Research Topics
Species | Benilde CosmiSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
D-dimer testing to determine the duration of anticoagulation therapyGualtiero Palareti
Department of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Bologna, Italy
N Engl J Med 355:1780-9. 2006..The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation...
The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbsBenilde Cosmi
Department of Angiology Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Albertoni 15, Bologna, Italy
Thromb Haemost 109:510-6. 2013..Male sex and isolated DVT were significantly associated with RVO in all patients. In conclusion, male sex and isolated DVT are associated with RVO, while FVL and FII mutations are not significantly associated with RVO in this study...- A randomized double-blind study of low-molecular-weight heparin (parnaparin) for superficial vein thrombosis: STEFLUX (Superficial ThromboEmbolism and Fluxum)B Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
J Thromb Haemost 10:1026-35. 2012..Optimal doses and duration of low-molecular-weight heparin (LMWH) for the treatment of superficial vein thrombosis (SVT) are still uncertain... - Old and new heparinsBenilde Cosmi
Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Thromb Res 129:388-91. 2012..The characteristics of these compounds are reviewed along with the description of their approved clinical uses... - Value of D-dimer testing to decide duration of anticoagulation after deep vein thrombosis: yesB Cosmi
Department of Angiology and Blood Coagulation 'Marino Golinelli, S. Orsola-Malpighi University Hospital, Bologna, Italy
J Thromb Haemost 4:2527-9. 2006 - D-dimer and factor VIII are independent risk factors for recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosisBenilde Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
Thromb Res 122:610-7. 2008..To assess the predictive value of D-dimer (D-d) and Factor VIII (FVIII) in combination for recurrent venous thromboembolism (VTE) after vitamin K antagonist (VKA) therapy suspension... - Use of D-dimer testing to determine duration of anticoagulation, risk of cardiovascular events and occult cancer after a first episode of idiopathic venous thromboembolism: the extended follow-up of the PROLONG studyBenilde Cosmi
Department Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Via Albertoni, 15, Bologna, Italy
J Thromb Thrombolysis 28:381-8. 2009..The PROLONG study showed that D-dimer (D-d) testing could help tailor the duration of anticoagulation after idiopathic venous thromboembolism (VTE). In this report the initial 18 month study follow-up was extended for 1 year... - Assessment of the risk of bleeding in patients undergoing surgery or invasive procedures: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)Benilde Cosmi
Department of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
Thromb Res 124:e6-e12. 2009..No studies are available in children for major surgery other than adenotonsillectomy, neurosurgery and invasive procedures... - Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective studyBenilde Cosmi
Department of Angiology and Blood Coagulation, Marino Golinelli University Hospital St Orsola Malpighi, Bologna, Italy
Blood 115:481-8. 2010..9; 95% CI: 2.1-30; P = .002). Repeated D-d testing after anticoagulation suspension for a first episode of unprovoked VTE could help tailor the duration of treatment. This trial is registered at http://clinicaltrials.gov as NCT00266045... - Residual venous obstruction, alone and in combination with D-dimer, as a risk factor for recurrence after anticoagulation withdrawal following a first idiopathic deep vein thrombosis in the prolong studyB Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15 Bologna, Italy
Eur J Vasc Endovasc Surg 39:356-65. 2010..This study aims to assess the predictive value of residual venous obstruction (RVO) for recurrent venous thrombo-embolism (VTE) in a study using D-dimer to predict outcome... - Comorbidities, alone and in combination with D-dimer, as risk factors for recurrence after a first episode of unprovoked venous thromboembolism in the extended follow-up of the PROLONG studyBenilde Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Thromb Haemost 103:1152-60. 2010.... - Update on the predictive value of D-dimer in patients with idiopathic venous thromboembolismBenilde Cosmi
Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital St Orsola Malpighi, Bologna, Italy
Thromb Res 125:S62-5. 2010..9% patient-years) (adjusted HR: 7.9; 95% CI:2.1-30; p = 0.002). These results indicate that repeated D-dimer testing after anticoagulation suspension may help tailor the individual duration of treatment after a first unprovoked VTE... - Sex, age and normal post-anticoagulation D-dimer as risk factors for recurrence after idiopathic venous thromboembolism in the Prolong study extensionB Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
J Thromb Haemost 8:1933-42. 2010..Patients with normal D-dimer after anticoagulation suspension had a low recurrence rate (4.4% patient-years) but their anticoagulation optimal duration remained uncertain... - D-dimer and residual vein obstruction as risk factors for recurrence during and after anticoagulation withdrawal in patients with a first episode of provoked deep-vein thrombosisB Cosmi
Division of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
Thromb Haemost 105:837-45. 2011.... - ARC-1779, a PEGylated aptamer antagonist of von Willebrand factor for potential use as an anticoagulant or antithrombotic agentBenilde Cosmi
Saint Orsola Malpighi University Hospital, Department of Angiology and Blood Coagulation, Bologna, Italy
Curr Opin Mol Ther 11:322-8. 2009..Further phase II and III trials are necessary and highly anticipated to establish the therapeutic potential of ARC-1779 as an antithrombotic agent... - Residual emboli on lung perfusion scan or multidetector computed tomography after a first episode of acute pulmonary embolismBenilde Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, Bologna, Italy
Intern Emerg Med 6:521-8. 2011..Further studies are warranted in which the presence of residual embolism is detected by repetition of the same test that had been initially carried out... - Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophiliaGualtiero Palareti
Dipartimento di Angiologia, Unità Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Circulation 108:313-8. 2003..The aim of the present study was to assess the predictive value of D-dimer for recurrent VTE in subjects with a previous unprovoked event who are either carriers of inherited thrombophilia or not... - Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stoppedGualtiero Palareti
Department of Angiology, Unità Ricerca Clinica sulla Trombofilia M Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Thromb Haemost 87:7-12. 2002..Only five idiopathic recurrences occurred in the 186 patients with consistently normal D-dimer. In conclusion, D-dimer has a high NPV for VTE recurrence when performed after OAT discontinuation... - D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosisBenilde Cosmi
Department of Angiology and Blood Coagulation M Golinelli, S Orsola Malpighi University Hospital, Bologna, Italy
Thromb Haemost 94:969-74. 2005.... - Risks factors for highly unstable response to oral anticoagulation: a case-control studyGualtiero Palareti
Dipartimento di Angiologia e Malattie della Coagulazione Marino Golinelli, Policlinico S Orsola Malpighi, Universita di Bologna, Bologna, Italy
Br J Haematol 129:72-8. 2005..9% vs.15.0%; P = 0.042). No differences were observed as regards the other variables. In conclusion, we found that high intra-individual variability in OAT control was multifactorial, but poor OAT comprehension was prevalent... - Different cut-off values of quantitative D-dimer methods to predict the risk of venous thromboembolism recurrence: a post-hoc analysis of the PROLONG studyCristina Legnani
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
Haematologica 93:900-7. 2008..The objective of this study was to evaluate the possible advantage of using quantitative D-dimer assays... - Bleeding with anticoagulation therapy - who is at risk, and how best to identify such patientsGualtiero Palareti
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138 Bologna, Italy
Thromb Haemost 102:268-78. 2009..The clinical prediction rules may help physicians stratify patients into categories of risk and thus to evaluate their individual risk/benefit ratio of starting or prolonging an anticoagulant treatment... - Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawalCristina Legnani
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Br J Haematol 134:227-32. 2006..The aPTT predictive value was independent of the presence of inherited thrombophilic alterations. In conclusion, abnormally short aPTT values are associated with a significantly increased risk of VTE recurrence... - Evolution of untreated calf deep-vein thrombosis in high risk symptomatic outpatients: the blind, prospective CALTHRO studyGualtiero Palareti
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Thromb Haemost 104:1063-70. 2010..7%; 95% CI: 1-13; p=0.049). Thrombotic evolution of untreated ICDVT in high-risk subjects may be relevant. Larger studies are needed to address this issue... - A new warfarin dosing algorithm including VKORC1 3730 G > A polymorphism: comparison with results obtained by other published algorithmsMichela Cini
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138 Bologna, Italy
Eur J Clin Pharmacol 68:1167-74. 2012..We developed a new dosing algorithm including polymorphisms associated both with warfarin sensitivity and resistance in the Italian population, and its performance was compared with those of eight previously published algorithms... - Risk of deep vein thrombosis: interaction between oral contraceptives and high factor VIII levelsCristina Legnani
Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
Haematologica 89:1347-51. 2004..High levels of factor VIII are a common risk factor for venous thromboembolism (VTE). The aim of this study was to evaluate the possible interaction between the presence of high factor VIII levels and oral contraceptive (OC) use... - Role of family history in identifying women with thrombophilia and higher risk of venous thromboembolism during oral contraceptionBenilde Cosmi
Division of Angiology, Cardiovascular Department, Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, University Hospital S Orsola Malpighi, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
Arch Intern Med 163:1105-9. 2003..We evaluated the sensitivity and specificity of a family history of VTE to identify thrombophilia in women before OC and after venous thrombotic complications during OC... - D-dimer testing to determine the duration of anticoagulant therapyGualtiero Palareti
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Curr Opin Pulm Med 13:393-7. 2007..Recent prospective observational studies show that D-dimer levels have a predictive value for the risk of recurrence. D-dimer testing may help in assessing the individual need for prolonged anticoagulation... - Additive thrombin inhibition by fast moving heparin and dermatan sulfate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycansBenilde Cosmi
Divisione di Angiologia e Malattie della Coagulazione, Policlinico S Orsola Malpighi, Universita degli Studi di Bologna, Bologna, Italy
Thromb Res 109:333-9. 2003..The aim of the study was to evaluate the mechanism of the anticoagulant action of sulodexide, a mixture of glycosaminoglycans (GAGs) composed of dermatan sulfate (DS) and fast moving heparin (FMH), in vitro... - Extended treatment for venous thromboembolism: how long is long enough?Benilde Cosmi
Division of Angiology and Blood Coagulation, S Orsola Malpighi University Hospital, Via Albertoni 15, 40138 Bologna, Italy
Curr Hematol Rep 3:375-81. 2004..More recently, studies have indicated that other factors such as D-dimer levels after the discontinuation of oral anticoagulant therapy or the residual vein thrombosis could be additional predictive factors for recurrences... - D-dimer, oral anticoagulation, and venous thromboembolism recurrenceBenilde Cosmi
Department of Angiology and Blood Coagulation Marino Golinelli, S. Orsola-Malpighi University Hospital, Bologna, Italy
Semin Vasc Med 5:365-70. 2005.... - Predicting the risk of recurrence of venous thromboembolismGualtiero Palareti
Department of Angiology and Blood Coagulation, University Hospital, S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
Curr Opin Hematol 11:192-7. 2004..Our review focused on studies that evaluated different risk factors that might be useful to stratify patients into categories at different risk for recurrence... - Oral contraceptive use in women with poor anticoagulant response to activated protein C but not carrying the factor V Leiden mutation increases the risk of venous thrombosisCristina Legnani
Dept Angiology and Blood Coagulation, University Hospital S Orsola Malpighi, Via Massarenti, 9, 40138, Bologna, Italy
Thromb Haemost 91:712-8. 2004..Our data also showed that OC use in women with altered APC resistance further increased the risk of VTE in a way that exceeded the additive expectation... - Oral anticoagulant therapy in venous thromboembolismBenilde Cosmi
Cardiovascular Department, Division of Angiology, S. Orsola-Malpighi University Hospital, Bologna, Italy
Semin Vasc Med 3:303-14. 2003..In patients with VTE and cancer, oral anticoagulation poses a higher risk of bleeding, and such patients are more prone to recurrences. Alternative treatment with LMWH could be safer and more effective in these patients... - Diagnosis of deep vein thrombosisGualtiero Palareti
Department of Angiology and Blood Coagulation, University Hospital Saint Orsola Malpighi, Bologna, Italy
Semin Thromb Hemost 32:659-72. 2006..Some areas are still a matter of debate, such as the clinical relevance of isolated distal DVT and the diagnosis of suspected ipsilateral recurrence... - Poor anticoagulation quality in the first 3 months after unprovoked venous thromboembolism is a risk factor for long-term recurrenceG Palareti
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
J Thromb Haemost 3:955-61. 2005..The aim of the study was to investigate whether the quality of oral anticoagulation therapy (OAT) is a long-term risk factor for recurrence of VTE after OAT interruption... - Age and gender specific cut-off values to improve the performance of D-dimer assays to predict the risk of venous thromboembolism recurrenceCristina Legnani
Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138, Bologna, Italy
Intern Emerg Med 8:229-36. 2013..These method-specific cut-off values are being evaluated in the ongoing prospective management multicenter DULCIS study... - Emerging drugs for venous thromboembolismGualtiero Palareti
University Hospital S Orsola Malpighi, Department of Angiology and Blood Coagulation Marino Golinelli, Via Albertoni 15, 40138 Bologna, Italy
Expert Opin Emerg Drugs 15:107-17. 2010..Anticoagulant (AC) drugs are necessary and effective for primary prevention, treatment of acute phase and prevention of recurrences. The currently available ACs have several drawbacks which have prompted the search for new drugs... - Accuracy of a portable prothrombin time monitor (Coagucheck) in patients on chronic oral anticoagulant therapy: a prospective multicenter studyB Cosmi
Divisione di Angiologia, Ospedale S Orsola Malpighi, Bologna, Italy
Thromb Res 100:279-86. 2000..7%, 8.5%, 4.7%, and 4.9%, respectively, in Centers 1, 2, 3, and 4. Coagucheck has an acceptable level of accuracy for INR values in the range between 2.0 and 3.0. A wide variation in monitor performance was found among centers... - Atherothrombosis and the pill: what ratio(nale) for the RATIO studies?S Coccheri
Cardiovascular Department, Unit of Vascular Medicine, University of Bologna, Italy
J Thromb Haemost 1:418-20. 2003 - Thrombophilia in young women candidate to the pill: reasons for and against screeningB Cosmi
Division of Angiology, S Orsola Malpighi Hospital, University of Bologna, Italy
Pathophysiol Haemost Thromb 32:315-7. 2002..A proper evaluation of the cost-effectiveness, the medical, psychosocial and legal consequences is needed before general screening with genetic testing for inherited thrombophilia can be recommended before OC... - Risk of early recurrent fetal loss and levels of thrombin-activatable fibrinolysis inhibitorCristina Legnani
Dept Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Bologna, Italy
Thromb Res 130:237-41. 2012..Though thrombin-activatable fibrinolysis inhibitor (TAFI) may contribute to hypercoagulability during pregnancy, limited data are available on the role of TAFI in women with recurrent fetal loss... - Influence of age, sex and vitamin status on fasting and post-methionine load plasma homocysteine levelsSimonetta Sassi
Cardiovascular Department, Central Laboratory, University Hospital S. Orsola-Malpighi, Bologna, Italy
Haematologica 87:957-64. 2002..49 and 44.06 mol/L for women above 45 years. INTERPRETATION AND CONCLUSIONS: Age, gender and vitamin status influence both FtHCy and PML-tHCy in normal subjects. Reference values should be calculated according to age and sex... - Is there a role for oral anticoagulant therapy in patients with peripheral arterial disease?B Cosmi
Cardiovascular Department, Division of Angiology, S Orsola Malpighi University Hospital, Bologna, Italy
Curr Drug Targets Cardiovasc Haematol Disord 4:269-73. 2004..However, the reduction of ischemic events by oral anticoagulants is associated with an increased risk of bleeding. As a result, oral anticoagulants have a limited role in patients with symptomatic PAD... - Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stentingAndrea Rubboli
Cardiac Catheterization Laboratory, Division of Cardiology, Maggiore Hospital, Bologna, Italy
Cardiology 104:101-6. 2005..65, 3.8, 4.2, 6.4 and 6.6%, respectively. In conclusion, due to the low AR of adverse events, the combination of OAC and aspirin appears an acceptable treatment after PCI-S in patients in whom long-term OAC is deemed mandatory... - Venous thromboembolism in young women; role of thrombophilic mutations and oral contraceptive useC Legnani
Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli Dipartimento Cardiovascolare, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
Eur Heart J 23:984-90. 2002..The interaction between the R506Q mutation of factor V and the G20210A mutation of prothrombin with oral contraceptives on venous thromboembolism was evaluated... - Venous thromboembolism, oral contraceptives and high prothrombin levelsC Legnani
Unità di Ricerca Clinica sulla Trombofilia Marino Golinelli, Dipartimento Cardiovascolare, Divisione di Angiologia, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
J Thromb Haemost 1:112-7. 2003..We conclude that elevated prothrombin levels, even in women without the G20210A prothrombin mutation, are associated with an increased risk for venous thromboembolism and that oral contraceptive use potentiates such association... - [From heparin to synthetic antithrombotic drugs]G Palareti
Dipartimento Cardiovascolare, Divisione di Angiologia, Ospedale S. Orsola-Malpighi, , Italy
Minerva Anestesiol 67:76-81. 2001..Oral direct thrombin inhibitors have the advantage of predictable dose response with the possibility of oral administration without laboratory monitoring...