Manuela Contin

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
  2. doi request reprint Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
    M Contin
    UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, corrected Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Epilepsy Res 98:130-4. 2012
  3. doi request reprint Pharmacokinetics of levodopa
    Manuela Contin
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Bologna, Italy
    J Neurol 257:S253-61. 2010
  4. doi request reprint Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:461-5. 2010
  5. doi request reprint The effect of entacapone on levodopa rate of absorption and latency to motor response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Clin Neuropharmacol 31:267-71. 2008
  6. doi request reprint Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 873:129-32. 2008
  7. ncbi request reprint Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:1573-5. 2006
  8. ncbi request reprint Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Mov Disord 20:734-9. 2005
  9. ncbi request reprint Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 828:113-7. 2005
  10. ncbi request reprint Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004

Detail Information

Publications19

  1. ncbi request reprint Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
    ..According to genotyping, subjects carrying one or two copies of the defective CYP2C19*2 allele might develop markedly elevated steady-state plasma concentrations of N-CLB and be at higher risk of adverse effects...
  2. doi request reprint Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
    M Contin
    UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, corrected Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Epilepsy Res 98:130-4. 2012
    ..001). LEV CL/F significantly declines with aging, elderly and very elderly patients requiring an about 30% and 50% lower dose, respectively, compared to nonelderly adults to achieve a given LEV plasma concentration...
  3. doi request reprint Pharmacokinetics of levodopa
    Manuela Contin
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Bologna, Italy
    J Neurol 257:S253-61. 2010
    ..Unfortunately, these attempts have proved so far only partly successful, due to the complex alterations in cerebral levodopa kinetics which accompany the progressive degeneration of the nigrostriatal dopaminergic system in PD patients...
  4. doi request reprint Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:461-5. 2010
    ..By grouping different new AEDs in the same assay the method can be advantageous for therapeutic drug monitoring (TDM)...
  5. doi request reprint The effect of entacapone on levodopa rate of absorption and latency to motor response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Clin Neuropharmacol 31:267-71. 2008
    ....
  6. doi request reprint Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 873:129-32. 2008
    ..Applied to a large population of patients with epilepsy this assay proved very practical in our therapeutic drug monitoring setting (TDM)...
  7. ncbi request reprint Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:1573-5. 2006
    ..We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy...
  8. ncbi request reprint Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Mov Disord 20:734-9. 2005
    ..We failed to identify clinically relevant levodopa pharmacokinetic-pharmacodynamic response patterns associated with the COMT polymorphism in PD patients...
  9. ncbi request reprint Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 828:113-7. 2005
    ..The simple sample pre-treatment, combined with the fast chromatographic run permit rapid processing of a large series of patient samples...
  10. ncbi request reprint Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004
    ....
  11. ncbi request reprint Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Ther Drug Monit 24:332-7. 2002
    ....
  12. ncbi request reprint Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Ther Drug Monit 26:375-9. 2004
    ..Concomitant AED inducers can contribute to variability in levetiracetam disposition in patients with epilepsy. The observed differences were moderate and possibly of minor clinical significance...
  13. doi request reprint The effect of a clinically practical exercise on levodopa bioavailability and motor response in patients with Parkinson disease
    Giovanna Lopane
    Department of Neurological Sciences University of Bologna, Bologna, Italy
    Clin Neuropharmacol 33:254-6. 2010
    ....
  14. ncbi request reprint Assessing dopaminergic function in Parkinson's disease: levodopa kinetic-dynamic modeling and SPECT
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    J Neurol 250:1475-81. 2003
    ..Levodopa PK-PD modeling can be a practical clinical tool indirectly assessing the functional integrity of the nigrostriatal dopaminergic system in PD patients...
  15. ncbi request reprint Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 26:115-8. 2003
    ..The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes...
  16. ncbi request reprint Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome
    Roberto Vetrugno
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Mov Disord 21:254-8. 2006
    ..This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile...
  17. ncbi request reprint Daytime sympathetic hyperactivity in OSAS is related to excessive daytime sleepiness
    Vincenzo Donadio
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Sleep Res 16:327-32. 2007
    ..The results obtained in this pilot study need, however, to be confirmed in a larger study involving more patients...
  18. ncbi request reprint Drug rash with eosinophilia and systemic symptoms secondary to phenobarbitone
    Agostino Baruzzi
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Clin Neuropharmacol 26:177-8. 2003
    ..They highlight the main characteristics of this syndrome and the diagnostic difficulties...
  19. doi request reprint Isolated noradrenergic failure in adult-onset autosomal dominant leukodystrophy
    Pietro Guaraldi
    Neurological Sciences Department, University of Bologna, Bologna, Italy
    Auton Neurosci 159:123-6. 2011
    ..This peculiar autonomic dysfunction may represent a hallmark for ADLD...