna, Italy
Med Res Rev 25:133-66. 2005..In particular, it will focus on the approaches recently proposed for the in silico screening of new compounds... - Enteric neuroplasticity evoked by inflammationValentina Vasina
Department of Pharmacology, University of Bologna, St. Orsola-Malpighi Hospital, Italy
Auton Neurosci 126:264-72. 2006..A better comprehension of ENS plasticity during inflammation could be instrumental to develop new therapeutic options for patients with IBD and inflammatory enteric neuropathies... - Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS)Elisabetta Poluzzi
Department of Pharmacology, University of Bologna, Bologna, Italy
Pharmacoepidemiol Drug Saf 18:512-8. 2009..To investigate spontaneous reports of TdP present in the public version of the FDA Adverse Event Reporting System (AERS) in the light of what is already known on their TdP-liability... - Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in ratsValentina Vasina
Department of Pharmacology, University of Bologna, Bologna, Italy
World J Gastroenterol 16:3642-50. 2010..To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate (IAC) in the dextran sodium sulphate (DSS) experimental model of ulcerative colitis... - Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting SystemElisabetta Poluzzi
Department of Pharmacology, University of Bologna, Bologna, Italy
Drug Saf 33:303-14. 2010..In this context, the US FDA Adverse Event Reporting System (AERS) is an important source of information, which can be applied to the analysis of TdP liability of marketed drugs... - Prokinetics in the treatment of acute intestinal pseudo-obstructionRoberto De Giorgio
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I 40138, Italy
IDrugs 7:160-5. 2004..New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome... - Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotilityRoberto De Giorgio
Department of Internal Medicine, University of Bologna, Italy
Gastroenterology 125:70-9. 2003.... - Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in ratsMaria Grazia Ursino
Department of Pharmacology, University of Bologna, Bologna, Italy
Eur J Pharmacol 603:133-7. 2009..These results suggest a role for NK(1) receptors and substance P in the development of intestinal inflammation and indicate tachykinin receptors as a potential pharmacological target in the treatment of inflammatory bowel disease... - Initial treatment of hypertension and adherence to therapy in general practice in ItalyElisabetta Poluzzi
Department of Pharmacology, and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Eur J Clin Pharmacol 61:603-9. 2005..However, the lack of adherence to antihypertensive treatment is undoubtedly a matter of concern for public health and should be addressed with appropriate interventions... - Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapyEmanuel Raschi
Department of Pharmacology, University of Bologna, Bologna, Italy
Pharmacol Ther 125:196-218. 2010..e. the unwanted target causing heart damage) and the development of guidelines to monitor patients undergoing treatment with cardiotoxic agents appear to constitute the basis for the management of drug-induced cardiotoxicity... - Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and SwedenCarlo Piccinni
Department of Medical and Surgical Sciences, University of Bologna, Via Irnerio, 48, I 40126 Bologna, BO, Italy
Eur J Clin Pharmacol 69:715-20. 2013..Our aim was to evaluate whether dronedarone authorization impacts antiarrhythmic drug prescribing in Sweden and Emilia Romagna (Italy)... - Cardiovascular events in statin recipients: impact of adherence to treatment in a 3-year record linkage studyElisabetta Poluzzi
Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
Eur J Clin Pharmacol 67:407-14. 2011..This study aimed to evaluate the occurrence of cardiovascular events in Italian statin recipients, focussing on the relationship between degree of adherence to therapy and occurrence of events in a 3-year follow-up... - Pattern of NSAID use in the Italian general population: a questionnaire-based surveyDomenico Motola
Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, BO, Italy
Eur J Clin Pharmacol 60:731-8. 2004..However, their large and often chronic use in the elderly, as well as the high frequency of self-treatment, recommends a higher awareness by all physicians... - Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year periodEmanuel Raschi
Department of Pharmacology, University of Bologna, Bologna, Italy
Br J Clin Pharmacol 67:88-98. 2009..i) To classify antibacterial agents with QT liability on the basis of the available evidence, and (ii) to assess trends in their consumption over an 8-year period (1998-2005) in 14 European countries... - Cardiovascular toxicity of anticancer-targeted therapy: emerging issues in the era of cardio-oncologyEmanuel Raschi
Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, BO, Italy
Intern Emerg Med 7:113-31. 2012..detection, treatment, monitoring and reporting of cardiovascular side effects). In this scenario, onco-vigilance (i.e., pharmacovigilance oriented to oncologic drugs) is emerging as a key to support cardio-oncologists inappropriateness... - Excipients in medicinal products used in gastroenterology as a possible cause of side effectsMaria Grazia Ursino
Department of Pharmacology, University of Bologna, Bologna, Italy
Regul Toxicol Pharmacol 60:93-105. 2011..The availability of alternative products of the same therapeutic class, but lacking specific excipient(s) should be considered in selected patients... - New developments in the treatment of functional dyspepsiaVincenzo Stanghellini
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
Drugs 63:869-92. 2003..e., P2X2/3 receptors), NMDA receptors (NR2B subtype), protease-activated receptor-2, the vanilloid receptor-1, tachykinin receptors (NK(1)/NK(2)) and cholecystokinin (CCK)(1) receptors... - Prescriptions of antidepressants in primary care in Italy: pattern of use after admission of selective serotonin reuptake inhibitors for reimbursementElisabetta Poluzzi
Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna BO, Italy
Eur J Clin Pharmacol 59:825-31. 2004..Recipients of newer drugs received doses consistent with a use for major depression more frequently than others; however, rates of 6 month duration did not differ among drug classes... - Inflammatory neuropathies of the enteric nervous systemRoberto De Giorgio
Department of Internal Medicine and Gastroenterology, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, I 40138 Bologna, Italy
Gastroenterology 126:1872-83. 2004.... - Antibacterial macrolides: a drug class with a complex pharmacological profileEman Abu-Gharbieh
Department of Pharmacology, University of Bologna, Via Irnerio, 48, I-40126 Bologna, Italy
Pharmacol Res 50:211-22. 2004.... - The hERG K+ channel: target and antitarget strategies in drug developmentEmanuel Raschi
Department of Pharmacology, University of Bologna, Via Irnerio, 48, I 40126 Bologna BO, Bologna, Italy
Pharmacol Res 57:181-95. 2008..g. neurons, smooth muscle and cancer cells) may have far reaching implications for drug development for a possible exploitation of hERG as a target, especially in oncology and cardiology... - The beta3-adrenoceptor as a therapeutic target: current perspectivesMaria Grazia Ursino
Department of Pharmacology, University of Bologna, Via Irnerio, 48, I 40126 Bologna, Italy
Pharmacol Res 59:221-34. 2009..The aim of this review is to highlight the functional role of beta(3)-ARs as well as to discuss their potential for drug development... - Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndromeCesare Cremon
Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
Am J Gastroenterol 106:1290-8. 2011.... - A 3 year survey on the use of antibacterial agents in five Italian hospitalsAlberto Vaccheri
Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
J Antimicrob Chemother 61:953-8. 2008..We investigated the pattern of antibiotic consumption in 2002-04 in a sample of Italian hospitals, and compared this with antibiotic consumption data in primary healthcare in the Emilia-Romagna region... - Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmiaAntonio Drago
Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli, 5, 40123 Bologna BO, Italy
Curr Med Chem 15:2472-517. 2008..The selected variants, both mutations and polymorphisms, may help in defining a next-to-come genetic assessment to be performed before drug prescription in order to improve drug safety... - Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockersAndrea Cavalli
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy
J Med Chem 45:3844-53. 2002..This in silico tool might be useful in the design of new drug candidates devoid of the physicochemical features likely to cause the above-mentioned side effect... - hERG-related drug toxicity and models for predicting hERG liability and QT prolongationEmanuel Raschi
University of Bologna, Department of Pharmacology, Italy
Expert Opin Drug Metab Toxicol 5:1005-21. 2009..Therefore, a number of preclinical models have been developed to predict hERG liability early in the drug development process... - Role of drugs and devices in patients at risk of sudden cardiac deathGiuseppe Boriani
Institute of Cardiology, University of Bologna, Azienda Ospedaliera S Orsola Malpighi, Bologna, Italy Department of Pharmacology, University of Bologna, Bologna, Italy
Fundam Clin Pharmacol 24:575-94. 2010.... - Targeting the arrhythmogenic substrate in atrial fibrillation: focus on structural remodelingEmanuel Raschi
Department of Pharmacology, University of Bologna, Bologna, Italy
Curr Drug Targets 12:263-86. 2011..g., miRNAs modulation), but the actual benefit is debated. This review will provide mechanistic insights into structural remodeling and highlight emerging upstream strategies in AF management... - Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three casesRoberto De Giorgio
Department of Internal Medicine, University of Bologna, Italy
Am J Gastroenterol 97:2454-9. 2002..The immunosuppressive approach deserves further investigation in patients with severe gut motor abnormalities attributable to idiopathic myenteric ganglionitis... - Effects of the non-peptidyl low molecular weight radical scavenger IAC in DNBS-induced colitis in ratsValentina Vasina
Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Eur J Pharmacol 614:137-45. 2009..The antioxidant IAC significantly ameliorates experimental colitis in rats. This strengthens the notion that antioxidant compounds may have therapeutic potential in inflammatory bowel disease... - Therapeutic innovation in the European Union: analysis of the drugs approved by the EMEA between 1995 and 2003Domenico Motola
Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
Br J Clin Pharmacol 59:475-8. 2005..Most (80%) of the EMEA-approved therapeutic agents were for serious diseases. The remaining ones were for risk factors (7%) or nonserious diseases (13%)... - Portal hypertension and liver cirrhosis in rats: effect of the β3-adrenoceptor agonist SR58611AValentina Vasina
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
Br J Pharmacol 167:1137-47. 2012..We aimed to assess the effect of pharmacological modulation of β(3) -adrenoceptors on portal pressure (PP) and systemic haemodynamics and their expression in the liver and mesenteric vessels of cirrhotic rats... - Profile of atypical-antipsychotics use in patients affected by dementia in the University Hospital of FerraraGiacomo Chiabrando
S Orsola University Hospital, Bologna, Italy
Eur J Clin Pharmacol 66:661-9. 2010..This study aimed to analyze the prescriptive profile of AAs in patients with dementia, in terms of the choice of active substance and of the clinical characteristics of the patients...