Fabio Coppede

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. request reprint
    Coppede F, Zitarosa M, Migheli F, Lo Gerfo A, Bagnoli S, Dardano A, et al. DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease. Curr Alzheimer Res. 2012;9:550-4 pubmed
    ..Overall, present results do not support a major role for rs2424913 or rs1569686 in LOAD pathogenesis. ..
  2. request reprint
    Coppede F, Mancuso M, Lo Gerfo A, Carlesi C, Piazza S, Rocchi A, et al. Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis. Neurosci Lett. 2007;420:163-8 pubmed
    ..Present results suggest a possible involvement of the hOGG1 Ser326Cys polymorphism in sALS pathogenesis. ..
  3. Coppede F, Migheli F, Ceravolo R, Bregant E, Rocchi A, Petrozzi L, et al. The hOGG1 Ser326Cys polymorphism and Huntington's disease. Toxicology. 2010;278:199-203 pubmed publisher
    ..041) earlier disease onset than Ser326Ser wild-type individuals, suggesting a possible role of the hOGG1 Ser326Cys polymorphism in HD phenotype. ..
  4. Coppede F. Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation. Cancer Lett. 2014;342:238-47 pubmed publisher
    ..Moreover, active research is also focused on the possible contribution of folic acid dietary fortification during pregnancy and the possible methylation of CRC-related genes in the offspring. ..
  5. Coppede F. The epidemiology of premature aging and associated comorbidities. Clin Interv Aging. 2013;8:1023-32 pubmed publisher
    ..The aim of this article is to review the most recent findings concerning the epidemiology of premature aging disorders, their genetic basis, and the most recent reports on the frequency of associated diseases. ..
  6. Coppede F, Tannorella P, Pezzini I, Migheli F, Ricci G, Caldarazzo Lenco E, et al. Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls. Antioxid Redox Signal. 2012;17:195-204 pubmed publisher
    ..Overall, present results support a contribution for one-carbon metabolism to LOAD pathogenesis. ..
  7. request reprint
    Coppede F, Mancuso M, Lo Gerfo A, Manca M, Petrozzi L, Migliore L, et al. A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease. Neurosci Lett. 2007;414:282-5 pubmed
    ..03, p=0.86) or genotype (chi2=0.25, p=0.882) frequencies of hOGG1 Ser326Cys and the risk of sAD. Present results suggest that the Ser326Cys polymorphism of the hOGG1 gene is not an independent risk factor for sAD. ..
  8. Coppede F, Lo Gerfo A, Carlesi C, Piazza S, Mancuso M, Pasquali L, et al. Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2010;31:353-5 pubmed publisher
    ..Present results do not support a role for the APEX1 Asp148Glu polymorphism in sALS pathogenesis in the Italian population. ..
  9. Coppede F, Migheli F, Bargagna S, Siciliano G, Antonucci I, Stuppia L, et al. Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring. Neurosci Lett. 2009;449:15-9 pubmed publisher
    ..0001) and, in the total population, a significant correlation between micronucleated cells and both MTHFR 677C>T (P=0.031) and 1298A>C (P=0.047) polymorphisms...

More Information

Publications13

  1. Coppede F, Ceravolo R, Migheli F, Fanucchi F, Frosini D, Siciliano G, et al. The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease. Neurosci Lett. 2010;473:248-51 pubmed publisher
    ..Moreover, the hOGG1 Ser326Cys polymorphism was not associated with disease age at onset (p=0.791). Overall, present results suggest that the hOGG1 Ser326Cys polymorphism is not associated with sporadic PD. ..
  2. request reprint
    Coppede F, Migliore L. DNA repair in premature aging disorders and neurodegeneration. Curr Aging Sci. 2010;3:3-19 pubmed
    ..Here, we review the current knowledge on the role of DNA repair in premature aging and neurodegenerative diseases...
  3. Coppede F, Bosco P, Tannorella P, Romano C, Antonucci I, Stuppia L, et al. DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome. Hum Reprod. 2013;28:545-50 pubmed publisher
    ..If confirmed in subsequent studies, DNMT3B promoter polymorphisms might be additional markers to be taken into account when evaluating the contribution of one-carbon (folate) metabolism to the maternal risk of birth of a child with DS. ..
  4. Coppede F, Bosco P, Lorenzoni V, Migheli F, Barone C, Antonucci I, et al. The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis. Mol Biol Rep. 2013;40:6913-25 pubmed publisher
    ..No association of the studied polymorphism with circulating levels of hcy, folates, and vitamin B12 was observed. Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a DS birth. ..