P Costelli

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi Ca(2+)-dependent proteolysis in muscle wasting
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Torino, Italy
    Int J Biochem Cell Biol 37:2134-46. 2005
  2. ncbi Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, I 10125 Torino, Italy
    Int J Oncol 26:1663-8. 2005
  3. ncbi Mechanisms of skeletal muscle depletion in wasting syndromes: role of ATP-ubiquitin-dependent proteolysis
    Paola Costelli
    Department of Experimental Medicine and Oncology, University of Torino, Italy
    Curr Opin Clin Nutr Metab Care 6:407-12. 2003
  4. ncbi IGF-1 is downregulated in experimental cancer cachexia
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Turin, Italy
    Am J Physiol Regul Integr Comp Physiol 291:R674-83. 2006
  5. ncbi Muscle myostatin signalling is enhanced in experimental cancer cachexia
    P Costelli
    Department of Experimental Medicine and Oncology Università di Torino, Italy
    Eur J Clin Invest 38:531-8. 2008
  6. ncbi Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats
    P Costelli
    Dipartimento di Medicina ed Oncologia Spermentale, Universitá di Toroino, Torino, Italy
    Cytokine 19:1-5. 2002
  7. ncbi Cancer cachexia: from experimental models to patient management
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Italy
    Curr Opin Clin Nutr Metab Care 3:177-81. 2000
  8. ncbi Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody
    P Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy
    Cell Death Differ 10:997-1004. 2003
  9. ncbi Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice
    A Bonetto
    Department of Experimental Medicine and Oncology, University of Torino, 10125 Torino, Italy
    Curr Cancer Drug Targets 9:608-16. 2009
  10. ncbi Humoral mediation for cachexia in tumour-bearing rats
    L Tessitore
    Dipartimento di Medicina ed Oncologia Sperimentale, , Italy
    Br J Cancer 67:15-23. 1993

Collaborators

Detail Information

Publications31

  1. ncbi Ca(2+)-dependent proteolysis in muscle wasting
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Torino, Italy
    Int J Biochem Cell Biol 37:2134-46. 2005
    ..How they are transduced to initiate the hypercatabolic response and to activate the proteolytic pathways remains largely unknown, however...
  2. ncbi Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, I 10125 Torino, Italy
    Int J Oncol 26:1663-8. 2005
    ....
  3. ncbi Mechanisms of skeletal muscle depletion in wasting syndromes: role of ATP-ubiquitin-dependent proteolysis
    Paola Costelli
    Department of Experimental Medicine and Oncology, University of Torino, Italy
    Curr Opin Clin Nutr Metab Care 6:407-12. 2003
    ....
  4. ncbi IGF-1 is downregulated in experimental cancer cachexia
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Turin, Italy
    Am J Physiol Regul Integr Comp Physiol 291:R674-83. 2006
    ..Moreover, no simple relation linking IGF-1 and/or atrogin-1 mRNA levels and muscle atrophy could be observed in these experimental conditions. Further studies are thus needed to clarify both issues...
  5. ncbi Muscle myostatin signalling is enhanced in experimental cancer cachexia
    P Costelli
    Department of Experimental Medicine and Oncology Università di Torino, Italy
    Eur J Clin Invest 38:531-8. 2008
    ....
  6. ncbi Anticytokine treatment prevents the increase in the activity of ATP-ubiquitin- and Ca(2+)-dependent proteolytic systems in the muscle of tumour-bearing rats
    P Costelli
    Dipartimento di Medicina ed Oncologia Spermentale, Universitá di Toroino, Torino, Italy
    Cytokine 19:1-5. 2002
    ....
  7. ncbi Cancer cachexia: from experimental models to patient management
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Italy
    Curr Opin Clin Nutr Metab Care 3:177-81. 2000
    ..Anticytokine treatments, either acting centrally or peripherally, have received particular attention, and are currently reaching the stage of clinical trials...
  8. ncbi Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody
    P Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy
    Cell Death Differ 10:997-1004. 2003
    ..The precise cellular and molecular details underlying this interplay between Fas- and TNFRs-mediated signaling systems in the general and liver-specific aFas toxicity largely remain to be clarified...
  9. ncbi Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice
    A Bonetto
    Department of Experimental Medicine and Oncology, University of Torino, 10125 Torino, Italy
    Curr Cancer Drug Targets 9:608-16. 2009
    ..Neither agent, however, counteracts muscle atrophy or ubiquitin ligase hyperexpression. Therefore, modulation of the myostatin/follistatin axis in itself does not appear sufficient to correct muscle atrophy in cancer cachexia...
  10. ncbi Humoral mediation for cachexia in tumour-bearing rats
    L Tessitore
    Dipartimento di Medicina ed Oncologia Sperimentale, , Italy
    Br J Cancer 67:15-23. 1993
    ....
  11. ncbi Cytotoxic properties of clofibrate and other peroxisome proliferators: relevance to cancer progression
    F Penna
    Department of Experimental, Medicine and Oncology, University of Torino, Corso Raffaello 30, Turin, Italy
    Curr Med Chem 17:309-20. 2010
    ....
  12. ncbi Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells
    F Penna
    Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
    Biochem Pharmacol 77:169-76. 2009
    ..Activation of the intrinsic apoptotic pathway and ER stress both play a major and concurrent role, while calpain activation seems to have only a marginal part in the process...
  13. ncbi Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?
    Fabio Penna
    Department of Experimental Medicine and Oncology, University of Turin, Turin, Italy
    Int J Cancer 127:1706-17. 2010
    ....
  14. ncbi Activation of Ca(2+)-dependent proteolysis in skeletal muscle and heart in cancer cachexia
    P Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Sezione di Patologia Generale, , Italy
    Br J Cancer 84:946-50. 2001
    ....
  15. ncbi Muscle wasting in diabetic and in tumor-bearing rats: role of oxidative stress
    Raffaella Mastrocola
    Department of Experimental Medicine and Oncology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy
    Free Radic Biol Med 44:584-93. 2008
    ..Moreover, despite oxidative stress being detectable in both experimental models, its contribution to muscle wasting is not comparable...
  16. ncbi Modulations of the calcineurin/NF-AT pathway in skeletal muscle atrophy
    Paola Costelli
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, Italy
    Biochim Biophys Acta 1770:1028-36. 2007
    ..These results suggest that modulations of calcineurin activity may be involved in the pathogenesis of muscle wasting in diabetes though not in cancer cachexia...
  17. ncbi Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase
    Rosa A Canuto
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Corso Raffaello 30, 10125 Torino, Italy
    J Lipid Res 44:56-64. 2003
    ..In conclusion, inhibition of HMGR and decreased cholesterol content are crucial events in clofibrate-induced apoptosis in AH-130 hepatoma cells...
  18. ncbi Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia
    Maria G Catalano
    Laboratorio di Endocrinologia Oncologica, Dipartimenti di Fisiopatologia Clinica and Oncologia, Universita di Torino, I 10126 Turin, Italy
    Int J Oncol 23:429-36. 2003
    ..This is the first demonstration of a selective up-regulation of TNF-RI in cancer cachexia and suggests that local production of TNF-alpha and IL-6 is a corner-stone in the induction/maintenance of this syndrome...
  19. ncbi Are antioxidants useful for treating skeletal muscle atrophy?
    Andrea Bonetto
    Dipartimento di Medicina e Oncologia Sperimentale, Universita di Torino, 10125 Torino, Italy
    Free Radic Biol Med 47:906-16. 2009
    ..This review focuses on the possibility of using antioxidant treatments to target molecular pathways involved in the pathogenesis of skeletal muscle wasting...
  20. ncbi 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line
    Stefano Laurora
    Department of Experimental Medicine and Oncology, Section of General Pathology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy
    Free Radic Biol Med 38:215-25. 2005
    ..Our results demonstrated that HNE inhibits SK-N-BE cell proliferation by increasing the expression of p53 family proteins and p53 target proteins which modulate cell cycle progression and apoptosis...
  21. ncbi Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c-ski oncogene
    Paola Costelli
    Dipartimento di Medicina ed Oncologia Sperimentale, Universita di Torino, Torino, Italy
    Cancer Lett 200:153-60. 2003
    ..The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways...
  22. ncbi Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia
    Fabio Penna
    University of Turin, Department of Experimental Medicine and Oncology, Turin, Italy
    Expert Opin Biol Ther 10:1241-50. 2010
    ..Among the general mechanisms proposed to account for cachexia, anorexia and altered homeostasis of hormones and cytokines appear to play a major role...
  23. ncbi Effects of simvastatin administration in an experimental model of cancer cachexia
    Maurizio Muscaritoli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nutrition 19:936-9. 2003
    ..We evaluated whether statins, in view of their anti-inflammatory properties, may effectively prevent the onset or modulate the severity of muscle wasting during cancer cachexia...
  24. ncbi Effect of c-ski overexpression on the development of cachexia in mice bearing the Lewis lung carcinoma
    Neus Carbó
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Int J Mol Med 14:719-23. 2004
    ....
  25. ncbi Muscle ubiquitin m-rNA levels in patients with end-stage renal disease on maintenance hemodialysis
    Maurizio Bossola
    Institute of Clinical Surgery, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Nephrol 15:552-7. 2002
    ..The present study was designed to investigate the expression of ubiquitin mRNAs in skeletal muscle of patients with ESRD on maintenance HD...
  26. ncbi Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia models
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Clin Nutr 26:239-44. 2007
    ..We decided to investigate the potential anti-wasting properties of resveratrol on different models of cancer cachexia in experimental animals...
  27. ncbi Increased muscle proteasome activity correlates with disease severity in gastric cancer patients
    Maurizio Bossola
    Istituto di Clinica Chirurgica, Universita Cattolica del Sacro Cuore, Roma, Italy
    Ann Surg 237:384-9. 2003
    ..To investigate the state of activation of the ATP-ubiquitin-dependent proteolytic system in the skeletal muscle of gastric cancer patients...
  28. ncbi Skeletal muscle apoptosis is not increased in gastric cancer patients with mild-moderate weight loss
    Maurizio Bossola
    Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore Largo A Gemelli, 8, 00168 Rome, Italy
    Int J Biochem Cell Biol 38:1561-70. 2006
    ....
  29. ncbi Proteasome activities in the rectus abdominis muscle of young and older individuals
    Maurizio Bossola
    Istituto di Clinica Chirurgica, Universita Cattolica del Sacro Cuore, Largo A Gemelli, 8, 00168, Rome, Italy
    Biogerontology 9:261-8. 2008
    ..22, P = 0.4), PGP (r = 0.002, P = 0.9), and TL (r = 0.28, P = 0.33) activities. In conclusion, the present study shows that the skeletal muscle proteasome activities do not differ with age in healthy male individuals...
  30. ncbi New strategies to overcome cancer cachexia: from molecular mechanisms to the 'Parallel Pathway'
    Maurizio Muscaritoli
    Department of Clinical Medicine, Sapienza University of Rome Viale dell Universita, 37 00185 Rome, Italy
    Asia Pac J Clin Nutr 17:387-90. 2008
    ....
  31. ncbi Statins, coenzyme Q10, and cachexia: what's the link?
    Alessio Molfino
    Am J Cardiol 100:1497-8. 2007