A Cossarizza

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. ncbi request reprint Tests for mitochondrial function and DNA: potentials and pitfalls
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena, Modena, Italy
    Curr Opin Infect Dis 16:5-10. 2003
  2. ncbi request reprint CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
    A Cossarizza
    Dipartimento di Scienze Biomediche, University of Modena, Italy
    Mech Ageing Dev 86:173-95. 1996
  3. ncbi request reprint Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    J Acquir Immune Defic Syndr 35:213-22. 2004
  4. ncbi request reprint Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Antivir Ther 8:315-21. 2003
  5. ncbi request reprint Mitochondria and HIV infection: the first decade
    A Cossarizza
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Italy
    J Biol Regul Homeost Agents 16:18-24. 2002
  6. ncbi request reprint Mitochondrial functionality and mitochondrial DNA content in lymphocytes of vertically infected human immunodeficiency virus-positive children with highly active antiretroviral therapy-related lipodystrophy
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, 41100 Modena, Italy
    J Infect Dis 185:299-305. 2002
  7. ncbi request reprint Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: actors or bystanders?
    A Cossarizza
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Bioessays 23:1070-80. 2001
  8. ncbi request reprint Apoptotic features of peripheral blood granulocytes and monocytes during primary, acute HIV infection
    A Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena School of Medicine, Via Campi 287, Modena, 41100, Italy
    Exp Cell Res 247:304-11. 1999
  9. ncbi request reprint MMP-7 promoter polymorphisms do not influence CD4+ recovery and changes in plasma viral load during antiretroviral therapy for HIV-1 infection
    E Lugli
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Int J Immunogenet 32:269-71. 2005
  10. ncbi request reprint Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type I-infected patients: the changes in opportunistic prophylaxis study
    C Mussini
    Dept of Infectious Diseases, Policlinico, University of Modena and Reggio Emilio Hospital, 41100 Modena, Italy
    J Infect Dis 181:1635-42. 2000

Detail Information

Publications75

  1. ncbi request reprint Tests for mitochondrial function and DNA: potentials and pitfalls
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena, Modena, Italy
    Curr Opin Infect Dis 16:5-10. 2003
    ....
  2. ncbi request reprint CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory
    A Cossarizza
    Dipartimento di Scienze Biomediche, University of Modena, Italy
    Mech Ageing Dev 86:173-95. 1996
    ..Moreover, the data on centenarians suggest that they may represent a very selected population where a slowing of immunosenescence occurs...
  3. ncbi request reprint Highly active antiretroviral therapy restores CD4+ Vbeta T-cell repertoire in patients with primary acute HIV infection but not in treatment-naive HIV+ patients with severe chronic infection
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    J Acquir Immune Defic Syndr 35:213-22. 2004
    ..Our results indicate that HAART can restore the T-cell repertoire in individuals whose immune system is not severely compromised by the infection...
  4. ncbi request reprint Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Antivir Ther 8:315-21. 2003
    ..However, further studies are needed to confirm these initial observations and ascertain whether the quantification of mtDNA in PBL is a useful and reliable marker to investigate and monitor HAART-related changes in fat distribution...
  5. ncbi request reprint Mitochondria and HIV infection: the first decade
    A Cossarizza
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Italy
    J Biol Regul Homeost Agents 16:18-24. 2002
    ..In this paper, data concerning the interactions between mitochondria and HIV infection will be reviewed...
  6. ncbi request reprint Mitochondrial functionality and mitochondrial DNA content in lymphocytes of vertically infected human immunodeficiency virus-positive children with highly active antiretroviral therapy-related lipodystrophy
    Andrea Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, 41100 Modena, Italy
    J Infect Dis 185:299-305. 2002
    ..mtDNA content was also similar in PBL of LD-positive children and HCs, suggesting that normal mt functionality and normal tendency to undergo apoptosis are present in PBL of children with HAART-associated LD...
  7. ncbi request reprint Mitochondria in the pathogenesis of lipodystrophy induced by anti-HIV antiretroviral drugs: actors or bystanders?
    A Cossarizza
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Bioessays 23:1070-80. 2001
    ..In this paper, we review data concerning the role of mitochondria in the pathogenesis of lipodystrophy, and advance a unifying hypothesis involving either direct or indirect effects of the drugs employed during HAART...
  8. ncbi request reprint Apoptotic features of peripheral blood granulocytes and monocytes during primary, acute HIV infection
    A Cossarizza
    Department of Biomedical Sciences, Section of General Pathology, University of Modena School of Medicine, Via Campi 287, Modena, 41100, Italy
    Exp Cell Res 247:304-11. 1999
    ....
  9. ncbi request reprint MMP-7 promoter polymorphisms do not influence CD4+ recovery and changes in plasma viral load during antiretroviral therapy for HIV-1 infection
    E Lugli
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Int J Immunogenet 32:269-71. 2005
    ..We evaluated whether two polymorphisms in MMP-7 promoter could influence CD4+ recover in response to antiretroviral therapy, and found that these polymorphisms are ineffective...
  10. ncbi request reprint Discontinuation of primary prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus type I-infected patients: the changes in opportunistic prophylaxis study
    C Mussini
    Dept of Infectious Diseases, Policlinico, University of Modena and Reggio Emilio Hospital, 41100 Modena, Italy
    J Infect Dis 181:1635-42. 2000
    ..The results of this study strongly indicate that primary prophylaxis for P. carinii pneumonia and toxoplasmic encephalitis can be safely discontinued in patients whose CD4+ T cell counts increase to >200 cells/mm3 during HAART...
  11. ncbi request reprint Use of flow cytometry as a tool to study mitochondrial membrane potential in isolated, living hepatocytes
    S Salvioli
    Department of Biomedical Sciences, Section of General Pathology, University of Modena, Via Campi, 287, 41100 Modena, Italy
    Biochemistry (Mosc) 63:235-8. 1998
    ..The results indicate that the proposed method may be used in laboratory practice...
  12. ncbi request reprint Hepatoma HepG2 cells as a model for in vitro studies on mitochondrial toxicity of antiviral drugs: which correlation with the patient?
    M Pinti
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    J Biol Regul Homeost Agents 17:166-71. 2003
    ....
  13. ncbi request reprint Immunophenotype of HIV+ patients during CD4 cell-monitored treatment interruption: role of the IL-7/IL-7 receptor system
    Elisa Nemes
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    AIDS 20:2021-32. 2006
    ..To investigate immunological changes during CD4-guided therapy interruption in HIV(+) patients who suspended HAART...
  14. ncbi request reprint Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/microl
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy
    AIDS 16:1551-4. 2002
    ..This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation...
  15. ncbi request reprint T cell homeostasis in centenarians: from the thymus to the periphery
    M Pinti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Curr Pharm Des 16:597-603. 2010
    ..Data on the possible use of these molecules, including cytokines like interleukin (IL)-7, IL-15 and keratinocyte growth factor, to restore thymic function are reviewed and discussed...
  16. ncbi request reprint Anti-HIV drugs and the mitochondria
    Marcello Pinti
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41100 Modena, Italy
    Biochim Biophys Acta 1757:700-7. 2006
    ....
  17. ncbi request reprint Features of 'CD4-exploders', HIV-positive patients with an optimal immune reconstitution after potent antiretroviral therapy
    Cristina Mussini
    Infectious Diseases Clinic, University of Modena and Reggio Emilia School of Medicine and Azienda Ospedaliera Policlinico Modena, Modena, Italy
    AIDS 16:1609-16. 2002
    ..To identify crucial immunological characteristics of a group of patients, defined 'CD4-exploders', who were able to fully reconstitute their immune system after receiving highly active antiretroviral therapy (HAART)...
  18. ncbi request reprint CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 106 cells/l
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy
    AIDS 19:287-94. 2005
    ..Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250-350 x 10 cells/l...
  19. ncbi request reprint Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians
    M Pinti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Cell Death Differ 9:431-8. 2002
    ..On the whole, our data suggest that Fas and FasL polymorphisms, as well as their haplotypes, are unlikely to be associated with successful human longevity...
  20. ncbi request reprint Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense
    E Blasi
    Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Universita di Modena e Reggio Emilia, Italy
    Med Microbiol Immunol 189:209-16. 2001
    ..neoformans growth inhibition...
  21. ncbi request reprint An observational study on patients treated or not for acute HIV infection
    C Mussini
    Clinic of Infectious Diseases, Policlinico and University of Modena and Reggio Emilia, Italy
    J Biol Regul Homeost Agents 16:79-82. 2002
    ..Open questions are how can we identify patients who will be slow progressors or long-term non progressors, and, as a consequence, do not require treatment...
  22. ncbi request reprint Ultraviolet B radiation induces activation of neutral and acidic sphingomyelinases and ceramide generation in cultured normal human keratinocytes
    C Magnoni
    Department of Dermatology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Toxicol In Vitro 16:349-55. 2002
    ..These data indicate that UVB induced ceramide generation and activation of both neutral and acidic SMases, suggesting that sphingolipids metabolism may be involved in the UVB signaling pathway...
  23. ncbi request reprint HIV coinfection and antiretroviral therapy enhances liver steatosis in patients with hepatitis C, but only in those infected by HCV genotype other than 3
    Vanni Borghi
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy
    Antivir Ther 13:1057-65. 2008
    ..We analysed the effect of HIV coinfection and antiretroviral therapy on hepatic steatosis and the effect of the steatosis on fibrosis in patients with or without HCV genotype 3 infection...
  24. ncbi request reprint Magnitude and determinants of CD4 recovery after HAART resumption after 1 cycle of treatment interruption
    Cristina Mussini
    Clinic of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy
    J Acquir Immune Defic Syndr 52:588-94. 2009
    ..The extent of immune reconstitution following HAART resumption after 1 cycle of treatment interruption (TI) is not well known...
  25. ncbi request reprint Effect of treatment interruption monitored by CD4 cell count on mitochondrial DNA content in HIV-infected patients: a prospective study
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy
    AIDS 19:1627-33. 2005
    ..HIV infection per se and HAART can alter mitochondrial functionality, leading to a decrease in mitochondrial DNA content...
  26. ncbi request reprint Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients
    Milena Nasi
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Via Campi 287, Modena, 41100, Italy
    Immunogenetics 57:628-35. 2005
    ....
  27. ncbi request reprint Altered mitochondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy
    Lorenzo Galluzzi
    Chair of Immunology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Antivir Ther 10:M91-9. 2005
    ..To further investigate mt changes during this syndrome, we analysed the expression of mtRNA in adipocytes from lipodystrophic HIV+ patients taking NRTI-containing HAART and compared it with similar cells from healthy individuals...
  28. ncbi request reprint Discontinuation of maintenance therapy for cryptococcal meningitis in patients with AIDS treated with highly active antiretroviral therapy: an international observational study
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena, Italy
    Clin Infect Dis 38:565-71. 2004
    ..Recurrent cryptococcal infection should be suspected in patients whose serum cryptococcal antigen test results revert back to positive after discontinuation of maintenance therapy...
  29. doi request reprint Predictive value of intracellular HIV-1 DNA levels during CD4-guided treatment interruption in HIV+ patients
    Milena Nasi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    AIDS Res Hum Retroviruses 26:553-8. 2010
    ..In conclusion, intracellular HIV-1 DNA is a predictive marker for the length of CD4-guided TI...
  30. ncbi request reprint Discontinuation of secondary prophylaxis for Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patients: a randomized trial by the CIOP Study Group
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, Azienda Ospedaliera Policlinico, University of Modena and Reggio Emilia, Modena, Italy
    Clin Infect Dis 36:645-51. 2003
    ..Patients who present with symptoms after discontinuation of secondary prophylaxis should be evaluated for PCP despite high CD4 count and complete virus suppression...
  31. ncbi request reprint Flow cytometric analysis of mitochondrial membrane potential using JC-1
    A Cossarizza
    University of Modena, Modena, Italy
    Curr Protoc Cytom . 2001
    ..A valuable component of this measurement system is the possibility of making quantitative measurements of changes in membrane potential...
  32. doi request reprint Absence of liver steatosis in HIV-HCV co-infected patients receiving regimens containing tenofovir or abacavir
    V Borghi
    Clinic of Infectious and Tropical Diseases, Azienda Ospedaliero Universitaria Policlinico di Modena, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy
    Infection 41:425-9. 2013
    ..We retrospectively investigated the presence of steatosis among HIV-HCV co-infected and HCV mono-infected patients, and the role of tenofovir disoproxil fumarate (TDF) or abacavir (ABC) in determining hepatic steatosis...
  33. ncbi request reprint Resistance to apoptosis in Fanconi's anaemia. An ex vivo study in peripheral blood mononuclear cells
    D Monti
    Department of Biomedical Sciences, University of Modena, Italy
    FEBS Lett 409:365-9. 1997
    ....
  34. ncbi request reprint Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs
    Roberta Ferraresi
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia, School of Medicine, Via Campi 287, 41100 Modena, Italy
    FEBS Lett 580:6612-6. 2006
    ..These data suggest that one of these effects could be a direct anti-oxidant action...
  35. ncbi request reprint Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin
    Roberta Ferraresi
    University of Modena and Reggio Emilia School of Medicine, Department of Biomedical Sciences, Italy
    Free Radic Res 39:1249-58. 2005
    ..Thus, QU can exert different effects (anti-/prooxidant) depending on exposure times and oxidative balance, and in particular on stores of GSH...
  36. ncbi request reprint Characterization of cells with different mitochondrial membrane potential during apoptosis
    Enrico Lugli
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Modena, Italy
    Cytometry A 68:28-35. 2005
    ..Using polychromatic flow cytometry based upon multiple laser and UV lamp excitation, we have characterized cells with different DeltaPsi during apoptosis...
  37. doi request reprint Mitochondrial DNA haplogroups and highly active antiretroviral therapy-related lipodystrophy
    Milena Nasi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Clin Infect Dis 47:962-8. 2008
    ....
  38. ncbi request reprint Subject classification obtained by cluster analysis and principal component analysis applied to flow cytometric data
    Enrico Lugli
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Cytometry A 71:334-44. 2007
    ..Here we show the use of cluster analysis (CA) and principal component analyses (PCA) to simplify multicolor data visualization and to allow subjects' classification...
  39. ncbi request reprint Apoptosis and HIV infection: about molecules and genes
    Andrea Cossarizza
    Chair of Immunology, University of Modena and Reggio Emilia School of Medicine, Italy
    Curr Pharm Des 14:237-44. 2008
    ..The role of the host genetic background is finally crucial in understanding the process of cell death in HIV infection...
  40. ncbi request reprint Mitochondria, HIV infection and its treatment: where do we go from here?
    Andrea Cossarizza
    University of Modena and Reggio Emilia, Modena, Italy
    Antivir Ther 10:M1-2. 2005
  41. ncbi request reprint Changes in mitochondrial RNA production in cells treated with nucleoside analogues
    Lorenzo Galluzzi
    Section of General Pathology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Antivir Ther 10:191-5. 2005
    ..We analysed the effects of stavudine (d4T), didanosine (ddl) and zidovudine (AZT) on the production of mtRNAs in different human cell lines and compared the production with the amount of mtDNA present in the same cells...
  42. ncbi request reprint Different sensitivity to apoptosis in cells of monocytic or lymphocytic origin chronically infected with human immunodeficiency virus type-1
    Marcello Pinti
    Department of Biomedical Sciences, Section of General Pathology, University of Modena and Reggio Emilia School of Medicine, Modena, Italy
    Exp Biol Med (Maywood) 228:1346-54. 2003
    ..However, further studies on ex-vivo collected fresh cells, as well as on other cell lines, are urgently needed to confirm such hypothesis...
  43. ncbi request reprint The human immunodeficiency virus (HIV) protease inhibitor indinavir directly affects the opportunistic fungal pathogen Cryptococcus neoformans
    Elisabetta Blasi
    Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Via Campi 287, 41100 Modena, Italy
    FEMS Immunol Med Microbiol 42:187-95. 2004
    ..neoformans, these data add new in vitro insights on the wide-spectrum efficacy of PIs, further arguing for the clinical relevance of HAART against opportunistic infections in AIDS...
  44. doi request reprint Randomized trial to evaluate cardiometabolic and endothelial function in patients with plasma HIV-1 RNA suppression switching to darunavir/ritonavir with or without nucleoside analogues
    G Guaraldi
    University of Modena and Reggio Emilia, Modena, Italy
    HIV Clin Trials 14:140-8. 2013
    ..We performed a study to evaluate change in cardiometabolic and endothelial function in HIV-infected patients switching to darunavir/ritonavir (DRV/r) monotherapy versus triple therapy...
  45. ncbi request reprint Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes
    A Di Nardo
    Departments of Dermatology and Biomedical Sciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
    Br J Dermatol 143:491-7. 2000
    ..In the skin, the generation of intracellular ceramide may also provide a link between an extracellular signal and the induction of the apoptosis programme for the elimination of damaged cells...
  46. doi request reprint Resistance of mtDNA-depleted cells to apoptosis
    Roberta Ferraresi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cytometry A 73:528-37. 2008
    ..The resistance to apoptosis of rho(0) cells could be not only due to an increased scavenger capacity of GSH, but also due to a selection of multidrug resistant cells that hyperexpress P-gp...
  47. ncbi request reprint Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome
    Erika Roat
    Chair of Immunology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    FEBS Lett 581:521-5. 2007
    ..However, in cells from DS subjects, mitochondria showed a higher loss of DeltaPsi(m), underlying the presence of an increasing susceptibility of these organelles to damaging agents...
  48. ncbi request reprint Balanced regulation of mRNA production for Fas and Fas ligand in lymphocytes from centenarians: how the immune system starts its second century
    Marcello Pinti
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Modena, Italy
    Circulation 110:3108-14. 2004
    ....
  49. ncbi request reprint Development of real time PCR assays for the quantification of Fas and FasL mRNA levels in lymphocytes: studies on centenarians
    Marcello Pinti
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Via Campi 287, 41100, Modena, Italy
    Mech Ageing Dev 124:511-6. 2003
    ....
  50. ncbi request reprint Complementary and alternative medicine during HIV infection
    Milena Nasi
    University of Modena and Reggio Emilia, Dept of Biomedical Sciences, Section of General Pathology, Via Campi 287, 41100 Modena, Italy
    Adv Exp Med Biol 546:105-10. 2004
  51. ncbi request reprint MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
    Milena Nasi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41100 Modena, Italy
    AIDS 17:1696-8. 2003
    ..The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype...
  52. doi request reprint Investigating T cells by polychromatic flow cytometry
    Enrico Lugli
    Department of Biomedical Sciences, Section of General Pathology, Modena, Italy
    Methods Mol Biol 514:47-63. 2009
    ..Protocols for performing PFC will be discussed in this chapter, together with some guidelines for data interpretation and analysis...
  53. doi request reprint Simultaneous analysis of reactive oxygen species and reduced glutathione content in living cells by polychromatic flow cytometry
    Andrea Cossarizza
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Nat Protoc 4:1790-7. 2009
    ..This approach is extremely useful to study the balance between ROS content and antioxidants in cells receiving different stimuli, and to analyze the relationship between oxidative stress and cell death...
  54. ncbi request reprint Polychromatic analysis of mitochondrial membrane potential using JC-1
    Enrico Lugli
    Department of Biomedical Sciences, General Pathology Section, University of Modena and Reggio Emilia, Modena, Italy
    Curr Protoc Cytom . 2007
    ....
  55. ncbi request reprint Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry
    Leonarda Troiano
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Nat Protoc 2:2719-27. 2007
    ..The procedure can be completed in less than 2 h...
  56. doi request reprint Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cells
    Enrico Lugli
    Department of Biomedical Sciences, Chair of Immunology, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Leuk Res 33:140-50. 2009
    ..Our data suggest that quercetin, while incapable of inducing apoptosis in normal cells under several conditions, could interfere with effector T cell function...
  57. ncbi request reprint Effects of the change from Stavudine to tenofovir in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy: studies on mitochondrial toxicity and thymic function
    Raffaella Rosso
    Infectious Diseases Clinics, San Martino Hospital, University of Genoa, Genoa, Italy
    Pediatr Infect Dis J 27:17-21. 2008
    ..Few data on mitochondrial toxicity of antiviral drugs are available in HIV-positive children...
  58. ncbi request reprint Early changes in intramitochondrial cardiolipin distribution during apoptosis
    Maria Garcia Fernandez
    Department of Human Physiology, University of Malaga, Campus Teatinos, 29080 Malaga, Spain
    Cell Growth Differ 13:449-55. 2002
    ....
  59. ncbi request reprint Antiretroviral nucleoside and nucleotide analogues and mitochondria
    Andrea Cossarizza
    AIDS 18:137-51. 2004
  60. ncbi request reprint HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients
    Antonella Isgro
    Division of Allergy and Clinical Immunology, University of Rome La Sapienza, 00185 Rome, Italy
    AIDS Res Hum Retroviruses 21:51-7. 2005
    ..RTV and IND increased colony growth of BM obtained either from HIV-1-infected patients or from normal individuals, in parallel with the normalization of functional and morphological characteristics of stromal cells...
  61. ncbi request reprint Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy
    Bruce Shiramizu
    University of Hawaii, Honolulu, Hawii, USA
    J Acquir Immune Defic Syndr 32:370-4. 2003
    ..Further studies are needed to better understand the morbidity to infants and mothers treated with NRTI to prevent vertical transmission of HIV...
  62. ncbi request reprint Decreased apoptosis of bone marrow progenitor cells in HIV-1-infected patients during highly active antiretroviral therapy
    Antonella Isgro
    Division of Allergy and Clinical Immunology, University of Rome La Sapienza, Italy
    AIDS 18:1335-7. 2004
    ....
  63. doi request reprint Genetic polymorphisms differently influencing the emergence of atrophy and fat accumulation in HIV-related lipodystrophy
    Barbara Zanone Poma
    Department of Clinical Sciences, Luigi Sacco Hospital, University of Milan, Milan, Italy
    AIDS 22:1769-78. 2008
    ..Crude rates of lipoatrophy and fat accumulation and adjusted relative rates were calculated using Poisson regression...
  64. pmc A whole-genome association study of major determinants for host control of HIV-1
    Jacques Fellay
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Science 317:944-7. 2007
    ..These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents...
  65. doi request reprint Altered clonogenic capability and stromal cell function characterize bone marrow of HIV-infected subjects with low CD4+ T cell counts despite viral suppression during HAART
    Antonella Isgro
    Mediterranean Institute of Hematology, International Center for Transplantation in Thalassemia and Sickle Cell Anemia, University of Rome Tor Vergata, Rome, Italy
    Clin Infect Dis 46:1902-10. 2008
    ....
  66. ncbi request reprint Plasma HIV load and proviral DNA decreases after two standard antiretroviral regimens in HIV-positive patients naïve to antiretrovirals
    Carlo Torti
    Institute for Infectious and Tropical Diseases, University of Brescia, Brescia, Italy
    Curr HIV Res 6:43-8. 2008
    ..Further studies are needed to compare pVL decay between antiretroviral regimens and assess whether proviral HIV-DNA load is a surrogate marker of treatment effectiveness...
  67. ncbi request reprint Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo
    Monica Ottaviani
    Laboratory of Cutaneous Physiopathology, IRCCS, Rome, Italy
    J Invest Dermatol 127:1226-33. 2007
    ..In basal conditions melanocytes maintain the redox balance whereas following chemical or physical stress ROS-mediated membrane peroxidation is increased with a possible further CL oxidation, leading to cell death or detachment...
  68. ncbi request reprint OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes
    Patrizia Amati-Bonneau
    Département de Biochimie et Génétique, Centre Hospitalier Universitaire d Angers, Angers, France
    Brain 131:338-51. 2008
    ..Our results show that certain OPA1 mutations exert a dominant negative effect responsible for multi-systemic disease, closely related to classical mitochondrial cytopathies, by a mechanism involving mtDNA instability...
  69. ncbi request reprint Digging for innate immunity since Darwin and Metchnikoff
    Edwin L Cooper
    Laboratory of Comparative Immunology, UCLA, Los Angeles 90095 1763, USA
    Bioessays 24:319-33. 2002
    ..The evolutionary context of the earthworm innate immune system is discussed at the end of this article...
  70. ncbi request reprint Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies
    Mariangela Sebastiani
    Dipartimento di Medicina Sperimentale, Polo Pontino, Sapienza, Universita di Roma, Rome, Italy
    J Am Coll Cardiol 50:1362-9. 2007
    ..The purpose of this study was to clarify the molecular mechanisms linking human mitochondrial deoxyribonucleic acid (mtDNA) dysfunction to cardiac remodeling...
  71. ncbi request reprint Biological importance of the two Toll-like receptors, TLR2 and TLR4, in macrophage response to infection with Candida albicans
    Elisabetta Blasi
    Department of Hygiene, Microbiology and Biostatistical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    FEMS Immunol Med Microbiol 44:69-79. 2005
    ..albicans appears to be TLR4 but not TLR2-dependent...
  72. doi request reprint Homeostatic cytokines and expansion of regulatory T cells accompany thymic impairment in children with Down syndrome
    Erika Roat
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Rejuvenation Res 11:573-83. 2008
    ....
  73. ncbi request reprint Mitochondrial neurogastrointestinal encephalomyopathy: evidence of mitochondrial DNA depletion in the small intestine
    Carla Giordano
    Dipartimento di Medicina Sperimentale e Patologia, Universita di Roma La Sapienza, Rome, Italy
    Gastroenterology 130:893-901. 2006
    ..Our study is aimed to define the molecular basis of gastrointestinal dysmotility in a case of MNGIE...
  74. pmc Gastrointestinal dysmotility in mitochondrial neurogastrointestinal encephalomyopathy is caused by mitochondrial DNA depletion
    Carla Giordano
    Dipartimento di Medicina Sperimentale, Sapienza, Universita di Roma, Roma, Italy
    Am J Pathol 173:1120-8. 2008
    ....
  75. doi request reprint OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion
    Claudia Zanna
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Via Irnerio 42, 40126 Bologna, Italy
    Brain 131:352-67. 2008
    ..The results disclose a novel link between OPA1, apoptosis inducing factor and the respiratory complexes that may shed some light on the pathogenic mechanism of DOA...