Pio Conti


Affiliation: University of Chieti
Country: Italy


  1. Conti P, Tettamanti L, Mastrangelo F, Ronconi G, Frydas I, Kritas S, et al. Impact of Fungi on Immune Responses. Clin Ther. 2018;40:885-888 pubmed publisher
    ..Some of these processes may be inhibited by the new anti-inflammatory cytokine interleukin 37. ..
  2. Conti P, Ronconi G, Kritas S, Caraffa A, Theoharides T. Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: Interleukin-37 Could be Beneficial. Can J Diabetes. 2018;: pubmed publisher
    ..This describes a new concept of inhibition of and cure for inflammatory diseases. However, the safety, dosage and tolerability of this novel therapeutic agent, IL-37, still remains to be determined. ..
  3. Conti P, Caraffa A, Ronconi G, Conti C, Kritas S, Mastrangelo F, et al. Impact of mast cells in depression disorder: inhibitory effect of IL-37 (new frontiers). Immunol Res. 2018;: pubmed publisher
    ..As a consequence, the concepts reviewed here have treatment implications. ..
  4. Conti P, Caraffa A, Ronconi G, Kritas S, Mastrangelo F, Tettamanti L, et al. Mast cells participate in allograft rejection: can IL-37 play an inhibitory role?. Inflamm Res. 2018;67:747-755 pubmed publisher
    ..Here, we report the relationship between inflammatory MCs, allograft rejection and pro-inflammatory and anti-inflammatory IL-37. ..
  5. Conti P, Shaik Dasthagirisaheb Y. Mast Cell Serotonin Immunoregulatory Effects Impacting on Neuronal Function: Implications for Neurodegenerative and Psychiatric Disorders. Neurotox Res. 2015;28:147-53 pubmed publisher
    ..Here, we review the relationship between MCs and serotonin and its role in inflammatory diseases and neuroimmune interactions. ..
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    Shaik Dasthagirisaheb Y, Conti P. Letter to Editor: Chemokine Network Involved in Inflammatory Skin Diseases. Ann Clin Lab Sci. 2015;45:452-7 pubmed
    ..However, the complete role of chemokines in inflammatory skin diseases remains to be further studied. Here we report the relationship between chemokines and skin inflammation. ..
  7. Conti P, Kempuraj D. Important role of mast cells in multiple sclerosis. Mult Scler Relat Disord. 2016;5:77-80 pubmed publisher
    ..The participation of mast cells in MS is demonstrated by gene overexpression of chemical mediators and inflammatory cytokines. Here we report the relationship and involvement between mast cells and multiple sclerosis. ..
  8. Kempuraj D, Caraffa A, Ronconi G, Lessiani G, Conti P. Are mast cells important in diabetes?. Pol J Pathol. 2016;67:199-206 pubmed publisher
    ..However, further studies are needed to clarify the role of mast cells in inflammation and metabolic disorders such as diabetes. ..
  9. Pandolfi F, Franza L, Mandolini C, Conti P. Immune Modulation by Vitamin D: Special Emphasis on Its Role in Prevention and Treatment of Cancer. Clin Ther. 2017;39:884-893 pubmed publisher
    ..The search terms included vitamin D, cancer, breast, colorectal, prostate, and melanoma. Our findings show that vitamin D has the potential to become a valid coadjuvant in the treatment of cancer. ..

More Information


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    Conti P, Reale M, Barbacane R, Castellani M, Orso C. Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee. Immunol Lett. 2002;80:105-11 pubmed
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    Castellani M, Petrarca C, Frydas S, Conti C, Salini V, Conti P, et al. Rat basophilic leukemia cells (RBL-2H3) generate prostaglandin D2 (PGD2) after regulated upon activation, normal T-cell expressed and secreted (RANTES) activation. Int J Biol Markers. 2006;21:211-7 pubmed
    ..Moreover, RBL-treated RANTES generated a large quantity of histamine. Our study confirms once again the proinflammatory action of RANTES, in this case acting on the stimulation of the arachidonic acid cascade product PGD2...
  3. Conti P, Lessiani G, Kritas S, Ronconi G, Caraffa A, Theoharides T. Mast cells emerge as mediators of atherosclerosis: Special emphasis on IL-37 inhibition. Tissue Cell. 2017;49:393-400 pubmed publisher
    ..The impact of IL-37 on inflammatory cytokines mediating atherosclerosis is beneficial and protective. However, more studies are needed to better define this mechanism and the safety and tolerability of IL-37. ..
  4. Conti P, Carinci F, Lessiani G, Spinas E, Kritas S, Ronconi G, et al. Potential therapeutic use of IL-37: a key suppressor of innate immunity and allergic immune responses mediated by mast cells. Immunol Res. 2017;65:982-986 pubmed publisher
    ..However, in these studies, the exact mechanism(s) of IL-37-induced anti-inflammatory and anti-allergic activity along with its side effect(s) remain to be determined. ..
  5. Conti P, Carinci F, Caraffa A, Ronconi G, Lessiani G, Theoharides T. Link between mast cells and bacteria: Antimicrobial defense, function and regulation by cytokines. Med Hypotheses. 2017;106:10-14 pubmed publisher
    ..We hope that the understanding of microbial and mast cell interaction leads to more efficient therapeutic development in relation to microbial resistance. ..
  6. Conti P, Caraffa A, Ronconi G, Kritas S, Mastrangelo F, Tettamanti L, et al. Impact of mast cells in mucosal immunity of intestinal inflammation: Inhibitory effect of IL-37. Eur J Pharmacol. 2018;818:294-299 pubmed publisher
    ..These studies contribute to clarify the mechanisms by which MCs profoundly affect immunity and inflammation of the intestine. ..