M Cugno

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Autoantibodies to coagulation factors: from pathophysiology to diagnosis and therapy
    Massimo Cugno
    Medicina Interna, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy Electronic address
    Autoimmun Rev 13:40-8. 2014
  2. ncbi request reprint Inflammation and coagulation in urticaria and angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Via Pace 9, 20122 Milano, Italy
    Curr Vasc Pharmacol 10:653-8. 2012
  3. doi request reprint Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Intern Emerg Med 7:237-42. 2012
  4. doi request reprint Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications
    Massimo Cugno
    Department of Internal Medicine, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
    Intern Emerg Med 5:97-101. 2010
  5. ncbi request reprint Bradykinin and the pathophysiology of angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace, 15, 20122 Milan, Italy
    Int Immunopharmacol 3:311-7. 2003
  6. ncbi request reprint Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients
    Massimo Cugno
    Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Via Pace 15, 20122 Milano, Italy
    Blood 103:2121-6. 2004
  7. doi request reprint Expression of tissue factor by eosinophils in patients with chronic urticaria
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Int Arch Allergy Immunol 148:170-4. 2009
  8. doi request reprint Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Autoimmun Rev 8:156-9. 2008
  9. ncbi request reprint Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Br J Haematol 126:85-92. 2004
  10. ncbi request reprint Potential effect of anti-tumour necrosis factor-alpha treatment on reducing the cardiovascular risk related to rheumatoid arthritis
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Curr Vasc Pharmacol 8:285-92. 2010

Detail Information

Publications64

  1. doi request reprint Autoantibodies to coagulation factors: from pathophysiology to diagnosis and therapy
    Massimo Cugno
    Medicina Interna, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy Electronic address
    Autoimmun Rev 13:40-8. 2014
    ....
  2. ncbi request reprint Inflammation and coagulation in urticaria and angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Via Pace 9, 20122 Milano, Italy
    Curr Vasc Pharmacol 10:653-8. 2012
    ..These observations have provided the rationale for the clinical evaluation of anticoagulant and antifibrinolytic drugs, the efficacy of which has sometimes been demonstrated...
  3. doi request reprint Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric banding
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Intern Emerg Med 7:237-42. 2012
    ..The weight loss induced by gastric banding decreases the parameters of inflammation, coagulation and impaired fibrinolysis, thus potentially reducing the thrombotic risk...
  4. doi request reprint Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implications
    Massimo Cugno
    Department of Internal Medicine, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
    Intern Emerg Med 5:97-101. 2010
    ..Taken together, all these findings provide the rationale for proposing clinical trials on the use of anticoagulant drugs as adjuvant treatment in CU patients...
  5. ncbi request reprint Bradykinin and the pathophysiology of angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace, 15, 20122 Milan, Italy
    Int Immunopharmacol 3:311-7. 2003
    ....
  6. ncbi request reprint Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients
    Massimo Cugno
    Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Via Pace 15, 20122 Milano, Italy
    Blood 103:2121-6. 2004
    ..Our data indicate that anti-tPA antibodies specifically interacting with the catalytic domain of tPA can be found in patients with APS, representing a possible cause of hypofibrinolysis...
  7. doi request reprint Expression of tissue factor by eosinophils in patients with chronic urticaria
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Int Arch Allergy Immunol 148:170-4. 2009
    ..Eosinophils, which are involved in CU skin lesions, have recently been demonstrated as the major source of TF in human blood. We assessed whether eosinophils are the cellular source of TF in CU skin lesions...
  8. doi request reprint Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Autoimmun Rev 8:156-9. 2008
    ....
  9. ncbi request reprint Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Br J Haematol 126:85-92. 2004
    ..Most of these abnormalities parallel each other, tend to normalize in patients treated with OATs and, although reduced, persist in patients undergoing successful heart transplantation, despite the absence of clinical signs of CHF...
  10. ncbi request reprint Potential effect of anti-tumour necrosis factor-alpha treatment on reducing the cardiovascular risk related to rheumatoid arthritis
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Curr Vasc Pharmacol 8:285-92. 2010
    ..This review provides an overview of the pathophysiological role of TNF-alpha in thrombotic mechanisms and the evidence so far available indicating that anti-TNF-alpha treatment can modify cardiovascular risk in RA...
  11. ncbi request reprint Activation of blood coagulation in autoimmune skin disorders
    Massimo Cugno
    Department of Internal Medicine, University of Milan and IRCCS Foundation Maggiore Hospital, Policlinico, Mangiagalli and Regina Elena, Via Pace 9, 20122, Milan, Italy
    Expert Rev Clin Immunol 5:605-13. 2009
    ..In psoriasis, the activation of coagulation seems to be mainly systemic, potentially contributing to the increased cardiovascular risk associated with this disease...
  12. doi request reprint Anti-t-PA antibodies in acute myocardial infarction after thrombolysis with rt-PA
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
    Eur J Intern Med 21:25-9. 2010
    ..Reocclusions follow rt-PA treatment in up to 30% of patients within one year. The infusion of rt-PA may induce the production of anti-t-PA antibodies which could interfere with the function of the native t-PA molecule...
  13. ncbi request reprint Impaired bradykinin response to ischaemia and exercise in patients with mild congestive heart failure during angiotensin-converting enzyme treatment. Relationships with endothelial function, coagulation and inflammation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Br J Haematol 130:113-20. 2005
    ..They are unable to respond adequately to stimuli of ischaemia and physical exercise which both require vasodilation...
  14. ncbi request reprint In vitro interaction of C1-inhibitor with thrombin
    M Cugno
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
    Blood Coagul Fibrinolysis 12:253-60. 2001
    ....
  15. ncbi request reprint Bradykinin in the ascitic fluid of patients with liver cirrhosis
    M Cugno
    Department of Internal Medicine, University of Milan, Maggiore Hospital IRCCS, Via Pace 15, 20122 Milan, Italy
    Clin Sci (Lond) 101:651-7. 2001
    ..Activation of the kinin system may therefore be involved in decompensating cirrhosis, but a cause-effect relationship remains to be established...
  16. ncbi request reprint Parallel reduction of plasma levels of high and low molecular weight kininogen in patients with cirrhosis
    M Cugno
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 82:1428-32. 1999
    ..The decrease of important regulatory proteins like kininogens may contribute to the imbalance in coagulation and fibrinolytic systems, which frequently occurs in cirrhotic patients...
  17. pmc Prothrombotic state and impaired fibrinolysis in bullous pemphigoid, the most frequent autoimmune blistering disease
    A V Marzano
    Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Milano, Italy
    Clin Exp Immunol 171:76-81. 2013
    ..Corticosteroids not only induce the regression of BP lesions, but also reduce the inhibition of fibrinolysis, which may contribute to decreasing thrombotic risk...
  18. pmc Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases
    A V Marzano
    Dipartimento di Medicina Interna, Universita degli Studi di Milano, Italy
    Clin Exp Immunol 165:44-50. 2011
    ..The coagulation cascade is activated in BP and other eosinophil-mediated skin disorders, but not in non-eosinophil driven conditions. This hypercoagulability may contribute to inflammation, tissue damage and, possibly, thrombotic risk...
  19. doi request reprint Activation of blood coagulation in bullous pemphigoid: role of eosinophils, and local and systemic implications
    A V Marzano
    Department of Internal Medicine, IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli, Regina Elena, Milan, Italy
    Br J Dermatol 160:266-72. 2009
    ..Eosinophils are a source of tissue factor (TF), an initiator of blood coagulation...
  20. ncbi request reprint Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatoses
    A V Marzano
    Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Italy
    Int J Immunopathol Pharmacol 24:451-60. 2011
    ..035), but less intense than in PG (p=0.020). Our study supports the role of proinflammatory cytokines/chemokines and MMPs as important effectors for the tissue damage in APF similarly to classic neutrophilic dermatoses...
  21. doi request reprint Markers of autoreactivity, coagulation and angiogenesis in patients with nonallergic asthma
    R Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milano, Italy
    Allergy 66:1339-44. 2011
    ..Activation of the coagulation cascade and hyper-expression of vascular endothelial growth factor (VEGF) were recently found in CU, and there is sparse evidence that the same may occur in asthma...
  22. ncbi request reprint Prothrombotic state in Churg-Strauss syndrome: a case report
    A V Marzano
    U O Dermatologia, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    J Investig Allergol Clin Immunol 20:616-9. 2010
    ..In conclusion, we present a patient with active CSS and a prothrombotic state that reverted during remission achieved by immunosuppressive therapy...
  23. ncbi request reprint Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticaria
    A Tedeschi
    Unità Operativa di Allergologia e Immunologia Clinica, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy
    Allergy 64:1616-22. 2009
    ..This suggests that other factors may contribute to its pathogenesis. We evaluated the possible involvement of vascular endothelial growth factor (VEGF), one of the major mediators of vascular permeability, in CU...
  24. pmc Coagulation activation in autoimmune bullous diseases
    A V Marzano
    Department of Anesthesiology, Intensive Care and Dermatological Sciences, University of Milan, Milan, Italy
    Clin Exp Immunol 158:31-6. 2009
    ..This suggests that BP but not PV patients have an increased thrombotic risk. The observation that thrombotic complications occur more frequently in BP than in PV further supports this view...
  25. ncbi request reprint Plasma levels of matrix metalloproteinase-9 in chronic urticaria patients correlate with disease severity and C-reactive protein but not with circulating histamine-releasing factors
    A Tedeschi
    Unità Operativa di Allergologia e Immunologia Clinica, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milano, Italy
    Clin Exp Allergy 40:875-81. 2010
    ..Matrix metalloproteinase-9 (MMP-9) is an endopeptidase produced by many inflammatory cells that has been found in increased amounts in plasma from patients with chronic urticaria (CU)...
  26. ncbi request reprint Antibodies to tissue-type plasminogen activator (t-PA) in patients with inflammatory bowel disease: high prevalence, interactions with functional domains of t-PA and possible implications in thrombosis
    S Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Fondazione Ospedale Policlinico, Mangiagalli and Regina Elena, University of Milan, Via Pace 9, 20122 Milan, Italy
    J Thromb Haemost 4:1510-6. 2006
    ..The pathogenetic mechanisms of these events include reduced fibrinolysis, which may be caused by antibodies to tissue-type plasminogen activator (t-PA)...
  27. pmc Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases
    A V Marzano
    Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milano, Italy
    Clin Exp Immunol 162:100-7. 2010
    ..In ulcerative PG, the wound bed is the site of neutrophil-recruitment, whereas in the wound edge activated T lymphocytes and macrophages pave the way to ulcer formation...
  28. ncbi request reprint Different rates of autoreactivity in patients with recurrent idiopathic angioedema associated or not with wheals
    A Tedeschi
    U O Allergologia e Immunologia Clinica, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy
    J Investig Allergol Clin Immunol 22:87-91. 2012
    ..The pathophysiology and triggers of idiopathic nonhistaminergic angioedema are unclear. This study aimed to assess autoreactivity in recurrent idiopathic angioedema associated or not with wheals...
  29. ncbi request reprint Time course of endogenous nitric oxide inhibitors in severe sepsis in humans
    G Iapichino
    Department of Anesthesiology, Intensive Therapy and Dermatologic Sciences, University of Milan, Italy
    Minerva Anestesiol 76:325-33. 2010
    ..We investigated plasma ADMA and SDMA levels during ICU stay to reveal the time course of endogenous NO inhibition in patients with sepsis...
  30. ncbi request reprint Anti-tumor necrosis factor alpha therapy normalizes fibrinolysis impairment in patients with active rheumatoid arthritis
    F Ingegnoli
    Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
    Clin Exp Rheumatol 28:254-7. 2010
    ..We carried out an observational study investigating plasma biomarkers of inflammation and fibrinolysis in RA patients before and after 14 weeks of infliximab treatment given according to the therapeutic guidelines for RA...
  31. doi request reprint Diagnosis and disease severity assessment of epidermolysis bullosa acquisita by ELISA for anti-type VII collagen autoantibodies: an Italian multicentre study
    A V Marzano
    Unità di Dermatologia, Dipartimento di Fisiopatologia e dei Trapianti, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milano, Italy
    Br J Dermatol 168:80-4. 2013
    ..Type VII collagen is composed of a collagenous domain linked by the noncollagenous (NC)1 and NC2 domains...
  32. ncbi request reprint Serum eotaxin levels in patients with chronic spontaneous urticaria
    A Tedeschi
    Allergy and Clinical Immunology Unit, IRCCS Ca Granda Foundation, Maggiore Policlinico Hospital, Milan, Italy
    Eur Ann Allergy Clin Immunol 44:188-92. 2012
    ..These findings indicate that serum eotaxin levels are increased in CU patients, although they do not reflect strictly disease activity. A role for eotaxin in eosinophil attraction and activation in CU can be envisaged...
  33. doi request reprint Tight glycemic control may favor fibrinolysis in patients with sepsis
    Monica Savioli
    Dipartimento di Anestesia, UO di Anestesia e Rianimazione, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Milan, Italy
    Crit Care Med 37:424-31. 2009
    ..To investigate whether tight glycemic control, in patients with sepsis, may restore a normal fibrinolysis by lowering plasminogen activator inhibitor (PAI)-1 levels...
  34. doi request reprint Patients with antiphospholipid syndrome display endothelial perturbation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Foundation Maggiore Hospital Policlinico, Mangiagalli, Regina Elena, Italy
    J Autoimmun 34:105-10. 2010
    ..The aim of this observational case-control study was to evaluate several parameters of endothelial perturbation in patients with APS and without any other atherosclerosis risk factor...
  35. ncbi request reprint Angioedema due to angiotensin-converting enzyme inhibitors
    A Agostoni
    Department of Internal Medicine, University of Milan, IRCCS Ospedale, Maggiore, Italy
    Immunopharmacology 44:21-5. 1999
    ..These observations indicate that in ACE-inhibitor-induced angioedema, contrary to hereditary angioedema, the reduction of bradykinin catabolic rate plays a predominant role...
  36. ncbi request reprint Increase of bradykinin in plasma of patients undergoing cardiopulmonary bypass: the importance of lung exclusion
    M Cugno
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Chest 120:1776-82. 2001
    ..CONCLUSIONS: During CPB, there is a progressive increase of plasma bradykinin that is at least partially due to reduced catabolism as a consequence of shunting the lungs. The increase in bradykinin may contribute to the fall in BP...
  37. doi request reprint Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency
    M Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Allergy 64:254-7. 2009
    ..Although cutaneous swelling is evident, abdominal angioedema is still a diagnostic challenge and attacks can mimic surgical emergencies. There is currently no laboratory marker for identifying angioedema attacks...
  38. pmc Alzheimer's beta-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent manner
    L Bergamaschini
    Department of Internal Medicine, Maggiore Hospital, IRCCS, Milan, Italy
    Clin Exp Immunol 115:526-33. 1999
    ....
  39. ncbi request reprint [The kinin system: biological mechanisms and clinical implications]
    A Agostoni
    Dipartimento di Medicina Interna, Universita, IRCCS Ospedale Maggiore, Milano
    Recenti Prog Med 92:764-73. 2001
    ..The study of the kinin system in clinical field, which had been limited by methodological difficulties, has now received an important stimulus by the recent availability of specific and sensitive methods of dosage...
  40. ncbi request reprint Homocysteine concentration in primary and systemic sclerosis associated Raynaud's phenomenon
    B Marasini
    Department of Medicine, Surgery and Dentistry, Institute of Radiological Sciences, San Paolo Hospital, Italy
    J Rheumatol 27:2621-3. 2000
    ....
  41. ncbi request reprint Chronic heart failure and the immune system
    Daniela Mari
    Department of Internal Medicine, University of Milan, Maggiore Hospital IRCCS, Via Pace 15, 20122 Milan, Italy
    Clin Rev Allergy Immunol 23:325-40. 2002
    ..The effort of define the immune system's role has opened new perspectives of therapeutic strategies, such as anti-cytokine drugs, to treat CHF...
  42. ncbi request reprint Activation of the contact system and inflammation after thrombolytic therapy in patients with acute myocardial infarction
    Piera Angelica Merlini
    IV Division of Cardiology, Ospedale Niguarda, Milan, Italy
    Am J Cardiol 93:822-5. 2004
    ....
  43. ncbi request reprint Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stenting
    Luisa Gregorini
    Experimental Surgery and Transplantation Institute, Ospedale Maggiore IRCCS, University of Milano, Italy
    Circulation 106:2901-7. 2002
    ..Coronary flow reserve (CFR) is not normalized shortly after coronary stenting. We hypothesized that alpha-adrenergic coronary vasoconstriction acts to limit CFR...
  44. doi request reprint Tight glycemic control does not affect asymmetric-dimethylarginine in septic patients
    Gaetano Iapichino
    Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Via A Di Rudini 8, 20142 Milan, Italy
    Intensive Care Med 34:1843-50. 2008
    ..We investigated whether preventing hyperglycemia in septic patients affected the plasma concentration of asymmetric-dimethylarginine and if this was associated with clinical benefit...
  45. ncbi request reprint Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic control
    F Polli
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 75:417-26. 2009
    ..Our aim was to evaluate the effects on the fibrinolytic system after the administration of rh-APC in septic patients undergoing conventional or TGC...
  46. doi request reprint Drug-induced subacute cutaneous lupus erythematosus: evidence for differences from its idiopathic counterpart
    A V Marzano
    Department of Anaesthesia, Intensive Care and Dermatological Sciences, Università degli Studi di Milano U O Dermatologia, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Br J Dermatol 165:335-41. 2011
    ..It usually presents with annular polycyclic or papulosquamous eruptions on sun-exposed skin and shows serum anti-Ro/SSA antibodies...
  47. ncbi request reprint Increased flow-mediated vasodilation in cirrhotic patients with ascites: relationship with renal resistive index
    Massimo Cazzaniga
    Department of Internal Medicine, IRCCS Policlinico San Donato, University of Milan, Milan, Italy
    Liver Int 28:1396-401. 2008
    ..Brachial artery flow-mediated dilation (FMD) after transient vascular occlusion is a non-invasive method to assess the shear stress-induced arterial vasodilation...
  48. doi request reprint Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: effects of tumor necrosis factor-alpha blockade
    Francesca Ingegnoli
    Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
    J Autoimmun 31:175-9. 2008
    ..We therefore investigated inflammation and coagulation plasma biomarkers before and after infliximab treatment in RA patients...
  49. ncbi request reprint Chronic urticaria and coagulation: pathophysiological and clinical aspects
    A Tedeschi
    U O Allergologia e Immunologia Clinica, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy
    Allergy 69:683-91. 2014
    ..The purpose of this review was to summarize the available data on the possible contribution of coagulation to the pathophysiology of CU focusing on clinical aspects and possible future therapeutic developments...
  50. pmc Alterations of coagulation and fibrinolysis in patients with angioedema due to C1-inhibitor deficiency
    M van Geffen
    Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 167:472-8. 2012
    ....
  51. ncbi request reprint Kallikrein-kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammation
    M Devani
    Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace 15, 20122 Milan, Italy
    Dig Liver Dis 37:665-73. 2005
    ..Observations on experimental models and humans with ulcerative colitis suggest a pathogenetic role of the kallikrein-kinin system in inflammatory bowel diseases...
  52. doi request reprint C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Mangiagalli e Regina Elena, Milan 20122, Italy
    Trends Mol Med 15:69-78. 2009
    ..Here, we review the molecular mechanisms underlying angioedema due to C1-inhibitor deficiency and clinical progress using molecular-targeted interventions...
  53. doi request reprint Skin autoimmunity and blood coagulation
    Massimo Cugno
    Department of Internal Medicine, University of Milan and IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli and Regina Elena, Italy
    Autoimmunity 43:189-94. 2010
    ..Taken together, these data provide the rationale for proposing clinical trials on the anticoagulant treatment in both CU and BP patients...
  54. ncbi request reprint Angiotensin-converting enzyme insertion/deletion gene polymorphism in inflammatory bowel diseases
    Simone Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena and University of Milan, Milan, Italy
    Eur J Gastroenterol Hepatol 19:976-81. 2007
    ..The ACE I/D (insertion/deletion) is a polymorphism of the gene encoding for ACE: participants who are homozygous for the D allele exhibit higher ACE levels, which in turn appear to play a deleterious role in several diseases...
  55. ncbi request reprint Kallikrein-kinin system activation in Crohn's disease: differences in intestinal and systemic markers
    Massimo Devani
    Department of Internal Medicine, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore and University of Milan, Italy
    Am J Gastroenterol 97:2026-32. 2002
    ..The aim of this study was to assess activation of the plasma and tissue kallikrein-kinin system in Crohn's disease...
  56. ncbi request reprint Activation of the tissue factor pathway of blood coagulation in patients with chronic urticaria
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    J Allergy Clin Immunol 119:705-10. 2007
    ..In patients with chronic urticaria (CU), plasma shows signs of thrombin generation and autologous plasma skin tests score positive in as many as 95% of cases...
  57. ncbi request reprint Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykinin
    Giuseppe Molinaro
    Faculte de Pharmacie, Departement de Mathematiques et de Statistique, Universite de Montreal, Canada
    J Pharmacol Exp Ther 303:232-7. 2002
    ....
  58. ncbi request reprint Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serum
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    J Allergy Clin Immunol 117:1113-7. 2006
    ..Autologous serum skin tests (ASSTs) and in vitro histamine release assays seem to look into distinct aspects of the disease, and the specificity of ASST has been questioned...
  59. ncbi request reprint Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
    Albert Adam
    Faculte de Pharmacie, Universite de Montreal, Montreal, Canada
    Lancet 359:2088-9. 2002
    ..Our data suggest that low plasma concentrations of aminopeptidase P could be a predisposing factor for development of angio-oedema in patients treated with ACE inhibitors...
  60. ncbi request reprint Chronic urticaria: a disease at a crossroad between autoimmunity and coagulation
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    Autoimmun Rev 7:71-6. 2007
    ..Such mechanism seems to be active in the majority of CU patients, however their relationship with anti-FcepsilonRI or anti-IgE autoantibodies is still matter of research...
  61. ncbi request reprint Bradykinin-mediated angioedema
    Juerg Nussberger
    N Engl J Med 347:621-2. 2002
  62. doi request reprint Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndrome
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
    Ann Allergy Asthma Immunol 100:44-8. 2008
    ..Recent investigations have found that patients with CU show signs of thrombin generation and activation of the tissue factor pathway of the coagulation cascade...
  63. ncbi request reprint Chronic urticaria: one step forward and two steps back
    Riccardo Asero
    J Am Acad Dermatol 57:368-9. 2007
  64. pmc A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors
    Qing Ling Duan
    Centre de Recherche du CHUM, Hopital Notre Dame, Montreal, Quebec, Canada
    Am J Hum Genet 77:617-26. 2005
    ..0364). In conclusion, our findings provide supporting evidence that the C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi...