S Cuzzocrea

Summary

Affiliation: University of Messina
Country: Italy

Publications

  1. request reprint
    Cuzzocrea S, Mazzon E, Costantino G, Serraino I, De Sarro A, Caputi A. Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury. Cardiovasc Res. 2000;47:537-48 pubmed
  2. request reprint
    Cuzzocrea S, McDonald M, Mazzon E, Mota Filipe H, Lepore V, Ciccolo A, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat. Lab Invest. 2000;80:1439-53 pubmed
    ..Thus, we provide the first evidence that the tyrosine kinase inhibitor Tyrphostin AG126 reduces the degree of colitis caused by DNBS. ..
  3. request reprint
    Cuzzocrea S, McDonald M, Mazzon E, Dugo L, Serraino I, Threadgill M, et al. Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury. Biochem Pharmacol. 2002;63:293-304 pubmed
    ..These findings provide the first evidence that the activation of PARS participates in neutrophil-mediated lung injury by regulating the expression of P-selectin and ICAM-1. ..
  4. request reprint
    Cuzzocrea S, Mazzon E, Sautebin L, Dugo L, Serraino I, De Sarro A, et al. Protective effects of Celecoxib on lung injury and red blood cells modification induced by carrageenan in the rat. Biochem Pharmacol. 2002;63:785-95 pubmed
    ..Therefore, selective inhibitor of COX-2 such as Celecoxib, offers a therapeutic approach for the management of various inflammatory diseases. ..
  5. request reprint
    Cuzzocrea S, Costantino G, Mazzon E, Micali A, De Sarro A, Caputi A. Beneficial effects of melatonin in a rat model of splanchnic artery occlusion and reperfusion. J Pineal Res. 2000;28:52-63 pubmed
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    Cuzzocrea S, McDonald M, Filipe H, Costantino G, Mazzon E, Santagati S, et al. Effects of tempol, a membrane-permeable radical scavenger, in a rodent model of carrageenan-induced pleurisy. Eur J Pharmacol. 2000;390:209-22 pubmed
    ..The mechanisms of the anti-inflammatory effect of tempol are discussed. ..
  7. request reprint
    Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabro G, Serraino I, et al. 17beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy. Endocrinology. 2000;141:1455-63 pubmed
    ..We conclude that E2 attenuates the degree of inflammation and tissue damage associated with carrageenan-induced pleurisy in the rat. ..
  8. request reprint
    Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T, et al. Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J. 2001;15:1187-200 pubmed
    ..Our results clearly demonstrate that NAC treatment exerts a protective effect and clearly indicate that NAC offers a novel therapeutic approach for the management of lung injury where radicals have been postulated to play a role. ..
  9. Cuzzocrea S, Chatterjee P, Mazzon E, Dugo L, Serraino I, Britti D, et al. Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol. 2002;135:496-510 pubmed
    ..Therefore, inhibition of NF-kappaB may represent a novel approach for the therapy of inflammation. ..

More Information

Publications15

  1. Cuzzocrea S, McDonald M, Mazzon E, Siriwardena D, Calabro G, Britti D, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000;157:145-58 pubmed
  2. Cuzzocrea S, Mazzon E, Bevilaqua C, Costantino G, Britti D, Mazzullo G, et al. Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. Br J Pharmacol. 2000;131:1399-407 pubmed
    ..7. This study provides the first evidence that cloricromene, a coumarine derivative, attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in the rat. ..
  3. request reprint
    Cuzzocrea S, De Sarro G, Costantino G, Ciliberto G, Mazzon E, De Sarro A, et al. IL-6 knock-out mice exhibit resistance to splanchnic artery occlusion shock. J Leukoc Biol. 1999;66:471-80 pubmed
    ..Part of this effect may be due to inhibition of the expression of adhesion molecules and subsequent reduction of neutrophil-mediated cellular injury. ..
  4. request reprint
    Cuzzocrea S, Sautebin L, De Sarro G, Costantino G, Rombola L, Mazzon E, et al. Role of IL-6 in the pleurisy and lung injury caused by carrageenan. J Immunol. 1999;163:5094-104 pubmed
    ..Taken together, our results clearly demonstrate that IL-6KO mice are more resistant to the acute inflammation of the lung caused by carrageenan injection into the pleural space than the corresponding WT mice...
  5. Cuzzocrea S, McDonald M, Mazzon E, Siriwardena D, Serraino I, Dugo L, et al. Calpain inhibitor I reduces the development of acute and chronic inflammation. Am J Pathol. 2000;157:2065-79 pubmed
    ..Thus, prevention of the activation of calpain I reduces the development of acute and chronic inflammation. Inhibition of calpain I activity may represent a novel therapeutic approach for the therapy of inflammation. ..
  6. Cuzzocrea S, Mazzon E, Sautebin L, Serraino I, Dugo L, Calabro G, et al. The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat. Mol Med. 2001;7:478-87 pubmed
    ..Here we investigate the effects of endogenous estrogens in rats subjected to carrageenan-induced pleurisy...