M Contin

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 26:115-8. 2003
  2. ncbi Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Ther Drug Monit 26:375-9. 2004
  3. ncbi Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004
  4. ncbi Assessing dopaminergic function in Parkinson's disease: levodopa kinetic-dynamic modeling and SPECT
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    J Neurol 250:1475-81. 2003
  5. ncbi Simple and rapid liquid chromatographic-turbo ion spray mass spectrometric determination of topiramate in human plasma
    M Contin
    Laboratory of Clinical Neuropharmacology, Institute of Neurology, University of Bologna, Italy
    J Chromatogr B Biomed Sci Appl 761:133-7. 2001
  6. ncbi Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
  7. ncbi Levodopa therapy monitoring in patients with Parkinson disease: a kinetic-dynamic approach
    M Contin
    Laboratory of Clinical Neuropharmacology, Institute of Neurology, University of Bologna, Bologna, Italy
    Ther Drug Monit 23:621-9. 2001
  8. ncbi Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Ther Drug Monit 24:332-7. 2002
  9. ncbi Combined levodopa-anticholinergic therapy in the treatment of Parkinson's disease. Effect on levodopa bioavailability
    M Contin
    Institute of Neurology, University of Bologna, Italy
    Clin Neuropharmacol 14:148-55. 1991
  10. ncbi Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?
    P Martinelli
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Bologna, Italy
    Neurol Sci 24:192-3. 2003

Detail Information

Publications22

  1. ncbi Excessive daytime sleepiness and levodopa in Parkinson's disease: polygraphic, placebo-controlled monitoring
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 26:115-8. 2003
    ..The subacute levodopa challenge was accompanied by physiologic sleep episodes, worsened reaction times, and a reduction in mean blood pressure and heart rate over baseline values, linked temporally to the sleep episodes...
  2. ncbi Levetiracetam therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Ther Drug Monit 26:375-9. 2004
    ..Concomitant AED inducers can contribute to variability in levetiracetam disposition in patients with epilepsy. The observed differences were moderate and possibly of minor clinical significance...
  3. ncbi Dopamine transporter gene polymorphism, spect imaging, and levodopa response in patients with Parkinson disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Clin Neuropharmacol 27:111-5. 2004
    ....
  4. ncbi Assessing dopaminergic function in Parkinson's disease: levodopa kinetic-dynamic modeling and SPECT
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    J Neurol 250:1475-81. 2003
    ..Levodopa PK-PD modeling can be a practical clinical tool indirectly assessing the functional integrity of the nigrostriatal dopaminergic system in PD patients...
  5. ncbi Simple and rapid liquid chromatographic-turbo ion spray mass spectrometric determination of topiramate in human plasma
    M Contin
    Laboratory of Clinical Neuropharmacology, Institute of Neurology, University of Bologna, Italy
    J Chromatogr B Biomed Sci Appl 761:133-7. 2001
    ....
  6. ncbi Evidence of polymorphic CYP2C19 involvement in the human metabolism of N-desmethylclobazam
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Italy
    Ther Drug Monit 24:737-41. 2002
    ..According to genotyping, subjects carrying one or two copies of the defective CYP2C19*2 allele might develop markedly elevated steady-state plasma concentrations of N-CLB and be at higher risk of adverse effects...
  7. ncbi Levodopa therapy monitoring in patients with Parkinson disease: a kinetic-dynamic approach
    M Contin
    Laboratory of Clinical Neuropharmacology, Institute of Neurology, University of Bologna, Bologna, Italy
    Ther Drug Monit 23:621-9. 2001
    ..From a practical point of view, knowledge of individual patients' kinetic-dynamic variables can help the physician assess patients' clinical needs objectively and optimize levodopa dosing according to disease progression...
  8. ncbi Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Ther Drug Monit 24:332-7. 2002
    ....
  9. ncbi Combined levodopa-anticholinergic therapy in the treatment of Parkinson's disease. Effect on levodopa bioavailability
    M Contin
    Institute of Neurology, University of Bologna, Italy
    Clin Neuropharmacol 14:148-55. 1991
    ..Our observations suggest that chronic anticholinergic intake may contribute to a less predictable pattern of levodopa absorption and related therapeutic response in some subjects...
  10. ncbi Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?
    P Martinelli
    Dipartimento di Scienze Neurologiche, Universita di Bologna, Bologna, Italy
    Neurol Sci 24:192-3. 2003
    ..No difference in the proportion of men and women experiencing dyskinesias was observed...
  11. ncbi Nocturnal body core temperature falls in Parkinson's disease but not in Multiple-System Atrophy
    G Pierangeli
    Institute of Neurology, University of Bologna, Bologna, Italy
    Mov Disord 16:226-32. 2001
    ..To evaluate whether the circadian rhythm of body core temperature (CRT degrees ) can differentiate Multiple-System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD)...
  12. doi Levetiracetam clinical pharmacokinetics in elderly and very elderly patients with epilepsy
    M Contin
    UOC Clinica Neurologica, IRCCS Istituto delle Scienze Neurologiche, corrected Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Epilepsy Res 98:130-4. 2012
    ..001). LEV CL/F significantly declines with aging, elderly and very elderly patients requiring an about 30% and 50% lower dose, respectively, compared to nonelderly adults to achieve a given LEV plasma concentration...
  13. ncbi Effect of meal timing on the kinetic-dynamic profile of levodopa/carbidopa controlled release [corrected] in parkinsonian patients
    M Contin
    Institute of Neurology, University of Bologna, Italy
    Eur J Clin Pharmacol 54:303-8. 1998
    ..The aim of the study was to assess the effect of the time of ingestion of a meal on the pharmacokinetics and pharmacodynamics of a levodopa/carbidopa controlled-release formulation in parkinsonian patients on chronic levodopa therapy...
  14. ncbi Simple and rapid GLC method for the determination of orphenadrine in human plasma
    M Contin
    Institute of Neurology, University of Bologna, Italy
    Biomed Chromatogr 2:193-4. 1987
    ..This procedure considerably simplifies previously reported assays and is specific and sensitive enough for the determination of orphenadrine in plasma of patients on chronic therapy...
  15. ncbi The cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failure
    F Magnifico
    Institute of Neurology, University of Bologna, Italy
    Clin Auton Res 11:163-8. 2001
    ....
  16. doi Simple and validated HPLC-UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 873:129-32. 2008
    ..Applied to a large population of patients with epilepsy this assay proved very practical in our therapeutic drug monitoring setting (TDM)...
  17. ncbi Daytime sympathetic hyperactivity in OSAS is related to excessive daytime sleepiness
    Vincenzo Donadio
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    J Sleep Res 16:327-32. 2007
    ..The results obtained in this pilot study need, however, to be confirmed in a larger study involving more patients...
  18. ncbi Variation in lamotrigine plasma concentrations with hormonal contraceptive monthly cycles in patients with epilepsy
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Epilepsia 47:1573-5. 2006
    ..We describe the variation in LTG plasma concentrations with hormonal contraceptive (HC) monthly intake cycles in a series of eight patients with epilepsy...
  19. ncbi Polysomnographic and pharmacokinetic findings in levodopa-induced augmentation of restless legs syndrome
    Roberto Vetrugno
    Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Mov Disord 21:254-8. 2006
    ..This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile...
  20. ncbi Simultaneous liquid chromatographic determination of lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in plasma of patients with epilepsy
    Manuela Contin
    Laboratory of Clinical Neuropharmacology, Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 828:113-7. 2005
    ..The simple sample pre-treatment, combined with the fast chromatographic run permit rapid processing of a large series of patient samples...
  21. ncbi Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease
    Manuela Contin
    Neurology Clinic, Department of Neurological Sciences, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Mov Disord 20:734-9. 2005
    ..We failed to identify clinically relevant levodopa pharmacokinetic-pharmacodynamic response patterns associated with the COMT polymorphism in PD patients...
  22. ncbi Drug rash with eosinophilia and systemic symptoms secondary to phenobarbitone
    Agostino Baruzzi
    Department of Neurological Sciences, Neurology Clinic, University of Bologna, Via Foscolo 7, 40123 Bologna, Italy
    Clin Neuropharmacol 26:177-8. 2003
    ..They highlight the main characteristics of this syndrome and the diagnostic difficulties...