S Cucchiara

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Nutritional challenge in pseudo-obstruction: the bridge between motility and nutrition
    Salvatore Cucchiara
    Department of Pediatrics, Gastroenterology Service, Sapienza University of Rome, Rome, Italy
    J Pediatr Gastroenterol Nutr 48:S83-5. 2009
  2. ncbi request reprint "New drugs: kids come first": children should be included in trials of new biological treatments
    Salvatore Cucchiara
    Pediatric Gastroenterology Unit, University of Rome La Sapienza, University Hospital Umberto I, Rome, Italy
    Inflamm Bowel Dis 13:1165-9; discussion 1176-7. 2007
  3. doi request reprint The microbiota in inflammatory bowel disease in different age groups
    Salvatore Cucchiara
    Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, IT 00161 Rome, Italy
    Dig Dis 27:252-8. 2009
  4. pmc Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial
    Giovanni Di Nardo
    Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
    BMC Gastroenterol 13:142. 2013
  5. pmc Efficacy and tolerability of peg-only laxative on faecal impaction and chronic constipation in children. A controlled double blind randomized study vs a standard peg-electrolyte laxative
    Francesco Savino
    Department of Pediatrics 1, Regina Margherita Children s Hospital, University of Turin, Azienda Ospedaliera Città della Salute e della Scienza della Città di Torino, Turin, Italy
    BMC Pediatr 12:178. 2012
  6. doi request reprint Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel disease
    Salvatore Cucchiara
    Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
    J Clin Gastroenterol 46:S64-6. 2012
  7. pmc A distinctive 'microbial signature' in celiac pediatric patients
    Serena Schippa
    Department of Public Health Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy
    BMC Microbiol 10:175. 2010
  8. pmc Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation
    Sandra Lucarelli
    Pediatric Gastroenterology Endoscopy and Liver Unit, Sapienza University of Rome, Azienda Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy
    BMC Gastroenterol 11:82. 2011
  9. doi request reprint Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter study
    S Cucchiara
    Division Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
    Dig Liver Dis 40:S260-4. 2008
  10. ncbi request reprint New therapeutic approach in the management of intestinal disease: probiotics in intestinal disease in paediatric age
    S Cucchiara
    Pediatric Gastroenterology and Gastrointestinal Endoscopy Unit, Department of Paediatrics, Rome, Italy
    Dig Liver Dis 34:S44-7. 2002

Collaborators

Detail Information

Publications56

  1. doi request reprint Nutritional challenge in pseudo-obstruction: the bridge between motility and nutrition
    Salvatore Cucchiara
    Department of Pediatrics, Gastroenterology Service, Sapienza University of Rome, Rome, Italy
    J Pediatr Gastroenterol Nutr 48:S83-5. 2009
    ..In the most severe cases, parenteral nutrition becomes mandatory in order to satisfy nutritional requirements and manage appropriately obstructive episodes...
  2. ncbi request reprint "New drugs: kids come first": children should be included in trials of new biological treatments
    Salvatore Cucchiara
    Pediatric Gastroenterology Unit, University of Rome La Sapienza, University Hospital Umberto I, Rome, Italy
    Inflamm Bowel Dis 13:1165-9; discussion 1176-7. 2007
    ..This, however, requires multicenter randomized controlled trials to prove...
  3. doi request reprint The microbiota in inflammatory bowel disease in different age groups
    Salvatore Cucchiara
    Pediatric Gastroenterology and Liver Unit, Department of Pediatrics, Sapienza University of Rome, IT 00161 Rome, Italy
    Dig Dis 27:252-8. 2009
    ..On the other hand, existing differences in gut microbial community between distinct classes of age make sense of an increasing research in microbial shifts in IBD...
  4. pmc Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children: a randomized, double-blind, placebo controlled trial
    Giovanni Di Nardo
    Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
    BMC Gastroenterol 13:142. 2013
    ..galactosidase has been shown to reduce gas production and related symptoms in adults. To evaluate the efficacy and tolerability of α-galactosidase in the treatment of gas-related symptoms in pediatric patients...
  5. pmc Efficacy and tolerability of peg-only laxative on faecal impaction and chronic constipation in children. A controlled double blind randomized study vs a standard peg-electrolyte laxative
    Francesco Savino
    Department of Pediatrics 1, Regina Margherita Children s Hospital, University of Turin, Azienda Ospedaliera Città della Salute e della Scienza della Città di Torino, Turin, Italy
    BMC Pediatr 12:178. 2012
    ....
  6. doi request reprint Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel disease
    Salvatore Cucchiara
    Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy
    J Clin Gastroenterol 46:S64-6. 2012
    ..In this paper, we focus on the mechanisms that mediate host-microbe interactions and how the disruption of this balance leads to chronic intestinal inflammation in IBD...
  7. pmc A distinctive 'microbial signature' in celiac pediatric patients
    Serena Schippa
    Department of Public Health Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy
    BMC Microbiol 10:175. 2010
    ..Total DNA was extracted from duodenal biopsies and amplification products of 16S ribosomal DNA were compared by temporal temperature gradient gel electrophoresis (TTGE). TTGE profiles were analyzed by statistical multivariate analysis...
  8. pmc Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation
    Sandra Lucarelli
    Pediatric Gastroenterology Endoscopy and Liver Unit, Sapienza University of Rome, Azienda Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy
    BMC Gastroenterol 11:82. 2011
    ..Additionally, we assessed the efficacy of an amino acid-based formula (AAF) when multiple food allergy is suspected. amino acid-based formula..
  9. doi request reprint Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter study
    S Cucchiara
    Division Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
    Dig Liver Dis 40:S260-4. 2008
    ..Infliximab (IFX), the chimeric anti TNFalpha antibody, an established treatment for Crohn's disease in adults and in children, is used less frequently in ulcerative colitis (UC)...
  10. ncbi request reprint New therapeutic approach in the management of intestinal disease: probiotics in intestinal disease in paediatric age
    S Cucchiara
    Pediatric Gastroenterology and Gastrointestinal Endoscopy Unit, Department of Paediatrics, Rome, Italy
    Dig Liver Dis 34:S44-7. 2002
    ..Much work needs to be done in this area by clearly defining indications, delivery system, costs, safety long-term effects...
  11. ncbi request reprint Infliximab heals intestinal inflammatory lesions and restores growth in children with Crohn's disease
    O Borrelli
    Division of Paediatric Gastroenterology, Department of Paediatrics, University of Rome La Sapienza, Viale Regina Elena, Rome 324 00161, Italy
    Dig Liver Dis 36:342-7. 2004
    ..There are only few studies on the use of infliximab in children with Crohn's disease: most of them are retrospective and deal only with the clinical response to the drug...
  12. ncbi request reprint Role of drug therapy in the treatment of gastro-oesophageal reflux disorder in children
    S Cucchiara
    Department of Paediatrics, University of Naples Federico II, Italy
    Paediatr Drugs 2:263-72. 2000
    ..It is still unclear whether patients with frequent relapses are candidates for long term administration of antisecretory drugs or for surgical fundoplication...
  13. pmc Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
    M P Conte
    Paediatric Gastroenterology Unit, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy
    Gut 55:1760-7. 2006
    ..No paediatric reports are available on intestinal endogenous microflora in IBD...
  14. ncbi request reprint Short- and long-term therapeutic efficacy of nutritional therapy and corticosteroids in paediatric Crohn's disease
    R Berni Canani
    Department of Paediatrics, University of Naples Federico II, Naples, Italy
    Dig Liver Dis 38:381-7. 2006
    ....
  15. ncbi request reprint Inflammation is the main determinant of low bone mineral density in pediatric inflammatory bowel disease
    Massimiliano Paganelli
    Pediatric Gastroenterology and Liver Unit, University of Rome La Sapienza, Rome Italy
    Inflamm Bowel Dis 13:416-23. 2007
    ..To assess bone mineral density (BMD) in children with Crohn's disease (CD) and ulcerative colitis (UC) and to investigate the role of inflammation and steroids on BMD...
  16. ncbi request reprint Autonomic imbalance in celiac children
    M Barbato
    Department of Pediatrics, La Sapienza University, Rome, Italy
    Minerva Pediatr 62:333-8. 2010
    ..The aim of the study was to evaluate autonomic function in children with celiac disease...
  17. ncbi request reprint Chronic intestinal inflammation and seronegative spondyloarthropathy in children
    F Conti
    Department of Rheumatology, University of Rome La Sapienza, Rome, Italy
    Dig Liver Dis 37:761-7. 2005
    ..Spondyloarthropathy in adults has been shown to be associated with either clinical or subclinical intestinal inflammation, however this association has rarely been described in children...
  18. pmc Mechanisms of gastro-oesophageal reflux in cystic fibrosis
    S Cucchiara
    Department of Paediatrics, 2nd School of Medicine, University of Naples, Italy
    Arch Dis Child 66:617-22. 1991
    ..The predominant reflux mechanism in these patients is a transient inappropriate lower oesophageal sphincter relaxation rather than a low steady state basal lower oesophageal sphincter pressure...
  19. pmc Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn's disease
    A Laghi
    Department of Radiology, University of Rome La Sapienza, Rome, Italy
    Gut 52:393-7. 2003
    ..MRI was performed using a polyethylene glycol (PEG) solution as oral contrast agent to distend the small bowel (CE-PEG-MRI)...
  20. doi request reprint Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac disease
    R La Scaleia
    Department of Experimental Medicine, Sapienza University, Rome, Italy
    Mucosal Immunol 5:513-23. 2012
    ....
  21. doi request reprint Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis
    S Oliva
    Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Italy
    Aliment Pharmacol Ther 35:327-34. 2012
    ..Intestinal microbiota manipulation, one of the pathogenetic components of inflammatory bowel disease (IBD), has become an attractive therapy for ulcerative colitis (UC)...
  22. doi request reprint Methotrexate in paediatric ulcerative colitis: a retrospective survey at a single tertiary referral centre
    M Aloi
    Department of Pediatrics, Sapienza University of Rome, Italy
    Aliment Pharmacol Ther 32:1017-22. 2010
    ..If unresponsive or intolerant to these agents, patients are treated with methotrexate, an antimetabolite never assessed in paediatric ulcerative colitis...
  23. doi request reprint Non-acid gastro-oesophageal reflux in children with suspected pulmonary aspiration
    O Borrelli
    Department of Paediatric Gastroenterology and Hepatology, Sapienza University of Rome, Italy
    Dig Liver Dis 42:115-21. 2010
    ....
  24. ncbi request reprint MR of the small bowel with a biphasic oral contrast agent (polyethylene glycol): technical aspects and findings in patients affected by Crohn's disease
    Andrea Laghi
    Dipartimento di Scienze Radiologiche, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Radiol Med 106:18-27. 2003
    ..To report our experience using MR of the small bowel with polyethylene glycol (PEG) solution as an oral contrast agent in a population of adults and children with known Crohn's disease...
  25. ncbi request reprint Vertebral fractures and increased sensitivity to corticosteroids in a child with ulcerative colitis: successful use of pamidronate
    Sandra Lucarelli
    Pediatric Gastroenterology Division, La Sapienza University of Rome, Italy
    J Pediatr Gastroenterol Nutr 43:533-5. 2006
  26. ncbi request reprint Coeliac disease and ganglioneuroblastoma: an unusual association
    Maria Barbato
    Pediatric Gastroenterology Unit, Istitute of Pediatrics, University of Rome La Sapienza, Italy
    Med Pediatr Oncol 39:215-6. 2002
  27. ncbi request reprint Headache and recurrent abdominal pain: a controlled study by the means of the Child Behaviour Checklist (CBCL)
    F Galli
    Faculty of Psychology 1, Univesity of Rome La Sapienza, Rome, Italy
    Cephalalgia 27:211-9. 2007
    ..In conclusion, headache and RAP show a very similar psychological profile that should be considered not only for diagnostic and therapeutic purposes, but also from the aetiological aspect...
  28. ncbi request reprint Effect of intragastric volume and osmolality on mechanisms of gastroesophageal reflux in children with gastroesophageal reflux disease
    G Salvia
    Department of Pediatrics, University of Naples, Federico II, Italy
    Am J Gastroenterol 96:1725-32. 2001
    ..This finding correlates with a high postfeeding antral distension...
  29. doi request reprint Dominant genotypes in mucosa-associated Escherichia coli strains from pediatric patients with inflammatory bowel disease
    Serena Schippa
    Department of Public Health Sciences, University of Rome La Sapienza, Rome, Italy
    Inflamm Bowel Dis 15:661-72. 2009
    ..The aim of this study was to characterize E. coli strains from the intestinal mucosa of pediatric IBD patients to investigate whether a particular subset of strains could be associated with the disease...
  30. ncbi request reprint Mucosal NOD2 expression and NF-kappaB activation in pediatric Crohn's disease
    Laura Stronati
    Section of Toxicology and Biomedical Sciences, ENEA, Rome, Italy
    Inflamm Bowel Dis 14:295-302. 2008
    ..The present study was aimed at investigating the expression and activity of NOD2, NF-kappaB, and of 2 proinflammatory cytokines, TNFalpha and IL-1beta, in mucosal biopsies of CD affected children compared to healthy controls...
  31. doi request reprint Neuroimmune interactions at different intestinal sites are related to abdominal pain symptoms in children with IBS
    G Di Nardo
    Department of Pediatrics, Pediatric Gastroenterology Unit, Sapienza University of Rome, Rome, Italy
    Neurogastroenterol Motil 26:196-204. 2014
    ..In children with IBS and healthy controls, we measured ileocolonic mast cell infiltration and fecal calprotectin and evaluated the relationships between these parameters and abdominal pain symptoms and stooling pattern...
  32. pmc Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa
    I Monteleone
    Dipartimento di Medicina Interna e Centro di Eccellenza per lo studio delle malattie complesse e multifattoriali, Universita Tor Vergata, Rome, Italy
    Gut 53:1090-5. 2004
    ..In coeliac disease (CD) mucosa, the histological lesion is associated with marked infiltration of T helper cell type 1 (Th1) cells. However, the molecular mechanisms which regulate Th1 cell differentiation in CD mucosa are unknown...
  33. ncbi request reprint Crohn's-like ileo-colitis in patients affected by glycogen storage disease Ib: two years' follow-up of patients with a wide spectrum of gastrointestinal signs
    D Melis
    Department of Paediatrics, Federico II University, Naples, Italy
    Acta Paediatr 92:1415-21. 2003
    ..To investigate the presence of inflammatory bowel disease (IBD) and to evaluate the progression of bowel involvement after two years' follow-up in seven patients affected by glycogen storage disease type Ib (GSDIb)...
  34. ncbi request reprint Domperidone is more effective than cisapride in children with diabetic gastroparesis
    A Franzese
    Department of Paediatrics, University of Naples Federico II, Naples, Italy
    Aliment Pharmacol Ther 16:951-7. 2002
    ..Disorders of gastrointestinal motility are commonly detected in patients with insulin-dependent diabetes mellitus and are associated with significant morbidity. They contribute to poor metabolic control of diabetes...
  35. ncbi request reprint A child with aphthae and diarrhoea
    Gianluca Terrin
    Pediatric Gastroenterology Unit, University of Rome La Sapienza, 00161 Rome, Italy
    Lancet 359:316. 2002
  36. ncbi request reprint Effects of disease activity on anti-Saccharomyces cerevisiae antibodies: implications for diagnosis and follow-up of children with Crohn's disease
    Roberto Berni Canani
    Department of Pediatrics, University Federico II, Naples, Italy
    Inflamm Bowel Dis 10:234-9. 2004
    ....
  37. ncbi request reprint Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn's disease: a randomized controlled open-label trial
    Osvaldo Borrelli
    Division of Pediatric Gastroenterology, Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
    Clin Gastroenterol Hepatol 4:744-53. 2006
    ..In a randomized controlled trial in children with active CD we compared the efficacy of nutritional therapy alone or corticosteroids on clinical variables and intestinal mucosal healing...
  38. ncbi request reprint Idiopathic dilated cardiomyopathy associated with coeliac disease: the effect of a gluten-free diet on cardiac performance
    M Curione
    Policlinico Umberto I, Rome, Italy
    Dig Liver Dis 34:866-9. 2002
    ..These preliminary data appear to suggest that the gluten-free diet may have a beneficial effect on cardiac performance in patients with idiopathic dilated cardiomyopathy...
  39. ncbi request reprint Extradigestive manifestations of IBD in pediatrics
    M Aloi
    Pediatric Gastroenterology and Hepatology Unit, Department of Pediatrics, University La Sapienza, Rome, Italy
    Eur Rev Med Pharmacol Sci 13:23-32. 2009
    ....
  40. doi request reprint Efficacy of adalimumab in moderate-to-severe pediatric Crohn's disease
    Franca Viola
    Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, University Hospital Umberto I, Sapienza University of Rome, Rome 324 00161, Italy
    Am J Gastroenterol 104:2566-71. 2009
    ..However, the use of ADA is rarely reported in pediatric CD. We performed an open prospective evaluation of short- and long-term efficacy and safety of ADA in children with moderate-to-severe CD...
  41. doi request reprint Activation of NOD2-mediated intestinal pathway in a pediatric population with Crohn's disease
    Anna Negroni
    Section of Toxicology and Biomedical Sciences, University of Rome, Sapienza University Hospital Umberto I, Rome, Italy
    Inflamm Bowel Dis 15:1145-54. 2009
    ....
  42. ncbi request reprint Pediatric inflammatory bowel diseases and the risk of lymphoma: should we revise our treatment strategies?
    Salvatore Cucchiara
    Pediatric Gastroenterology Unit, University of Rome La Sapienza, University Hospital Umberto I, Rome, Italy
    J Pediatr Gastroenterol Nutr 48:257-67. 2009
    ..There is a major need for comparative studies before evidence-based guidelines can be established for safest and best treatment strategies of pediatric patients with IBD...
  43. ncbi request reprint Enteric neuropathology of congenital intestinal obstruction: A case report
    Giovanni Di Nardo
    Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome La Sapienza, Rome, Italy
    World J Gastroenterol 12:5229-33. 2006
    ..Such ENS changes mimic neuronal abnormalities observed in intestinal pseudo-obstruction...
  44. ncbi request reprint Evolution of gastric electrical features and gastric emptying in children with Duchenne and Becker muscular dystrophy
    Osvaldo Borrelli
    Department of Pediatrics, Pediatric Gastroenterology Unit, University of Rome, Rome, Italy
    Am J Gastroenterol 100:695-702. 2005
    ..We recorded gastric electrical activity and gastric emptying time (GET) in children with MD at initial presentation and at 3-yr follow-up in order to detect gastric motor abnormalities and study their evolution along the clinical course...
  45. ncbi request reprint Polymorphisms of tumor necrosis factor-alpha but not MDR1 influence response to medical therapy in pediatric-onset inflammatory bowel disease
    Salvatore Cucchiara
    Clinica Pediatrica Universita La Sapienza, Roma, Italy
    J Pediatr Gastroenterol Nutr 44:171-9. 2007
    ....
  46. ncbi request reprint Cardiac involvement in children with IBD during infliximab therapy
    Maria Barbato
    Inflamm Bowel Dis 12:828-9. 2006
  47. ncbi request reprint Comment on: Gadolinium-enhance magnetic resonance imaging: a useful radiologic tool in diagnosing pediatric IBD
    Pasquale Paolantonio
    Inflamm Bowel Dis 11:79-80. 2005
  48. ncbi request reprint Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.A
    Claudio Fiocchi
    Case Western Reserve University, Cleveland, Ohio, USA
    J Pediatr Gastroenterol Nutr 40:S1. 2005
  49. ncbi request reprint Dual vs. triple therapy for childhood Helicobacter pylori gastritis: a double-blind randomized multicentre trial
    Giuseppina Oderda
    Pediatric Department of the University of Novara, Italy
    Helicobacter 9:293-301. 2004
    ..Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce...
  50. ncbi request reprint The infant gastroesophageal reflux questionnaire revised: development and validation as an evaluative instrument
    Leah Kleinman
    Center for Health Outcomes Research, United BioSource Corporation, Seattle, Washington 98121, USA
    Clin Gastroenterol Hepatol 4:588-96. 2006
    ..We revised the Infant Gastroesophageal Reflux Questionnaire (I-GERQ) on the basis of information from parents of infants with GERD and physicians and subjected it to a psychometric evaluation...
  51. ncbi request reprint Nitric oxide production in rectal dialysate is a marker of disease activity and location in children with inflammatory bowel disease
    Roberto Berni Canani
    Am J Gastroenterol 97:1574-6. 2002
  52. ncbi request reprint Motility disorders in childhood: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Peter Milla
    European Society for Paediatric Gastroenterology, Hepatology, and Nutrition
    J Pediatr Gastroenterol Nutr 35:S187-95. 2002
  53. ncbi request reprint Tacrolimus and food allergy
    Lucia Pacifico
    Transplantation 76:1778. 2003
  54. ncbi request reprint Analysis of candidate genes on chromosomes 5q and 19p in celiac disease
    Anna Latiano
    U O Gastroenterologia e Lab di Ricerca I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Pediatr Gastroenterol Nutr 45:180-6. 2007
    ..Additionally, any possible correlation with the HLA-DQ status was investigated. Finally, our data were pooled with the results of other studies by a meta-analysis...
  55. pmc Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
    Subra Kugathasan
    Department of Pediatrics, Children s Research Institute and Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Nat Genet 40:1211-5. 2008
    ..30 x 10(-8) and 6.95 x 10(-8), respectively; odds ratio (OR) = 0.74 for both) and 21q22 (rs2836878[A]; P = 6.01 x 10(-8); OR = 0.73), located close to the TNFRSF6B and PSMG1 genes, respectively...
  56. ncbi request reprint Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 13:1509-15. 2007
    ..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon...