Mario Cozzolino

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Reprint of: Vitamin D receptor activation and prevention of arterial ageing
    M Cozzolino
    Renal Division, DMCO, University of Milan, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:S31-6. 2013
  2. doi request reprint Blood pressure, proteinuria, and phosphate as risk factors for progressive kidney disease: a hypothesis
    Mario Cozzolino
    Department of Health Sciences, University of Milan, Renal Division, San Paolo Hospital, Milan, Italy Electronic address
    Am J Kidney Dis 62:984-92. 2013
  3. doi request reprint [Role of vitamin D in the pathogenesis of chronic kidney disease]
    Mario Cozzolino
    Divisione Renale, Dipartimento di Scienze della Salute, Ospedale San Paolo, Universita di Milano
    Recenti Prog Med 104:33-40. 2013
  4. ncbi request reprint VDRA therapy is associated with improved survival in dialysis patients with serum intact PTH ≤ 150 pg/mL: results of the Italian FARO Survey
    Mario Cozzolino
    Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, University of Milan, San Paolo Hospital, Milan, Italy
    Nephrol Dial Transplant 27:3588-94. 2012
  5. doi request reprint What would we like to know, and what do we not know about fibroblast growth factor 23?
    Mario Cozzolino
    Department of Medicine, Surgery, University of Milan, Milan, Italy
    J Nephrol 24:696-706. 2011
  6. doi request reprint Phosphate handling in CKD-MBD from stage 3 to dialysis and the three strengths of lanthanum carbonate
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Scienze della Salute, Universita di Milano, S Paolo Hospita, Via A Di Rudini 8, Milan, Italy
    Expert Opin Pharmacother 13:2337-53. 2012
  7. doi request reprint Vitamin D receptor activation and prevention of arterial ageing
    M Cozzolino
    Renal Division, DMCO, University of Milan, San Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    Nutr Metab Cardiovasc Dis 22:547-52. 2012
  8. doi request reprint Phosphate control in peritoneal dialysis
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Facolta di Medicina e Chirurgia, Universita di Milano, Milan, Italy
    Contrib Nephrol 178:116-23. 2012
  9. doi request reprint Role of vitamin d receptor activators in cardio-renal syndromes
    Mario Cozzolino
    Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, University of Milan School of Medicine, San Paolo Hospital, Milan, Italy
    Semin Nephrol 32:63-9. 2012
  10. doi request reprint Restoring the physiology of vitamin D receptor activation and the concept of selectivity
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, University of Milan, Milan, Italy
    Contrib Nephrol 171:151-6. 2011

Collaborators

Detail Information

Publications59

  1. doi request reprint Reprint of: Vitamin D receptor activation and prevention of arterial ageing
    M Cozzolino
    Renal Division, DMCO, University of Milan, San Paolo Hospital, Via A Di Rudini 8, 20142 Milan, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:S31-6. 2013
    ..The potential positive impact of the use of paricalcitol on diabetic nephropathy, cardiac disease, hypertension, and VC may open new paths in the fight against CV disease in CKD patients. ..
  2. doi request reprint Blood pressure, proteinuria, and phosphate as risk factors for progressive kidney disease: a hypothesis
    Mario Cozzolino
    Department of Health Sciences, University of Milan, Renal Division, San Paolo Hospital, Milan, Italy Electronic address
    Am J Kidney Dis 62:984-92. 2013
    ..The aim of this review is to discuss the links between high blood pressure, proteinuria, phosphate levels, and CKD progression and explore new therapeutic strategies to win the fight against CKD. ..
  3. doi request reprint [Role of vitamin D in the pathogenesis of chronic kidney disease]
    Mario Cozzolino
    Divisione Renale, Dipartimento di Scienze della Salute, Ospedale San Paolo, Universita di Milano
    Recenti Prog Med 104:33-40. 2013
    ..These findings strongly support the importance of an early diagnosis of mineral homeostasis disorders in CKD and the need for correction of vitamin D deficiency to prevent related disabilities and major events...
  4. ncbi request reprint VDRA therapy is associated with improved survival in dialysis patients with serum intact PTH ≤ 150 pg/mL: results of the Italian FARO Survey
    Mario Cozzolino
    Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, University of Milan, San Paolo Hospital, Milan, Italy
    Nephrol Dial Transplant 27:3588-94. 2012
    ..However, the reason why these patients have higher mortality compared to patients with normal PTH levels has not yet been fully elucidated...
  5. doi request reprint What would we like to know, and what do we not know about fibroblast growth factor 23?
    Mario Cozzolino
    Department of Medicine, Surgery, University of Milan, Milan, Italy
    J Nephrol 24:696-706. 2011
    ..In this sense, increased knowledge of mineral metabolism disorder alterations in CKD may be used to improve diagnostics and select future treatments...
  6. doi request reprint Phosphate handling in CKD-MBD from stage 3 to dialysis and the three strengths of lanthanum carbonate
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Scienze della Salute, Universita di Milano, S Paolo Hospita, Via A Di Rudini 8, Milan, Italy
    Expert Opin Pharmacother 13:2337-53. 2012
    ..Phosphate load is thereafter involved in the progression of vascular calcification (VC) and bone disorder typical of CKD-MBD...
  7. doi request reprint Vitamin D receptor activation and prevention of arterial ageing
    M Cozzolino
    Renal Division, DMCO, University of Milan, San Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    Nutr Metab Cardiovasc Dis 22:547-52. 2012
    ..The potential positive impact of the use of paricalcitol on diabetic nephropathy, cardiac disease, hypertension, and VC may open new paths in the fight against CV disease in CKD patients...
  8. doi request reprint Phosphate control in peritoneal dialysis
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Facolta di Medicina e Chirurgia, Universita di Milano, Milan, Italy
    Contrib Nephrol 178:116-23. 2012
    ..In this context, the use of P binders appears to be an essential treatment to control P overload in CKD patients. In this review, we analyzed the use of calcium-based and calcium-free P binders in peritoneal dialysis patients...
  9. doi request reprint Role of vitamin d receptor activators in cardio-renal syndromes
    Mario Cozzolino
    Renal Division, Dipartimento di Medicina, Chirurgia e Odontoiatria, University of Milan School of Medicine, San Paolo Hospital, Milan, Italy
    Semin Nephrol 32:63-9. 2012
    ..In clinical practice, therefore, the use of this hormone may play an important role in cardio-renal syndrome prevention...
  10. doi request reprint Restoring the physiology of vitamin D receptor activation and the concept of selectivity
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, University of Milan, Milan, Italy
    Contrib Nephrol 171:151-6. 2011
    ..As such, paricalcitol's selectivity allows for a wider therapeutic window with effects beyond parathyroid hormone control and mineral management, and may explain, in part, the increased survival advantage with paricalcitol treatment...
  11. doi request reprint New insights into the role of calcium-sensing receptor activation
    Mario Cozzolino
    Renal Division, Department of Medicine, Surgery, and Dentistry, S Paolo Hospital, University of Milan, Milan, Italy
    J Nephrol 24:S38-41. 2011
    ..A complete understanding of the properties of calcimimetics are of obvious clinical interest, since therapeutic indications may be affected accordingly...
  12. doi request reprint Vascular calcification in chronic kidney disease: a changing scenario
    Mario Cozzolino
    Department of Medicine, Surgery, and Dentistry, Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    J Nephrol 24:S3-10. 2011
    ..Between them, the matrix Gla protein and fetuin-A have recently been investigated in CKD. In this review, along with the most promising possible treatments, the new molecular mechanisms involved in the VC process will be elucidated...
  13. doi request reprint The impact of paricalcitol on left ventricular hypertrophy
    Mario Cozzolino
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Facolta di Medicina e Chirurgia, Universita di Milano, Milan, Italy
    Contrib Nephrol 171:161-5. 2011
    ..Therefore, paricalcitol may offer a novel and interesting approach to supplement and potentially enhance the standard of care in CKD patients...
  14. doi request reprint New acquisitions in therapy of secondary hyperparathyroidism in chronic kidney disease and peritoneal dialysis patients: role of vitamin D receptor activators
    Diego Brancaccio
    University of Milan, Ospedale San Paolo, Milan, Italy
    Contrib Nephrol 163:219-26. 2009
    ..Finally, we will consider a series of nonclassical interesting potential mechanisms of selective vitamin D receptor activation leading to reduced cardiovascular and all-cause mortality...
  15. ncbi request reprint Gene polymorphisms and serum alpha-2-Heremans-Schmid levels in Italian haemodialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Nephrol 27:639-42. 2007
    ..In the present study, we investigated the associations between serum fetuin-A levels and its gene (AHSG) polymorphisms in an Italian HD population...
  16. doi request reprint Importance of vitamin D receptor activation in clinical practice
    Mario Cozzolino
    Department of Medicine, Surgery and Dentistry, University of Milan School of Medicine, Milan, Italy
    Contrib Nephrol 163:213-8. 2009
    ..As such, paricalcitol's selectivity allows for a wider therapeutic window with effects beyond PTH control and mineral management, and may explain, in part, the increased survival advantage with paricalcitol treatment...
  17. doi request reprint Preventive measures and new pharmacological approaches of calcium and phosphate disorders
    Mario Cozzolino
    Chair and Division of Nephrology, University of Milan, S Paolo Hospital, Milan, Italy
    Contrib Nephrol 161:234-9. 2008
    ....
  18. doi request reprint The calcimimetic calindol prevents high phosphate-induced vascular calcification by upregulating matrix GLA protein
    Paola Ciceri
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Scienze della Salute, Universita di Milano, Milan, Italy
    Nephron Exp Nephrol 122:75-82. 2012
    ..The aim of this in vitro study was to investigate the direct effects of the calcimimetic calindol on the progression of high Pi-induced VC...
  19. ncbi request reprint Arterial accelerated aging in dialysis patients: the clinical impact of vascular calcification
    Diego Brancaccio
    Department of Nephrology, San Paolo Hospital, University of Milan, Italy diego brancaccio tiscalinet it
    Curr Vasc Pharmacol 7:374-80. 2009
    ..We herein summarize the current understanding and evidence supporting strategies available for VC treatment...
  20. ncbi request reprint Management of secondary hyperparathyroidism in uremic patients: the role of the new vitamin D analogs
    Diego Brancaccio
    Chair of Nephrology, University of Milan, Ospedale San Paolo, Milan Italy
    J Nephrol 20:3-9. 2007
    ..This review will also elucidate the possible role of paricalcitol - a new vitamin D analog - in conditioning morbidity and mortality of patients on renal replacement therapy (RRT)...
  21. doi request reprint Management of secondary hyperparathyroidism in the elderly patient with chronic kidney disease
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Drugs Aging 26:457-68. 2009
    ....
  22. doi request reprint Lanthanum prevents high phosphate-induced vascular calcification by preserving vascular smooth muscle lineage markers
    Paola Ciceri
    Laboratory of Experimental Nephrology, Dipartimento di Scienze della Salute, Universita di Milano, Milan, Italy
    Calcif Tissue Int 92:521-30. 2013
    ..Thus, our results suggest that LaCl3 prevents VC by preserving VSMC lineage markers and by decreasing high Pi-induced osteoblastic differentiation...
  23. doi request reprint Secondary hyperparathyroidism in chronic dialysis patients: results of the Italian FARO survey on treatment and mortality
    Diego Brancaccio
    Nephrology Unit, University of Milan, Milan, Italy
    Blood Purif 32:124-32. 2011
    ..However, differences between VDRAs in their ability to reduce both all-cause and cardiovascular-related mortality rates are not yet fully elucidated...
  24. ncbi request reprint Serum fetuin-A levels link inflammation and cardiovascular calcification in hemodialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Nephrol 26:423-9. 2006
    ..Fetuin-A is an important inhibitor of CVC. Reduced fetuin-A levels associate with inflammation and increased cardiovascular (CV) mortality in HD. In this study we investigated the association of fetuin-A levels and CVC...
  25. ncbi request reprint Pathogenesis of secondary hyperparathyroidism
    Mario Cozzolino
    Renal Division, San Paolo Hospital, University of Milan, Milan Italy
    Int J Artif Organs 32:75-80. 2009
    ..In contrast, the discovery of a parathyroid phosphate sensor or receptor has yet to be made...
  26. ncbi request reprint Vitamin D retains an important role in the pathogenesis and management of secondary hyperparathyroidism in chronic renal failure
    Mario Cozzolino
    Renal Division, S Paolo Hospital, Milan Italy
    J Nephrol 19:566-77. 2006
    ..To reduce the impact of such adverse effects while retaining anti-PTH activity, 1,25(OH)2 D3 analogues with lower calcemic effects have been synthesized and are now available for clinical use...
  27. ncbi request reprint Pathogenesis of parathyroid hyperplasia in renal failure
    Mario Cozzolino
    Renal Division, San Paolo Hospital, Milan Italy
    J Nephrol 18:5-8. 2005
    ..In this review, we analyze the current understanding concerning the new insights into the molecular mechanisms of parathyroid hyperplasia and PTH secretion in renal failure regulated by calcium, phosphate and vitamin D...
  28. doi request reprint The combination of lanthanum chloride and the calcimimetic calindol delays the progression of vascular smooth muscle cells calcification
    Paola Ciceri
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Universita di Milano, Milan, Italy
    Biochem Biophys Res Commun 418:770-3. 2012
    ..In addition, LaCl(3) cooperates with the calcimimetic calindol in decreasing Ca deposition in this in vitro model. These results suggest the potential role of lanthanum in the treatment of VC induced by high Pi...
  29. ncbi request reprint A role for enhanced integrin and FAK expression in uremia-induced parathyroid hyperplasia
    Maria Vittoria Arcidiacono
    Pharmacological Laboratories, Department of Medicine, Surgery, and Dentistry, San Paolo Hospital, University of Milan, Milan, Italy
    J Nephrol 20:228-33. 2007
    ..These findings suggest that in kidney disease, the increased PT cell growth driven by enhanced EGFR could be further aggravated through elevations in integrin beta1 and FAK expression...
  30. ncbi request reprint [Vascular calcification in chronic kidney disease]
    Mario Cozzolino
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale S Paolo, Milano
    Recenti Prog Med 101:442-52. 2010
    ..Therefore, the use of calcium-free phosphate-binders may reduce the risk of cardiovascular disease by reducing both serum phosphate and FGF-23 levels...
  31. ncbi request reprint Vitamin D: physiology and pathophysiology
    Maurizio Gallieni
    Nephrology and Dialysis Unit, San Paolo Hospital, University of Milan, Milan Italy
    Int J Artif Organs 32:87-94. 2009
    ..We also examine non-genomic actions, biological responses to vitamin D in classic target organs (intestine, bone, kidneys, and parathyroid glands), and in organs and tissues not related to mineral homeostasis...
  32. ncbi request reprint Matrix GLA protein gene polymorphisms: clinical correlates and cardiovascular mortality in chronic kidney disease patients
    Diego Brancaccio
    Renal Division and Clinical Chemistry and Microbiology, S Paolo Hospital, University of Milan, Italy
    Am J Nephrol 25:548-52. 2005
    ..It is the result of an active ossification process counteracted by 'protective' proteins, such as matrix GLA protein (MGP). Polymorphisms of MGP have been identified...
  33. doi request reprint Vascular calcification and cardiovascular outcome in dialysis patients: the role of gene polymorphisms
    Mario Cozzolino
    S Paolo Hospital, Milan, Italy
    Blood Purif 29:347-51. 2010
    ..These data may have important implications for better understanding the pathogenesis of the increased mortality in this population...
  34. doi request reprint Emerging role for the vitamin D receptor activator (VDRA), paricalcitol, in the treatment of secondary hyperparathyroidism
    Mario Cozzolino
    University of Milan, S Paolo Hospital, Renal Division, Via A Di Rudini, 8 20142, Milan, Italy
    Expert Opin Pharmacother 9:947-54. 2008
    ..Classically, SHPT is induced by hypocalcemia, hyperphosphatemia, and calcitriol deficiency, that cause not only renal osteodystrophy but also systemic toxicity, particularly cardiovascular disease...
  35. ncbi request reprint The fibroblast growth factor 23: a new player in the field of cardiovascular, bone and renal disease
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, 20142 Milan, Italy
    Curr Vasc Pharmacol 8:404-11. 2010
    ..The discovery of FGF23 represents a novel factor in the pathogenesis of phosphate handling and secondary hyperparathyroidism in cardiovascular, bone and renal disease...
  36. ncbi request reprint Management of calcium refilling post-parathyroidectomy in end-stage renal disease
    Mario Cozzolino
    Renal Unit, San Paolo Hospital, University of Milan, Milan, Italy
    J Nephrol 17:3-8. 2004
    ..Management of post-parathyroidectomy hypocalcemia in dialysis patients is not well defined. We reviewed published approaches to treatment in an effort to define a clinical algorithm for controlling serum calcium levels post-operatively...
  37. doi request reprint Pathophysiology of calcium and phosphate metabolism impairment in chronic kidney disease
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Via A Di Rudini 8, Milan, Italy
    Blood Purif 27:338-44. 2009
    ..Certainly, in the next future, these new insights into the pathogenesis of SHPT will give the possibility to improve the treatment of this condition in the CKD population...
  38. ncbi request reprint Hyperparathyroidism and anemia in uremic subjects: a combined therapeutic approach
    Diego Brancaccio
    Renal Division, Ospedale San Paolo, Milan, Italy
    J Am Soc Nephrol 15:S21-4. 2004
    ..The increased sensitivity to EPO therapy can also induce a successful reduction of its dosage, thus allowing an interesting reduction of costs...
  39. ncbi request reprint Calcium and phosphate handling in peritoneal dialysis
    Mario Cozzolino
    Renal Unit, S Paolo Hospital, Milan, Italy
    Contrib Nephrol 150:214-25. 2006
    ..Further efforts to control hyperphosphatemia are essential, in order to reduce the impact of secondary hyperparathyroidism both on bone and cardiovascular system...
  40. ncbi request reprint The mechanism of calcium deposition in soft tissues
    Diego Brancaccio
    Renal Unit, San Paolo Hospital, Milan, Italy
    Contrib Nephrol 149:279-86. 2005
    ..Actually, it is well known that extraskeletal calcification is also related to an active process. In this review, we analyzed some of the factors potentially involved in the pathogenesis of vascular calcification in CKD patients...
  41. ncbi request reprint Pathogenesis and treatment of secondary hyperparathyroidism in dialysis patients: the role of paricalcitol
    Mario Cozzolino
    Division of Nephrology, University of Milan, S Paolo Hospital, Milan, Italy
    Curr Vasc Pharmacol 6:148-53. 2008
    ..v. and oral administration, commonly 3 times weekly after HD. The purpose of the present review is to analyze the pathogenesis and treatment of SHPT in HD patients, and the role of paricalcitol in the prevention of arterial calcification...
  42. ncbi request reprint Vascular access planning in peritoneal dialysis patients
    Giusy Chiarelli
    Nephrology and Dialysis Unit, San Paolo Hospital, University of Milan, Italy
    Perit Dial Int 28:585-90. 2008
    ....
  43. doi request reprint Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients
    Mario Cozzolino
    Renal Division, Department of Medicine, Surgery and Dentistry, University of Milan School of Medicine, Milan, Italy
    Nephrol Dial Transplant 24:2207-12. 2009
    ..The aim of this study was to evaluate the association of MMP1 and MMP3 polymorphisms with end-stage renal failure (ESRD) and all-cause mortality risk in HD...
  44. ncbi request reprint Vascular calcification in uremic conditions: new insights into pathogenesis
    Mario Cozzolino
    Renal Unit, San Paolo Hospital, Milan, Italy
    Semin Nephrol 26:33-7. 2006
    ..This review presents the current understanding of the pathogenesis of vascular calcification in CKD patients, focusing on these 3 proteins and their protective action on extraskeletal calcification...
  45. ncbi request reprint Clinical consequences and novel therapy of hyperphosphatemia: Lanthanum carbonate for dialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Italy
    Recent Pat Cardiovasc Drug Discov 2:29-34. 2007
    ....
  46. ncbi request reprint Pathogenesis of vascular calcification in chronic kidney disease
    Mario Cozzolino
    Department of Nephrology and Dialysis, Ospedale San Paolo, Milan, Italy
    Kidney Int 68:429-36. 2005
    ..Conclusion. Additional investigations are necessary to examine the benefits of different phosphate-binders in reducing mortality from cardiovascular disease...
  47. pmc The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control
    Mario Cozzolino
    Renal Division, DMCO, San Paolo Hospital, School of Medicine, University of Milan, via A Di Rudinì 8 20142, Milan, Italy
    Int J Nephrol 2011:269060. 2011
    ..Moreover, paricalcitol prevents vascular calcification in experimental models of renal failure, compared with calcitriol...
  48. doi request reprint CCN2 (CTGF) gene polymorphism is a novel prognostic risk factor for cardiovascular outcomes in hemodialysis patients
    Mario Cozzolino
    Renal Division, S Paolo Hospital, Milan, Italy
    Blood Purif 30:272-6. 2010
    ..The aim of this study was to investigate a possible association between CCN2 gene polymorphism and CV morbidity and mortality in HD patients...
  49. ncbi request reprint Vascular calcification and uremia: what do we know?
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Milan, Italy
    Am J Nephrol 28:339-46. 2008
    ..We conclude that at present it is too early to introduce these novel markers into clinical practice...
  50. doi request reprint CKD-MBD: an endless story
    Diego Brancaccio
    Renal Unit Simone Martini, Milan, Italy
    J Nephrol 24:S42-8. 2011
    ..The aim of this review is the analysis of some of the recent contributions in the field of CKD-MBD, to update the understanding of the pathogenetic mechanisms and possibly the most appropriate therapeutic approach in this field...
  51. doi request reprint Combined effects of ascorbic acid and phosphate on rat VSMC osteoblastic differentiation
    Paola Ciceri
    Renal Division and Laboratory of Experimental Nephrology, Dipartimento di Medicina e Chirurgia, Facolta di Medicina e Chirurgia, Universita di Milano, Milan, Italy
    Nephrol Dial Transplant 27:122-7. 2012
    ..The aim of these studies was to characterize the combined effects of AA and P on VC...
  52. doi request reprint Interaction between parathyroid hormone and the Charlson comorbidity index on survival of incident haemodialysis patients
    Luigi Francesco Morrone
    Renal Division, A O Rummo, Benevento, Italy
    Nephrol Dial Transplant 24:2859-65. 2009
    ..Haemodialysis patients are ageing and have with a high rate of comorbidities. The impact of this novel clinical setting on intact parathyroid hormone (iPTH) is not well established...
  53. doi request reprint Calcium and phosphate control by dialysis treatments
    PierGiorgio Messa
    Nephrology, Dialysis and Renal Transplant Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Via Commenda 15, Milan, Italy
    Blood Purif 27:360-8. 2009
    ..However, some experimental attempts at increasing phosphate removal independently of increasing dialysis duration are mentioned...
  54. doi request reprint The vitamin D system: a crosstalk between the heart and kidney
    Mario Cozzolino
    Renal Division, S Paolo Hospital, University of Milan, Via A di Rudin ı, 8 20142 Milan, Italy
    Eur J Heart Fail 12:1031-41. 2010
    ..Vitamin D receptor activators, commonly used to treat CKD-MBD, and an appropriate treatment of vitamin D hormonal system failure in patients with CKD, may help to reduce cardiovascular morbidity and mortality in these patients...
  55. pmc Calcium-sensing receptor and calcium kidney stones
    Giuseppe Vezzoli
    Nephrology and Dialysis Unit, San Raffaele Hospital, Vita Salute University, Milan, Italy
    J Transl Med 9:201. 2011
    ..Stone formation may be favored by an altered CaSR expression in kidney medulla involving the normal balance among calcium, phosphate, protons and water excretion...
  56. ncbi request reprint Warfarin: to use or not to use in chronic kidney disease patients?
    Mario Cozzolino
    Division of Nephrology, University of Milan, S Paolo Hospital, Via A Di Rudini 8, Milan, Italy
    J Nephrol 23:648-52. 2010
    ....
  57. ncbi request reprint Bone disease in uremic patients: advances in PTH suppression
    Diego Brancaccio
    Nephrology and Dialysis Department, Ospedale San Paolo, Milan, Italy
    J Nephrol 15:S86-93. 2002
    ..A broader spectrum of therapeutic approaches will enable the nephrologist to individually tailor the treatment of secondary hyperparathyroidism...
  58. ncbi request reprint [Vascular calcification: is there a link between hyperphosphatemia and hyperglycemia?]
    Mario Cozzolino
    U O Nefrologia e Dialisi, Azienda Ospedaliera San Paolo, Polo Univeritario, Milan, Italy
    G Ital Nefrol 25:271. 2008