Emmanuela Corsini

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells
    Emanuela Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari DiSFeB, Universita degli Studi di Milano, via G Balzaretti 9, 20133, Milan, Italy
    Arch Toxicol 88:415-24. 2014
  2. doi request reprint Comparison of wood smoke PM2.5 obtained from the combustion of FIR and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines
    Emanuela Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari DiSFeB, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy
    Arch Toxicol 87:2187-99. 2013
  3. doi request reprint Role of oxidative stress in chemical allergens induced skin cells activation
    Emanuela Corsini
    Laboratory of Toxicology, DiSFeB, Universita degli Studi di Milano, Italy Electronic address
    Food Chem Toxicol 61:74-81. 2013
  4. doi request reprint Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence
    E Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Toxicology 307:123-35. 2013
  5. doi request reprint NCTC 2544 and IL-18 production: a tool for the identification of contact allergens
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Toxicol In Vitro 27:1127-34. 2013
  6. pmc Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Italy
    J Immunotoxicol 8:251-7. 2011
  7. doi request reprint In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Toxicol Appl Pharmacol 258:248-55. 2012
  8. pmc Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
    Fabrizio Gardoni
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Neuroinflammation 8:14. 2011
  9. ncbi request reprint Immunotoxicology: opportunities for non-animal test development
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Milan, Italy
    Altern Lab Anim 37:387-97. 2009
  10. ncbi request reprint High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, Milan, Italy
    J Leukoc Biol 80:376-82. 2006

Detail Information

Publications44

  1. doi request reprint Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells
    Emanuela Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari DiSFeB, Universita degli Studi di Milano, via G Balzaretti 9, 20133, Milan, Italy
    Arch Toxicol 88:415-24. 2014
    ..Overall, our findings demonstrate the role of PKC-β and RACK-1 in allergen-induced CD86 expression and IL-8 production, supporting a central role of PKC-β in the initiation of chemical allergen-induced DC activation. ..
  2. doi request reprint Comparison of wood smoke PM2.5 obtained from the combustion of FIR and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines
    Emanuela Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari DiSFeB, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy
    Arch Toxicol 87:2187-99. 2013
    ..Overall, results suggest that combustion conditions can significantly affect the characteristics of particles and the consequent toxicity, and that different woods can generate different amounts of PM2.5. ..
  3. doi request reprint Role of oxidative stress in chemical allergens induced skin cells activation
    Emanuela Corsini
    Laboratory of Toxicology, DiSFeB, Universita degli Studi di Milano, Italy Electronic address
    Food Chem Toxicol 61:74-81. 2013
    ..The purpose of this review is to provide both conceptual and technical frameworks on the role of oxidative stress in chemical allergy. ..
  4. doi request reprint Pesticide induced immunotoxicity in humans: a comprehensive review of the existing evidence
    E Corsini
    Laboratory of Toxicology, Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Toxicology 307:123-35. 2013
    ..Animal and in vitro studies are also important and necessary to scientifically support epidemiological evidences on pesticide-induced immunotoxicity...
  5. doi request reprint NCTC 2544 and IL-18 production: a tool for the identification of contact allergens
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Milan, Italy
    Toxicol In Vitro 27:1127-34. 2013
    ..Overall, results obtained indicated that cell-associated IL-18 might provide an in vitro tool for identification and discrimination of contact vs. respiratory allergens and/or irritants...
  6. pmc Alterations in regulatory T-cells: rediscovered pathways in immunotoxicology
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Italy
    J Immunotoxicol 8:251-7. 2011
    ....
  7. doi request reprint In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Toxicol Appl Pharmacol 258:248-55. 2012
    ..Our results indicate that PFOA is the least active of the PFCs examined followed by PFBS, PFDA, PFOS, PFOSA and fluorotelomer...
  8. pmc Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
    Fabrizio Gardoni
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Neuroinflammation 8:14. 2011
    ....
  9. ncbi request reprint Immunotoxicology: opportunities for non-animal test development
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Milan, Italy
    Altern Lab Anim 37:387-97. 2009
    ....
  10. ncbi request reprint High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, Milan, Italy
    J Leukoc Biol 80:376-82. 2006
    ....
  11. ncbi request reprint Molecular mechanisms underlying mancozeb-induced inhibition of TNF-alpha production
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 212:89-98. 2006
    ..Overall, this study contributes to our understanding of the mechanism underlying mancozeb-induced immunotoxicity...
  12. ncbi request reprint Factors governing susceptibility to chemical allergy
    Emanuela Corsini
    Laboratory of Toxicology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Lett 168:255-9. 2007
    ..Following the influence of condition of exposure, heritable and acquired factors, such as age, genetic background, gender etc. on chemical allergy is discussed...
  13. ncbi request reprint Immunomodulatory effects of the herbicide propanil on cytokine production in humans: In vivo and in vitro exposure
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 222:202-10. 2007
    ..These findings improve our understanding of the mechanism underlying propanil-induced immunotoxicity...
  14. doi request reprint Effects of pesticide exposure on the human immune system
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Hum Exp Toxicol 27:671-80. 2008
    ..More knowledge is required regarding the prognostic significance of the small changes observed...
  15. doi request reprint Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens
    Emanuela Corsini
    Department of Pharmacological Sciences, Faculty of Pharmacy, Laboratory of Toxicology, University of Milan, Milan, Italy
    Toxicol In Vitro 23:789-96. 2009
    ..Overall, results obtained indicated that cell-associated IL-18 may provide an in vitro tool for identification and discrimination of contact versus respiratory allergens and/or irritants...
  16. doi request reprint Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    J Agric Food Chem 58:6678-84. 2010
    ..EL and ED were also able to pass the intestinal barrier and modulate cytokine production. The findings of the present study reveal potential mechanisms that could explain some in vivo beneficial effects of lignans...
  17. doi request reprint In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs)
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Toxicol Appl Pharmacol 250:108-16. 2011
    ..Overall, these studies suggest that PFCs directly suppress cytokine secretion by immune cells, and that PFOA and PFOS have different mechanisms of action...
  18. ncbi request reprint Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses
    E Corsini
    Laboratory of Toxicology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Immunol Lett 76:89-93. 2001
    ..Our results show an age-associated increase in the expression of PKC betaII and RACK1, which correlated with a maturation of alveolar macrophage functional responses...
  19. pmc Increased carrageenan-induced acute lung inflammation in old rats
    Emanuela Corsini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Immunology 115:253-61. 2005
    ..Indeed, we found decreased cAMP-responsive element binding protein (CREB) and phosphorous-CREB (P-CREB) expression in old rats, which may account for reduced IL-10 production in old rats...
  20. ncbi request reprint Selective induction of cell-associated interleukin-1alpha in murine keratinocytes by chemical allergens
    E Corsini
    Center for Cosmetic Toxicology, Institute of Pharmacological Sciences, University of Milan, Italy
    Toxicology 129:193-200. 1998
    ....
  21. ncbi request reprint Use of differential display-polymerase chain reaction to identify genes selectively modulated by chemical allergens in reconstituted human epidermis
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol In Vitro 16:427-31. 2002
    ....
  22. ncbi request reprint Cyclosporin A exacerbates skin irritation induced by tributyltin by increasing nuclear factor kappa B activation
    E Corsini
    Center for Cosmetic Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Milan, Italy
    J Invest Dermatol 117:1627-34. 2001
    ..Cyclophilin D suppression prevented cyclosporine A potentiation of tributyltin-induced cellular oxidative activity, indicating the key role of the binding of cyclosporine A to mitochondrial cyclophilin D in mediating this effect...
  23. ncbi request reprint In vivo dehydroepiandrosterone restores age-associated defects in the protein kinase C signal transduction pathway and related functional responses
    Emanuela Corsini
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Immunol 168:1753-8. 2002
    ..These findings suggest that the age-related loss in immunological responses, linked to defective pathways of signal transduction, are partially under hormonal control and can be restored by appropriate replacement therapy...
  24. ncbi request reprint Cloricromene, a semi-synthetic coumarin derivative, inhibits tumor necrosis factor-alpha production at a pre-transcriptional level
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Eur J Pharmacol 418:231-7. 2001
    ..Our results show that cloricromene interferes with the early signal transduction pathway triggered by lipopolysaccharide...
  25. ncbi request reprint Epidermal cytokines in experimental contact dermatitis
    E Corsini
    Center for Cosmetic Toxicology, Laboratory of Toxicology, Institute of Pharmacological Sciences, University of Milan, Italy
    Toxicology 142:203-11. 2000
    ..In this article the role of cytokines in the development and differentiation of irritant and allergic contact dermatitis is discussed...
  26. ncbi request reprint Sodium arsenate induces overproduction of interleukin-1alpha in murine keratinocytes: role of mitochondria
    E Corsini
    Laboratory of Toxicology, Institute of Pharmological Sciences, University of Milan, Italy
    J Invest Dermatol 113:760-5. 1999
    ....
  27. ncbi request reprint A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophages
    E Corsini
    Institute of Pharmacological Sciences, University of Milan, Italy
    J Immunol 163:3468-73. 1999
    ....
  28. ncbi request reprint Cytokines and irritant contact dermatitis
    E Corsini
    Center for Cosmetic Toxicology, Institute of Pharmacological Sciences, University of Milan, Italy
    Toxicol Lett 102:277-82. 1998
    ..cellular immunity (IL-10, IL-12, IL-18). The role of cytokines in xenobiotics-induced skin irritation and the early molecular events that follow the treatment with irritant compounds will be discussed...
  29. ncbi request reprint Induction of adipose differentiation related protein and neutral lipid droplet accumulation in keratinocytes by skin irritants
    Emmanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
    J Invest Dermatol 121:337-44. 2003
    ..ADRP expression was also induced in vivo following treatment with sodium dodecyl sulfate in an experimental model of skin irritation, indicating that the in vitro model represents irritation...
  30. ncbi request reprint Resistance to acute silicosis in senescent rats: role of alveolar macrophages
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Chem Res Toxicol 16:1520-7. 2003
    ....
  31. ncbi request reprint Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone
    Emanuela Corsini
    Laboratories of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Leukoc Biol 77:247-56. 2005
    ..Overall, our findings contribute to the understanding of the complex process of immunosenescence and identify age-related loss in immunological responses as partially associated with decreased RACK-1 expression...
  32. ncbi request reprint Resistance to silica-induced lung fibrosis in senescent rats: role of alveolar macrophages and tumor necrosis factor-alpha (TNF)
    E Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy
    Mech Ageing Dev 125:145-6. 2004
    ..Overall, these data indicate that the understanding of the molecular mechanisms undelaying toxicity is crucial to define the influence of age on the toxic response and progression of the disease...
  33. ncbi request reprint Immunomodulatory effects of the fungicide Mancozeb in agricultural workers
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 208:178-85. 2005
    ....
  34. ncbi request reprint Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis
    Alessandra Gennari
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy
    Toxicol Appl Pharmacol 181:27-31. 2002
    ..Antisense oligonucleotide inhibition of nur77 expression prevented apoptosis induced by DBTC, supporting a role for nur77 in organotin-induced apoptotic cell death...
  35. ncbi request reprint Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: an Italian study
    Claudio Colosio
    Department of Occupational and Environmental Health of the University of Milan, S Paolo Hospital Unit, Milan, Italy
    Biomarkers 12:574-88. 2007
    ..Altogether the differences between exposed and controls were not consistently correlated to any clinical impairment and suggest that the seasonal application of mancozeb does not pose a significant health risk to exposed subjects...
  36. ncbi request reprint Identification of the basic subunit of Ara h 3 as the major allergen in a group of children allergic to peanuts
    Patrizia Restani
    Department of Pharmacological Sciences, University of Milano, Milano, Italy
    Ann Allergy Asthma Immunol 94:262-6. 2005
    ..Several proteins have been identified as peanut allergens; among them, Ara h 1 (7S globulin) and Ara h 2 (2S globulin) are usually considered the major allergens...
  37. ncbi request reprint Cytokines role in neurodegenerative events
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Lett 149:85-9. 2004
    ..Here, tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) contribute to neurodegeneration and the molecular mechanisms involved will be shortly reviewed...
  38. ncbi request reprint Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb
    Marina Marinovich
    Laboratory of Toxicology and Section of Theoretical Pharmacology and Receptor Modeling, Department Pharmacological Sciences, University of Milan, Italy
    Chem Res Toxicol 15:26-32. 2002
    ..In LMMPs, the potentiation of cholinergic transmission is partly dependent on the activation of ganglionic nicotinic receptors. Other targets relevant to cholinergic transmission seem not to be affected by propineb...
  39. ncbi request reprint Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor
    Barbara Viviani
    Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 93:412-21. 2005
    ..These data demonstrate that erythropoietin activates the CREB transcription pathway and increases BDNF expression and production, which contributes to erythropoietin mediated neuroprotection...
  40. ncbi request reprint The anti-inflammatory activity of estrogen in glial cells is regulated by the PKC-anchoring protein RACK-1
    Barbara Viviani
    Centre of Excellence on Neurodegenerative Diseases and Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Neurochem 83:1180-7. 2002
    ..These results demonstrate that estrogen reduction of the RACK-1 expression, leading to a defective protein kinase-C activation counteracts the inflammatory response in astrocytes...
  41. doi request reprint Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells
    Barbara Viviani
    Department of Pharmacological Sciences, Laboratory of Toxicology, University of Milan, Italy
    Toxicol Lett 182:63-8. 2008
    ..These data suggest that dithiocarbamates, through the activation of intracellular cascade(s), impair cytoskeletal actin. This effect may contribute to affect synaptic vesicles processing resulting in an impaired cholinergic transmission...
  42. ncbi request reprint Erythropoietin: a novel neuroprotective cytokine
    Stefano Bartesaghi
    Laboratory of Toxicology and Centre of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurotoxicology 26:923-8. 2005
    ....
  43. ncbi request reprint Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 281:30212-22. 2006
    ..Thus, tyrosine phosphorylation may contribute to the sensitization of the receptor increasing its function and synaptic localization. Both of these effects are relevant for neurodegeneration...
  44. pmc Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo
    Tiziana Mennini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 12:153-60. 2006
    ..Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration...