Luciano Conti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Gene therapy using neural stem cells
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Methods Mol Biol 198:233-44. 2002
  2. ncbi Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture
    Yirui Sun
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Cell Neurosci 38:245-58. 2008
  3. ncbi REST controls self-renewal and tumorigenic competence of human glioblastoma cells
    Luciano Conti
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    PLoS ONE 7:e38486. 2012
  4. ncbi Novel neural stem cell systems
    Luciano Conti
    University of Milano, Department of Pharmacological Sciences and Center for Stem Cell Research, Via Balzaretti 9, 20133 Milano, Italy
    Expert Opin Biol Ther 8:153-60. 2008
  5. ncbi Controlling neural stem cell division within the adult subventricular zone: an APPealing job
    Luciano Conti
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Trends Neurosci 28:57-9. 2005
  6. ncbi Neural stem cell systems: physiological players or in vitro entities?
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, Milan, Italy
    Nat Rev Neurosci 11:176-87. 2010
  7. ncbi Neural stem cells: a pharmacological tool for brain diseases?
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 47:289-97. 2003
  8. ncbi The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1049:39-50. 2005
  9. ncbi An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
    Valentina Lo Sardo
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Nat Neurosci 15:713-21. 2012
  10. ncbi Systematic chromosomal analysis of cultured mouse neural stem cell lines
    Giuseppe R Diaferia
    Department of Functional Biology, BioRep, Milan, Italy
    Stem Cells Dev 20:1411-23. 2011

Collaborators

Detail Information

Publications28

  1. ncbi Gene therapy using neural stem cells
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Methods Mol Biol 198:233-44. 2002
  2. ncbi Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture
    Yirui Sun
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Cell Neurosci 38:245-58. 2008
    ..Human NS cells can be stably transfected to provide reporter lines and readily imaged in live monolayer cultures, creating the potential for high content genetic and chemical screens...
  3. ncbi REST controls self-renewal and tumorigenic competence of human glioblastoma cells
    Luciano Conti
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    PLoS ONE 7:e38486. 2012
    ....
  4. ncbi Novel neural stem cell systems
    Luciano Conti
    University of Milano, Department of Pharmacological Sciences and Center for Stem Cell Research, Via Balzaretti 9, 20133 Milano, Italy
    Expert Opin Biol Ther 8:153-60. 2008
    ....
  5. ncbi Controlling neural stem cell division within the adult subventricular zone: an APPealing job
    Luciano Conti
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Trends Neurosci 28:57-9. 2005
    ..This result opens the hypothesis that changes in the levels of sAPP could influence activity of the neurogenic regions of the adult brain in normal and pathological conditions...
  6. ncbi Neural stem cell systems: physiological players or in vitro entities?
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, Milan, Italy
    Nat Rev Neurosci 11:176-87. 2010
    ..A better understanding of these systems will be crucial to control NSC fate and functional integration following transplantation and to make NSCs suitable for regenerative efforts following injury or disease...
  7. ncbi Neural stem cells: a pharmacological tool for brain diseases?
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 47:289-97. 2003
    ..Here, we will review the recent advancements on the biology of brain stem cells and discuss the mechanisms and drugs regulating adult neurogenesis, aiming at better estimating the possible future applications of NSCs for brain repair...
  8. ncbi The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1049:39-50. 2005
    ....
  9. ncbi An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
    Valentina Lo Sardo
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Nat Neurosci 15:713-21. 2012
    ....
  10. ncbi Systematic chromosomal analysis of cultured mouse neural stem cell lines
    Giuseppe R Diaferia
    Department of Functional Biology, BioRep, Milan, Italy
    Stem Cells Dev 20:1411-23. 2011
    ..Although chromosomal aberrations are known to occur less frequently in human cells, studies performed on murine stem cells provide an important complement to understand the biological events occurring in human lines...
  11. ncbi Neural stem cell systems: diversities and properties after transplantation in animal models of diseases
    Luciano Conti
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Brain Pathol 16:143-54. 2006
    ..Our aim is to review the available information on the grafting of different NSC types into the adult rodent brain, focusing on critical aspects for the development of clinical therapies to replace damaged neurons...
  12. ncbi Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nat Genet 35:76-83. 2003
    ..These data identify a new mechanism by which mutation of huntingtin causes loss of transcription of neuronal genes...
  13. ncbi Novel and immortalization-based protocols for the generation of neural CNS stem cell lines for gene therapy approaches
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Milan, Italy
    Methods Mol Biol 438:319-32. 2008
    ..Furthermore, we describe the use of retroviral particles for genetic engineering...
  14. ncbi mSEL-1L (Suppressor/enhancer Lin12-like) protein levels influence murine neural stem cell self-renewal and lineage commitment
    Marina Cardano
    Doctorate School of Molecular Medicine, Universita degli Studi di Milano, 20100 Milan, Italy
    J Biol Chem 286:18708-19. 2011
    ..The results reported here denote mSEL-1L as a primitive marker with a possible involvement in the regulation of neural progenitor stemness maintenance and lineage determination...
  15. ncbi Neural stem and progenitor cells: choosing the right Shc
    Tiziana Cataudella
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, I-20133 Milan, Italy
    Prog Brain Res 146:127-33. 2004
    ..Here we will discuss values and unsolved aspects of the system and the employment of potentially key molecular targets for proper control of NSCs fate...
  16. ncbi p66(ShcA) adaptor molecule accelerates ES cell neural induction
    Evangelia Papadimou
    Centre for Stem Cell Research and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Mol Cell Neurosci 41:74-84. 2009
    ..Similar effects are obtained in human ES cells over-expressing p66(ShcA). This study reveals a role for p66(ShcA) in the modulation of Wnt/beta-catenin pathway and in ES cell neuralization which is consistent between mouse and human...
  17. ncbi Neural stem cells engrafted in the adult brain fuse with endogenous neurons
    Elisa Brilli
    1 Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Stem Cells Dev 22:538-47. 2013
    ..The frequent and cell type-specific fusion of donor NSCs with host neurons highlights a previously underestimated biological property of the nervous tissue that might prove profitable for basic and therapeutically oriented studies...
  18. ncbi Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments
    Marco Onorati
    Department of Pharmacological Sciences and Center for Stem Cell Research, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy
    Cell Mol Life Sci 68:1769-83. 2011
    ..We also showed that traits of this positional code are maintained during neuronal differentiation, leading to the generation of electrophysiologically active neurons, even if they do not acquire a complete neurochemical identity...
  19. ncbi Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
    Simonetta Sipione
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Hum Mol Genet 11:1953-65. 2002
    ..Interestingly, this study revealed differential expression of a number of genes involved in cholesterol and fatty acid metabolism, suggesting that these metabolic pathways may play a role in HD pathogenesis...
  20. ncbi Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo
    Sara Paina
    Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    J Neurosci 31:2675-87. 2011
    ..Finally, we show that the Dlx-mutant environment is unfavorable for GABA differentiation, in vivo and in vitro. We conclude that Dlx genes favor interneuron differentiation also in a non-cell-autonomous fashion, via expression of Wnt5a...
  21. ncbi Sexual differentiation of the rodent hypothalamus: hormonal and environmental influences
    Paola Negri-Cesi
    Department of Endocrinology, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    J Steroid Biochem Mol Biol 109:294-9. 2008
    ..Some recent data on the influence exerted by PCBs on these metabolic systems are also reported...
  22. ncbi Freshly dissociated fetal neural stem/progenitor cells do not turn into blood
    Lorenzo Magrassi
    Neurochirurgia Dipartimento di Chirurgia, Universita di Pavia, IRCCS Policlinico S 27100, Matteo, Pavia, Italy
    Mol Cell Neurosci 22:179-87. 2003
    ..Our data indicate that ability to transdifferentiate from neural into the hematopoietic phenotype, if present, is acquired only after in vitro expansion of neural stem/progenitor cells and it is not present in vivo...
  23. ncbi Exploitation of adherent neural stem cells in basic and applied neurobiology
    Steven Pollard
    University of Edinburgh, Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Regen Med 1:111-8. 2006
    ..Longer term, NS cells offer an opportunity to rigorously test the efficacy of cell-based therapies and develop strategies for tissue engineering...
  24. ncbi Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    Luciano Conti
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 3:e283. 2005
    ..These homogenous cultures will enable delineation of molecular mechanisms that define a tissue-specific stem cell and allow direct comparison with pluripotent ES cells...
  25. ncbi Adherent neural stem (NS) cells from fetal and adult forebrain
    Steven M Pollard
    Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King s Buildings, Edinburgh EH9 3JQ, UK
    Cereb Cortex 16:i112-20. 2006
    ..We also characterize the growth factor requirements for NS cell derivation and self-renewal. We discuss our current understanding of the relationship of NS cell lines to physiological progenitor cells of fetal and adult CNS...
  26. ncbi Investigating radial glia in vitro
    Steven M Pollard
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Prog Neurobiol 83:53-67. 2007
    ..We discuss how these approaches, together with an ability to expand radial glia-like neural stem (NS) cell lines, may offer unique opportunities in basic and applied neurobiology...
  27. ncbi Shc3 affects human high-grade astrocytomas survival
    Lorenzo Magrassi
    Neurochirurgia, Dipartimento di Chirurgia, Universita di Pavia, IRCCS Policlinico S Matteo, and IGM CNR, P le Golgi 2, Pavia 27100, Italy
    Oncogene 24:5198-206. 2005
    ..These data suggest that Shc molecules play an important role in glioblastoma cell growth and survival...
  28. ncbi Decreased density of peripheral benzodiazepine receptors in psychiatric patients after a suicide attempt
    Donatella Marazziti
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    Life Sci 77:3268-75. 2005
    ....