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Genomes and Genes | M CugnoSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
Inflammation and coagulation in urticaria and angioedemaMassimo Cugno
Department of Internal Medicine, University of Milan, Via Pace 9, 20122 Milano, Italy
Curr Vasc Pharmacol 10:653-8. 2012..These observations have provided the rationale for the clinical evaluation of anticoagulant and antifibrinolytic drugs, the efficacy of which has sometimes been demonstrated...
Inflammatory and prothrombotic parameters in normotensive non-diabetic obese women: effect of weight loss obtained by gastric bandingMassimo Cugno
Department of Internal Medicine, University of Milan, Milan, Italy
Intern Emerg Med 7:237-42. 2012..The weight loss induced by gastric banding decreases the parameters of inflammation, coagulation and impaired fibrinolysis, thus potentially reducing the thrombotic risk...- Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patientsMassimo Cugno
Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Via Pace 15, 20122 Milano, Italy
Blood 103:2121-6. 2004..Our data indicate that anti-tPA antibodies specifically interacting with the catalytic domain of tPA can be found in patients with APS, representing a possible cause of hypofibrinolysis... - Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantationMassimo Cugno
Department of Internal Medicine, University of Milan, Milan, Italy
Br J Haematol 126:85-92. 2004..Most of these abnormalities parallel each other, tend to normalize in patients treated with OATs and, although reduced, persist in patients undergoing successful heart transplantation, despite the absence of clinical signs of CHF... - Impaired bradykinin response to ischaemia and exercise in patients with mild congestive heart failure during angiotensin-converting enzyme treatment. Relationships with endothelial function, coagulation and inflammationMassimo Cugno
Department of Internal Medicine, University of Milan, Milan, Italy
Br J Haematol 130:113-20. 2005..They are unable to respond adequately to stimuli of ischaemia and physical exercise which both require vasodilation... - Activation of blood coagulation in autoimmune skin disordersMassimo Cugno
Department of Internal Medicine, University of Milan and IRCCS Foundation Maggiore Hospital, Policlinico, Mangiagalli and Regina Elena, Via Pace 9, 20122, Milan, Italy
Expert Rev Clin Immunol 5:605-13. 2009..In psoriasis, the activation of coagulation seems to be mainly systemic, potentially contributing to the increased cardiovascular risk associated with this disease... - Anti-t-PA antibodies in acute myocardial infarction after thrombolysis with rt-PAMassimo Cugno
Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
Eur J Intern Med 21:25-9. 2010..Reocclusions follow rt-PA treatment in up to 30% of patients within one year. The infusion of rt-PA may induce the production of anti-t-PA antibodies which could interfere with the function of the native t-PA molecule... - Activation of blood coagulation in chronic urticaria: pathophysiological and clinical implicationsMassimo Cugno
Department of Internal Medicine, Universita degli Studi di Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
Intern Emerg Med 5:97-101. 2010..Taken together, all these findings provide the rationale for proposing clinical trials on the use of anticoagulant drugs as adjuvant treatment in CU patients... - Potential effect of anti-tumour necrosis factor-alpha treatment on reducing the cardiovascular risk related to rheumatoid arthritisMassimo Cugno
Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Curr Vasc Pharmacol 8:285-92. 2010..This review provides an overview of the pathophysiological role of TNF-alpha in thrombotic mechanisms and the evidence so far available indicating that anti-TNF-alpha treatment can modify cardiovascular risk in RA... - Expression of tissue factor by eosinophils in patients with chronic urticariaMassimo Cugno
Department of Internal Medicine, University of Milan, Milan, Italy
Int Arch Allergy Immunol 148:170-4. 2009..Eosinophils, which are involved in CU skin lesions, have recently been demonstrated as the major source of TF in human blood. We assessed whether eosinophils are the cellular source of TF in CU skin lesions... - Bradykinin and the pathophysiology of angioedemaMassimo Cugno
Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace, 15, 20122 Milan, Italy
Int Immunopharmacol 3:311-7. 2003.... - Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferationMassimo Cugno
Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Autoimmun Rev 8:156-9. 2008.... - Parallel reduction of plasma levels of high and low molecular weight kininogen in patients with cirrhosisM Cugno
Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
Thromb Haemost 82:1428-32. 1999..The decrease of important regulatory proteins like kininogens may contribute to the imbalance in coagulation and fibrinolytic systems, which frequently occurs in cirrhotic patients... - In vitro interaction of C1-inhibitor with thrombinM Cugno
Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
Blood Coagul Fibrinolysis 12:253-60. 2001.... - Bradykinin in the ascitic fluid of patients with liver cirrhosisM Cugno
Department of Internal Medicine, University of Milan, Maggiore Hospital IRCCS, Via Pace 15, 20122 Milan, Italy
Clin Sci (Lond) 101:651-7. 2001..Activation of the kinin system may therefore be involved in decompensating cirrhosis, but a cause-effect relationship remains to be established... 
Prothrombotic state and impaired fibrinolysis in bullous pemphigoid, the most frequent autoimmune blistering diseaseA V Marzano
Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Milano, Italy
Clin Exp Immunol 171:76-81. 2013..Corticosteroids not only induce the regression of BP lesions, but also reduce the inhibition of fibrinolysis, which may contribute to decreasing thrombotic risk...- Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseasesA V Marzano
Dipartimento di Medicina Interna, Universita degli Studi di Milano, Italy
Clin Exp Immunol 165:44-50. 2011..The coagulation cascade is activated in BP and other eosinophil-mediated skin disorders, but not in non-eosinophil driven conditions. This hypercoagulability may contribute to inflammation, tissue damage and, possibly, thrombotic risk... - Activation of blood coagulation in bullous pemphigoid: role of eosinophils, and local and systemic implicationsA V Marzano
Department of Internal Medicine, IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli, Regina Elena, Milan, Italy
Br J Dermatol 160:266-72. 2009..Eosinophils are a source of tissue factor (TF), an initiator of blood coagulation... - Inflammatory cells, cytokines and matrix metalloproteinases in amicrobial pustulosis of the folds and other neutrophilic dermatosesA V Marzano
Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Italy
Int J Immunopathol Pharmacol 24:451-60. 2011..035), but less intense than in PG (p=0.020). Our study supports the role of proinflammatory cytokines/chemokines and MMPs as important effectors for the tissue damage in APF similarly to classic neutrophilic dermatoses... - Prothrombotic state in Churg-Strauss syndrome: a case reportA V Marzano
U O Dermatologia, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
J Investig Allergol Clin Immunol 20:616-9. 2010..In conclusion, we present a patient with active CSS and a prothrombotic state that reverted during remission achieved by immunosuppressive therapy... - Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticariaA Tedeschi
Unità Operativa di Allergologia e Immunologia Clinica, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy
Allergy 64:1616-22. 2009..This suggests that other factors may contribute to its pathogenesis. We evaluated the possible involvement of vascular endothelial growth factor (VEGF), one of the major mediators of vascular permeability, in CU... - Coagulation activation in autoimmune bullous diseasesA V Marzano
Department of Anesthesiology, Intensive Care and Dermatological Sciences, University of Milan, Milan, Italy
Clin Exp Immunol 158:31-6. 2009..This suggests that BP but not PV patients have an increased thrombotic risk. The observation that thrombotic complications occur more frequently in BP than in PV further supports this view... - Plasma levels of matrix metalloproteinase-9 in chronic urticaria patients correlate with disease severity and C-reactive protein but not with circulating histamine-releasing factorsA Tedeschi
Unità Operativa di Allergologia e Immunologia Clinica, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Milano, Italy
Clin Exp Allergy 40:875-81. 2010..Matrix metalloproteinase-9 (MMP-9) is an endopeptidase produced by many inflammatory cells that has been found in increased amounts in plasma from patients with chronic urticaria (CU)... - Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseasesA V Marzano
Unita Operativa di Dermatologia, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milano, Italy
Clin Exp Immunol 162:100-7. 2010..In ulcerative PG, the wound bed is the site of neutrophil-recruitment, whereas in the wound edge activated T lymphocytes and macrophages pave the way to ulcer formation... - Antibodies to tissue-type plasminogen activator (t-PA) in patients with inflammatory bowel disease: high prevalence, interactions with functional domains of t-PA and possible implications in thrombosisS Saibeni
Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Fondazione Ospedale Policlinico, Mangiagalli and Regina Elena, University of Milan, Via Pace 9, 20122 Milan, Italy
J Thromb Haemost 4:1510-6. 2006..The pathogenetic mechanisms of these events include reduced fibrinolysis, which may be caused by antibodies to tissue-type plasminogen activator (t-PA)... - Different rates of autoreactivity in patients with recurrent idiopathic angioedema associated or not with whealsA Tedeschi
U O Allergologia e Immunologia Clinica, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milano, Italy
J Investig Allergol Clin Immunol 22:87-91. 2012..The pathophysiology and triggers of idiopathic nonhistaminergic angioedema are unclear. This study aimed to assess autoreactivity in recurrent idiopathic angioedema associated or not with wheals... - Time course of endogenous nitric oxide inhibitors in severe sepsis in humansG Iapichino
Department of Anesthesiology, Intensive Therapy and Dermatologic Sciences, University of Milan, Italy
Minerva Anestesiol 76:325-33. 2010..We investigated plasma ADMA and SDMA levels during ICU stay to reveal the time course of endogenous NO inhibition in patients with sepsis... - Anti-tumor necrosis factor alpha therapy normalizes fibrinolysis impairment in patients with active rheumatoid arthritisF Ingegnoli
Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
Clin Exp Rheumatol 28:254-7. 2010..We carried out an observational study investigating plasma biomarkers of inflammation and fibrinolysis in RA patients before and after 14 weeks of infliximab treatment given according to the therapeutic guidelines for RA... - Serum eotaxin levels in patients with chronic spontaneous urticariaA Tedeschi
Allergy and Clinical Immunology Unit, IRCCS Ca Granda Foundation, Maggiore Policlinico Hospital, Milan, Italy
Eur Ann Allergy Clin Immunol 44:188-92. 2012..These findings indicate that serum eotaxin levels are increased in CU patients, although they do not reflect strictly disease activity. A role for eotaxin in eosinophil attraction and activation in CU can be envisaged... - Tight glycemic control may favor fibrinolysis in patients with sepsisMonica Savioli
Dipartimento di Anestesia, UO di Anestesia e Rianimazione, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Milan, Italy
Crit Care Med 37:424-31. 2009..To investigate whether tight glycemic control, in patients with sepsis, may restore a normal fibrinolysis by lowering plasminogen activator inhibitor (PAI)-1 levels... - Patients with antiphospholipid syndrome display endothelial perturbationMassimo Cugno
Department of Internal Medicine, University of Milan, IRCCS Foundation Maggiore Hospital Policlinico, Mangiagalli, Regina Elena, Italy
J Autoimmun 34:105-10. 2010..The aim of this observational case-control study was to evaluate several parameters of endothelial perturbation in patients with APS and without any other atherosclerosis risk factor... - Angioedema due to angiotensin-converting enzyme inhibitorsA Agostoni
Department of Internal Medicine, University of Milan, IRCCS Ospedale, Maggiore, Italy
Immunopharmacology 44:21-5. 1999..These observations indicate that in ACE-inhibitor-induced angioedema, contrary to hereditary angioedema, the reduction of bradykinin catabolic rate plays a predominant role... - Increase of bradykinin in plasma of patients undergoing cardiopulmonary bypass: the importance of lung exclusionM Cugno
Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
Chest 120:1776-82. 2001..CONCLUSIONS: During CPB, there is a progressive increase of plasma bradykinin that is at least partially due to reduced catabolism as a consequence of shunting the lungs. The increase in bradykinin may contribute to the fall in BP... - Diagnosis and disease severity assessment of epidermolysis bullosa acquisita by ELISA for anti-type VII collagen autoantibodies: an Italian multicentre studyA V Marzano
Unità di Dermatologia, Dipartimento di Fisiopatologia e dei Trapianti, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122, Milano, Italy
Br J Dermatol 168:80-4. 2013..Type VII collagen is composed of a collagenous domain linked by the noncollagenous (NC)1 and NC2 domains... - Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiencyM Cugno
Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Allergy 64:254-7. 2009..Although cutaneous swelling is evident, abdominal angioedema is still a diagnostic challenge and attacks can mimic surgical emergencies. There is currently no laboratory marker for identifying angioedema attacks... - Alzheimer's beta-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent mannerL Bergamaschini
Department of Internal Medicine, Maggiore Hospital, IRCCS, Milan, Italy
Clin Exp Immunol 115:526-33. 1999.... - Homocysteine concentration in primary and systemic sclerosis associated Raynaud's phenomenonB Marasini
Department of Medicine, Surgery and Dentistry, Institute of Radiological Sciences, San Paolo Hospital, Italy
J Rheumatol 27:2621-3. 2000.... - [The kinin system: biological mechanisms and clinical implications]A Agostoni
Dipartimento di Medicina Interna, Universita, IRCCS Ospedale Maggiore, Milano
Recenti Prog Med 92:764-73. 2001..The study of the kinin system in clinical field, which had been limited by methodological difficulties, has now received an important stimulus by the recent availability of specific and sensitive methods of dosage... - Chronic heart failure and the immune systemDaniela Mari
Department of Internal Medicine, University of Milan, Maggiore Hospital IRCCS, Via Pace 15, 20122 Milan, Italy
Clin Rev Allergy Immunol 23:325-40. 2002..The effort of define the immune system's role has opened new perspectives of therapeutic strategies, such as anti-cytokine drugs, to treat CHF... - Tight glycemic control does not affect asymmetric-dimethylarginine in septic patientsGaetano Iapichino
Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Via A Di Rudini 8, 20142 Milan, Italy
Intensive Care Med 34:1843-50. 2008..We investigated whether preventing hyperglycemia in septic patients affected the plasma concentration of asymmetric-dimethylarginine and if this was associated with clinical benefit... - Effects of selective alpha1- and alpha2-adrenergic blockade on coronary flow reserve after coronary stentingLuisa Gregorini
Experimental Surgery and Transplantation Institute, Ospedale Maggiore IRCCS, University of Milano, Italy
Circulation 106:2901-7. 2002..Coronary flow reserve (CFR) is not normalized shortly after coronary stenting. We hypothesized that alpha-adrenergic coronary vasoconstriction acts to limit CFR... - Activation of the contact system and inflammation after thrombolytic therapy in patients with acute myocardial infarctionPiera Angelica Merlini
IV Division of Cardiology, Ospedale Niguarda, Milan, Italy
Am J Cardiol 93:822-5. 2004.... - Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic controlF Polli
Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
Minerva Anestesiol 75:417-26. 2009..Our aim was to evaluate the effects on the fibrinolytic system after the administration of rh-APC in septic patients undergoing conventional or TGC... - Drug-induced subacute cutaneous lupus erythematosus: evidence for differences from its idiopathic counterpartA V Marzano
Department of Anaesthesia, Intensive Care and Dermatological Sciences, Università degli Studi di Milano U O Dermatologia, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
Br J Dermatol 165:335-41. 2011..It usually presents with annular polycyclic or papulosquamous eruptions on sun-exposed skin and shows serum anti-Ro/SSA antibodies... - Increased flow-mediated vasodilation in cirrhotic patients with ascites: relationship with renal resistive indexMassimo Cazzaniga
Department of Internal Medicine, IRCCS Policlinico San Donato, University of Milan, Milan, Italy
Liver Int 28:1396-401. 2008..Brachial artery flow-mediated dilation (FMD) after transient vascular occlusion is a non-invasive method to assess the shear stress-induced arterial vasodilation... - Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: effects of tumor necrosis factor-alpha blockadeFrancesca Ingegnoli
Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
J Autoimmun 31:175-9. 2008..We therefore investigated inflammation and coagulation plasma biomarkers before and after infliximab treatment in RA patients... - Alterations of coagulation and fibrinolysis in patients with angioedema due to C1-inhibitor deficiencyM van Geffen
Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Exp Immunol 167:472-8. 2012.... - Kallikrein-kinin system in inflammatory bowel diseases: Intestinal involvement and correlation with the degree of tissue inflammationM Devani
Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace 15, 20122 Milan, Italy
Dig Liver Dis 37:665-73. 2005..The normal pattern observed in the disease-free samples seems to rule out a genetic defect of kallikrein and kallistatin in inflammatory bowel diseases... - C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progressMassimo Cugno
Department of Internal Medicine, University of Milan, Mangiagalli e Regina Elena, Milan 20122, Italy
Trends Mol Med 15:69-78. 2009..Here, we review the molecular mechanisms underlying angioedema due to C1-inhibitor deficiency and clinical progress using molecular-targeted interventions... - Skin autoimmunity and blood coagulationMassimo Cugno
Department of Internal Medicine, University of Milan and IRCCS Foundation Maggiore Policlinico Hospital, Mangiagalli and Regina Elena, Italy
Autoimmunity 43:189-94. 2010..Taken together, these data provide the rationale for proposing clinical trials on the anticoagulant treatment in both CU and BP patients... - Angiotensin-converting enzyme insertion/deletion gene polymorphism in inflammatory bowel diseasesSimone Saibeni
Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena and University of Milan, Milan, Italy
Eur J Gastroenterol Hepatol 19:976-81. 2007..The ACE I/D (insertion/deletion) is a polymorphism of the gene encoding for ACE: participants who are homozygous for the D allele exhibit higher ACE levels, which in turn appear to play a deleterious role in several diseases... - Kallikrein-kinin system activation in Crohn's disease: differences in intestinal and systemic markersMassimo Devani
Department of Internal Medicine, Instituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore and University of Milan, Italy
Am J Gastroenterol 97:2026-32. 2002..The lack of contact system activation in peripheral blood might be related to the high plasma levels of Cl-inhibitor, the most important inhibitor of the contact system in the circulation... - Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)-bradykininGiuseppe Molinaro
, , , Canada
J Pharmacol Exp Ther 303:232-7. 2002.... - Activation of the tissue factor pathway of blood coagulation in patients with chronic urticariaRiccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
J Allergy Clin Immunol 119:705-10. 2007..In patients with chronic urticaria (CU), plasma shows signs of thrombin generation and autologous plasma skin tests score positive in as many as 95% of cases... - Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitorsAlbert Adam
Faculte de Pharmacie, Universite de Montreal, Montreal, Canada
Lancet 359:2088-9. 2002..Our data suggest that low plasma concentrations of aminopeptidase P could be a predisposing factor for development of angio-oedema in patients treated with ACE inhibitors... - Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal-and-flare reactions much more frequently than autologous serumRiccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
J Allergy Clin Immunol 117:1113-7. 2006..Autologous serum skin tests (ASSTs) and in vitro histamine release assays seem to look into distinct aspects of the disease, and the specificity of ASST has been questioned... - Bradykinin-mediated angioedemaJuerg Nussberger
N Engl J Med 347:621-2. 2002 - Chronic urticaria: a disease at a crossroad between autoimmunity and coagulationRiccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
Autoimmun Rev 7:71-6. 2007..Such mechanism seems to be active in the majority of CU patients, however their relationship with anti-FcepsilonRI or anti-IgE autoantibodies is still matter of research... - A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitorsQing Ling Duan
Centre de Recherche du CHUM, Hopital Notre Dame, Montreal, Quebec, Canada
Am J Hum Genet 77:617-26. 2005..0364). In conclusion, our findings provide supporting evidence that the C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi... - Coagulation cascade and fibrinolysis in patients with multiple-drug allergy syndromeRiccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano MI, Italy
Ann Allergy Asthma Immunol 100:44-8. 2008..Recent investigations have found that patients with CU show signs of thrombin generation and activation of the tissue factor pathway of the coagulation cascade... - Chronic urticaria: one step forward and two steps backRiccardo Asero
J Am Acad Dermatol 57:368-9. 2007