Fabio Coppede

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Italy
    Curr Alzheimer Res 9:550-4. 2012
  2. pmc One-carbon metabolism and Alzheimer's disease: focus on epigenetics
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Genomics 11:246-60. 2010
  3. ncbi request reprint The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via S Giuseppe 22, 56126, Pisa, IT, Italy
    Mol Biol Rep 40:6913-25. 2013
  4. pmc Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer's disease and healthy matched individuals
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy
    PLoS ONE 8:e74012. 2013
  5. pmc The epidemiology of premature aging and associated comorbidities
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
    Clin Interv Aging 8:1023-32. 2013
  6. doi request reprint Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation
    Fabio Coppede
    Department DAI of Neuroscience, Pisa University Hospital AOUP, Italy Faculty of Medicine, University of Pisa, Italy Electronic address
    Cancer Lett 342:238-47. 2014
  7. pmc The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Via S Giuseppe 22, Pisa 56126, Italy
    Nutrients 5:2551-63. 2013
  8. doi request reprint DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome
    Fabio Coppede
    Department of Laboratory Medicine, Pisa University Hospital AOUP, Via S Giuseppe 22, Pisa 56126, Italy
    Hum Reprod 28:545-50. 2013
  9. pmc Genetics and epigenetics of Parkinson's disease
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    ScientificWorldJournal 2012:489830. 2012
  10. doi request reprint Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    Antioxid Redox Signal 17:195-204. 2012

Collaborators

Detail Information

Publications46

  1. ncbi request reprint DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Italy
    Curr Alzheimer Res 9:550-4. 2012
    ..Overall, present results do not support a major role for rs2424913 or rs1569686 in LOAD pathogenesis...
  2. pmc One-carbon metabolism and Alzheimer's disease: focus on epigenetics
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Genomics 11:246-60. 2010
    ..There is also evidence of epigenetic modifications in the DNA extracted from blood and brains of AD subjects. Here I review one-carbon metabolism in AD, with emphasis on possible epigenetic consequences...
  3. ncbi request reprint The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via S Giuseppe 22, 56126, Pisa, IT, Italy
    Mol Biol Rep 40:6913-25. 2013
    ..No association of the studied polymorphism with circulating levels of hcy, folates, and vitamin B12 was observed. Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a DS birth. ..
  4. pmc Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer's disease and healthy matched individuals
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy
    PLoS ONE 8:e74012. 2013
    ..The semantic connectivity map provided important information on the complex biological connections among one-carbon metabolic variables highlighting those most closely linked to the AD condition. ..
  5. pmc The epidemiology of premature aging and associated comorbidities
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
    Clin Interv Aging 8:1023-32. 2013
    ..The aim of this article is to review the most recent findings concerning the epidemiology of premature aging disorders, their genetic basis, and the most recent reports on the frequency of associated diseases. ..
  6. doi request reprint Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation
    Fabio Coppede
    Department DAI of Neuroscience, Pisa University Hospital AOUP, Italy Faculty of Medicine, University of Pisa, Italy Electronic address
    Cancer Lett 342:238-47. 2014
    ..Moreover, active research is also focused on the possible contribution of folic acid dietary fortification during pregnancy and the possible methylation of CRC-related genes in the offspring...
  7. pmc The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Via S Giuseppe 22, Pisa 56126, Italy
    Nutrients 5:2551-63. 2013
    ..14, 95% CI 1.01-1.30; p = 0.03). Present results suggest that the maternal RFC-1 80A>G polymorphism might be associated with an increased risk of having a birth with DS, particularly among carriers of the GG genotype. ..
  8. doi request reprint DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome
    Fabio Coppede
    Department of Laboratory Medicine, Pisa University Hospital AOUP, Via S Giuseppe 22, Pisa 56126, Italy
    Hum Reprod 28:545-50. 2013
    ..Are DNMT3B promoter polymorphisms among maternal risk factors for the birth of a child with Down syndrome (DS)?..
  9. pmc Genetics and epigenetics of Parkinson's disease
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    ScientificWorldJournal 2012:489830. 2012
    ..In addition, increasing evidence suggests that epigenetic mechanisms, such as DNA methylation, histone modifications, and small RNA-mediated mechanisms, could regulate the expression of PD-related genes...
  10. doi request reprint Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    Antioxid Redox Signal 17:195-204. 2012
    ..Moreover, we searched for correlation between each of the studied polymorphisms and available data on plasma homocysteine (Hcy), serum folate, and vitamin B12 values...
  11. doi request reprint Premature aging syndrome
    Fabio Coppede
    Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy
    Adv Exp Med Biol 724:317-31. 2012
    ..A description of available diagnostic and therapeutic approaches is included...
  12. pmc Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks
    Fabio Coppede
    Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy
    BMC Med Genomics 3:42. 2010
    ..Data were analysed using TWIST system in combination with supervised artificial neural networks, and a semantic connectivity map...
  13. ncbi request reprint DNA repair in premature aging disorders and neurodegeneration
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Aging Sci 3:3-19. 2010
    ..Here, we review the current knowledge on the role of DNA repair in premature aging and neurodegenerative diseases...
  14. doi request reprint The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 473:248-51. 2010
    ..Moreover, the hOGG1 Ser326Cys polymorphism was not associated with disease age at onset (p=0.791). Overall, present results suggest that the hOGG1 Ser326Cys polymorphism is not associated with sporadic PD...
  15. doi request reprint Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    J Alzheimers Dis 20:953-66. 2010
    ....
  16. doi request reprint The hOGG1 Ser326Cys polymorphism and Huntington's disease
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Toxicology 278:199-203. 2010
    ..041) earlier disease onset than Ser326Ser wild-type individuals, suggesting a possible role of the hOGG1 Ser326Cys polymorphism in HD phenotype...
  17. doi request reprint Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Italy
    Amyotroph Lateral Scler 11:122-4. 2010
    ..We observed a statistically significant difference in XRCC1 Gln399 allele frequencies between SALS cases and controls (0.39/0.28; p=0.001). The present study suggests that the XRCC1 Arg399Gln polymorphism might contribute to SALS risk...
  18. ncbi request reprint A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 414:282-5. 2007
    ..03, p=0.86) or genotype (chi2=0.25, p=0.882) frequencies of hOGG1 Ser326Cys and the risk of sAD. Present results suggest that the Ser326Cys polymorphism of the hOGG1 gene is not an independent risk factor for sAD...
  19. ncbi request reprint Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neurosciences, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 420:163-8. 2007
    ..Present results suggest a possible involvement of the hOGG1 Ser326Cys polymorphism in sALS pathogenesis...
  20. ncbi request reprint Genes and the environment in neurodegeneration
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Via Roma 67, Pisa 56126, Italy
    Biosci Rep 26:341-67. 2006
    ..and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes...
  21. doi request reprint Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, 56126 Pisa, Italy
    Neurobiol Aging 31:353-5. 2010
    ..Present results do not support a role for the APEX1 Asp148Glu polymorphism in sALS pathogenesis in the Italian population...
  22. doi request reprint Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Neurosci Lett 449:15-9. 2009
    ..0001) and, in the total population, a significant correlation between micronucleated cells and both MTHFR 677C>T (P=0.031) and 1298A>C (P=0.047) polymorphisms...
  23. ncbi request reprint DNA damage and repair in Alzheimer's disease
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Curr Alzheimer Res 6:36-47. 2009
    ..The few studies performed so far suggest that some variants might play a role in AD pathogenesis and deserve further investigations. Here, we summarize the current knowledge of DNA damage and repair in AD pathogenesis...
  24. pmc An overview of DNA repair in amyotrophic lateral sclerosis
    Fabio Coppede
    Section of Medical Genetics, Faculty of Medicine, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    ScientificWorldJournal 11:1679-91. 2011
    ..Moreover, biochemical and genetic data on DNA repair in ALS are discussed in light of similar findings in other neurodegenerative diseases...
  25. ncbi request reprint Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 143:2006-15. 2007
    ....
  26. ncbi request reprint Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
    Fabio Coppede
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 140:1083-91. 2006
    ....
  27. ncbi request reprint Mitochondrial dysfunction, oxidative stress and neurodegeneration
    Michelangelo Mancuso
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Alzheimers Dis 10:59-73. 2006
    ..Here we examine the current evidences in this field, which indicate a key role of mitochondria and oxidative stress in contributing to the neurodegenerative processes...
  28. doi request reprint Susceptibility to aneuploidy in young mothers of Down syndrome children
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    ScientificWorldJournal 9:1052-60. 2009
    ..Studies performed in the last years that have shown that the brain is, in fact, a complex genetic mosaic of aneuploid and euploid cells support the unified hypothesis trying to relate DS, trisomy 21, and AD...
  29. doi request reprint The complex relationship between folate/homocysteine metabolism and risk of Down syndrome
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Mutat Res 682:54-70. 2009
    ..Further studies are also required to address the possible contribution of both the paternal diet and the maternal grandmother dietary habits to chromosome 21 nondisjunction events...
  30. doi request reprint Efficacy and feasibility of the epithelial cell adhesion molecule (EpCAM) immunomagnetic cell sorter for studies of DNA methylation in colorectal cancer
    Alessandra Failli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy
    Int J Mol Sci 15:44-57. 2014
    ..The efficacy and feasibility of the immunomagnetic cell sorting for methylation studies are discussed. ..
  31. ncbi request reprint Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases
    Fabio Coppede
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 579:107-14. 2005
    ....
  32. ncbi request reprint A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer's Disease in Italian Caucasians
    Fabio Coppede
    Division of Medical Genetics, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Medical School, Via Roma 56, 56126 Pisa, Italy
    Biomed Res Int 2014:608104. 2014
    ..Present results do not support a role for the RFC-1 c.80G>A polymorphism as independent risk factor for sporadic AD in Italian Caucasians. ..
  33. ncbi request reprint Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine
    Renato Colognato
    Dip Scienze dell Uomo e dell Ambiente, Universita di Pisa, Sezione di Genetica Via S Giuseppe 22, 56126 Pisa, Italy
    Clin Nutr 25:135-45. 2006
    ..The aim of this study was to assess the effect of EGT in the prevention of H2O2-dependent cell death and oxidative damage on a model of neural cell derived from rat pheocromocytoma, the PC12...
  34. doi request reprint Association of micronucleus frequency with neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 26:85-92. 2011
    ..These changes in buccal cytome ratios may prove useful as potential future diagnostics to identify individuals of increased risk for these disorders...
  35. doi request reprint Environmental-induced oxidative stress in neurodegenerative disorders and aging
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Faculty of Medicine, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 674:73-84. 2009
    ..The emerging interplay between environmental-induced oxidative stress and epigenetic modifications of critical genes for neurodegeneration is also discussed...
  36. ncbi request reprint Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 667:82-97. 2009
    ....
  37. pmc Genetics, cytogenetics, and epigenetics of colorectal cancer
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Street S Giuseppe 22, 56126 Pisa, Italy
    J Biomed Biotechnol 2011:792362. 2011
    ....
  38. doi request reprint Clock T3111C and Per2 C111G SNPs do not influence circadian rhythmicity in healthy Italian population
    Anna Choub
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy
    Neurol Sci 32:89-93. 2011
    ..Present results do not support a role of these polymorphisms in the circadian phenotypes...
  39. ncbi request reprint Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality?
    Michelangelo Mancuso
    Department of Neuroscience, Neurological Clinic, University of Pisa, Italy
    Antioxid Redox Signal 9:1631-46. 2007
    ..This review presents the ways in which malfunctioning mitochondria and oxidative stress might contribute to neuronal death in AD...
  40. ncbi request reprint Genetic and environmental factors in cancer and neurodegenerative diseases
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126, Pisa, Italy
    Mutat Res 512:135-53. 2002
    ....
  41. pmc Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation
    Francesca Migheli
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy
    PLoS ONE 8:e52501. 2013
    ..Overall, our new approach allows MS-HRM to be used as a quantitative assay which provides results which are comparable with those obtained by pyrosequencing...
  42. ncbi request reprint Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Pharmacogenet Genomics 16:87-99. 2006
    ..These observations may have relevance considering the risk of lymphatic and haematopoietic malignancies tentatively associated with styrene exposure...
  43. doi request reprint Epigenetic effects of nano-sized materials
    Andrea Stoccoro
    Department of Translational Research and New Technologies in Medicine and Surgery, Medical Genetics Laboratory, University of Pisa, Pisa, Italy
    Toxicology 313:3-14. 2013
    ....
  44. ncbi request reprint Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer
    Fabio Coppede
    Fabio Coppedè, Angela Lopomo, Lucia Migliore, Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, 56126 Pisa, Italy
    World J Gastroenterol 20:943-56. 2014
    ..Overall, combining genetic and epigenetic data might represent the most promising tool for a proper diagnostic, prognostic and therapeutic approach. ..
  45. pmc Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
    PLoS ONE 8:e80846. 2013
    ..Present results suggest that the DNMT3B-579T allele might contribute to the risk of developing thymoma in MG patients, particularly in homozygous TT subjects. ..