Agostino Cortelezzi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
    Agostino Cortelezzi
    Haematology BMT Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico Foundation, Milan, Italy
    Br J Haematol 156:481-9. 2012
  2. doi request reprint Bone marrow glycophorin-positive erythroid cells of myelodysplastic patients responding to high-dose rHuEPO therapy have a different gene expression pattern from those of nonresponders
    Agostino Cortelezzi
    Hematology Bone Marrow Transplant Unit, Fondazione Ospedale Maggiore Maggiore Policlinico, Mangiagalli, Regina Elena IRCCS, Milan
    Am J Hematol 83:531-9. 2008
  3. doi request reprint Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study
    A Cortelezzi
    Department of Medical Sciences, University of Milan, Milan, Italy
    Leukemia 23:2027-33. 2009
  4. ncbi request reprint Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H
    Agostino Cortelezzi
    Hematology 1 Bone Marrow Transplantation Unit and the IRCCS Fondazione Ospedale Maggiore, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy
    J Clin Virol 35:467-9. 2006
  5. ncbi request reprint Endothelial precursors and mature endothelial cells are increased in the peripheral blood of myelodysplastic syndromes
    A Cortelezzi
    Hematology 1 Bone Marrow Transplantation Unit, IRCCS Fondazione Ospedale Maggiore and University of Milan, Italy
    Leuk Lymphoma 46:1345-51. 2005
  6. doi request reprint High levels of vascular endothelial growth factor protein expression are associated with an increased risk of transfusion dependence in myelodysplastic syndromes
    Umberto Gianelli
    Pathology Unit, Department of Pathophysiology and Transplantation, University of Milan School of Medicine, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Am J Clin Pathol 139:380-7. 2013
  7. ncbi request reprint Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease
    Gabriella Moroni
    Division of Nephrology, Ospedale Maggiore IRCCS, Milan, Italy
    Kidney Int 68:562-8. 2005
  8. ncbi request reprint Bone marrow endothelial progenitors are defective in systemic sclerosis
    Nicoletta Del Papa
    Ospedale G Pini, University of Milan, Italy
    Arthritis Rheum 54:2605-15. 2006
  9. doi request reprint Circulating and progenitor endothelial cells are abnormal in patients with different types of von Willebrand disease and correlate with markers of angiogenesis
    Giuseppe Gritti
    Department of Hematology 1, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital and Università degli Studi di Milano, Milan, Italy
    Am J Hematol 86:650-6. 2011
  10. doi request reprint Low-dose alemtuzumab-associated immune thrombocytopenia in chronic lymphocytic leukemia
    Gianluigi Reda
    Hematology and Transplantation Unit, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Am J Hematol 87:936-7. 2012

Collaborators

Detail Information

Publications35

  1. doi request reprint An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
    Agostino Cortelezzi
    Haematology BMT Unit, IRCCS Ca Granda Ospedale Maggiore Policlinico Foundation, Milan, Italy
    Br J Haematol 156:481-9. 2012
    ..This retrospective analysis confirms that low-dose alemtuzumab is a valid and currently used therapeutic option for the treatment of relapsed/refractory CLL...
  2. doi request reprint Bone marrow glycophorin-positive erythroid cells of myelodysplastic patients responding to high-dose rHuEPO therapy have a different gene expression pattern from those of nonresponders
    Agostino Cortelezzi
    Hematology Bone Marrow Transplant Unit, Fondazione Ospedale Maggiore Maggiore Policlinico, Mangiagalli, Regina Elena IRCCS, Milan
    Am J Hematol 83:531-9. 2008
    ..The different gene expression profiles of ERs and ENRs may provide a basis for early gene testing as a means of predicting the response to rhEPO of MDS patients with low endogenous EPO levels...
  3. doi request reprint Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study
    A Cortelezzi
    Department of Medical Sciences, University of Milan, Milan, Italy
    Leukemia 23:2027-33. 2009
    ..This study confirms that low-dose subcutaneous alemtuzumab is effective in poor prognosis CLL, and has a particularly favourable toxicity profile...
  4. ncbi request reprint Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H
    Agostino Cortelezzi
    Hematology 1 Bone Marrow Transplantation Unit and the IRCCS Fondazione Ospedale Maggiore, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy
    J Clin Virol 35:467-9. 2006
    ..During 20 months of anti-HBV therapy, ALT and HBV-DNA levels progressively declined and B-CLL was successfully kept under control by long-term alemtuzumab administration...
  5. ncbi request reprint Endothelial precursors and mature endothelial cells are increased in the peripheral blood of myelodysplastic syndromes
    A Cortelezzi
    Hematology 1 Bone Marrow Transplantation Unit, IRCCS Fondazione Ospedale Maggiore and University of Milan, Italy
    Leuk Lymphoma 46:1345-51. 2005
    ..Taken together these data strengthen the hypothesis of a possible role of angiogenesis in MDS pathogenesis...
  6. doi request reprint High levels of vascular endothelial growth factor protein expression are associated with an increased risk of transfusion dependence in myelodysplastic syndromes
    Umberto Gianelli
    Pathology Unit, Department of Pathophysiology and Transplantation, University of Milan School of Medicine, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Am J Clin Pathol 139:380-7. 2013
    ..Our findings support the clinical relevance of VEGFi expression in the bone marrow biopsy specimens of patients with MDS...
  7. ncbi request reprint Increased levels of circulating endothelial cells in chronic periaortitis as a marker of active disease
    Gabriella Moroni
    Division of Nephrology, Ospedale Maggiore IRCCS, Milan, Italy
    Kidney Int 68:562-8. 2005
    ..To clarify the role of vascular damage we looked for the presence and the surface phenotype of circulating endothelial cells (CECs) in the peripheral blood of patients with chronic periaortitis...
  8. ncbi request reprint Bone marrow endothelial progenitors are defective in systemic sclerosis
    Nicoletta Del Papa
    Ospedale G Pini, University of Milan, Italy
    Arthritis Rheum 54:2605-15. 2006
    ....
  9. doi request reprint Circulating and progenitor endothelial cells are abnormal in patients with different types of von Willebrand disease and correlate with markers of angiogenesis
    Giuseppe Gritti
    Department of Hematology 1, Fondazione IRCCS Cà Granda Maggiore Policlinico Hospital and Università degli Studi di Milano, Milan, Italy
    Am J Hematol 86:650-6. 2011
    ..19). Based on these data, CEC are increased in VWD and are associated with the high levels of cytokines involved in angiogenesis (up-regulation). EPC are decreased, suggesting down-regulation of bone marrow-derived angiogenesis in VWD...
  10. doi request reprint Low-dose alemtuzumab-associated immune thrombocytopenia in chronic lymphocytic leukemia
    Gianluigi Reda
    Hematology and Transplantation Unit, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Am J Hematol 87:936-7. 2012
    ..Our data, associated with the report of Cuker et al., seem to suggest an important role of alemtuzumab in the pathogenesis of ITP which could be related to its induced dysregulation of T-lymphocyte activity...
  11. ncbi request reprint Metabolic syndrome in patients with hematological diseases
    Claudio Annaloro
    Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico U O Ematologia 1 CTMO, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy
    Expert Rev Hematol 5:439-58. 2012
    ....
  12. doi request reprint Successful management with intravenous immunoglobulins in alemtuzumab-induced acute inflammatory demyelinating neuropathy: clinical report of three patients
    Roberto Castelli
    Dipartimento di Medicina Interna, Università degli Studi di Milano and Dipartimento di Medicina, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Immunopharmacol Immunotoxicol 34:717-20. 2012
    ..As alemtuzumab represents, nowadays, a key therapeutic option for CLL, clinicians should be aware of this rare and disabling toxicity...
  13. ncbi request reprint ZAP-70 immunoreactivity is a prognostic marker of disease progression in chronic lymphocytic leukemia
    Claudia Vener
    Ematologia I Centro Trapianti di Midollo, IRCCS Ospedale Maggiore e Università degli Studi di Milano, Milan, Italy
    Leuk Lymphoma 47:245-51. 2006
    ..The observations support the inclusion of the immunohistochemical expression of ZAP-70 in clinical trials involving CLL patients...
  14. doi request reprint Oxidative stress is increased in primary and post-polycythemia vera myelofibrosis
    Claudia Vener
    Dipartimento di Scienze Mediche, Ematologia, Centro Trapianti di Midollo, Milan, Italy
    Exp Hematol 38:1058-65. 2010
    ..To determine if increased cell turnover in chronic myeloproliferative disorders can lead to hyperhomocysteinemia as a result of folate and/or cobalamin depletion, and contribute to oxidative stress...
  15. doi request reprint RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant
    Clara Ricci
    Fondazione Matarelli, Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica e Università di Milano, Milan, Italy
    Clin Cancer Res 16:2246-56. 2010
    ....
  16. doi request reprint The European Consensus on grading of bone marrow fibrosis allows a better prognostication of patients with primary myelofibrosis
    Umberto Gianelli
    U O C di Anatomia Patologica, Universita degli Studi di Milano, Dipartimento di Medicina, Chirurgia e Odontoiatria, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Mod Pathol 25:1193-202. 2012
    ..In conclusion, our analysis suggests that better prognostication can be achieved in primary myelofibrosis patients when both systems are used together...
  17. doi request reprint Immunomodulatory drugs in multiple myeloma: from molecular mechanisms of action to clinical practice
    Roberto Castelli
    Department of Internal Medicine, University of Milan, and Department of Medicine, IRCCS Ca Granda Policlinico, Milan, Italy
    Immunopharmacol Immunotoxicol 34:740-53. 2012
    ..In this paper, we review the pharmacology, mechanisms of action, pre-clinical and clinical efficacy, and the current status of IMIDs in the treatment of MM...
  18. pmc Effects of simulated altitude (normobaric hypoxia) on cardiorespiratory parameters and circulating endothelial precursors in healthy subjects
    Michele M Ciulla
    Istituto di Medicina Cardiovascolare, Centro Interuniversitario di Fisiologia Clinica e Ipertensione, University of Milan, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Fondazione IRCCS, Milano, Italy
    Respir Res 8:58. 2007
    ....
  19. ncbi request reprint Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis
    Nicoletta Del Papa
    Department of Rheumatology, G Pini Hospital, University of Milan, Milan, Italy
    Arthritis Rheum 50:1296-304. 2004
    ..The aim of this study was to search for the presence of CECs in patients with SSc and to evaluate their clinical associations and possible pathogenic role...
  20. ncbi request reprint Endothelial colony forming capacity is related to C-reactive protein levels in healthy subjects
    Michele M Ciulla
    Istituto di Medicina Cardiovascolare, Centro di Fisiologia Clinica e Ipertensione, Universita di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS, Italy
    Curr Neurovasc Res 3:99-106. 2006
    ..The EPC clonogenic potential seems to be related to hs-CRP and VEGF levels even in healthy population supporting the concept that these mediators are involved in physiological ECs function...
  21. doi request reprint Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies
    Wilma Barcellini
    Unità Operativa Ematologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Blood 119:3691-7. 2012
    ..This study is registered at www.clinicaltrials.gov as NCT01345708...
  22. doi request reprint B-cell receptor configuration and adverse cytogenetics are associated with autoimmune hemolytic anemia in chronic lymphocytic leukemia
    Francesco Maura
    Department of Clinical Sciences and Community Health, University of Milan, Italy
    Am J Hematol 88:32-6. 2013
    ....
  23. doi request reprint Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    Giuseppe Gritti
    Department of Medical Sciences, University of Milan, Milan, Italy
    Leuk Lymphoma 53:424-9. 2012
    ..No deaths occurred during therapy. In conclusion, low-dose alemtuzumab shows a promising safety profile coupled with satisfactory effectiveness in this category of poor prognosis CLL patients...
  24. ncbi request reprint Hematopoietic stem cell transplantation in adult acute lymphoblastic leukemia: a single-centre analysis
    Claudio Annaloro
    Bone Marrow Transplantation Centre, Department of Hematology, Ospedale Maggiore and University of Milano, Milan, Italy
    Leuk Lymphoma 45:1175-80. 2004
    ..Conversely, the results in more advanced disease phases are discouraging, due to poor quality CRs and inefficacy of GVL in managing large residual disease...
  25. pmc Biosensors in clinical practice: focus on oncohematology
    Nicola S Fracchiolla
    Department of Hematology Oncology and BMT Unit, IRCCS Cà Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Sensors (Basel) 13:6423-47. 2013
    ..The review also considers the challenges and future perspectives of biosensors in clinical practice...
  26. pmc Lenalidomide in the treatment of chronic lymphocytic leukemia
    Agostino Cortelezzi
    Hematology and Transplantation Unit, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico and Università degli Studi Di Milano, 20122 Milan, Italy
    Adv Hematol 2012:393864. 2012
    ..Further understanding of the exact mechanism of action in CLL will allow more efficacious use of lenalidomide alone or in combination regimens...
  27. pmc Diagnostic power of laboratory tests for hereditary spherocytosis: a comparison study in 150 patients grouped according to molecular and clinical characteristics
    Paola Bianchi
    Hematology 2 Unit, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, 20122 Milan, Italy
    Haematologica 97:516-23. 2012
    ..None of the available tests identifies all cases of hereditary spherocytosis...
  28. ncbi request reprint Thromboembolic complications in malignant haematological disorders
    Roberto Castelli
    Department of Internal Medicine, University of Milan, Via Pace 9, 20122 Milan, Italy
    Curr Vasc Pharmacol 8:482-94. 2010
    ..The very high risk of haemorrhaging in these patients warrants prospective randomised trials evaluating optimal anti-thrombotic prophylaxis and treatment...
  29. ncbi request reprint Relationship between autoimmune phenomena and disease stage and therapy in B-cell chronic lymphocytic leukemia
    Wilma Barcellini
    Department of Haematology, Padiglione Granelli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via F Sforza 35 20122 Milan, Italy
    Haematologica 91:1689-92. 2006
    ....
  30. ncbi request reprint Survivin expression in "low-risk" and "high-risk" myelodysplastic syndromes
    Umberto Gianelli
    II Cattedra di Anatomia Patologica, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, A O S Paolo e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena di Milano, Italy
    Ann Hematol 86:185-9. 2007
    ..Moreover, higher levels of transcripts are related to "low-risk" MDS. Our results suggest an active role of Survivin in normal and in myelodysplastic hematopoiesis...
  31. ncbi request reprint A gender-based score system predicts the clinical outcome of patients with early B-cell chronic lymphocytic leukemia
    Stefano Molica
    Medical Oncology Unit, Department of Oncology and Hematology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Leuk Lymphoma 46:553-60. 2005
    ....
  32. ncbi request reprint A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with hemotherapy-refractory chronic lymphocytic leukemia
    Agostino Cortelezzi
    Haematologica 90:410-2. 2005
    ..Subcutaneous low-dose alemtuzumab is effective in poor prognosis B-CLL, and has a particularly favourable toxicity profile...
  33. ncbi request reprint Possible association between reactive oxygen metabolites and karyotypic abnormalities in myelodysplastic syndromes
    Nicola S Fracchiolla
    Haematologica 88:594-7. 2003
  34. ncbi request reprint The prevalence and clinical relevance of p27 and cyclin E immunoreactivity in myelodysplastic syndromes
    Giancarlo Pruneri
    Haematologica 88:109-10. 2003
  35. ncbi request reprint Pneumocystis carinii pneumonia in patients with malignant haematological diseases: 10 years' experience of infection in GIMEMA centres
    Livio Pagano
    Institute of Hematology, Sacred Heart Catholic University, Largo Francesco Vito 1, I 00168 Rome, Italy
    Br J Haematol 117:379-86. 2002
    ..Multivariate analysis showed that prolonged steroid treatment (P < 0.006) and a radiological picture of diffuse lung involvement (P < 0.003) were negative diagnostic factors...