B Costa

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. pmc Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat
    Silvia Conti
    Department of Biotechnology and Bioscience, Faculty of Sciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Br J Pharmacol 135:181-7. 2002
  2. ncbi request reprint Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide
    Isabella Bettoni
    Department of Environmental Sciences, University of Milano Bicocca, Milano, Italy
    CNS Neurol Disord Drug Targets 12:34-44. 2013
  3. doi request reprint The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Pharmacol Res 61:537-46. 2010
  4. doi request reprint The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
  5. ncbi request reprint On the pharmacological properties of Delta9-tetrahydrocannabinol (THC)
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126 Milano
    Chem Biodivers 4:1664-77. 2007
  6. pmc Rimonabant: more than an anti-obesity drug?
    B Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milano, Italy
    Br J Pharmacol 150:535-7. 2007
  7. ncbi request reprint The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Eur J Pharmacol 556:75-83. 2007
  8. pmc AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Br J Pharmacol 148:1022-32. 2006
  9. ncbi request reprint Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Pain 116:52-61. 2005
  10. pmc Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milan Bicocca, Piazza della Scienza 2, Milan 20126, Italy
    Br J Pharmacol 143:247-50. 2004

Collaborators

Detail Information

Publications37

  1. pmc Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat
    Silvia Conti
    Department of Biotechnology and Bioscience, Faculty of Sciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Br J Pharmacol 135:181-7. 2002
    ..6. Our findings show the antiinflammatory effect of nabilone and confirm that of palmitoylethanolamide indicating that these actions are mediated by an uncharacterized CB(2)-like cannabinoid receptor...
  2. ncbi request reprint Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide
    Isabella Bettoni
    Department of Environmental Sciences, University of Milano Bicocca, Milano, Italy
    CNS Neurol Disord Drug Targets 12:34-44. 2013
    ..In this context PEA could represent an innovative molecule, combining a dual analgesic activity, both on neurons and on nonneuronal cells...
  3. doi request reprint The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Pharmacol Res 61:537-46. 2010
    ..In conclusion AA-5-HT has both anti-inflammatory and anti-hyperalgesic properties and its employment offers advantages, in terms of efficacy and lack of adverse effects, deriving from its dual activity...
  4. doi request reprint The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine...
  5. ncbi request reprint On the pharmacological properties of Delta9-tetrahydrocannabinol (THC)
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126 Milano
    Chem Biodivers 4:1664-77. 2007
    ..However, emerging evidence highlights the beneficial effects of the whole cannabis extract over those observed with single components, indicating cannabis-based medicines as new perspective to revisit the pharmacology of this plant...
  6. pmc Rimonabant: more than an anti-obesity drug?
    B Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milano, Italy
    Br J Pharmacol 150:535-7. 2007
    ....
  7. ncbi request reprint The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Eur J Pharmacol 556:75-83. 2007
    ..The results indicate a potential for therapeutic use of cannabidiol in chronic painful states...
  8. pmc AM404, an inhibitor of anandamide uptake, prevents pain behaviour and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Br J Pharmacol 148:1022-32. 2006
    ..Taken together, these findings suggest that inhibition of endocannabinoid uptake, by blocking the putative anandamide carrier, results in the relief of neuropathic pain and may represent a novel strategy for treating chronic pain...
  9. ncbi request reprint Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Pain 116:52-61. 2005
    ..In conclusion, the present findings suggest that SR141716 is effective not only in alleviating neuropathic pain but also in favouring the nerve myelin repair...
  10. pmc Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milan Bicocca, Piazza della Scienza 2, Milan 20126, Italy
    Br J Pharmacol 143:247-50. 2004
    ..These results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action...
  11. pmc Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milan Bicocca, Piazza della Scienza 2, Italy
    Br J Pharmacol 137:413-20. 2002
    ..The inhibition of COX activity and of NO and free radical production at the site of inflammation might account for this activity...
  12. ncbi request reprint Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    Barbara Costa
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Naunyn Schmiedebergs Arch Pharmacol 369:294-9. 2004
    ..The effect on NO seemed to depend on a lower expression of the endothelial isoform of NO synthase. In conclusion, oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia...
  13. pmc Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain
    B Costa
    Department of Biotechnology and Bioscience, University of Milan Bicocca, Piazza della Scienza 2, Milan 20126, Italy
    Br J Pharmacol 141:4-8. 2004
    ....
  14. pmc The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation
    F Comelli
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milano, Italy
    Br J Pharmacol 152:787-94. 2007
    ..On these bases, URB602, a MAGL inhibitor, was tested in a murine model of inflammation/inflammatory pain...
  15. doi request reprint Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: mechanisms involved
    Francesca Comelli
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Phytother Res 22:1017-24. 2008
    ....
  16. doi request reprint Rimonabant, a cannabinoid CB1 receptor antagonist, attenuates mechanical allodynia and counteracts oxidative stress and nerve growth factor deficit in diabetic mice
    Francesca Comelli
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milano, Italy
    Eur J Pharmacol 637:62-9. 2010
    ....
  17. doi request reprint Glial TLR4 receptor as new target to treat neuropathic pain: efficacy of a new receptor antagonist in a model of peripheral nerve injury in mice
    Isabella Bettoni
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Milano, Italy
    Glia 56:1312-9. 2008
    ....
  18. ncbi request reprint Relation between blood pressure variability and carotid artery damage in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis (ELSA)
    G Mancia
    Clinica Medica, Università di Milano Bicocca and Ospedale San Gerardo, Monza, Italy
    J Hypertens 19:1981-9. 2001
    ..The aim of the present study was to determine whether IMT independently relates to additional information obtained through ambulatory BP, in particular to SBP or PP variability...
  19. ncbi request reprint Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Angew Chem Int Ed Engl 46:3308-12. 2007
  20. doi request reprint Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress
    Francesca Comelli
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Phytother Res 23:1678-84. 2009
    ..These findings highlighted the beneficial effects of cannabis extract treatment in attenuating diabetic neuropathic pain, possibly through a strong antioxidant activity and a specific action upon nerve growth factor...
  21. doi request reprint The effects of accumulation of an environmentally relevant polychlorinated biphenyl mixture on cytochrome P450 and P-glycoprotein expressions in fetuses and pregnant rats
    Patrizia Bonfanti
    Department of Environmental Sciences, University of Milano Bicocca, Italy
    Chemosphere 75:572-9. 2009
    ..Moreover they highlight the lack of a coordinated response between the investigated defence mechanism...
  22. doi request reprint Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization
    Matteo Piazza
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    J Med Chem 52:1209-13. 2009
    ..The lack of toxicity and the good in vivo activity suggest the use of some compounds of the panel as hits for antisepsis drug development...
  23. ncbi request reprint Chronic treatment with the endocannabinoid anandamide increases cytochrome P450 metabolizing system in the rat
    Barbara Costa
    Dipartimento di Biotecnologie e Bioscienze, Facolta di Scienze, Universita Milano Bicocca, Milan 20126, Italy
    Eur J Pharmacol 449:61-9. 2002
    ..The present findings demonstrate that anandamide administration increased the metabolic activity of the cytochrome P450 system in rat liver and brain...
  24. doi request reprint CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation
    Ivan Zanoni
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Nature 460:264-8. 2009
    ....
  25. ncbi request reprint Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells
    Maria L Trincavelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, Italy
    Biochem Pharmacol 64:625-31. 2002
    ..The biological significance of this regulation might be associated with modulating cellular activity in response to tissue damage associated with inflammatory mediator production...
  26. pmc Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors
    Sandra Holt
    Department of Pharmacology and Clinical Neuroscience, Umea University, Sweden
    Br J Pharmacol 146:467-76. 2005
    ..In conclusion, the results show that in mice, treatment with indomethacin and URB597 produce SR144528-sensitive anti-inflammatory effects in the carrageenan model of acute inflammation...
  27. doi request reprint TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells
    Mariarosa Rechichi
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Via Volta 4, Pisa, Italy
    Biochim Biophys Acta 1782:118-25. 2008
    ..These findings suggest that the use of TSPO ligands as chemotherapeutic agents could be effective on aggressive tumor cells with a high TSPO expression level...
  28. ncbi request reprint Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells
    Beatrice Chelli
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    Biochem Pharmacol 68:125-34. 2004
    ..Moreover, PK 11195 and Ro5-4864 induced a decrease of DeltaPsi(m), as evidenced by JC-1 flow cytometry analysis. Our data demonstrate the pro-apoptotic effects of specific PBR ligands on rat C6 glioma cells...
  29. ncbi request reprint PIGA (N,N-Di-n-butyl-5-chloro-2-(4-chlorophenyl)indol-3-ylglyoxylamide), a new mitochondrial benzodiazepine-receptor ligand, induces apoptosis in C6 glioma cells
    Beatrice Chelli
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Chembiochem 6:1082-8. 2005
    ....
  30. ncbi request reprint Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation
    Silvia Selleri
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via U Schiff, 6, 50019 Sesto F no Firenze, Italy
    Bioorg Med Chem 13:4821-34. 2005
    ..In addition, a subset of the novel compounds showing high affinity for PBR was tested for their ability to modulate the steroid biosynthesis in C6 glioma cells...
  31. ncbi request reprint Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells
    Barbara Costa
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno, 6 56126 Pisa, Italy
    Mol Pharmacol 69:37-44. 2006
    ....
  32. ncbi request reprint Benzodiazepine receptor ligands. 8: synthesis and pharmacological evaluation of new pyrazolo[5,1-c] [1,2,4]benzotriazine 5-oxide 3- and 8-disubstituted: high affinity ligands endowed with inverse-agonist pharmacological efficacy
    Gabriella Guerrini
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Firenze, Via U Schiff, 6, 50019 Polo Scientifico, Sesto Fiorentino, Florence, Italy
    Bioorg Med Chem 14:758-75. 2006
    ..Compounds 4d and 6d showed an inverse-agonist profile. These compounds were evaluated also for their binding at benzodiazepine site on GABAA receptor complex (GABAA/BzR complex) subtype to evaluate their subtype selectivity...
  33. doi request reprint Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    Federico Da Settimo
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:5798-806. 2008
    ..The results of this study suggested that the novel N,N-disubstituted indol-3-ylglyoxylamides may represent a promising class of compounds potentially suited for the treatment of anxiety disorders...
  34. ncbi request reprint A novel selective GABA(A) alpha1 receptor agonist displaying sedative and anxiolytic-like properties in rodents
    Silvia Selleri
    Department of Pharmaceutical Sciences, University of Firenze, via U Schiff 6, 50019 Sesto Fiorentino, Italy
    J Med Chem 48:6756-60. 2005
    ..Compound 4 displayed affinity only for alpha1beta2gamma2 subtype (K(i) = 31 nM), and in an in-depth, in vivo study it revealed sedative and anxiolytic-like properties without any amnesic and myorelaxant effects in rodents...
  35. ncbi request reprint A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis
    Maria L Trincavelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy
    Biochem Pharmacol 66:1953-62. 2003
    ....
  36. doi request reprint DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization
    Michelle L James
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    J Nucl Med 49:814-22. 2008
    ..Radioligands for the TSPO can therefore measure active disease in the brain. This article details the synthesis, radiofluorination, and pharmacologic evaluation of a new TSPO-specific pyrazolopyrimidine, DPA-714...
  37. ncbi request reprint Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression
    Chiara Bardella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo, Turin, Italy
    Cancer Res 64:5154-61. 2004
    ..Altogether, these data show that expression of a naturally occurring, constitutively active truncated RON kinase results in loss of epithelial phenotype and aggressive behavior and, thus, it might contribute to tumor progression...