Silvano Costa

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna
    Gynecol Oncol 85:119-24. 2002
  2. ncbi Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy
    Gynecol Oncol 90:358-65. 2003
  3. ncbi Activation of the ERK/MAP kinase pathway in cervical intraepithelial neoplasia is related to grade of the lesion but not to high-risk human papillomavirus, virus clearance, or prognosis in cervical cancer
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Rome
    Am J Clin Pathol 122:902-11. 2004
  4. ncbi Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di, Epidemiologia, Sorveglianza e Promozione della Salute, Rome, Italy
    Am J Clin Pathol 124:113-21. 2005
  5. ncbi HPV DNA patterns and disease implications in the follow-up of patients treated for HPV16 high-grade carcinoma in situ
    Monica Cricca
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 78:494-500. 2006
  6. ncbi CD44 isoform 6 (CD44v6) is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma
    S Costa
    Department of Obstetrics and Gynecology, St Orsola Malpighi Hospital, Bologna, Italy
    Gynecol Oncol 80:67-73. 2001
  7. ncbi Outcome of conservatively treated microinvasive squamous cell carcinoma of the uterine cervix during a 10-year follow-up
    Silvano Costa
    Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Bologna, Italy
    Int J Gynecol Cancer 19:33-8. 2009
  8. ncbi Human papillomavirus (HPV) test and PAP smear as predictors of outcome in conservatively treated adenocarcinoma in situ (AIS) of the uterine cervix
    Silvano Costa
    Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Bologna, Italy
    Gynecol Oncol 106:170-6. 2007
  9. ncbi Independent determinants of inaccuracy of colposcopically directed punch biopsy of the cervix
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy
    Gynecol Oncol 90:57-63. 2003
  10. ncbi Correlation of high-risk human papillomavirus genotypes persistence and risk of residual or recurrent cervical disease after surgical treatment
    Simona Venturoli
    Division of Microbiology, University of Bologna, Bologna, Italy
    J Med Virol 80:1434-40. 2008

Collaborators

Detail Information

Publications21

  1. ncbi Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna
    Gynecol Oncol 85:119-24. 2002
    ..The primary aim of this study of patients treated with electrosurgical conization was to evaluate the association of cone margin status and other clinical and pathologic factors with the probability of residual disease...
  2. ncbi Factors predicting human papillomavirus clearance in cervical intraepithelial neoplasia lesions treated by conization
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy
    Gynecol Oncol 90:358-65. 2003
    ..The objective was to identify the factors, if any, that may predict long-term results of CIN treatment and HPV clearance/persistence after locally excisional therapy...
  3. ncbi Activation of the ERK/MAP kinase pathway in cervical intraepithelial neoplasia is related to grade of the lesion but not to high-risk human papillomavirus, virus clearance, or prognosis in cervical cancer
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Rome
    Am J Clin Pathol 122:902-11. 2004
    ..ERK1 overexpression is not a specific marker of HR-HPV in CIN and cervical cancer, nor does it predict virus clearance after CIN treatment or disease outcome in cervical cancer...
  4. ncbi Survivin as a marker of cervical intraepithelial neoplasia and high-risk human papillomavirus and a predictor of virus clearance and prognosis in cervical cancer
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di, Epidemiologia, Sorveglianza e Promozione della Salute, Rome, Italy
    Am J Clin Pathol 124:113-21. 2005
    ..Up-regulated survivin expression was an independent predictor of HR-HPV in cervical lesions, most plausibly explained by its normal transcriptional repression by wild-type p53 being eliminated by HR-HPV E6 oncoprotein...
  5. ncbi HPV DNA patterns and disease implications in the follow-up of patients treated for HPV16 high-grade carcinoma in situ
    Monica Cricca
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 78:494-500. 2006
    ....
  6. ncbi CD44 isoform 6 (CD44v6) is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma
    S Costa
    Department of Obstetrics and Gynecology, St Orsola Malpighi Hospital, Bologna, Italy
    Gynecol Oncol 80:67-73. 2001
    ....
  7. ncbi Outcome of conservatively treated microinvasive squamous cell carcinoma of the uterine cervix during a 10-year follow-up
    Silvano Costa
    Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Bologna, Italy
    Int J Gynecol Cancer 19:33-8. 2009
    ....
  8. ncbi Human papillomavirus (HPV) test and PAP smear as predictors of outcome in conservatively treated adenocarcinoma in situ (AIS) of the uterine cervix
    Silvano Costa
    Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Bologna, Italy
    Gynecol Oncol 106:170-6. 2007
    ....
  9. ncbi Independent determinants of inaccuracy of colposcopically directed punch biopsy of the cervix
    Silvano Costa
    Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy
    Gynecol Oncol 90:57-63. 2003
    ..The goal of this study was to determine the clinical factors independently associated with inaccuracy of colposcopically directed punch biopsy in defining extent and severity of epithelial lesions of the cervix...
  10. ncbi Correlation of high-risk human papillomavirus genotypes persistence and risk of residual or recurrent cervical disease after surgical treatment
    Simona Venturoli
    Division of Microbiology, University of Bologna, Bologna, Italy
    J Med Virol 80:1434-40. 2008
    ..3%). These data defined HR-HPV groups for the risk of progression of disease and suggested that the identification of persistent infection with different HR-HPV genotypes has the potential to improve the management of these patients...
  11. ncbi Viral DNA load, physical status and E2/E6 ratio as markers to grade HPV16 positive women for high-grade cervical lesions
    Monica Cricca
    Department of Clinical and Experimental Medicine, Microbiology Section, University of Bologna, and Department of Obstetrics and Gynecology, S Orsola Malpighi Hospital, Italy
    Gynecol Oncol 106:549-57. 2007
    ..This study has evaluated the significance of viral markers, such as viral load, physical status and E2/E6 ratio, to stratify HPV16 infected women at a single point in time for grade of cervical lesions...
  12. doi Factors predicting the outcome of conservatively treated adenocarcinoma in situ of the uterine cervix: an analysis of 166 cases
    Silvano Costa
    Department of Obstetrics and Gynecology, S Orsola Malpighi University Hospital, Bologna, Italy
    Gynecol Oncol 124:490-5. 2012
    ....
  13. doi Comparison of Abbott RealTime High Risk HPV and Hybrid Capture 2 for the detection of high-risk HPV DNA in a referral population setting
    Simona Venturoli
    Department of Haematology, Oncology an Laboratory Medicine, Section of Microbiology, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Virol 53:121-4. 2012
    ..The Abbott RealTime High Risk HPV assay (ART) is an automated multiplex real-time PCR test for detection of DNA from 14 high risk (HR) HPV types in cervical specimens and simultaneous distinction of HPV16 and HPV18 from other HR-HPV...
  14. doi Molecular analysis of HPV 16 E6I/E6II spliced mRNAs and correlation with the viral physical state and the grade of the cervical lesion
    Monica Cricca
    Department of Haematology and Oncological Sciences L e A Seragnoli, Microbiology Section, University of Bologna, Bologna, Italy
    J Med Virol 81:1276-82. 2009
    ..The detection of HPV 16 E6*I/E6*II mRNAs may serve to identify transcription patterns indicative of cervical disease progression and help physicians to decide clinical management...
  15. doi Disruption of HPV 16 E1 and E2 genes in precancerous cervical lesions
    Monica Cricca
    Department of Haematology and Oncological Sciences L e A Seragnoli, Microbiology Section, University of Bologna, Italy
    J Virol Methods 158:180-3. 2009
    ..In conclusion, in high-grade cervical lesions E2 gene seems a suitable target to identify HPV 16 DNA integration into cellular genome...
  16. doi Cervical and hysteroscopic injection for identification of sentinel lymph node in endometrial cancer
    Anna Myriam Perrone
    Centre for Sexual Health, S Orsola Hospital, University of Bologna, Bologna, Italy
    Gynecol Oncol 111:62-7. 2008
    ..The aims of our study were to evaluate the possibility of identifying the sentinel lymph node (SLN) in patients with endometrial cancer (EC) and to directly compare two injection techniques, cervical and hysteroscopic injection...
  17. ncbi Follow-up of screening patients conservatively treated for cervical intraepithelial neoplasia grade 2-3
    Paolo Cristiani
    Cervical Cancer Screening Unit, Bologna Health Care District, Bologna, Italy
    Eur J Obstet Gynecol Reprod Biol 133:227-31. 2007
    ..To evaluate the frequency and correlates of non-adherence to follow-up among patients conservatively treated for CIN2-3...
  18. ncbi Follow-up study of patients with cervical intraepithelial neoplasia grade 1 overexpressing p16Ink4a
    Stefania Cortecchia
    Department of Pathology, Health Care District Hospital, Imola, Italy National AIDS Center, Istituto Superiore di Sanita, Rome, Italy Department of Obstetrics and Gynecology, St Orsola Hospital, University of Bologna, Bologna, Italy Department of Experimental Medicine, University of Tor Vergata, Rome, Italy and Romagna Cancer Registry, IRCCS IRST, Meldola, Forli, Italy
    Int J Gynecol Cancer 23:1663-9. 2013
    ..This study was aimed at evaluating the risk for progression to CIN2 or worse during a 3-year follow-up of an unselected series of 739 patients with CIN1 biopsy specimens tested for p16 expression...
  19. doi Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, Rome, Italy
    Int J Gynecol Pathol 27:265-73. 2008
    ..However, testing the performance of this marker combination in a screening setting necessitates their analysis in cytological samples...
  20. ncbi Over-expression of topoisomerase IIalpha is related to the grade of cervical intraepithelial neoplasia (CIN) and high-risk human papillomavirus (HPV), but does not predict prognosis in cervical cancer or HPV clearance after cone treatment
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanita, ISS, Rome, Italy
    Int J Gynecol Pathol 25:383-92. 2006
    ..Their links to oncogenic human papillomavirus (HPV) types and their prognostic value in cervical cancer are practically unexplored...
  21. ncbi Relationship of up-regulation of 67-kd laminin receptor to grade of cervical intraepithelial neoplasia and to high-risk HPV types and prognosis in cervical cancer
    Margherita Branca
    Unità Citoistopatologia, Centro Nazionale di, Epidemiologia, Sorveglianza e Promozione della Salute, Rome, Italy
    Acta Cytol 50:6-15. 2006
    ..To evaluate the 67-kd laminin receptor (67LR) in cervical cancer and its molecular links to oncogenic HPV types...