Maurizio Cutolo

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint Altered neuroendocrine immune (NEI) networks in rheumatology
    Maurizio Cutolo
    University of Genova, Italy
    Ann N Y Acad Sci 966:xiii-xviii. 2002
  2. doi request reprint Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes
    Paola Montagna
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:30-5. 2010
  3. ncbi request reprint Intracellular NF-kB-decrease and IKBα increase in human macrophages following CTLA4-Ig treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:943-6. 2013
  4. doi request reprint State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology?
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    Rheumatology (Oxford) 52:1933-40. 2013
  5. doi request reprint Autoimmune polyendocrine syndromes
    Maurizio Cutolo
    Research Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova Italy, Viale Benedetto XV, 6, 16132 Genova Italy Electronic address
    Autoimmun Rev 13:85-9. 2014
  6. pmc Effect of pregnancy on serum cytokines in SLE patients
    Andrea Doria
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, Padova, 35128, Italy
    Arthritis Res Ther 14:R66. 2012
  7. ncbi request reprint Efficacy of the switch to modified-release prednisone in rheumatoid arthritis patients treated with standard glucocorticoids
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:498-505. 2013
  8. doi request reprint How to perform and interpret capillaroscopy
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine DIMI, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 27:237-48. 2013
  9. doi request reprint Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Autoimmun Rev 12:758-67. 2013
  10. doi request reprint Efficacy and safety of leflunomide in DMARD-naive patients with early rheumatoid arthritis: comparison of a loading and a fixed-dose regimen
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Rheumatology (Oxford) 52:1132-40. 2013

Detail Information

Publications143 found, 100 shown here

  1. ncbi request reprint Altered neuroendocrine immune (NEI) networks in rheumatology
    Maurizio Cutolo
    University of Genova, Italy
    Ann N Y Acad Sci 966:xiii-xviii. 2002
  2. doi request reprint Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes
    Paola Montagna
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:30-5. 2010
    ..001 vs. E2). E2 seems to contrast the LEF-M activity. These results might support a more efficient therapeutical effect of LEF in male with respect to female RA patients...
  3. ncbi request reprint Intracellular NF-kB-decrease and IKBα increase in human macrophages following CTLA4-Ig treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:943-6. 2013
    ..We investigated cytokine production and NF-kB expression following CTLA4-Ig (abatacept) treatment of cultured human macrophages...
  4. doi request reprint State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology?
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    Rheumatology (Oxford) 52:1933-40. 2013
    ..Because of its clinical and research role, eyes are geared in Europe to expand the knowledge of this tool. Both the European League Against Rheumatism (EULAR) and the ACR are stepping forward to this need. ..
  5. doi request reprint Autoimmune polyendocrine syndromes
    Maurizio Cutolo
    Research Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova Italy, Viale Benedetto XV, 6, 16132 Genova Italy Electronic address
    Autoimmun Rev 13:85-9. 2014
    ....
  6. pmc Effect of pregnancy on serum cytokines in SLE patients
    Andrea Doria
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, Padova, 35128, Italy
    Arthritis Res Ther 14:R66. 2012
    ..The aim of this study was to evaluate an extensive panel of cytokines involved in immune regulation during pregnancy in patients with systemic lupus erythematosus (SLE) and in healthy women...
  7. ncbi request reprint Efficacy of the switch to modified-release prednisone in rheumatoid arthritis patients treated with standard glucocorticoids
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:498-505. 2013
    ..Modified-release (MR) prednisone taken at bedtime (released 2am) is more effective than immediate-release (IR) GC taken in the morning...
  8. doi request reprint How to perform and interpret capillaroscopy
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine DIMI, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 27:237-48. 2013
    ..In other connective tissue diseases (CTDs) prospective clinical studies resulting in indices which can predict future clinical complications have not been published, as yet...
  9. doi request reprint Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Autoimmun Rev 12:758-67. 2013
    ..Here, we provide an overview of recent mechanistic studies of the action of CTLA-4-Ig on different cell types involved in mediating inflammation and joint damage in RA...
  10. doi request reprint Efficacy and safety of leflunomide in DMARD-naive patients with early rheumatoid arthritis: comparison of a loading and a fixed-dose regimen
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Rheumatology (Oxford) 52:1132-40. 2013
    ..To assess the efficacy of LEF administered with or without a loading dose in DMARD-naïve patients with early RA...
  11. doi request reprint Chronobiology and the treatment of rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Curr Opin Rheumatol 24:312-8. 2012
    ....
  12. doi request reprint Estrogen metabolism and autoimmunity
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Dept Internal Medicine, University of Genova Italy, Viale Benedetto XV, 6 16132 Genova, Italy
    Autoimmun Rev 11:A460-4. 2012
    ..g. macrophages and fibroblasts) represents a common pathway that characterizes a similar final immune reactivity in both male and female patients...
  13. pmc Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, and Medcare Oy, Hämeentie 1, 44100 Aanekoski, Finland
    Arthritis Res Ther 11:R7. 2009
    ....
  14. pmc Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Arthritis Res Ther 7:R1124-32. 2005
    ..Androgens were found to increase the apoptosis, and oestrogens showed a protective trend on cell death--both acting as modulators of the NF-kappaB complex...
  15. ncbi request reprint Neuroendocrine-immune interactions in synovitis
    Maurizio Cutolo
    Department of Rheumatology, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Nat Clin Pract Rheumatol 3:627-34. 2007
    ..In particular, studying neuroendocrine-immune interactions in the inflamed synovium will potentially uncover new mechanisms in the pathophysiology of rheumatoid arthritis and might lead to new methods of therapeutic intervention...
  16. ncbi request reprint Vitamin D in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Autoimmun Rev 7:59-64. 2007
    ..Recently, greater intake of vitamin D was associated with a lower risk of RA, as well as a significant clinical improvement was strongly correlated with the immunomodulating potential in vitamin D-treated RA patients...
  17. ncbi request reprint Estrogens and autoimmune diseases
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Ann N Y Acad Sci 1089:538-47. 2006
    ..e., TNF-alpha, Il-1, IL-12). In this respect, it is interesting that male patients with RA seem to profit more from anti-TNFalpha strategies than do female patients...
  18. ncbi request reprint Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe
    M Cutolo
    Division of Rheumatology Dept Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 24:702-4. 2006
    ..Greater intake of vitamin D has been associated with a lower risk of rheumatoid arthritis (RA) and low serum vitamin D together with higher prevalence of RA seem common among North European people when compared to Southern Europe...
  19. ncbi request reprint Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases. A future tool for the analysis of microvascular heart involvement?
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Rheumatology (Oxford) 45:iv43-6. 2006
    ....
  20. ncbi request reprint Stress as a risk factor in the pathogenesis of rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genoa, Italy, and Department of Internal Medicine I, University Hospital, Regensburg, Germany
    Neuroimmunomodulation 13:277-82. 2006
    ..Long-lasting (chronic) stress may lead to proinflammatory effects because no adequate long-term responses of stress axes (anti-inflammatory) are to be expected...
  21. ncbi request reprint Anti-TNF and sex hormones
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine University of Genova, Viale Benedetto XV6, 16132, Genova, Italy
    Ann N Y Acad Sci 1069:391-400. 2006
    ..In patients with at least long-standing RA, this indicates that alterations of serum sex hormones and altered activity of respective converting enzymes are imprinted for a long-lasting period over at least 12 weeks...
  22. ncbi request reprint Circadian rhythms: glucocorticoids and arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV6, 16132 Genova, Italy
    Ann N Y Acad Sci 1069:289-99. 2006
    ..In conclusion, the right timing (early morning) for the glucocorticoid therapy in arthritis is fundamental and well justified by the circadian rhythms of the inflammatory mechanisms...
  23. ncbi request reprint Cortisol, dehydroepiandrosterone sulfate, and androstenedione levels in patients with polymyalgia rheumatica during twelve months of glucocorticoid therapy
    M Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Italy
    Ann N Y Acad Sci 966:91-6. 2002
    ....
  24. ncbi request reprint Capillaroscopy
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 19:437-52. 2005
    ..Other major NVC patterns have been described in the field of rheumatic diseases. Interestingly, correlations are evident between the NVC and the clinical symptoms, severity of the disease and the laboratory findings...
  25. ncbi request reprint [Capillaroscopy and rheumatic diseases: state of the art]
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132, Genova, Italy
    Z Rheumatol 65:290-6. 2006
    ..However, further epidemiological and clinical studies are needed to better standardize NVC patterns...
  26. pmc Serum cytokines and steroidal hormones in polymyalgia rheumatica and elderly-onset rheumatoid arthritis
    M Cutolo
    Department of Internal Medicine, Research Laboratory and Division of Rheumatology, University Hospital San Martino, Viale Benedetto XV no 6, 16132 Genova, Italy
    Ann Rheum Dis 65:1438-43. 2006
    ..Polymyalgia rheumatica (PMR) may create some difficulties in the differential diagnosis of elderly-onset rheumatoid arthritis (EORA) and of EORA with PMR-like onset (EORA/PMR)...
  27. pmc The melatonin-cytokine connection in rheumatoid arthritis
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Ann Rheum Dis 64:1109-11. 2005
  28. pmc Anti-inflammatory effects of leflunomide in combination with methotrexate on co-culture of T lymphocytes and synovial macrophages from rheumatoid arthritis patients
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, 6 16132 Genoa, Italy
    Ann Rheum Dis 65:728-35. 2006
    ....
  29. ncbi request reprint Estrogens, autoimmunity and the heart
    M Cutolo
    Research Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Lupus 14:675-8. 2005
    ..New roles for estrogen peripheral metabolites (hydroxylated) and their increased formation in inflammatory sites, might partially introduce some explanations for several apparently contrasting evidences...
  30. ncbi request reprint Nocturnal hormones and clinical rhythms in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Immunology and Endocrinology, University of Genoa, Viale Benedetto XV, 16132 Genoa I, Italy
    Ann N Y Acad Sci 1051:372-81. 2005
    ....
  31. ncbi request reprint Altered circadian rhythms in rheumatoid arthritis patients play a role in the disease's symptoms
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Immunology and Endocrinology, University of Genova, Italy Viale Benedetto XV, 16132 Genova I, Italy
    Autoimmun Rev 4:497-502. 2005
    ....
  32. ncbi request reprint The contribution of capillaroscopy to the differential diagnosis of connective autoimmune diseases
    Maurizio Cutolo
    Internal Medicine and Rheumatology, Research Laboratory and Clinical Academic Unit of Rheumatology, University of Genova, Italy
    Best Pract Res Clin Rheumatol 21:1093-108. 2007
    ..In systemic sclerosis, the recognition of clear and different NVC morphological patterns ("early", "active", "late") should suggest including this analysis in the classification criteria of the disease...
  33. ncbi request reprint Review: vitamin D, immunity and lupus
    M Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova Italy
    Lupus 17:6-10. 2008
    ..Treatment of vitamin D deficiency could be particularly important in SLE patients due to concomitant insults on their tissues such as bone, and in view of the possible immunomodulatory effects exerted by vitamin D...
  34. doi request reprint Vitamin D endocrine system involvement in autoimmune rheumatic diseases
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Autoimmun Rev 11:84-7. 2011
    ..Recently, the onset of symptoms of early arthritis during winter or spring have been associated with greater radiographic evidence of disease progression at 12 months possibly are also related to seasonal lower vitamin D serum levels...
  35. doi request reprint How should morning function in rheumatoid arthritis be assessed? Bibliographic study of current assessment
    M Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Scand J Rheumatol Suppl 125:17-22. 2011
    ..These findings suggest the need for consistent reporting of a measure to reflect the impaired morning function, arising from joint stiffness and pain that is commonly experienced by patients...
  36. ncbi request reprint Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 29:72-9. 2011
    ....
  37. ncbi request reprint [The role of nailfold videocapillaroscopy in Raynaud's phenomenon monitoring and early diagnosis of systemic sclerosis]
    M Cutolo
    Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di Genova, Genova, Italia
    Reumatismo 62:237-47. 2010
    ..This implies the possibility of early treatment of SSc, with an eye of predicting and preventing its major clinical complications...
  38. doi request reprint Assessing microvascular changes in systemic sclerosis diagnosis and management
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, 6 16132 Genova, Italy
    Nat Rev Rheumatol 6:578-87. 2010
    ....
  39. doi request reprint Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    J Rheumatol 37:1174-80. 2010
    ..The effects on FBP of intravenous (IV) treatment with the prostacyclin analog iloprost were also investigated...
  40. doi request reprint The immunomodulatory effects of estrogens: clinical relevance in immune-mediated rheumatic diseases
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:36-42. 2010
    ..In conclusion, estrogens are generally considered as enhancers of cell proliferation and humoral immune response...
  41. doi request reprint Hormone therapy in rheumatic diseases
    Maurizio Cutolo
    University of Genova, Italy
    Curr Opin Rheumatol 22:257-63. 2010
    ..Purpose of the review is to update on recent roles and mechanisms of action of important steroid hormones such as glucocorticoids, estrogens, and D hormone (vitamin D) in order to optimize their therapeutical use...
  42. pmc CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 16132 Genova, Italy
    Arthritis Res Ther 11:R176. 2009
    ..In addition, the anti-inflammatory effects of CTLA4-Ig on co-cultures of RA SM and M with activated T cells were tested...
  43. pmc Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova Italy, Genova, Italy
    Arthritis Res Ther 11:218. 2009
    ..Consequently, estrogens (especially in patients affected by B-cell-driven immunity) and melatonin should be avoided, and glucocorticoids (as replacement therapy) and vitamin D are allowed in the treatment of autoimmunity...
  44. doi request reprint Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    J Autoimmun 32:254-60. 2009
    ..05 and p < 0.001). E2 seems to contrast, but T seems to synergize the LEF-M activity. Results might support a stronger therapeutical efficacy, at least for LEF, in male RA patients, as already reported by clinical evidences...
  45. doi request reprint Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:15-21. 2010
    ..The results suggest that the combination of PN and LEF seems to play a synergistic effect by modulating some inflammatory genes in early RA...
  46. doi request reprint Capillaroscopy
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 22:1093-108. 2008
    ..Several other NVC patterns have also been identified, such as in dermatomyosistis, systemic lupus eythaematosus, mixed connective tissue disease and antiphospholipid syndrome...
  47. doi request reprint Use of glucocorticoids and risk of infections
    Maurizio Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Autoimmun Rev 8:153-5. 2008
    ..Consequently, the use of the lowest possible GC dose, at the night time and even for the shortest possible time, should decrease dramatically the risk of infections...
  48. doi request reprint Oestrogens in rheumatic diseases: friend or foe?
    M Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova, Viale Benedetto XV, 6, 16132, Genova, Italy
    Rheumatology (Oxford) 47:iii2-5. 2008
    ..However, as supported by the higher prevalence of rheumatic autoimmune diseases in women, oestrogens are generally considered as enhancers of cell proliferation and humoral immune response...
  49. doi request reprint Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, IT 16132 Genova, Italy
    Autoimmun Rev 7:223-8. 2008
    ....
  50. ncbi request reprint [Therapy of rheumatic polymyalgia: the pathophysiologic management]
    M Cutolo
    U O C Clinica Reumatologica, Dipartimento di Medicina Interna Università degli Studi di Genova, 16132 Genova, Italia
    Reumatismo 59:271-9. 2007
    ..Combination therapy between glucocorticoids and inhibitors of pro-inflammatory cytokines should be tested in large studies and early cases of PMR...
  51. ncbi request reprint Regulation of glucocorticoids by the central nervous system
    M Cutolo
    Department of Internal Medicine, University of Genova, Italy
    Clin Exp Rheumatol 29:S-19-22. 2011
    ....
  52. pmc Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison
    M Cutolo
    Division of Rheumatology, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16136 Genoa, Italy
    Ann Rheum Dis 64:212-6. 2005
    ..Altered functioning of the hypothalamic-pituitary-adrenal axis and altered melatonin production might modulate the circadian symptoms in patients with rheumatoid arthritis...
  53. ncbi request reprint Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
    Rheumatology (Oxford) 43:719-26. 2004
    ....
  54. ncbi request reprint Effects of DMARDs on IL-1Ra levels in rheumatoid arthritis: is there any evidence?
    M Cutolo
    Research Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV no 6, 16132 Genova, Italy
    Clin Exp Rheumatol 20:S26-31. 2002
    ..The effects of different DMARDs and GC on IL-1Ra levels in RA patients, as reviewed in this paper, support the important role that selected anticytokine treatments might exert in the pathophysiology of the disease...
  55. ncbi request reprint Antiproliferative-antiinflammatory effects of methotrexate and sex hormones on cultured differentiating myeloid monocytic cells (THP-1)
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:232-7. 2002
    ..Therefore, the enhancing antiinflammatory effects exerted by androgens might represent a further explanation for the reduced frequency of inflammatory diseases in male subjects...
  56. ncbi request reprint Sex hormone adjuvanting therapy in rheumatoid arthritis
    M Cutolo
    Department of Internal Medicine, University of Genova, Italy
    Lupus 11:670-4. 2002
  57. ncbi request reprint The Second International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases
    Maurizio Cutolo
    Division of Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Isr Med Assoc J 4:309-11. 2002
  58. ncbi request reprint Sex hormone adjuvant therapy in rheumatoid arthritis
    M Cutolo
    Department of Internal Medicine, University of Genova, Italy
    Rheum Dis Clin North Am 26:881-95. 2000
    ..e., testosterone, DHT, DHEAS) or indirectly (i.e., antiestrogens) may represent a valuable concomitant or adjuvant treatment to be associated with other disease-modifying antirheumatic drugs (i.e., MTX, CSA) in the management of RA...
  59. ncbi request reprint Methotrexate in psoriatic arthritis
    M Cutolo
    Research Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Clin Exp Rheumatol 20:S76-80. 2002
    ..The concomitant use of folic acid reduces both the frequency of serum liver enzyme level increases but also the efficacy of MTX by competing with the folate receptors...
  60. ncbi request reprint Hypothalamic-pituitary-adrenal axis impairment in the pathogenesis of rheumatoid arthritis and polymyalgia rheumatica
    M Cutolo
    University of Genova, Genova, Italy
    J Endocrinol Invest 25:19-23. 2002
    ..Given its multifaceted properties, including the ability to counteract the negative side effects of glucocorticoids, the therapeutical administration of DHEA might be considered in these pathologies, provided its safety is proved...
  61. ncbi request reprint Raynaud's phenomenon and the role of capillaroscopy
    Maurizio Cutolo
    University of Genoa, Genoa, Italy
    Arthritis Rheum 48:3023-30. 2003
  62. ncbi request reprint Adrenal gland hypofunction in active polymyalgia rheumatica. effect of glucocorticoid treatment on adrenal hormones and interleukin 6
    Maurizio Cutolo
    Department of Internal Medicine and Medical Specialities, University of Genova, Italy
    J Rheumatol 29:748-56. 2002
    ....
  63. ncbi request reprint Sex hormones and rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy
    Autoimmun Rev 1:284-9. 2002
    ..Local increased estrogen concentrations and decreased androgen levels have been observed in RA synovial fluids and seem to play a more important role in the immune/inflammatory local response...
  64. ncbi request reprint Hypothalamic-pituitary-adrenocortical and gonadal functions in rheumatoid arthritis
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genoa, 16136, Genoa, Italy
    Ann N Y Acad Sci 992:107-17. 2003
    ....
  65. ncbi request reprint The hypothalamic-pituitary-adrenal and gonadal axes in rheumatoid arthritis
    M Cutolo
    Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Ann N Y Acad Sci 917:835-43. 2000
    ..The interactions between the immunological and neuroendocrine circuits is the subject of active and extensive ongoing research and might in the near future offer highly promising strategies for hormone-replacement therapies in RA...
  66. ncbi request reprint Presence of estrogen receptors in human myeloid monocytic cells (THP-1 cell line)
    M Cutolo
    Division of Rheumatology, Department of Internal Medicine, Viale Benedetto XV, 6 16132 Genova, Italy
    Eur Cytokine Netw 12:368-72. 2001
    ..e. macrophages), and since it has been demonstrated that human myeloid monocytic THP-1 cells acquire phenotypic and functional macrophage-like features after incubation with several cytokines or pharmacological agents...
  67. pmc Anti-inflammatory effects of leflunomide on cultured synovial macrophages from patients with rheumatoid arthritis
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine University of Genova, Italy
    Ann Rheum Dis 62:297-302. 2003
    ....
  68. ncbi request reprint Melatonin serum levels in rheumatoid arthritis
    A Sulli
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:276-83. 2002
    ....
  69. ncbi request reprint Circadian rhythms and arthritis
    Maurizio Cutolo
    Research Laboratory, Division of Rheumatology, Department of Internal Medicine, Universita degli Studi di Genova, Viale Benedetto XV 6, 16132 Genova, Italy
    Rheum Dis Clin North Am 31:115-29, ix-x. 2005
    ....
  70. ncbi request reprint Estrogens and arthritis
    Maurizio Cutolo
    Research Laboratory, Division of Rheumatology, Department of Internal Medicine, Universita degli Studi di Genova, Viale Benedetto XV 6, 16132 Genova, Italy
    Rheum Dis Clin North Am 31:19-27, vii. 2005
    ..All of these data further suggest caution in exogenous estrogen administration in patients who have autoimmune diseases...
  71. ncbi request reprint Nailfold video-capillaroscopy in systemic sclerosis
    M Cutolo
    Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Z Rheumatol 63:457-62. 2004
    ..Further clinical and epidemiological studies, as well as a standardized and computerized quantitation of the observed damages are required...
  72. ncbi request reprint Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Lupus 13:635-8. 2004
    ..In conclusion, locally increased estrogens (i.e., synovial tissue in RA or skin in SLE) might exert activating effects on cell proliferation, including macrophages and fibroblasts, suggesting new roles for estrogens in autoimmunity...
  73. ncbi request reprint [IL-1Ra: its role in rheumatoid arthritis]
    M Cutolo
    Dipartimento di Medicina Interna e Specialita Mediche, Universita di Genova, Italia
    Reumatismo 56:41-5. 2004
    ....
  74. ncbi request reprint Synovial fluid estrogens in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Bebedetto XV, 6, Genova 16132, Italy
    Autoimmun Rev 3:193-8. 2004
    ..e. SF in RA) of 16alpha-hydroxyestrone or 2-hydroxyestrogens...
  75. ncbi request reprint Modulation of cell growth and apoptosis by sex hormones in cultured monocytic THP-1 cells
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:204-10. 2002
    ..In conclusion, these results support the possibility of sex hormone modulation of apoptosis in macrophage-like cells, with interesting therapeutic perspectives in rheumatoid arthritis...
  76. ncbi request reprint Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Division of Rheumatology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Arthritis Rheum 54:2039-46. 2006
  77. pmc Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3
    P Sarzi-Puttini
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann Rheum Dis 65:301-5. 2006
    ..IGF1 is decreased in rheumatoid arthritis and juvenile idiopathic arthritis because its synthesis is inhibited by inflammation. In parallel, glucocorticoids induce IGF1 resistance and add to muscle degradation...
  78. doi request reprint Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis
    Rainer H Straub
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Arthritis Rheum 58:976-84. 2008
    ..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy...
  79. ncbi request reprint Anti-inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro
    Rainer H Straub
    Division of Rheumatology, Department of Internal Medicine I, University Hospital, Regensburg, Germany
    FASEB J 16:993-1000. 2002
    ..These results underscore that coupling of an efficient secretion of systemic cortisol together with local production of NE is important in order to lower synovial inflammation...
  80. ncbi request reprint Steroid hormones and disease activity during pregnancy in systemic lupus erythematosus
    Andrea Doria
    Division of Rheumatology, University of Padova, Padua, Italy
    Arthritis Rheum 47:202-9. 2002
    ..Moreover, to investigate whether, during gestation, there is any relationship between steroid concentration and SLE activity...
  81. ncbi request reprint Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy
    Rainer H Straub
    Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Medical Center, Regensburg, Germany
    J Rheumatol 32:1253-8. 2005
    ..Since tumor necrosis factor (TNF) alters production of these hormones, we investigated changes of these hormones during anti-TNF antibody (anti-TNF) therapy with adalimumab in longstanding RA...
  82. ncbi request reprint [Nailfold capillaroscopy and blood flow laser-doppler analysis of the microvascular damage in systemic sclerosis: preliminary results]
    M E Secchi
    Laboratorio di Ricerca e U O C di Reumatologia, Dipartimento di Medicina Interna, Universita degli Studi di Genova, Italia
    Reumatismo 61:34-40. 2009
    ..The aim of this study was to investigate possible relationships between capillary morphology and blood flow in SSc...
  83. doi request reprint Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment
    Daniela Rollando
    Academic Unit of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 37:1168-73. 2010
    ..Evidence has shown that vascular impairment in SSc may be a sign of endothelial dysfunction involving both microvascular and macrovascular systems, although the pathological mechanisms of the dysfunction are poorly understood...
  84. ncbi request reprint Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:131-42. 2002
    ....
  85. ncbi request reprint [Diagnostic perspectives in the rheumatologic vasculitis: the role of video-capillaroscopy]
    C Pizzorni
    Cattedra e Divisione di Reumatologia, Dipartimento di Medicina Interna e Specialita Mediche, Universita degli Studi di Genova, Italia
    Reumatismo 54:99-104. 2002
    ..Interesting, correlations between the NVC and clinical aspects of SSc, as well as the effects of therapeutical interventions have been observed...
  86. pmc Quantitative determination of steroid hormone receptor positive cells in the synovium of patients with rheumatoid arthritis and osteoarthritis: is there a link to inflammation?
    S Capellino
    Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Ann Rheum Dis 66:53-8. 2007
    ..Steroid hormone receptors such as glucocorticoid receptors, androgen receptors, and oestrogen receptors alpha (ERalpha) and beta (ERbeta) have been identified in synovial cells of patients with rheumatoid arthritis and osteoarthritis...
  87. ncbi request reprint Scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients
    A Sulli
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann Rheum Dis 67:885-7. 2008
    ..Longitudinal study to define a scoring system to quantify the specific capillary abnormalities, as observed by capillary microscopy in systemic sclerosis (SSc)...
  88. pmc Circadian rhythms in RA
    M Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Ann Rheum Dis 62:593-6. 2003
  89. ncbi request reprint Delayed neutrophil apoptosis induced by synovial fluid in rheumatoid arthritis: role of cytokines, estrogens, and adenosine
    Luciano Ottonello
    Division of Internal Medicine, Department of Internal Medicine and Medical Specialities, University of Genova, I 16132 Genova, Italy
    Ann N Y Acad Sci 966:226-31. 2002
    ..Our results suggest that the microenvironment of rheumatoid synovial fluid is a proinflammatory milieu responsible for the in loco persistence of activated and long-surviving neutrophils...
  90. ncbi request reprint Serum prolactin concentrations in male patients with rheumatoid arthritis
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, 16132 Genova, Italy
    Ann N Y Acad Sci 966:258-62. 2002
    ..The serum PRL concentration was found to be increased in relation to the duration and the activity of the disease. Serum PRL levels do not seem to have any relationship with the BMD, at least in RA...
  91. doi request reprint Effects of estrogens on extracellular matrix synthesis in cultures of human normal and scleroderma skin fibroblasts
    Stefano Soldano
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:25-9. 2010
    ..This study seems to support important modulatory effects of E2 in the fibrotic progression of the SSc process via ER interactions...
  92. ncbi request reprint Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol
    David Janele
    Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital, 93042 Regensburg, Germany
    Ann N Y Acad Sci 1069:168-82. 2006
    ..This study underlines the proinflammatory role of E2, which is probably dependent on conversion to a proinflammatory cocktail of downstream estrogens and the presence of cortisol...
  93. doi request reprint Modern imaging techniques: a revolution for rheumatology practice
    Marco A Cimmino
    Clinica Reumatologica, Dipartimento di Medicina Interna, Universita di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 22:951-9. 2008
    ..In conclusion, new imaging techniques and refinements of the established techniques have opened exciting perspectives in our understanding and treatment of many rheumatic diseases...
  94. ncbi request reprint Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation
    Paola Montagna
    Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Fertil Steril 90:156-64. 2008
    ..To investigate the expression of estrogen receptors (ERs) and inflammatory cytokines in macrophages obtained from peritoneal fluid (PF) of women with endometriosis...
  95. ncbi request reprint Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis
    Alberto Sulli
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, San Martino Hospital, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Ann N Y Acad Sci 1069:307-14. 2006
    ..Interestingly, in PMR and EORA/PMR patients, GC treatment was found to downregulate PRG serum levels...
  96. ncbi request reprint Serum osteocalcin levels in premenopausal rheumatoid arthritis patients
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:502-7. 2002
    ..This study suggests that generalized bone loss occurs in active RA and is characterized by an evident bone resorption correlated with the high levels of inflammation...
  97. ncbi request reprint Cardiac magnetic resonance imaging detects subclinical right ventricular impairment in systemic sclerosis
    Gian Paolo Bezante
    Division of Cardiology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 34:2431-7. 2007
    ..To assess myocardial involvement in patients with systemic sclerosis (SSc) with no signs or symptoms of cardiac impairment (New York Heart Association functional class I)...