Fabrizio De Ponti

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi request reprint Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, and Ahterosclerosis and Metabolic Diseases Study Centre, G Descovich, Department of Clinical Medicine and Applied Biotechnology D Campanacci, S Orsola Malpighi University Hospital, Bologna, Italy
    Eur J Clin Pharmacol 64:425-32. 2008
  2. ncbi request reprint QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience
    F De Ponti
    Department of Pharmacology, University of Bologna and Interuniversity Research Centre for Pharmacoepidemiology, Italy
    Eur J Clin Pharmacol 56:1-18. 2000
  3. ncbi request reprint Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Via Irnerio 48, I 40126 Bologna, Italy
    Am J Physiol Gastrointest Liver Physiol 285:G96-104. 2003
  4. pmc Non-antiarrhythmic drugs prolonging the QT interval: considerable use in seven countries
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 54:171-7. 2002
  5. ncbi request reprint Methylnaltrexone Progenics
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Curr Opin Investig Drugs 3:614-20. 2002
  6. ncbi request reprint Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 25:263-86. 2002
  7. ncbi request reprint Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon
    F De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 13:543-53. 2001
  8. ncbi request reprint [Physiopathology of the enteric nervous system: recent advances and clinical implications]
    Fabrizio De Ponti
    Dipartimento di Farmacologia, Universita, Bologna
    Recenti Prog Med 93:40-4. 2002
  9. ncbi request reprint Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus
    F De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Eur J Clin Pharmacol 57:185-209. 2001
  10. ncbi request reprint Irritable bowel syndrome: new agents targeting serotonin receptor subtypes
    F De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Drugs 61:317-32. 2001

Collaborators

Detail Information

Publications49

  1. doi request reprint Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, and Ahterosclerosis and Metabolic Diseases Study Centre, G Descovich, Department of Clinical Medicine and Applied Biotechnology D Campanacci, S Orsola Malpighi University Hospital, Bologna, Italy
    Eur J Clin Pharmacol 64:425-32. 2008
    ..To evaluate the pattern of use of statins in the Emilia Romagna Region, with a focus on the therapeutic regimens and the patient's risk profile as predictors of adherence to therapy...
  2. ncbi request reprint QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience
    F De Ponti
    Department of Pharmacology, University of Bologna and Interuniversity Research Centre for Pharmacoepidemiology, Italy
    Eur J Clin Pharmacol 56:1-18. 2000
    ..g. torsades de pointes) may occur, especially in case of overdosage or pharmacokinetic interactions...
  3. ncbi request reprint Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Via Irnerio 48, I 40126 Bologna, Italy
    Am J Physiol Gastrointest Liver Physiol 285:G96-104. 2003
    ..In conclusion, 5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus. An exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation...
  4. pmc Non-antiarrhythmic drugs prolonging the QT interval: considerable use in seven countries
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 54:171-7. 2002
    ..The aim of this study was to assess the relevance and the magnitude of the problem in seven countries by grouping all nonantiarrhythmic drugs according to the type of evidence on QT prolongation and analysing their sales data...
  5. ncbi request reprint Methylnaltrexone Progenics
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Curr Opin Investig Drugs 3:614-20. 2002
    ..These trials were initiated in February 2002 [440995]...
  6. ncbi request reprint Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview
    Fabrizio De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 25:263-86. 2002
    ..Therefore, the use of several models facilitates decision making and is recommended by most experts in the field...
  7. ncbi request reprint Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon
    F De Ponti
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 13:543-53. 2001
    ..Tachykininergic pathways are not involved in the ML10302-induced prokinesia in the small bowel, but they play an important role in mediating the colonic motor response to ML10302...
  8. ncbi request reprint [Physiopathology of the enteric nervous system: recent advances and clinical implications]
    Fabrizio De Ponti
    Dipartimento di Farmacologia, Universita, Bologna
    Recenti Prog Med 93:40-4. 2002
    ..The role of neurotrophins and the potential therapeutic applications are also briefly discussed...
  9. ncbi request reprint Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus
    F De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Eur J Clin Pharmacol 57:185-209. 2001
    ..Second, drug-induced Torsades de Pointes are still considered idiosyncratic, totally unpredictable adverse drug reactions, whereas a number of risk factors for their occurrence is now recognised...
  10. ncbi request reprint Irritable bowel syndrome: new agents targeting serotonin receptor subtypes
    F De Ponti
    Department of Pharmacology, University of Bologna, Italy
    Drugs 61:317-32. 2001
    ....
  11. pmc Adherence to chronic cardiovascular therapies: persistence over the years and dose coverage
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 63:346-55. 2007
    ..To evaluate adherence to chronic cardiovascular drug treatments, in terms of long-term persistence and dose coverage...
  12. ncbi request reprint Gastro-intestinal problems and concomitant medication in NSAID users: additional findings from a questionnaire-based survey in Italy
    Maria Chiara Silvani
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Eur J Clin Pharmacol 62:235-41. 2006
    ..In a previous questionnaire-based survey, we found extensive use of nonsteroidal anti-inflammatory drugs (NSAIDs) in subjects with risk factors for serious gastrointestinal complications...
  13. doi request reprint Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden
    Carlo Piccinni
    Department of Medical and Surgical Sciences, University of Bologna, Via Irnerio, 48, I 40126 Bologna, BO, Italy
    Eur J Clin Pharmacol 69:715-20. 2013
    ..Our aim was to evaluate whether dronedarone authorization impacts antiarrhythmic drug prescribing in Sweden and Emilia Romagna (Italy)...
  14. pmc An update on the first decade of the European centralized procedure: how many innovative drugs?
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 62:610-6. 2006
    ..nonbiotechnological agents in the first decade of European Medicines Agency activity, also studying a possible time trend...
  15. ncbi request reprint Enteric neuroplasticity evoked by inflammation
    Valentina Vasina
    Department of Pharmacology, University of Bologna, St Orsola Malpighi Hospital, Italy
    Auton Neurosci 126:264-72. 2006
    ..A better comprehension of ENS plasticity during inflammation could be instrumental to develop new therapeutic options for patients with IBD and inflammatory enteric neuropathies...
  16. ncbi request reprint QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development
    Maurizio Recanatini
    Department of Pharmaceutical Sciences, Via Belmeloro 6, University of Bologna, I 40126 Bologna, Italy
    Med Res Rev 25:133-66. 2005
    ..In particular, it will focus on the approaches recently proposed for the in silico screening of new compounds...
  17. doi request reprint Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS)
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Pharmacoepidemiol Drug Saf 18:512-8. 2009
    ..To investigate spontaneous reports of TdP present in the public version of the FDA Adverse Event Reporting System (AERS) in the light of what is already known on their TdP-liability...
  18. pmc Non-peptidyl low molecular weight radical scavenger IAC attenuates DSS-induced colitis in rats
    Valentina Vasina
    Department of Pharmacology, University of Bologna, Bologna, Italy
    World J Gastroenterol 16:3642-50. 2010
    ..To investigate the effects of the free radical scavenger bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioate (IAC) in the dextran sodium sulphate (DSS) experimental model of ulcerative colitis...
  19. ncbi request reprint Prokinetics in the treatment of acute intestinal pseudo-obstruction
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I 40138, Italy
    IDrugs 7:160-5. 2004
    ..New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome...
  20. doi request reprint Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 33:303-14. 2010
    ..In this context, the US FDA Adverse Event Reporting System (AERS) is an important source of information, which can be applied to the analysis of TdP liability of marketed drugs...
  21. doi request reprint Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats
    Maria Grazia Ursino
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Eur J Pharmacol 603:133-7. 2009
    ..These results suggest a role for NK(1) receptors and substance P in the development of intestinal inflammation and indicate tachykinin receptors as a potential pharmacological target in the treatment of inflammatory bowel disease...
  22. doi request reprint Anticancer drugs and cardiotoxicity: Insights and perspectives in the era of targeted therapy
    Emanuel Raschi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Pharmacol Ther 125:196-218. 2010
    ..e. the unwanted target causing heart damage) and the development of guidelines to monitor patients undergoing treatment with cardiotoxic agents appear to constitute the basis for the management of drug-induced cardiotoxicity...
  23. ncbi request reprint Initial treatment of hypertension and adherence to therapy in general practice in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Eur J Clin Pharmacol 61:603-9. 2005
    ..The approach to the pharmacological treatment of hypertension is guided by international recommendations and adherence to treatment is known to result in effective prevention of cardiovascular risk...
  24. ncbi request reprint Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Gastroenterology 125:70-9. 2003
    ....
  25. doi request reprint Cardiovascular events in statin recipients: impact of adherence to treatment in a 3-year record linkage study
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Eur J Clin Pharmacol 67:407-14. 2011
    ..This study aimed to evaluate the occurrence of cardiovascular events in Italian statin recipients, focussing on the relationship between degree of adherence to therapy and occurrence of events in a 3-year follow-up...
  26. pmc Exposure to antibacterial agents with QT liability in 14 European countries: trends over an 8-year period
    Emanuel Raschi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 67:88-98. 2009
    ..i) To classify antibacterial agents with QT liability on the basis of the available evidence, and (ii) to assess trends in their consumption over an 8-year period (1998-2005) in 14 European countries...
  27. ncbi request reprint Pattern of NSAID use in the Italian general population: a questionnaire-based survey
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, BO, Italy
    Eur J Clin Pharmacol 60:731-8. 2004
    ..A detailed knowledge of the pattern of use of NSAIDs may help doctors in advising their patients about appropriateness and safety of use...
  28. doi request reprint Cardiovascular toxicity of anticancer-targeted therapy: emerging issues in the era of cardio-oncology
    Emanuel Raschi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, BO, Italy
    Intern Emerg Med 7:113-31. 2012
    ..detection, treatment, monitoring and reporting of cardiovascular side effects). In this scenario, onco-vigilance (i.e., pharmacovigilance oriented to oncologic drugs) is emerging as a key to support cardio-oncologists inappropriateness...
  29. ncbi request reprint Antibacterial macrolides: a drug class with a complex pharmacological profile
    Eman Abu-Gharbieh
    Department of Pharmacology, University of Bologna, Via Irnerio, 48, I 40126 Bologna, Italy
    Pharmacol Res 50:211-22. 2004
    ....
  30. doi request reprint Excipients in medicinal products used in gastroenterology as a possible cause of side effects
    Maria Grazia Ursino
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Regul Toxicol Pharmacol 60:93-105. 2011
    ..The availability of alternative products of the same therapeutic class, but lacking specific excipient(s) should be considered in selected patients...
  31. ncbi request reprint New developments in the treatment of functional dyspepsia
    Vincenzo Stanghellini
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Drugs 63:869-92. 2003
    ..e., P2X2/3 receptors), NMDA receptors (NR2B subtype), protease-activated receptor-2, the vanilloid receptor-1, tachykinin receptors (NK(1)/NK(2)) and cholecystokinin (CCK)(1) receptors...
  32. ncbi request reprint Prescriptions of antidepressants in primary care in Italy: pattern of use after admission of selective serotonin reuptake inhibitors for reimbursement
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna BO, Italy
    Eur J Clin Pharmacol 59:825-31. 2004
    ..Italy is reported to have a relatively low consumption of antidepressants. This is probably due to the fact that until 2000 antidepressants were reimbursed with some restrictions...
  33. doi request reprint The hERG K+ channel: target and antitarget strategies in drug development
    Emanuel Raschi
    Department of Pharmacology, University of Bologna, Via Irnerio, 48, I 40126 Bologna BO, Bologna, Italy
    Pharmacol Res 57:181-95. 2008
    ..g. neurons, smooth muscle and cancer cells) may have far reaching implications for drug development for a possible exploitation of hERG as a target, especially in oncology and cardiology...
  34. ncbi request reprint Inflammatory neuropathies of the enteric nervous system
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 126:1872-83. 2004
    ....
  35. doi request reprint The beta3-adrenoceptor as a therapeutic target: current perspectives
    Maria Grazia Ursino
    Department of Pharmacology, University of Bologna, Via Irnerio, 48, I 40126 Bologna, Italy
    Pharmacol Res 59:221-34. 2009
    ..The aim of this review is to highlight the functional role of beta(3)-ARs as well as to discuss their potential for drug development...
  36. doi request reprint Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    Cesare Cremon
    Department of Clinical Medicine and Center for Applied Biomedical Research, University of Bologna, Bologna, Italy
    Am J Gastroenterol 106:1290-8. 2011
    ....
  37. doi request reprint A 3 year survey on the use of antibacterial agents in five Italian hospitals
    Alberto Vaccheri
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    J Antimicrob Chemother 61:953-8. 2008
    ..We investigated the pattern of antibiotic consumption in 2002-04 in a sample of Italian hospitals, and compared this with antibiotic consumption data in primary healthcare in the Emilia-Romagna region...
  38. pmc Antipsychotics and Torsadogenic risk: signals emerging from the US FDA Adverse Event Reporting System Database
    Elisabetta Poluzzi
    Department of Medical and Surgical Sciences, Pharmacology Unit, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Drug Saf 36:467-79. 2013
    ..Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden...
  39. ncbi request reprint Strategy for a genetic assessment of antipsychotic and antidepressant-related proarrhythmia
    Antonio Drago
    Institute of Psychiatry, University of Bologna, Viale Carlo Pepoli, 5, 40123 Bologna BO, Italy
    Curr Med Chem 15:2472-517. 2008
    ..The selected variants, both mutations and polymorphisms, may help in defining a next-to-come genetic assessment to be performed before drug prescription in order to improve drug safety...
  40. doi request reprint hERG-related drug toxicity and models for predicting hERG liability and QT prolongation
    Emanuel Raschi
    University of Bologna, Department of Pharmacology, Italy
    Expert Opin Drug Metab Toxicol 5:1005-21. 2009
    ..Therefore, a number of preclinical models have been developed to predict hERG liability early in the drug development process...
  41. ncbi request reprint Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers
    Andrea Cavalli
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    J Med Chem 45:3844-53. 2002
    ..This in silico tool might be useful in the design of new drug candidates devoid of the physicochemical features likely to cause the above-mentioned side effect...
  42. doi request reprint Animal models of chemically induced intestinal inflammation: predictivity and ethical issues
    Giovanni Dothel
    Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Pharmacol Ther 139:71-86. 2013
    ....
  43. ncbi request reprint Clinical and morphofunctional features of idiopathic myenteric ganglionitis underlying severe intestinal motor dysfunction: a study of three cases
    Roberto De Giorgio
    Department of Internal Medicine, University of Bologna, Italy
    Am J Gastroenterol 97:2454-9. 2002
    ..The immunosuppressive approach deserves further investigation in patients with severe gut motor abnormalities attributable to idiopathic myenteric ganglionitis...
  44. doi request reprint Role of drugs and devices in patients at risk of sudden cardiac death
    Giuseppe Boriani
    Institute of Cardiology, University of Bologna, Azienda Ospedaliera S Orsola Malpighi, Bologna, Italy Department of Pharmacology, University of Bologna, Bologna, Italy
    Fundam Clin Pharmacol 24:575-94. 2010
    ....
  45. pmc Therapeutic innovation in the European Union: analysis of the drugs approved by the EMEA between 1995 and 2003
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 59:475-8. 2005
    ..Most (80%) of the EMEA-approved therapeutic agents were for serious diseases. The remaining ones were for risk factors (7%) or nonserious diseases (13%)...
  46. doi request reprint Effects of the non-peptidyl low molecular weight radical scavenger IAC in DNBS-induced colitis in rats
    Valentina Vasina
    Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Eur J Pharmacol 614:137-45. 2009
    ..The antioxidant IAC significantly ameliorates experimental colitis in rats. This strengthens the notion that antioxidant compounds may have therapeutic potential in inflammatory bowel disease...
  47. ncbi request reprint Targeting the arrhythmogenic substrate in atrial fibrillation: focus on structural remodeling
    Emanuel Raschi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Curr Drug Targets 12:263-86. 2011
    ..g., miRNAs modulation), but the actual benefit is debated. This review will provide mechanistic insights into structural remodeling and highlight emerging upstream strategies in AF management...
  48. pmc Portal hypertension and liver cirrhosis in rats: effect of the β3-adrenoceptor agonist SR58611A
    Valentina Vasina
    Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
    Br J Pharmacol 167:1137-47. 2012
    ..We aimed to assess the effect of pharmacological modulation of β(3) -adrenoceptors on portal pressure (PP) and systemic haemodynamics and their expression in the liver and mesenteric vessels of cirrhotic rats...
  49. doi request reprint Profile of atypical-antipsychotics use in patients affected by dementia in the University Hospital of Ferrara
    Giacomo Chiabrando
    S Orsola University Hospital, Bologna, Italy
    Eur J Clin Pharmacol 66:661-9. 2010
    ..This study aimed to analyze the prescriptive profile of AAs in patients with dementia, in terms of the choice of active substance and of the clinical characteristics of the patients...