Franco Dammacco

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term study
    Franco Dammacco
    Sections of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Blood 116:343-53. 2010
  2. doi request reprint [Internal medicine and the holistic approach to the patient between globalization and advanced technologies]
    Franco Dammacco
    Dipartimento di Scienze Biomediche e Oncologia Umana, Università Aldo Moro, Bari
    Recenti Prog Med 103:248-55. 2012
  3. doi request reprint Pentraxin 3 (PTX3) inhibits plasma cell/stromal cell cross-talk in the bone marrow of multiple myeloma patients
    Antonio Basile
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    J Pathol 229:87-98. 2013
  4. doi request reprint Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma
    Michele Moschetta
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Italy
    Eur J Cancer 46:420-9. 2010
  5. ncbi request reprint A VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine and Clinical Oncology, Piazza Giulio Cesare, 11, Policlinico, I 70124, Bari, Italy
    Thromb Haemost 92:1438-45. 2004
  6. pmc Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma
    Vito Racanelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 115:1185-93. 2010
  7. ncbi request reprint Two structurally different rituximab-specific CD20 mimotope peptides reveal that rituximab recognizes two different CD20-associated epitopes
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 182:416-23. 2009
  8. doi request reprint The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead box E3 (FOXE3)
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology DIMO, University of Bari Medical School, Bari, Italy
    Clin Immunol 137:60-73. 2010
  9. doi request reprint Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitro
    Marco Tucci
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, Bari, Italy
    Exp Hematol 39:773-83.e1. 2011
  10. ncbi request reprint Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma
    Claudio Scavelli
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Mol Cancer Ther 6:3256-62. 2007

Collaborators

Detail Information

Publications76

  1. ncbi request reprint Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term study
    Franco Dammacco
    Sections of Internal Medicine and Clinical Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Blood 116:343-53. 2010
    ..No response occurred in remaining 5 patients of both groups. PIRR therapy is well tolerated and more effective than Peg-IFN-alpha/RBV combination in HCV-related MC. Its effect may last for more than 3 years...
  2. doi request reprint [Internal medicine and the holistic approach to the patient between globalization and advanced technologies]
    Franco Dammacco
    Dipartimento di Scienze Biomediche e Oncologia Umana, Università Aldo Moro, Bari
    Recenti Prog Med 103:248-55. 2012
    ..Indeed, familism, nepotism, unfairness, inefficiency and comparative evaluations marked by an excess of local factors have inevitably caused merciless and often deserved criticism that has been extensively debated in several monographs...
  3. doi request reprint Pentraxin 3 (PTX3) inhibits plasma cell/stromal cell cross-talk in the bone marrow of multiple myeloma patients
    Antonio Basile
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    J Pathol 229:87-98. 2013
    ..We conclude that PTX3 is an anti-angiogenic factor in MM and behaves as a cytotoxic molecule on MM cells by inhibiting the cross-talk between PCs and ECs/FBs...
  4. doi request reprint Bortezomib and zoledronic acid on angiogenic and vasculogenic activities of bone marrow macrophages in patients with multiple myeloma
    Michele Moschetta
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Italy
    Eur J Cancer 46:420-9. 2010
    ....
  5. ncbi request reprint A VEGF-dependent autocrine loop mediates proliferation and capillarogenesis in bone marrow endothelial cells of patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine and Clinical Oncology, Piazza Giulio Cesare, 11, Policlinico, I 70124, Bari, Italy
    Thromb Haemost 92:1438-45. 2004
    ..Since this is very likely a mechanism for the amplification of VEGF activity in neovascularization, it would constitute an appropriate target for antiangiogenic management in MM...
  6. pmc Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma
    Vito Racanelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 115:1185-93. 2010
    ..APM changes may allow transformed plasma cells to elude immunesurveillance in the MGUS-MM pathogenetic sequence...
  7. ncbi request reprint Two structurally different rituximab-specific CD20 mimotope peptides reveal that rituximab recognizes two different CD20-associated epitopes
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 182:416-23. 2009
    ..Altogether, these results indicate that the two structurally different peptides are also conformationally different, and suggest that rituximab recognizes two different CD20-associated epitopes...
  8. doi request reprint The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead box E3 (FOXE3)
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology DIMO, University of Bari Medical School, Bari, Italy
    Clin Immunol 137:60-73. 2010
    ..This study sets the ground for future investigations on a possible relationship between antibody specificity and clinical manifestations of systemic sclerosis, as well as on a possible role of FOXE3 in priming these antibodies...
  9. doi request reprint Immature dendritic cells from patients with multiple myeloma are prone to osteoclast differentiation in vitro
    Marco Tucci
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, Bari, Italy
    Exp Hematol 39:773-83.e1. 2011
    ..Here, we investigated these interactions as well as iDC behavior in terms of both migration and OC differentiation...
  10. ncbi request reprint Zoledronic acid affects over-angiogenic phenotype of endothelial cells in patients with multiple myeloma
    Claudio Scavelli
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Mol Cancer Ther 6:3256-62. 2007
    ..Tentatively, we suggest that the zoledronic acid antitumoral activity in multiple myeloma is also sustained by antiangiogenesis, which would partly account for its therapeutic efficacy in multiple myeloma...
  11. pmc Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    J Immunol 183:6013-20. 2009
    ....
  12. doi request reprint Constitutive down-regulation of Osterix in osteoblasts from myeloma patients: in vitro effect of Bortezomib and Lenalidomide
    Monica De Matteo
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza Giulio Cesare 11, 70124, Bari, Italy
    Leuk Res 34:243-9. 2010
    ..Instead, Lenalidomide was unable to modify Osterix transcription. These findings provide additional evidence suggesting that, at least in vitro, Bortezomib promotes the osteoblast maturation whereas Lenalidomide is ineffective...
  13. ncbi request reprint Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma
    Angelo Vacca
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 108:1661-7. 2006
    ..Our data indicate that loss of endothelial SEMA3A in favor of VEGF165 could be responsible for the angiogenic switch from MGUS to MM...
  14. doi request reprint Endothelial differentiation of hematopoietic stem and progenitor cells from patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine, University of Bari Medical School, Bari, Italy
    Clin Cancer Res 14:1678-85. 2008
    ..Here, we show that hematopoietic stem and progenitor cells (HSPC) of multiple myeloma (MM) patients are able to differentiate into cells with endothelial phenotype on exposure to angiogenic cytokines...
  15. ncbi request reprint Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1620-7. 2008
    ..Higher levels of this chemokine in the liver as well as in the skin of patients with active MC vasculitis suggest a possible interrelation between these biologic compartments...
  16. doi request reprint Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma
    Annunziata De Luisi
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Cancer Res 17:1935-46. 2011
    ..To determine the in vivo and in vitro antiangiogenic power of lenalidomide, a "lead compound" of IMiD immunomodulatory drugs in bone marrow (BM) endothelial cells (EC) of patients with multiple myeloma (MM) in active phase (MMEC)...
  17. ncbi request reprint Generation of biologically active linear and cyclic peptides has revealed a unique fine specificity of rituximab and its possible cross-reactivity with acid sphingomyelinase-like phosphodiesterase 3b precursor
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology DIMO, University of Bari Medical School, Bari, Italy
    Blood 107:1070-7. 2006
    ..A possible rituximab interaction with ASMLPD is suggested...
  18. ncbi request reprint Functional osteoclast-like transformation of cultured human myeloma cell lines
    Nicola Calvani
    Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Br J Haematol 130:926-38. 2005
    ..Resorption of bone substrates was prevented by a neutralising anti-RANK-L antibody. Our data indicate that osteoclast-like transformation of both U-266 and MCC-2 cellular models of human myeloma is dependent on RANK-L stimulation...
  19. ncbi request reprint Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells
    Franco Silvestris
    Department of Internal Medicine and Oncology, University of Bari, Bari, Italy
    Br J Haematol 126:475-86. 2004
    ....
  20. doi request reprint Immature dendritic cells in multiple myeloma are prone to osteoclast-like differentiation through interleukin-17A stimulation
    Marco Tucci
    Department of Biomedical Science and Clinical Oncology, University of Bari Aldo Moro, Piazza Giulio Cesare, Bari, Italy
    Br J Haematol 161:821-31. 2013
    ..These data emphasize the involvement of iDCs in MM hyperactive osteoclastogenesis and suggest that their bone resorption activity is also regulated, at least in vitro, by IL17RA...
  21. doi request reprint Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells
    Franco Silvestris
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza Giulio Cesare 11, Bari, Italy
    Clin Cancer Res 14:6081-91. 2008
    ..To explore the pathogenetic mechanisms that suppress the osteoblast function in multiple myeloma because osteogenesis results in defective new bone formation and repair...
  22. doi request reprint Serum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Clin Exp Med 8:141-5. 2008
    ....
  23. doi request reprint Oversecretion of cytokines and chemokines in lupus nephritis is regulated by intraparenchymal dendritic cells: a review
    Marco Tucci
    Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1173:449-57. 2009
    ..Therefore, the depletion of DCs reflects the inflammation severity in LN, whereas measurement of Th1 cytokines may represent an effective tool for monitoring the onset of LN...
  24. doi request reprint Cancer-related coagulopathy (Trousseau's syndrome): review of the literature and experience of a single center of internal medicine
    Franco Dammacco
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, 11 Piazza G Cesare, 70124 Bari, Italy
    Clin Exp Med 13:85-97. 2013
    ..The main features of VTE based on our own observations of 92 cancer patients and 159 patients with non-neoplastic disease are briefly described herein...
  25. ncbi request reprint Cell fusion in myeloma marrow microenvironment: role in tumor progression
    Mauro Cives
    Department of Internal Medicine and Oncology, Section of Clinical Oncology, University of Bari A Moro, Bari, Italy
    Crit Rev Oncog 18:75-95. 2013
    ....
  26. pmc Transarterial chemoembolization plus sorafenib: a sequential therapeutic scheme for HCV-related intermediate-stage hepatocellular carcinoma: a randomized clinical trial
    Domenico Sansonno
    Liver Unit, Department of Internal Medicine and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Oncologist 17:359-66. 2012
    ....
  27. doi request reprint Bone-resorbing cells in multiple myeloma: osteoclasts, myeloma cell polykaryons, or both?
    Franco Silvestris
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Oncologist 14:264-75. 2009
    ....
  28. pmc Neutropenia and G-CSF in lymphoproliferative diseases
    Roberto Ria
    University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, Bari, Italy
    Hematology 18:131-7. 2013
    ..However, a better knowledge of the incidence, day of onset after therapy, and duration of neutropenia is essential to optimize the use of G-CSF...
  29. doi request reprint MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells
    Patrizia Leone
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Natl Cancer Inst 105:1172-87. 2013
    ..Detailed knowledge of APM is crucial for the optimization of T cell-based immunotherapy protocols. ..
  30. ncbi request reprint Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease
    Franco Silvestris
    Department of Internal Medicine and Oncology DIMO, University of Bari, Bari, Italy
    Br J Haematol 122:39-52. 2003
    ..It is suggested that this cytotoxic effect plays a pivotal role in the pathogenesis of defective bone repair...
  31. doi request reprint Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma
    Roberto Ria
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Clin Cancer Res 15:5369-78. 2009
    ..To determine a "gene/molecular fingerprint" of multiple myeloma endothelial cells and identify vascular mechanisms governing the malignant progression from quiescent monoclonal gammopathy of undetermined significance...
  32. doi request reprint Cell fusion and hyperactive osteoclastogenesis in multiple myeloma
    Franco Silvestris
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, 70124, Bari, Italy
    Adv Exp Med Biol 714:113-28. 2011
    ....
  33. ncbi request reprint Osteoclast-like cell formation by circulating myeloma B lymphocytes: role of RANK-L
    Nicola Calvani
    DIMO, Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Piazza G Cesare, 11 70124 Bari, Italy
    Leuk Lymphoma 45:377-80. 2004
    ..Clonotypic B lymphocytes may contribute to the pathogenesis of bone disease in MM by acting as RANK-L-dependent osteoclast progenitors...
  34. ncbi request reprint Identification of an antigenic and immunogenic motif expressed by two 7-mer rituximab-specific cyclic peptide mimotopes: implication for peptide-based active immunotherapy
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 179:7967-74. 2007
    ..They also suggest strategies to implement the specificity of peptide-induced Abs against the target Ag...
  35. ncbi request reprint Intrahepatic B cell clonal expansions and extrahepatic manifestations of chronic HCV infection
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Eur J Immunol 34:126-36. 2004
    ..These findings emphasize the profound B cell function derangement in at least half of HCV-infected patients. Thus, the restriction of V gene usage has a direct impact on the clinical spectrum of HCV infection...
  36. ncbi request reprint Loss of bone mineral density and secondary hyperparathyroidism are complications of autologous stem cell transplantation
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Leuk Lymphoma 48:923-30. 2007
    ....
  37. doi request reprint Interleukin 28B gene polymorphisms in hepatitis C virus-related cryoglobulinemic vasculitis
    Domenico Sansonno
    From the Section of Internal Medicine and Clinical Oncology, Laboratory of General Pathology and Experimental Oncology, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari Section of Internal Medicine, Department of Medical Sciences, and Section of Medical Genetics, Department of Biomedical Sciences, University of Foggia, Foggia, Italy
    J Rheumatol 41:91-8. 2014
    ..We also searched for their association with peculiar clinical manifestations of CV and potential influence on the complete response (virological, molecular, and immunological) to the therapy...
  38. doi request reprint Umbilical cord mesenchymal stem cells: role of regulatory genes in their differentiation to osteoblasts
    Sabino Ciavarella
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza Giulio Cesare 11, Bari, Italy
    Stem Cells Dev 18:1211-20. 2009
    ..They may, thus, constitute a promising option for bone remodeling in regenerative medicine...
  39. pmc Antibody V(h) repertoire differences between resolving and chronically evolving hepatitis C virus infections
    Vito Racanelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    PLoS ONE 6:e25606. 2011
    ....
  40. doi request reprint Biological functions and therapeutic use of erythropoiesis-stimulating agents: perplexities and perspectives
    Francesca Merchionne
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari 70124, Italy
    Br J Haematol 146:127-41. 2009
    ..While these findings offer new perspectives, they nonetheless demand caution in the employment of ESAs. Further, well-designed experimental and clinical studies are warranted...
  41. ncbi request reprint CXCR3-binding chemokines in multiple myeloma
    Antonio Pellegrino
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari I 70124, Italy
    Cancer Lett 207:221-7. 2004
    ..Data suggest that CXCR3/chemokine loop may be important for progression of MM in terms of intramedullary and extramedullary dissemination...
  42. ncbi request reprint HCV-associated B cell clonalities in the liver do not carry the t(14;18) chromosomal translocation
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Hepatology 42:1019-27. 2005
    ..Liver overexpression of Bcl-2 protein may occur in at least a minor proportion of HCV-infected patients...
  43. ncbi request reprint CD20: a target antigen for immunotherapy of autoimmune diseases
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Autoimmun Rev 4:526-31. 2005
    ..Active immunotherapy is a more feasible way to control these chronic diseases. A peptide that mimics the CD20 epitope recognized by Rituximab is employed to stimulate the host immune response against CD20...
  44. ncbi request reprint Bone marrow of persistently hepatitis C virus-infected individuals accumulates memory CD8+ T cells specific for current and historical viral antigens: a study in patients with benign hematological disorders
    Vito Racanelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 179:5387-98. 2007
    ..These findings provide a snapshot view of the distribution, differentiation, and functioning of virus-specific memory T cells in patients with persistent HCV infection...
  45. ncbi request reprint CD20 mimicry by a mAb rituximab-specific linear peptide: a potential tool for active immunotherapy of autoimmune diseases
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology DIMO, University of Bari Medical School, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Ann N Y Acad Sci 1051:672-83. 2005
    ..This peptide is currently being investigated to determine the effectiveness of CD20-based active IT for the treatment of autoimmune diseases...
  46. doi request reprint Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib
    Addolorata Maria Luce Coluccia
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 112:1346-56. 2008
    ..Overall data highlight the biologic and therapeutic relevance of the combined targeting of PDGFRbeta/c-Src TKs in MM, providing a framework for future clinical trials...
  47. ncbi request reprint Angiogenesis and anti-angiogenesis in hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy
    Cancer Treat Rev 32:437-44. 2006
    ..Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed...
  48. doi request reprint HIF-1α of bone marrow endothelial cells implies relapse and drug resistance in patients with multiple myeloma and may act as a therapeutic target
    Roberto Ria
    Authors Affiliations Section of Internal Medicine, Department of Biomedical Sciences and Human Oncology Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy, National Cancer Institute Giovanni Paolo II, Bari, Italy Department of Human Anatomy, Histology and Embryology, and Pathological Anatomy, University of Bari Medical School Hematology Unit, Istituto di Ricerca e Cura a Carattere Scientifico IRCCS Oncologic Hospital Laboratory of Preclinical and Translational Research, IRCCS Basilicata Cancer Reference Centre, Potenza Department of Clinical and Experimental Medicine, University of Foggia Medical School, Foggia Hematology Unit, Ospedale Di Venere, Carbonara di Bari, Bari and Department of Haematology, Businco Hospital, Cagliari, Italy
    Clin Cancer Res 20:847-58. 2014
    ..To investigate the role of hypoxia-inducible factor-1α (HIF-1α) in angiogenesis and drug resistance of bone marrow endothelial cells of patients with multiple myeloma...
  49. doi request reprint Functional expression of the calcitonin receptor by human T and B cells
    Paola Cafforio
    Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Hum Immunol 70:678-85. 2009
    ..We therefore suppose that expression of this functional receptor may contribute to the modulation of cytoplasmic calcium(2+) levels needed to regulate T and B cell activation and perhaps other immune functions...
  50. doi request reprint Extra-articular manifestations of rheumatoid arthritis: An update
    Marcella Prete
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza G Cesare 11, Bari, Italy
    Autoimmun Rev 11:123-31. 2011
    ..Understanding the complexity of EAM and their management remains a challenge for clinicians, especially since the effectiveness of drug therapy on EAM has not been systematically evaluated in randomized clinical trials...
  51. ncbi request reprint Antiangiogenesis for rheumatoid arthritis
    Aldo M Roccaro
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, I 70124 Bari, Italy
    Curr Drug Targets Inflamm Allergy 4:27-30. 2005
    ..This view is supported by recent studies in animal models of arthritis where antiangiogenic drugs deliver a therapeutic benefit...
  52. doi request reprint Staging multiple myeloma patients with active disease using serum levels of beta2m-free HLA class I heavy chain together with IgM or platelet count
    Federico Perosa
    Department of Internal Medicine and Clinical Oncology DIMO, University of Bari Medical School, Bari, Italy
    Blood Cells Mol Dis 42:71-6. 2009
    ..We investigated the possibility of stratifying patients with active disease according to FHC and other clinical parameters...
  53. ncbi request reprint Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon alpha with an anti-CD20
    Domenico Sansonno
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Blood 101:3818-26. 2003
    ..However, in view of the increased viremia in the responders, additional modes of application and combination of rituximab with other agents need to be investigated...
  54. doi request reprint Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18
    Marco Tucci
    University of Bari, Bari, Italy
    Arthritis Rheum 58:251-62. 2008
    ..We investigated the potential role of interleukin-18 (IL-18) in driving the glomerular migration of DCs in lupus nephritis (LN) and in affecting the ability of DCs to induce an imbalance in the Th1:Th2 ratio...
  55. doi request reprint Goodpasture's disease: a report of ten cases and a review of the literature
    Franco Dammacco
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Autoimmun Rev 12:1101-8. 2013
    ....
  56. pmc A retrospective study of skeletal and disease-free survival benefits of zoledronic acid therapy in patients with multiple myeloma treated with novel agents
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School Bari, Italy
    Int J Clin Exp Med 6:30-8. 2013
    ..However, clinical data describing the combination of zoledronic acid with newer antimyeloma regimens are limited...
  57. doi request reprint H. pylori infection and gastric cancer: state of the art (review)
    Vincenza Conteduca
    Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy
    Int J Oncol 42:5-18. 2013
    ....
  58. doi request reprint Lenalidomide in multiple myeloma: current experimental and clinical data
    Mauro Cives
    Department of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, Bari, Italy
    Eur J Haematol 88:279-91. 2012
    ....
  59. ncbi request reprint Serum levels of angiogenic cytokines decrease after antineoplastic radiotherapy
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Policlinico, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Cancer Lett 216:103-7. 2004
    ..We demonstrate that levels of FGF-2 and VEGF, but not HGF, decrease significantly, and that the extent of their diminution is related to the radiation dose and response...
  60. ncbi request reprint Human CD4 mimicry by anti-idiotypic monoclonal antibody 16D7 is based on a conformational epitope
    Federico Perosa
    Department of Biomedical Sciences and Human Oncology DIMO, Section of Internal Medicine, University of Bari Medical School, Piazza G Cesare 11, 70124 Bari, Italy
    Immunol Lett 95:145-53. 2004
    ..The results suggest that CD4 mimicry by 16D7 is based on a conformational epitope and L2 is only one of the HP2/6-specific contact points of 16D7...
  61. ncbi request reprint Mixed cryoglobulinemia: a model of virus-related disease in internal medicine
    Franco Dammacco
    Department of Biomedical Seiences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical Sehool, Bari, Italy
    Dig Liver Dis 39:S8-S12. 2007
    ....
  62. doi request reprint 90Y-ibritumomab tiuxetan as consolidation therapy after autologous stem cell transplantation in aggressive non-Hodgkin lymphoma
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Nucl Med 52:891-5. 2011
    ..Targeted radioimmunotherapy with (90)Y-labeled ibritumomab tiuxetan is a novel therapeutic approach for CD20-positive relapsed or refractory non-Hodgkin lymphoma (NHL)...
  63. doi request reprint Barrett's esophagus and esophageal cancer: an overview
    Vincenza Conteduca
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Int J Oncol 41:414-24. 2012
    ..Claimed chemopreventive agents and biomarkers that in the near future may help identify people with a higher risk of EC are also considered...
  64. pmc Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules
    Vito Racanelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico 11, Piazza G Cesare, 70124 Bari, Italy
    J Virol 80:3923-34. 2006
    ....
  65. ncbi request reprint Endothelial cells in the bone marrow of patients with multiple myeloma
    Angelo Vacca
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Blood 102:3340-8. 2003
    ..In view of the heterogeneity of the antigenic phenotype of MMECs, a mixture (or a sequence) of antiangiogenic agents coupled with thalidomide would seem plausible for the biologic management of MM...
  66. ncbi request reprint Recent advances in understanding the pathogenesis of anemia in multiple myeloma
    Franco Silvestris
    DIMO, Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Int J Hematol 78:121-5. 2003
    ..This newly discovered pathogenetic mechanism of anemia in MM is based on persistent erythroblast cytotoxicity within the bone marrow that leads to progressive destruction of the erythroid matrix...
  67. doi request reprint Mesenchymal stem cells: a new promise in anticancer therapy
    Sabino Ciavarella
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 20:1-10. 2011
    ..Here, we revisit the experimental history of MSCs, the most exciting features of their biology in keeping with their promising applications in cell-based therapeutic strategies for cancer treatment...
  68. ncbi request reprint Hepatitis C virus, cryoglobulinaemia, and vasculitis: immune complex relations
    Domenico Sansonno
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Lancet Infect Dis 5:227-36. 2005
    ..Emphasis, in fact, is now placed on abatement of the viral load and deletion of B-cell clonalities...
  69. doi request reprint Novel strategies in the treatment of castration-resistant prostate cancer (Review)
    Ilaria Marech
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Int J Oncol 40:1313-20. 2012
    ..More recently, a nuclear factor-β ligand (RANKL) inhibitor, denosumab, has been developed for the treatment of bone metastases...
  70. ncbi request reprint Melphalan versus melphalan plus busulphan in conditioning to autologous stem cell transplantation for low-risk multiple myeloma
    Roberto Ria
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Hematol J 5:118-22. 2004
    ..High-dose chemotherapy conditioning regimens for autologous stem cell transplantation generally give similar results in multiple myeloma. We compared two regimens: melphalan versus melphalan plus busulphan...
  71. doi request reprint Long-term survival in multiple myeloma: a single-center experience
    Francesca Merchionne
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Piazza Giulio Cesare 11, Bari, Italy
    Clin Exp Med 8:133-9. 2008
    ..The use of prognostic factors to identify a subset of low-risk patients could be of assistance in the selection of targeted treatments and the elucidation of poorly known features of myeloma biology...
  72. ncbi request reprint Increased IL-18 production by dendritic cells in active inflammatory myopathies
    Marco Tucci
    DIMO, Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1107:184-92. 2007
    ..High concentrations of serum and muscular IL-18 suggest that deregulated IL-18/IL-18R pathway may be pathogenetic in IM and measurement of IL-18 might be predictive of the disease activity...
  73. doi request reprint Waldenström's macroglobulinemia. An overview of its clinical, biochemical, immunological and therapeutic features and our series of 121 patients collected in a single center
    Francesca Merchionne
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Italy
    Crit Rev Oncol Hematol 80:87-99. 2011
    ..We review these general features and describe our series of 121 patients with clearly established WM...
  74. ncbi request reprint Beta 2-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide
    Federico Perosa
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    J Immunol 171:1918-26. 2003
    ..This information contributes to our understanding of the molecular basis of the antigenic profiles of beta(2)m-free and beta(2)m-associated HLA-I HC and may serve to develop active specific immunotherapy of spondyloarthropathies...
  75. ncbi request reprint Upregulation of erythroblast apoptosis by malignant plasma cells: a new pathogenetic mechanism of anemia in multiple myeloma
    Franco Silvestris
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari, Italy
    Rev Clin Exp Hematol . 2002
    ..Immunophenotyping of myeloma cells could help to identify patients with a higher risk of erythropoiesis exhaustion...
  76. ncbi request reprint Angiogenesis and anti-angiogenesis in hematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    J Hematother Stem Cell Res 12:11-22. 2003
    ....