F Cucca

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi [Correlation between major histocompatibility complex (MHC)-class II and type 1 diabetes]
    F Cucca
    Laboratorio di Immunogenetica, Dipartimento di Scienze Biomediche e Biotecnologie, Universita degli Studi di Cagliari, Cagliari, Italy
    Minerva Endocrinol 28:111-22. 2003
  2. ncbi A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    F Cucca
    Dipartimento di Scienze Biomediche e Biotecnologie, University of Cagliari, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 10:2025-37. 2001
  3. ncbi The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1
    F Cucca
    Department of Biomedical Science and Biotechnology, University of Cagliari, Italy
    Diabetes 50:1200-5. 2001
  4. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000
  5. ncbi Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci
    P Zavattari
    Dipartimento di Scienze Biomediche e Biotecnologie, University of Cagliari, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 10:881-9. 2001
  6. ncbi The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Ospedale Microcitemico, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 9:2959-65. 2000
  7. ncbi DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population
    M G Marrosu
    Chair of Neurophysiopathology, University of Cagliari, 09124 Cagliari, Italy
    Hum Mol Genet 7:1235-7. 1998
  8. ncbi Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia
    M G Marrosu
    Dipartimento di Neuroscienze, University of Cagliari, Centro Sclerosi Multipla, Ospedale Binaghi, Via Is Guadazzonis 2, Cagliari 09126, Italy
    Hum Mol Genet 10:2907-16. 2001
  9. ncbi ICAM-1 gene is not associated with multiple sclerosis in sardinian patients
    M G Marrosu
    Department of Neuroscience, University of Cagliari, Ospedale Binaghi, Italy
    J Neurol 247:677-80. 2000
  10. ncbi Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia
    E Schirru
    Biomedical Science and Biotechnologies, University of Cagliari, Via Jenner, Cagliari, Italy
    Eur J Clin Nutr 61:1220-5. 2007

Collaborators

Detail Information

Publications17

  1. ncbi [Correlation between major histocompatibility complex (MHC)-class II and type 1 diabetes]
    F Cucca
    Laboratorio di Immunogenetica, Dipartimento di Scienze Biomediche e Biotecnologie, Universita degli Studi di Cagliari, Cagliari, Italy
    Minerva Endocrinol 28:111-22. 2003
    ..Overall these observations suggest shared pathways in human and murine T1D...
  2. ncbi A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
    F Cucca
    Dipartimento di Scienze Biomediche e Biotecnologie, University of Cagliari, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 10:2025-37. 2001
    ..Overall, these results suggest shared epitope(s) in the target autoantigen(s), and common pathways in human and murine T1D...
  3. ncbi The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1
    F Cucca
    Department of Biomedical Science and Biotechnology, University of Cagliari, Italy
    Diabetes 50:1200-5. 2001
    ..The main component of the DPB1 contribution to IDDM1 in these populations appears to be the protection associated with DPB1*0402 on DR4-negative haplotypes. We suggest that the HLA-DP molecule itself contributes to IDDM1...
  4. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000
    ....
  5. ncbi Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci
    P Zavattari
    Dipartimento di Scienze Biomediche e Biotecnologie, University of Cagliari, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 10:881-9. 2001
    ..This conditional analysis approach can be applied to any chromosome region involved in the predisposition to complex traits...
  6. ncbi The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Ospedale Microcitemico, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 9:2959-65. 2000
    ..These results indicate that robust case-control studies can be carried out in Sardinia offering cost efficiency over certain family-based designs...
  7. ncbi DRB1-DQA1-DQB1 loci and multiple sclerosis predisposition in the Sardinian population
    M G Marrosu
    Chair of Neurophysiopathology, University of Cagliari, 09124 Cagliari, Italy
    Hum Mol Genet 7:1235-7. 1998
    ..Alternatively, the presence of complex interactions between different HLA haplotypes, other non-HLA predisposing genes and environmental factors may explain different associations in different populations...
  8. ncbi Dissection of the HLA association with multiple sclerosis in the founder isolated population of Sardinia
    M G Marrosu
    Dipartimento di Neuroscienze, University of Cagliari, Centro Sclerosi Multipla, Ospedale Binaghi, Via Is Guadazzonis 2, Cagliari 09126, Italy
    Hum Mol Genet 10:2907-16. 2001
    ..Overall these results are consistent with a multilocus model of the MHC encoded susceptibility to MS...
  9. ncbi ICAM-1 gene is not associated with multiple sclerosis in sardinian patients
    M G Marrosu
    Department of Neuroscience, University of Cagliari, Ospedale Binaghi, Italy
    J Neurol 247:677-80. 2000
    ..Our data suggest that the increased expression of the ICAM-1 molecule observed in both blood and periplaque microvessels may be considered a consequence of the inflammatory process rather than the result of a genetic variation...
  10. ncbi Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia
    E Schirru
    Biomedical Science and Biotechnologies, University of Cagliari, Via Jenner, Cagliari, Italy
    Eur J Clin Nutr 61:1220-5. 2007
    ..In this work, we wanted to verify if in the Mediterranean island of Sardinia, located in Southern Europe, the C/T-13910 polymorphism may be useful or not for the diagnosis of adult type hypolactasia...
  11. pmc Evaluation of IgA deficiency in Sardinians indicates a susceptibility gene is encoded within the HLA class III region
    F Cucca
    Divisione Pediatrica, Ospedale S Michele, Cagliari, Italy
    Clin Exp Immunol 111:76-80. 1998
    ..Our data favour the hypothesis that a class III region allele, present on the common North European but not on the Sardinian HLA-DR3 haplotype, confers susceptibility to IgA-D...
  12. ncbi Nutritional factors and worldwide incidence of childhood type 1 diabetes
    S Muntoni
    Center for Metabolic Diseases and Atherosclerosis, Ministero dell Università e della Ricerca Scientifica e Tecnologica, The ME DI CO Association, Cagliari, Italy
    Am J Clin Nutr 71:1525-9. 2000
    ..Some dietary factors have been associated with the risk of type 1 diabetes in childhood...
  13. ncbi Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease
    B P C Koeleman
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    Genes Immun 5:381-8. 2004
    ..This result provides new evidence for the potential importance of trans-encoded HLA DQ molecules in the determination of HLA-associated risk in T1D...
  14. ncbi Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
    L M Maier
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 4:469-75. 2003
    ..001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one...
  15. ncbi No evidence for SEL1L as a candidate gene for IDDM11-conferred susceptibility
    F Pociot
    Steno Diabetes Center, Niels Steensensvej 2, DK 2820 Gentofte, Denmark
    Diabetes Metab Res Rev 17:292-5. 2001
    ..Sel-1 is a negative regulator of the Notch signalling pathway and SEL1L is selectively expressed in adult pancreas and islets of Langerhans. This suggests that SEL1L may be a candidate gene for IDDM11...
  16. ncbi Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis
    G Thomson
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Tissue Antigens 70:110-27. 2007
    ..Our results show that meta-analyses and use of the P/C ratio and rankings thereof can be valuable in determining T1D risk factors at the haplotype and amino acid residue levels...
  17. ncbi The distribution of DQ genes in the Saharawi population provides only a partial explanation for the high celiac disease prevalence
    C Catassi
    Department of Pediatrics, University of Ancona, Ancona, Italy
    Tissue Antigens 58:402-6. 2001
    ..Other factors, such as rapidly changing dietary habits and/or non-DQ genes, may also play some role...