Benilde Cosmi

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Accuracy of a portable prothrombin time monitor (Coagucheck) in patients on chronic oral anticoagulant therapy: a prospective multicenter study
    B Cosmi
    Divisione di Angiologia, Ospedale S Orsola Malpighi, Bologna, Italy
    Thromb Res 100:279-86. 2000
  2. ncbi Thrombophilia in young women candidate to the pill: reasons for and against screening
    B Cosmi
    Division of Angiology, S Orsola Malpighi Hospital, University of Bologna, Italy
    Pathophysiol Haemost Thromb 32:315-7. 2002
  3. ncbi Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans
    Benilde Cosmi
    Divisione di Angiologia e Malattie della Coagulazione, Policlinico S Orsola Malpighi, Universita degli Studi di Bologna, Bologna, Italy
    Thromb Res 109:333-9. 2003
  4. ncbi Role of family history in identifying women with thrombophilia and higher risk of venous thromboembolism during oral contraception
    Benilde Cosmi
    Division of Angiology, Cardiovascular Department, Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Arch Intern Med 163:1105-9. 2003
  5. ncbi D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis
    Benilde Cosmi
    Department of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    Thromb Haemost 94:969-74. 2005
  6. doi The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs
    Benilde Cosmi
    Department of Angiology Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Albertoni 15, Bologna, Italy
    Thromb Haemost 109:510-6. 2013
  7. ncbi Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia
    Gualtiero Palareti
    Dipartimento di Angiologia, Unità Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Circulation 108:313-8. 2003
  8. ncbi Comorbidities, alone and in combination with D-dimer, as risk factors for recurrence after a first episode of unprovoked venous thromboembolism in the extended follow-up of the PROLONG study
    Benilde Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 103:1152-60. 2010
  9. doi Use of D-dimer testing to determine duration of anticoagulation, risk of cardiovascular events and occult cancer after a first episode of idiopathic venous thromboembolism: the extended follow-up of the PROLONG study
    Benilde Cosmi
    Department Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Via Albertoni, 15, Bologna, Italy
    J Thromb Thrombolysis 28:381-8. 2009
  10. ncbi D-dimer testing to determine the duration of anticoagulation therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
    N Engl J Med 355:1780-9. 2006

Detail Information

Publications52

  1. ncbi Accuracy of a portable prothrombin time monitor (Coagucheck) in patients on chronic oral anticoagulant therapy: a prospective multicenter study
    B Cosmi
    Divisione di Angiologia, Ospedale S Orsola Malpighi, Bologna, Italy
    Thromb Res 100:279-86. 2000
    ..7%, 8.5%, 4.7%, and 4.9%, respectively, in Centers 1, 2, 3, and 4. Coagucheck has an acceptable level of accuracy for INR values in the range between 2.0 and 3.0. A wide variation in monitor performance was found among centers...
  2. ncbi Thrombophilia in young women candidate to the pill: reasons for and against screening
    B Cosmi
    Division of Angiology, S Orsola Malpighi Hospital, University of Bologna, Italy
    Pathophysiol Haemost Thromb 32:315-7. 2002
    ..A proper evaluation of the cost-effectiveness, the medical, psychosocial and legal consequences is needed before general screening with genetic testing for inherited thrombophilia can be recommended before OC...
  3. ncbi Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans
    Benilde Cosmi
    Divisione di Angiologia e Malattie della Coagulazione, Policlinico S Orsola Malpighi, Universita degli Studi di Bologna, Bologna, Italy
    Thromb Res 109:333-9. 2003
    ..The aim of the study was to evaluate the mechanism of the anticoagulant action of sulodexide, a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH), in vitro...
  4. ncbi Role of family history in identifying women with thrombophilia and higher risk of venous thromboembolism during oral contraception
    Benilde Cosmi
    Division of Angiology, Cardiovascular Department, Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Arch Intern Med 163:1105-9. 2003
    ..We evaluated the sensitivity and specificity of a family history of VTE to identify thrombophilia in women before OC and after venous thrombotic complications during OC...
  5. ncbi D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis
    Benilde Cosmi
    Department of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    Thromb Haemost 94:969-74. 2005
    ....
  6. doi The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs
    Benilde Cosmi
    Department of Angiology Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Albertoni 15, Bologna, Italy
    Thromb Haemost 109:510-6. 2013
    ..Male sex and isolated DVT were significantly associated with RVO in all patients. In conclusion, male sex and isolated DVT are associated with RVO, while FVL and FII mutations are not significantly associated with RVO in this study...
  7. ncbi Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilia
    Gualtiero Palareti
    Dipartimento di Angiologia, Unità Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Circulation 108:313-8. 2003
    ..The aim of the present study was to assess the predictive value of D-dimer for recurrent VTE in subjects with a previous unprovoked event who are either carriers of inherited thrombophilia or not...
  8. ncbi Comorbidities, alone and in combination with D-dimer, as risk factors for recurrence after a first episode of unprovoked venous thromboembolism in the extended follow-up of the PROLONG study
    Benilde Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 103:1152-60. 2010
    ....
  9. doi Use of D-dimer testing to determine duration of anticoagulation, risk of cardiovascular events and occult cancer after a first episode of idiopathic venous thromboembolism: the extended follow-up of the PROLONG study
    Benilde Cosmi
    Department Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Via Albertoni, 15, Bologna, Italy
    J Thromb Thrombolysis 28:381-8. 2009
    ..The PROLONG study showed that D-dimer (D-d) testing could help tailor the duration of anticoagulation after idiopathic venous thromboembolism (VTE). In this report the initial 18 month study follow-up was extended for 1 year...
  10. ncbi D-dimer testing to determine the duration of anticoagulation therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
    N Engl J Med 355:1780-9. 2006
    ..The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation...
  11. ncbi Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped
    Gualtiero Palareti
    Department of Angiology, Unità Ricerca Clinica sulla Trombofilia M Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 87:7-12. 2002
    ..Only five idiopathic recurrences occurred in the 186 patients with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for VTE recurrence when performed after OAT discontinuation...
  12. doi Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study
    Benilde Cosmi
    Department of Angiology and Blood Coagulation, Marino Golinelli University Hospital St Orsola Malpighi, Bologna, Italy
    Blood 115:481-8. 2010
    ..9; 95% CI: 2.1-30; P = .002). Repeated D-d testing after anticoagulation suspension for a first episode of unprovoked VTE could help tailor the duration of treatment. This trial is registered at http://clinicaltrials.gov as NCT00266045...
  13. ncbi D-dimer and factor VIII are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis
    Benilde Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    Thromb Res 122:610-7. 2008
    ..To assess the predictive value of D-dimer (D-d) and Factor VIII (FVIII) in combination for recurrent venous thromboembolism (VTE) after vitamin K antagonist (VKA) therapy suspension...
  14. doi Age and gender specific cut-off values to improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrence
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138, Bologna, Italy
    Intern Emerg Med 8:229-36. 2013
    ..These method-specific cut-off values are being evaluated in the ongoing prospective management multicenter DULCIS study...
  15. doi Evolution of untreated calf deep-vein thrombosis in high risk symptomatic outpatients: the blind, prospective CALTHRO study
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Haemost 104:1063-70. 2010
    ..7%; 95% CI: 1-13; p=0.049). Thrombotic evolution of untreated ICDVT in high-risk subjects may be relevant. Larger studies are needed to address this issue...
  16. doi A new warfarin dosing algorithm including VKORC1 3730 G > A polymorphism: comparison with results obtained by other published algorithms
    Michela Cini
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138 Bologna, Italy
    Eur J Clin Pharmacol 68:1167-74. 2012
    ..We developed a new dosing algorithm including polymorphisms associated both with warfarin sensitivity and resistance in the Italian population, and its performance was compared with those of eight previously published algorithms...
  17. doi Different cut-off values of quantitative D-dimer methods to predict the risk of venous thromboembolism recurrence: a post-hoc analysis of the PROLONG study
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Haematologica 93:900-7. 2008
    ..The objective of this study was to evaluate the possible advantage of using quantitative D-dimer assays...
  18. ncbi Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal
    Cristina Legnani
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Br J Haematol 134:227-32. 2006
    ..The aPTT predictive value was independent of the presence of inherited thrombophilic alterations. In conclusion, abnormally short aPTT values are associated with a significantly increased risk of VTE recurrence...
  19. ncbi Bleeding with anticoagulation therapy - who is at risk, and how best to identify such patients
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138 Bologna, Italy
    Thromb Haemost 102:268-78. 2009
    ..The clinical prediction rules may help physicians stratify patients into categories of risk and thus to evaluate their individual risk/benefit ratio of starting or prolonging an anticoagulant treatment...
  20. ncbi Risks factors for highly unstable response to oral anticoagulation: a case-control study
    Gualtiero Palareti
    Dipartimento di Angiologia e Malattie della Coagulazione Marino Golinelli, Policlinico S Orsola Malpighi, Universita di Bologna, Bologna, Italy
    Br J Haematol 129:72-8. 2005
    ..9% vs.15.0%; P = 0.042). No differences were observed as regards the other variables. In conclusion, we found that high intra-individual variability in OAT control was multifactorial, but poor OAT comprehension was prevalent...
  21. ncbi D-dimer to guide the duration of anticoagulation in patients with venous thromboembolism: a management study
    Gualtiero Palareti
    Angiology and Blood Coagulation, University Hospital of Bologna, Bologna, Italy
    Blood 124:196-203. 2014
    ..Serial D-dimer measurement is suitable in clinical practice for the identification of VTE patients in whom anticoagulation can be safely discontinued. This study was registered at clinicaltrials.gov as #NCT00954395. ..
  22. doi Old and new heparins
    Benilde Cosmi
    Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Res 129:388-91. 2012
    ..The characteristics of these compounds are reviewed along with the description of their approved clinical uses...
  23. ncbi Risk of deep vein thrombosis: interaction between oral contraceptives and high factor VIII levels
    Cristina Legnani
    Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Haematologica 89:1347-51. 2004
    ..High levels of factor VIII are a common risk factor for venous thromboembolism (VTE). The aim of this study was to evaluate the possible interaction between the presence of high factor VIII levels and oral contraceptive (OC) use...
  24. ncbi D-dimer testing to determine the duration of anticoagulant therapy
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Curr Opin Pulm Med 13:393-7. 2007
    ..Recent prospective observational studies show that D-dimer levels have a predictive value for the risk of recurrence. D-dimer testing may help in assessing the individual need for prolonged anticoagulation...
  25. ncbi Oral anticoagulant therapy in venous thromboembolism
    Benilde Cosmi
    Cardiovascular Department, Division of Angiology, S Orsola Malpighi University Hospital, Bologna, Italy
    Semin Vasc Med 3:303-14. 2003
    ..In patients with VTE and cancer, oral anticoagulation poses a higher risk of bleeding, and such patients are more prone to recurrences. Alternative treatment with LMWH could be safer and more effective in these patients...
  26. ncbi Oral contraceptive use in women with poor anticoagulant response to activated protein C but not carrying the factor V Leiden mutation increases the risk of venous thrombosis
    Cristina Legnani
    Dept Angiology and Blood Coagulation, University Hospital S Orsola Malpighi, Via Massarenti, 9, 40138, Bologna, Italy
    Thromb Haemost 91:712-8. 2004
    ..Our data also showed that OC use in women with altered APC resistance further increased the risk of VTE in a way that exceeded the additive expectation...
  27. ncbi D-dimer, oral anticoagulation, and venous thromboembolism recurrence
    Benilde Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    Semin Vasc Med 5:365-70. 2005
    ....
  28. ncbi Predicting the risk of recurrence of venous thromboembolism
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, University Hospital, S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Curr Opin Hematol 11:192-7. 2004
    ..Our review focused on studies that evaluated different risk factors that might be useful to stratify patients into categories at different risk for recurrence...
  29. ncbi Diagnosis of deep vein thrombosis
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation, University Hospital Saint Orsola Malpighi, Bologna, Italy
    Semin Thromb Hemost 32:659-72. 2006
    ..Some areas are still a matter of debate, such as the clinical relevance of isolated distal DVT and the diagnosis of suspected ipsilateral recurrence...
  30. ncbi Poor anticoagulation quality in the first 3 months after unprovoked venous thromboembolism is a risk factor for long-term recurrence
    G Palareti
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    J Thromb Haemost 3:955-61. 2005
    ..The aim of the study was to investigate whether the quality of oral anticoagulation therapy (OAT) is a long-term risk factor for recurrence of VTE after OAT interruption...
  31. doi Residual emboli on lung perfusion scan or multidetector computed tomography after a first episode of acute pulmonary embolism
    Benilde Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, Bologna, Italy
    Intern Emerg Med 6:521-8. 2011
    ..Further studies are warranted in which the presence of residual embolism is detected by repetition of the same test that had been initially carried out...
  32. doi Emerging drugs for venous thromboembolism
    Gualtiero Palareti
    University Hospital S Orsola Malpighi, Department of Angiology and Blood Coagulation Marino Golinelli, Via Albertoni 15, 40138 Bologna, Italy
    Expert Opin Emerg Drugs 15:107-17. 2010
    ..Anticoagulant (AC) drugs are necessary and effective for primary prevention, treatment of acute phase and prevention of recurrences. The currently available ACs have several drawbacks which have prompted the search for new drugs...
  33. doi Update on the predictive value of D-dimer in patients with idiopathic venous thromboembolism
    Benilde Cosmi
    Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital St Orsola Malpighi, Bologna, Italy
    Thromb Res 125:S62-5. 2010
    ..9% patient-years) (adjusted HR: 7.9; 95% CI:2.1-30; p = 0.002). These results indicate that repeated D-dimer testing after anticoagulation suspension may help tailor the individual duration of treatment after a first unprovoked VTE...
  34. ncbi Extended treatment for venous thromboembolism: how long is long enough?
    Benilde Cosmi
    Division of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Via Albertoni 15, 40138 Bologna, Italy
    Curr Hematol Rep 3:375-81. 2004
    ..More recently, studies have indicated that other factors such as D-dimer levels after the discontinuation of oral anticoagulant therapy or the residual vein thrombosis could be additional predictive factors for recurrences...
  35. ncbi Atherothrombosis and the pill: what ratio(nale) for the RATIO studies?
    S Coccheri
    Cardiovascular Department, Unit of Vascular Medicine, University of Bologna, Italy
    J Thromb Haemost 1:418-20. 2003
  36. doi Residual venous obstruction, alone and in combination with D-dimer, as a risk factor for recurrence after anticoagulation withdrawal following a first idiopathic deep vein thrombosis in the prolong study
    B Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15 Bologna, Italy
    Eur J Vasc Endovasc Surg 39:356-65. 2010
    ..This study aims to assess the predictive value of residual venous obstruction (RVO) for recurrent venous thrombo-embolism (VTE) in a study using D-dimer to predict outcome...
  37. ncbi Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: yes
    B Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    J Thromb Haemost 4:2527-9. 2006
  38. doi Sex, age and normal post-anticoagulation D-dimer as risk factors for recurrence after idiopathic venous thromboembolism in the Prolong study extension
    B Cosmi
    Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    J Thromb Haemost 8:1933-42. 2010
    ..Patients with normal D-dimer after anticoagulation suspension had a low recurrence rate (4.4% patient-years) but their anticoagulation optimal duration remained uncertain...
  39. ncbi Two years outcome of isolated distal deep vein thrombosis
    Michelangelo Sartori
    Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, 40138 Bologna, Italy Electronic address
    Thromb Res 134:36-40. 2014
    ..Isolated distal deep vein thrombosis (IDDVT) is frequently found in symptomatic outpatients, but its long term outcome is still uncertain...
  40. ncbi Risk factors for recurrent events in subjects with superficial vein thrombosis in the randomized clinical trial SteFlux (Superficial Thromboembolism Fluxum)
    Benilde Cosmi
    Dept Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy Electronic address
    Thromb Res 133:196-202. 2014
    ....
  41. doi Risk of early recurrent fetal loss and levels of thrombin-activatable fibrinolysis inhibitor
    Cristina Legnani
    Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
    Thromb Res 130:237-41. 2012
    ..Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss...
  42. ncbi Assessment of the risk of bleeding in patients undergoing surgery or invasive procedures: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)
    Benilde Cosmi
    Department of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
    Thromb Res 124:e6-e12. 2009
    ..No studies are available in children for major surgery other than adenotonsillectomy, neurosurgery and invasive procedures...
  43. ncbi Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levels
    Simonetta Sassi
    Cardiovascular Department, Central Laboratory, University Hospital S Orsola Malpighi, Bologna, Italy
    Haematologica 87:957-64. 2002
    ..The secondary aim was to determine the reference values for FtHCy and PML-tHCy...
  44. ncbi Is there a role for oral anticoagulant therapy in patients with peripheral arterial disease?
    B Cosmi
    Cardiovascular Department, Division of Angiology, S Orsola Malpighi University Hospital, Bologna, Italy
    Curr Drug Targets Cardiovasc Haematol Disord 4:269-73. 2004
    ..However, the reduction of ischemic events by oral anticoagulants is associated with an increased risk of bleeding. As a result, oral anticoagulants have a limited role in patients with symptomatic PAD...
  45. ncbi Anticoagulants (heparin, low molecular weight heparin and oral anticoagulants) for intermittent claudication
    Benilde Cosmi
    Division of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Via Albertoni 15, Bologna, Italy, 40138
    Cochrane Database Syst Rev 5:CD001999. 2014
    ..This is an update of the review first published in 2001...
  46. ncbi Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting
    Andrea Rubboli
    Cardiac Catheterization Laboratory, Division of Cardiology, Maggiore Hospital, Bologna, Italy
    Cardiology 104:101-6. 2005
    ..65, 3.8, 4.2, 6.4 and 6.6%, respectively. In conclusion, due to the low AR of adverse events, the combination of OAC and aspirin appears an acceptable treatment after PCI-S in patients in whom long-term OAC is deemed mandatory...
  47. ncbi ARC-1779, a PEGylated aptamer antagonist of von Willebrand factor for potential use as an anticoagulant or antithrombotic agent
    Benilde Cosmi
    Saint Orsola Malpighi University Hospital, Department of Angiology and Blood Coagulation, Bologna, Italy
    Curr Opin Mol Ther 11:322-8. 2009
    ..Further phase II and III trials are necessary and highly anticipated to establish the therapeutic potential of ARC-1779 as an antithrombotic agent...
  48. ncbi Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive use
    C Legnani
    Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli Dipartimento Cardiovascolare, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    Eur Heart J 23:984-90. 2002
    ..The interaction between the R506Q mutation of factor V and the G20210A mutation of prothrombin with oral contraceptives on venous thromboembolism was evaluated...
  49. ncbi [From heparin to synthetic antithrombotic drugs]
    G Palareti
    Dipartimento Cardiovascolare, Divisione di Angiologia, Ospedale S. Orsola-Malpighi, , Italy
    Minerva Anestesiol 67:76-81. 2001
    ..Oral direct thrombin inhibitors have the advantage of predictable dose response with the possibility of oral administration without laboratory monitoring...
  50. ncbi Venous thromboembolism, oral contraceptives and high prothrombin levels
    C Legnani
    Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, Dipartimento Cardiovascolare, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    J Thromb Haemost 1:112-7. 2003
    ..We conclude that elevated prothrombin levels, even in women without the G20210A prothrombin mutation, are associated with an increased risk for venous thromboembolism and that oral contraceptive use potentiates such association...
  51. ncbi Low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism
    Benilde Cosmi
    N Engl J Med 349:398-400; author reply 398-400. 2003
  52. ncbi The role of D-dimer and residual venous obstruction in recurrence of venous thromboembolism after anticoagulation withdrawal in cancer patients
    Benilde Cosmi
    Haematologica 90:713-5. 2005
    ..RVO, determined by compression ultrasonography on the day of OAT suspension (T1), and abnormal D-d (cut-off value: 500 ng/mL), measured at T1 and 30+/-10 days afterwards, are independent risk factors for recurrent VTE in cancer patients...