Research Topics
Genomes and GenesSpecies | Rosa M CorboSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Publications
Gender-specific association between FSHR and PPARG common variants and human longevityRosa Maria Corbo
Department of Biology and Biotechnology, La Sapienza University, Rome, Italy
Rejuvenation Res 16:21-7. 2013..A review of the studies showed that genetic factors tend to have a greater relevance in determining longevity in men than in women. The possible impact of this phenomenon is discussed...
How contemporary human reproductive behaviors influence the role of fertility-related genes: the example of the p53 geneRosa Maria Corbo
Department of Biology and Biotechnology Charles Darwin, La Sapienza University, Rome, Italy
PLoS ONE 7:e35431. 2012..Set within an evolutionary framework, this change could lead to the selection of a set of gene variants fitter to current reproductive behaviors as the shift to later child-bearing age in developed countries...
Apolipoprotein E polymorphism and fertility: a study in pre-industrial populationsR M Corbo
Department of Genetics and Molecular Biology, University La Sapienza, P le A Moro 5, 00185 Rome, Italy
Mol Hum Reprod 10:617-20. 2004..A possible explanation for this inconsistency could be due to the different functional properties associated with the e*3 and e*4 alleles and to genotype interactions with environmental factors including reproductive strategies...- Association of estrogen receptor alpha (ESR1) PvuII and XbaI polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrationsRosa Maria Corbo
Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Dement Geriatr Cogn Disord 22:67-72. 2006.... - Estrogen receptor alpha polymorphisms and fertility in populations with different reproductive patternsR M Corbo
Department of Genetics and Molecular Biology, University La Sapienza, P le A Moro 5, 00185 Rome, Italy
Mol Hum Reprod 13:537-40. 2007..These results are consistent with previous observations indicating a role of ESR1 genotypes in human infertility and give insight into the complex interactions between genotypes and reproductive behaviours in human populations... - Combined effect of apolipoprotein e genotype and past fertility on age at onset of Alzheimer's disease in womenRosa Maria Corbo
CNR Institute of Molecular Biology and Pathology, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Dement Geriatr Cogn Disord 24:82-5. 2007..With this study, we investigated possible relationships between APOE genotype, past fertility, and AD onset age... - Study on a possible effect of four longevity candidate genes (ACE, PON1, PPAR-gamma, and APOE) on human fertilityRosa Maria Corbo
Department of Genetics and Molecular Biology, University La Sapienza, P A Moro 5, 00185 Rome, Italy
Biogerontology 9:317-23. 2008..These data suggest that the APOE*2 allele follows the model of antagonist pleiotropy, while the PPAR-gamma Pro/Ala genotype seems to exert beneficial effects both early in life and in advanced age in a gender-specific way... - Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer's disease in womenRosa Maria Corbo
Department of Genetics and Molecular Biology, University La Sapienza, IT 00185 Rome, Italy
Dement Geriatr Cogn Disord 27:513-8. 2009..One likely contributing factor is the reduced estrogen neuroprotective action following menopause. In this context, an AD risk gene could be CYP19, encoding aromatase, an enzyme involved in estrogen biosynthesis... - Association of CYP19 and ESR1 pleiotropic genes with human longevityRosa Maria Corbo
Department of Genetics and Molecular Biology, La Sapienza University, P le A Moro 5, 00185 Rome, Italy
J Gerontol A Biol Sci Med Sci 66:51-5. 2011..As the ESR1 PP genotypes were found associated with reduced fertility in the same sample, we may infer that ESR1 genotypes could exert an antagonistic pleiotropic effect on longevity and fertility... - Differential reproductive efficiency associated with common apolipoprotein e alleles in postreproductive-aged subjectsRosa M Corbo
Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Fertil Steril 81:104-7. 2004..To investigate the possible impact of apolipoprotein E (APOE) polymorphism on reproductive efficiency... - Alpha2-macroglobulin deletion polymorphism and plasma levels in late onset Alzheimer's diseaseRenato Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Clin Chem Lab Med 40:333-6. 2002.... - An analysis of peroxisome proliferator-activated receptor gamma (PPAR-gamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habitsR Scacchi
CNR Institute of Molecular Biology and Pathology, Rome, Italy
Nutr Metab Cardiovasc Dis 17:632-41. 2007..The Ala allele of the Pro12Ala polymorphism has been associated with a protective effect against T2DM. Ala allele frequencies are known for many populations, but data are absent for other interesting human groups... - Screening of two mutations at exon 3 of the apolipoprotein E gene (sites 28 and 42) in a sample of patients with sporadic late-onset Alzheimer's diseaseR Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Neurobiol Aging 24:339-43. 2003..and from our study. The results indicated that, compared with all the other APOE genotypes, those carrying the Leu28-->Pro mutation were at a substantially higher risk of developing AD (OR=4.25; 95% CI=1.21-14.97)... - C-338A polymorphism of the endothelin-converting enzyme (ECE-1) gene and the susceptibility to sporadic late-onset Alzheimer's disease and coronary artery diseaseRenato Scacchi
CNR Institute of Molecular Biology and Pathology, c o Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Dis Markers 24:175-9. 2008.... - The H+ allele of the lipoprotein lipase (LPL) HindIII intronic polymorphism and the risk for sporadic late-onset Alzheimer's diseaseRenato Scacchi
CNR Institute of Molecular Biology and Pathology, c o Department of Genetics and Molecular Biology, University La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
Neurosci Lett 367:177-80. 2004..029). This means that carrying this allele significantly increases the risk of developing AD, and the risk is mostly associated with the H+H+ genotype... - Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery diseaseRenato Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, P le Aldo Moro 5, 00185, Rome, Italy
Neurosci Lett 339:17-20. 2003..41, 95% CI=0.19-0.90; P=0.025), whereas in CAD it appeared to be a significant risk factor (OR=5.11, 95% CI=1.09-23.9; P=0.038) limited to younger patients... - The peroxisome proliferator-activated receptor gamma (PPAR-gamma2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenariansRenato Scacchi
CNR Institute of Molecular Biology and Pathology, c o Department of Genetics and Molecular Biology, University, La Sapienza, Rome, P le Aldo Moro 5, 00185 Rome, Italy
Brain Res 1139:1-5. 2007..03-3.80, p=0.04). Though this difference was borderline significant after correction for multiple comparisons, our results suggest a possible involvement of the PPAR-gamma gene in susceptibility to late-onset AD in octogenarians... - Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?R M Corbo
Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Ann Hum Genet 63:301-10. 1999..The absence of the association of APOE*4 with CAD and AD in Sub-Saharan Africans, and its presence in African Americans, seems to confirm this hypothesis... - Polymorphisms in the apolipoprotein E gene regulatory region in relation to coronary heart disease and their effect on plasma apolipoprotein ER M Corbo
Department of Genetics and Molecular Biology, La Sapienza University, Rome, Italy
Clin Chem Lab Med 39:2-6. 2001..In the present study, carried out on CHD patients and controls, the genetic variation at -427 and -491 sites of the APOE regulatory region had no apparent effect on apoE plasma concentration... - Polymorphisms of the apolipoprotein E gene regulatory region and of the LDL receptor gene in late-onset Alzheimer's disease in relation to the plasma lipidic patternR Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Dement Geriatr Cogn Disord 12:63-8. 2001..This result confirmed in vivo the already observed in vitro effects of -491 A/T and -427 T/C polymorphisms on APOE promoter transcription activity... - Plasma alpha1-antichymotrypsin in Alzheimer's disease; relationships with APOE genotypesR Scacchi
CNR Center of Evolutionary Genetics and Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Neurobiol Aging 22:413-6. 2001..67). Taken together our results seem to suggest that inflammation is a relevant factor in AD pathogenesis for subjects with E3-E3 and E3-E2 genotypes but less important for APOE*4 carrying subjects... - Apolipoprotein E genotype and plasma levels in coronary artery disease. A case-control study in the Italian populationR M Corbo
Department of Genetics and Molecular Biology and CNR Center of Evolutionary Genetics, La Sapienza University, Rome, Italy
Clin Biochem 32:217-22. 1999..To investigate the role of the apolipoprotein B and apolipoprotein E polymorphisms in coronary artery disease (CAD) susceptibility in the Italian population and their relation to plasma lipid and apolipoprotein levels... - New data on the world distribution of paraoxonase (PON1 Gln 192 --> Arg) gene frequenciesR Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Hum Biol 75:365-73. 2003..313, 0.248, 0.408, 0.612, and 0.789, respectively. The data show a large variability in allele frequencies, and, in particular, that PON1 allele distribution depends on membership to different geographic populations... - Genetic variation atapolipoprotein E locus in Ethiopia: an E5 variant corresponds to two different mutant alleles: E*5 (Glu212Lys) and E*5 (Gln204Lys; Cys112Arg)R Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Hum Biol 75:293-300. 2003..The occurrence of the two variants in the populations of Ethiopia and of the Mediterranean basin could be explained by taking into account the relevant Caucasoid contribution to the Ethiopian gene pool... - Distribution of ORM1, C6, C7 and APO C-II allele frequencies in populations from mainland Italy and SardiniaR Scacchi
CNR Center of Evolutionary Genetics, University La Sapienza, Rome, Italy
Hum Hered 42:309-15. 1992..The two populations showed a significant difference in the gene frequencies distribution for ORM1... - Structural and phylogenetic approaches to assess the significance of human Apolipoprotein E variationRosa Maria Corbo
Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Mol Genet Metab 89:261-9. 2006..The two combined methods provided helpful indications for distinguishing between mutations possibly involved in AD susceptibility and not deleterious mutations... - Plasma levels of apolipoprotein E and genetic markers in elderly patients with Alzheimer's diseaseR Scacchi
CNR Center of Evolutionary Genetics, Department of Genetics and Molecular Biology, University La Sapienza, Rome, Italy
Neurosci Lett 259:33-6. 1999..An interaction between APOE and APOC1 polymorphisms and apoE levels was observed in patients: subjects carrying the APOE E3/E2 or the APOC1 2-2 genotype have higher apoE concentrations than those who do not... - Clinal patterns of human Y chromosomal diversity in continental Italy and Greece are dominated by drift and founder effectsF Di Giacomo
Tor Vergata University, Rome, Italy
Mol Phylogenet Evol 28:387-95. 2003..We conclude that local founder or drift effects are the main determinants in shaping the microgeographic Y chromosomal diversity... - A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's diseaseRenato Scacchi
CNR Institute of Molecular Biology and Pathology, c o Department of Genetics and Molecular Biology, University La Sapienza, P le Aldo Moro 5, 00185 Rome, Italy
Neurosci Lett 418:282-5. 2007..We concluded that the variation in the screened exons of the APP and PSEN1 genes, reportedly associated with familial AD, is not present in LOAD...