Alessandra Cucina

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    J Surg Res 178:233-41. 2012
  2. doi request reprint Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
    J Surg Res 150:227-35. 2008
  3. doi request reprint The effect of locally administered anti-growth factor antibodies on neointimal hyperplasia formation in expanded polytetrafluoroethylene grafts
    Paolo Sapienza
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
    Ann Vasc Surg 23:398-409. 2009
  4. ncbi request reprint Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
    Toxicol In Vitro 27:2256-63. 2013
  5. ncbi request reprint High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
    Atherosclerosis 189:303-9. 2006
  6. pmc Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines
    Fabrizio D'Anselmi
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e83770. 2013
  7. ncbi request reprint Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni University of Rome La Sapienza, Via A Scarpa 14, 00161, Rome, Italy
    J Surg Res 109:16-23. 2003
  8. pmc TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis
    Francesca Ferranti
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e76192. 2013
  9. doi request reprint Role of growth factors on human parathyroid adenoma cell proliferation
    Giuseppe Cavallaro
    Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University, Viale del Policlinico, Rome, Italy
    World J Surg 34:48-54. 2010
  10. doi request reprint Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells
    Alessandra Cucina
    Surgery Department Pietro Valdoni, Rome, Italy
    J Pineal Res 46:172-80. 2009

Collaborators

Detail Information

Publications16

  1. doi request reprint Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    J Surg Res 178:233-41. 2012
    ..However, although nicotine appears to have a role in stimulating cell proliferation of colon cancer cells, there is no information on its role in inhibiting apoptosis in these cells...
  2. doi request reprint Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
    J Surg Res 150:227-35. 2008
    ..We also showed that nicotine signaling occurs as a result of activation of the classical nicotine receptor pathways...
  3. doi request reprint The effect of locally administered anti-growth factor antibodies on neointimal hyperplasia formation in expanded polytetrafluoroethylene grafts
    Paolo Sapienza
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
    Ann Vasc Surg 23:398-409. 2009
    ..001). The combined use of locally administered anti-PDGF-BB, bFGF, and TGF-beta1 monoclonal antibodies reduces neointimal hyperplasia formation...
  4. ncbi request reprint Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs
    Simona Dinicola
    Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
    Toxicol In Vitro 27:2256-63. 2013
    ..Nicotine interfered with colorectal cancer pharmacological treatment in vitro by inhibiting apoptosis induced by chemotherapeutic drugs. Nicotine anti-apoptotic effects were exerted through ERK and AKT pathway activation. ..
  5. ncbi request reprint High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
    Atherosclerosis 189:303-9. 2006
    ..0) produced the inhibition of MM-LDL effects. Our data suggest that the protective role of HDL could also be exerted through the inhibition of the pro-atherosclerotic effects of MM-LDL on SMCs...
  6. pmc Microenvironment promotes tumor cell reprogramming in human breast cancer cell lines
    Fabrizio D'Anselmi
    Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e83770. 2013
    ..Given that egg-conditioned medium behaves as a 3D-medium, it is likely that cancer phenotype reversion could be ascribed to the changed interactions between cells and their microenvironment. ..
  7. ncbi request reprint Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni University of Rome La Sapienza, Via A Scarpa 14, 00161, Rome, Italy
    J Surg Res 109:16-23. 2003
    ..The purpose of our study was to assess if VEGF might indirectly stimulate SMC migration and proliferation in a EC-SMC coculture system, through the mediation of growth factors released by EC...
  8. pmc TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric Analysis
    Francesca Ferranti
    Department of Anatomy, Histology, Forensic Medicine and Orthopedics Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e76192. 2013
    ..Prompted by these observations we hypothesize that EW treatment could rescue, at least in part, the neoplastic-metastatic behaviour of seminoma cells. ..
  9. doi request reprint Role of growth factors on human parathyroid adenoma cell proliferation
    Giuseppe Cavallaro
    Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University, Viale del Policlinico, Rome, Italy
    World J Surg 34:48-54. 2010
    ....
  10. doi request reprint Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells
    Alessandra Cucina
    Surgery Department Pietro Valdoni, Rome, Italy
    J Pineal Res 46:172-80. 2009
    ....
  11. ncbi request reprint Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review
    Mariano Bizzarri
    University La Sapienza, Department of Experimental Medicine, Systems Biology Group, Rome, Italy
    Expert Opin Ther Targets 17:1483-96. 2013
    ..Melatonin behaves as a 'smart killer', i.e., modulating anti-apoptotic processes in normal cells, and triggering pro-apoptotic signals in cancer cells...
  12. ncbi request reprint Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasion
    Simona Dinicola
    Department of Clinical and Molecular Medicine, La Sapienza University, Piazza Sassari 3, 00161, Rome, Italy
    Eur J Nutr 53:421-31. 2014
    ..e., cell migration and invasion...
  13. doi request reprint Molecular mechanisms of melatonin's inhibitory actions on breast cancers
    Sara Proietti
    Department of Clinical and Molecular Medicine, University La Sapienza, Rome, Italy
    Cell Mol Life Sci 70:2139-57. 2013
    ..Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation...
  14. ncbi request reprint TIMP-2 modulates neointimal formation in experimental ePTFE arterial grafts
    Giuseppe Cavallaro
    Department of Surgery P Valdoni, University La Sapienza, Rome, Italy
    J Surg Res 137:122-9. 2007
    ..The aims of our study was to investigate the effects of selective MMP-2 inhibitor (TIMP-2) in endothelialization rate, SMC proliferation, and myointimal hyperplasia in experimental ePTFE arterial grafts...
  15. doi request reprint Theoretical aspects of Systems Biology
    Mariano Bizzarri
    Department of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, Via Scarpa 14 16, 00161 Rome, Italy
    Prog Biophys Mol Biol 112:33-43. 2013
    ..Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a 'simple' 'gradual' extension of Molecular Biology...
  16. ncbi request reprint Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cells
    Alessandra Cucina
    First Department of Surgery, University of Rome La Sapienza, Rome, Italy
    Cell Biochem Funct 20:39-46. 2002
    ..In conclusion, thrombin-induced mitogenesis was partially mediated by the autocrine production of bFGF, mainly due to protein synthesis by novel mRNA with a transcription peak at 24 h and a later translation peak...