Affiliation: University of Rome La Sapienza
- Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathwaysAlessandra Cucina
Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
J Surg Res 178:233-41. 2012..However, although nicotine appears to have a role in stimulating cell proliferation of colon cancer cells, there is no information on its role in inhibiting apoptosis in these cells...
- Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptorAlessandra Cucina
Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
J Surg Res 150:227-35. 2008..We also showed that nicotine signaling occurs as a result of activation of the classical nicotine receptor pathways...
- The effect of locally administered anti-growth factor antibodies on neointimal hyperplasia formation in expanded polytetrafluoroethylene graftsPaolo Sapienza
Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy
Ann Vasc Surg 23:398-409. 2009..001). The combined use of locally administered anti-PDGF-BB, bFGF, and TGF-beta1 monoclonal antibodies reduces neointimal hyperplasia formation...
- Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugsSimona Dinicola
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Piazza Sassari 3, 00161 Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
Toxicol In Vitro 27:2256-63. 2013..Nicotine interfered with colorectal cancer pharmacological treatment in vitro by inhibiting apoptosis induced by chemotherapeutic drugs. Nicotine anti-apoptotic effects were exerted through ERK and AKT pathway activation. ..
- High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cellsAlessandra Cucina
Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
Atherosclerosis 189:303-9. 2006..0) produced the inhibition of MM-LDL effects. Our data suggest that the protective role of HDL could also be exerted through the inhibition of the pro-atherosclerotic effects of MM-LDL on SMCs...
- Microenvironment promotes tumor cell reprogramming in human breast cancer cell linesFabrizio D'Anselmi
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
PLoS ONE 8:e83770. 2013..Given that egg-conditioned medium behaves as a 3D-medium, it is likely that cancer phenotype reversion could be ascribed to the changed interactions between cells and their microenvironment. ..
- Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cellsAlessandra Cucina
Department of Surgery Pietro Valdoni University of Rome La Sapienza, Via A Scarpa 14, 00161, Rome, Italy
J Surg Res 109:16-23. 2003..The purpose of our study was to assess if VEGF might indirectly stimulate SMC migration and proliferation in a EC-SMC coculture system, through the mediation of growth factors released by EC...
- TCam-2 Seminoma Cells Exposed to Egg-Derived Microenvironment Modify Their Shape, Adhesive Pattern and Migratory Behaviour: A Molecular and Morphometric AnalysisFrancesca Ferranti
Department of Anatomy, Histology, Forensic Medicine and Orthopedics Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
PLoS ONE 8:e76192. 2013..Prompted by these observations we hypothesize that EW treatment could rescue, at least in part, the neoplastic-metastatic behaviour of seminoma cells. ..
- Role of growth factors on human parathyroid adenoma cell proliferationGiuseppe Cavallaro
Department of Surgery P Valdoni, Policlinico Umberto I, Sapienza University, Viale del Policlinico, Rome, Italy
World J Surg 34:48-54. 2010....
- Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cellsAlessandra Cucina
Surgery Department Pietro Valdoni, Rome, Italy
J Pineal Res 46:172-80. 2009....
- Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a reviewMariano Bizzarri
University La Sapienza, Department of Experimental Medicine, Systems Biology Group, Rome, Italy
Expert Opin Ther Targets 17:1483-96. 2013..Melatonin behaves as a 'smart killer', i.e., modulating anti-apoptotic processes in normal cells, and triggering pro-apoptotic signals in cancer cells...
- Grape seed extract suppresses MDA-MB231 breast cancer cell migration and invasionSimona Dinicola
Department of Clinical and Molecular Medicine, La Sapienza University, Piazza Sassari 3, 00161, Rome, Italy
Eur J Nutr 53:421-31. 2014..e., cell migration and invasion...
- Molecular mechanisms of melatonin's inhibitory actions on breast cancersSara Proietti
Department of Clinical and Molecular Medicine, University La Sapienza, Rome, Italy
Cell Mol Life Sci 70:2139-57. 2013..Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation...
- TIMP-2 modulates neointimal formation in experimental ePTFE arterial graftsGiuseppe Cavallaro
Department of Surgery P Valdoni, University La Sapienza, Rome, Italy
J Surg Res 137:122-9. 2007..The aims of our study was to investigate the effects of selective MMP-2 inhibitor (TIMP-2) in endothelialization rate, SMC proliferation, and myointimal hyperplasia in experimental ePTFE arterial grafts...
- Theoretical aspects of Systems BiologyMariano Bizzarri
Department of Experimental Medicine, Systems Biology Group Lab, Sapienza University of Rome, Via Scarpa 14 16, 00161 Rome, Italy
Prog Biophys Mol Biol 112:33-43. 2013..Indeed, both evolution and physiology work on these levels. Thus, by no means Systems Biology could be considered a 'simple' 'gradual' extension of Molecular Biology...
- Autocrine production of basic fibroblast growth factor translated from novel synthesized mRNA mediates thrombin-induced mitogenesis in smooth muscle cellsAlessandra Cucina
First Department of Surgery, University of Rome La Sapienza, Rome, Italy
Cell Biochem Funct 20:39-46. 2002..In conclusion, thrombin-induced mitogenesis was partially mediated by the autocrine production of bFGF, mainly due to protein synthesis by novel mRNA with a transcription peak at 24 h and a later translation peak...