Antonio Contestabile

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Benefits of caloric restriction on brain aging and related pathological States: understanding mechanisms to devise novel therapies
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 16:350-61. 2009
  2. ncbi request reprint Histone acetylation in neurodevelopment
    Antonio Contestabile
    Department of Pharmacy and Biotechnology, University of Bologna, Italy
    Curr Pharm Des 19:5043-50. 2013
  3. doi request reprint Role of nitric oxide in cerebellar development and function: focus on granule neurons
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Cerebellum 11:50-61. 2012
  4. doi request reprint The history of the cholinergic hypothesis
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Behav Brain Res 221:334-40. 2011
  5. ncbi request reprint Amyotrophic lateral sclerosis: from research to therapeutic attempts and therapeutic perspectives
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 18:5655-65. 2011
  6. ncbi request reprint The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurochem Res 33:318-27. 2008
  7. doi request reprint Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cells
    Antonio Contestabile
    Department of Biology and Interdepartmental Center for the Study of Complex Systems Luigi Galvani, University of Bologna, Via Selmi 3, Bologna, Italy
    Prog Neurobiol 84:317-28. 2008
  8. ncbi request reprint Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40127, Bologna, Italy
    J Cell Sci 117:4727-37. 2004
  9. doi request reprint Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Neurotox Res 17:130-41. 2010
  10. doi request reprint Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity
    Simona Eleuteri
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurotox Res 15:127-32. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Benefits of caloric restriction on brain aging and related pathological States: understanding mechanisms to devise novel therapies
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 16:350-61. 2009
    ....
  2. ncbi request reprint Histone acetylation in neurodevelopment
    Antonio Contestabile
    Department of Pharmacy and Biotechnology, University of Bologna, Italy
    Curr Pharm Des 19:5043-50. 2013
    ..Future steps and goals of research on the role and mechanisms of histone acetylation in neurodevelopment are briefly discussed. ..
  3. doi request reprint Role of nitric oxide in cerebellar development and function: focus on granule neurons
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Cerebellum 11:50-61. 2012
    ....
  4. doi request reprint The history of the cholinergic hypothesis
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Behav Brain Res 221:334-40. 2011
    ..Thus, rather than being consigned to history, the cholinergic hypothesis will likely contribute to further understanding dementia and neurodegenerative diseases and will hopefully be integrated in novel therapies and treatments...
  5. ncbi request reprint Amyotrophic lateral sclerosis: from research to therapeutic attempts and therapeutic perspectives
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 18:5655-65. 2011
    ..Future perspectives related to genetic and stem cell approaches are briefly considered...
  6. ncbi request reprint The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurochem Res 33:318-27. 2008
    ....
  7. doi request reprint Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cells
    Antonio Contestabile
    Department of Biology and Interdepartmental Center for the Study of Complex Systems Luigi Galvani, University of Bologna, Via Selmi 3, Bologna, Italy
    Prog Neurobiol 84:317-28. 2008
    ....
  8. ncbi request reprint Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40127, Bologna, Italy
    J Cell Sci 117:4727-37. 2004
    ....
  9. doi request reprint Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Neurotox Res 17:130-41. 2010
    ..Thus, the ability of VPA to increase histone acetylation is a novel candidate mechanism for its neuroprotective action...
  10. doi request reprint Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity
    Simona Eleuteri
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurotox Res 15:127-32. 2009
    ....
  11. ncbi request reprint Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Hippocampus 15:1041-9. 2005
    ..However, while calcineurin expression decreases in the hippocampus of young adults after learning, no changes are observed in the hippocampus of aged, learning-impaired rats...
  12. ncbi request reprint Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    J Neuroimmunol 172:104-11. 2006
    ....
  13. ncbi request reprint Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy
    J Cell Sci 119:3161-70. 2006
    ..The finding that nitric oxide deprivation during early cerebellar neurogenesis, stimulates a brief increase in cell proliferation may contribute to a better understanding of the controversial role of nitric oxide in brain development...
  14. ncbi request reprint Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice
    Christophe Crochemore
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 46:357-68. 2005
    ..Gestational supplementation of choline, while able to result in long-term enhancement of cholinergic activity, did not improve transgenic mice lifespan nor counteracted cholinergic impairment in brain regions and spinal cord...
  15. ncbi request reprint Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide
    Elisabetta Ciani
    Department of Biology, University of Bologna, Italy
    J Neurochem 82:1282-9. 2002
    ..These results not only confirm the role of CREB in neuronal survival but also provide circumstantial evidence for a novel link among NO, CREB activation and survival...
  16. ncbi request reprint Postnatal neurogenesis in the dentate gyrus of the guinea pig
    Sandra Guidi
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Bologna, Italy
    Hippocampus 15:285-301. 2005
    ..This developmental pattern, resembling the human and nonhuman primate condition, may make the guinea pig a useful rodent model in developmental studies on dentate gyrus neurogenesis...
  17. doi request reprint Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells
    Simona Eleuteri
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurosci Lett 448:74-8. 2008
    ....
  18. ncbi request reprint Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation
    Elisabetta Ciani
    Department of Biology, Luigi Galvani Interdepartmental Center, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    J Biol Chem 277:49896-902. 2002
    ..These experiments indicate that CREB activity is an important step for NO-mediated survival in neuronal cells...
  19. ncbi request reprint In vitro and in vivo toxicity of type 2 ribosome-inactivating proteins lanceolin and stenodactylin on glial and neuronal cells
    Barbara Monti
    Department of Experimental Evolutionary Biology, Alma Mater Studiorum University of Bologna, Via Selmi 3, I 40126 Bologna, Italy
    Neurotoxicology 28:637-44. 2007
    ..The retrograde transport of RIPs along neurons allows to perform experiments of target-selective lesioning, and can be exploited also to perform specific experiments of immunolesioning of selected neuronal populations...
  20. ncbi request reprint Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    Andrea Contestabile
    Department of Human and General Physiology, University of Bologna, Italy
    J Neurochem 97:515-26. 2006
    ....
  21. ncbi request reprint Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    J Neurochem 103:518-30. 2007
    ..These results are relevant to more precisely define the role of alpha-synuclein in neuronal cells and to better understand its putative involvement in neurodegeneration...
  22. doi request reprint Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis
    Cristophe Crochemore
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Muscle Nerve 39:548-52. 2009
    ..We report that long-term dietary supplementation with RA has no effect on the decrease of the cholinergic marker in the spinal cord, but it significantly shortens lifespan of G93A mice...
  23. ncbi request reprint Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurochem Int 44:579-84. 2004
    ..Some age-related alterations in the expression of different subunits of the NMDA-type glutamate receptors in some CNS regions of aged rats were instead, at least in some cases, counteracted by long-term dietary manipulation...
  24. ncbi request reprint Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neurons
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Italy
    Neurotoxicology 26:467-74. 2005
    ..Medical relevance of the data on unique vulnerability of the Hb-IPN connection to nicotine in relation to heavy smoking habits, is briefly discussed...
  25. doi request reprint Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Italy
    J Neurochem 110:545-56. 2009
    ..Our results identify TGF-beta2 as an essential neuroprotective factor released by microglia in its culture medium that requires to be fully effective the concomitant presence of other factor(s) of low molecular weight...
  26. ncbi request reprint Neuron-conditioned media differentially affect the survival of activated or unstimulated microglia: evidence for neuronal control on apoptotic elimination of activated microglia
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Bologna, Italy
    J Neuropathol Exp Neurol 62:351-62. 2003
    ..They also suggest that immature neurons may, on the contrary, favor the survival of microglia during development...
  27. ncbi request reprint Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Mol Pharmacol 2:95-109. 2009
    ..Perspective applications of the VPA neuroprotective potential in human neurodegenerative diseases are discussed, when relevant...
  28. doi request reprint Chronic valproic acid administration impairs contextual memory and dysregulates hippocampal GSK-3β in rats
    Silvia Sintoni
    Department of Pharmacy and Biotechnology, University of Bologna, Italy
    Pharmacol Biochem Behav 106:8-15. 2013
    ..The VPA amnesic effect in the animal model here reported is also supported by some observations in patients and, therefore, it should be taken into account and monitored in VPA-based therapies...
  29. ncbi request reprint NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Eur J Neurosci 16:1490-8. 2002
    ..These results provide good circumstantial evidence for a functional link between the NMDA receptor and CREB activity in promoting neuronal survival during development...
  30. ncbi request reprint Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells
    Elisabetta Ciani
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res Dev Brain Res 142:193-202. 2003
    ..When cerebellar granule cells were exposed to different neurotoxic challenges, Lot1 appeared not affected by purely apoptotic cell death, while transitorily induced by mixed necrotic-apoptotic cell death...
  31. ncbi request reprint Regional and temporal alterations of ODC/polyamine system during ALS-like neurodegenerative motor syndrome in G93A transgenic mice
    Marco Virgili
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 48:201-7. 2006
    ..The present data demonstrate considerable alterations of the ODC/polyamine system in a reliable animal model of ASL, consistent with their role in neurodegeneration and in particular in motor neuron diseases...
  32. ncbi request reprint Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 10:2147-74. 2003
    ..In the final sections, main classes of drugs able to interfere with NO physiopathology are examined, in order to try to devise possible directions for future NO-based therapeutical strategies...
  33. ncbi request reprint Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin
    Antonio Porro
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Pharm Des 16:431-9. 2010
    ..Overall, data reviewed here and novel results presented, unveil a NO-MYCN-ABC transporters axis with important implication on development and control of the chemoresistance phenotype in neuronal tumours...
  34. ncbi request reprint Selective alteration of DNA fragmentation and caspase activity in the spinal cord of aged rats and effect of dietary restriction
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res 992:137-41. 2003
    ..The increase in caspase-1 activation, but not the increased level of DNA fragmentation, was substantially reverted by long-lasting dietary restriction...
  35. ncbi request reprint Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear
    Barbara Monti
    Department of Biology, University of Bologna, Italy
    Neuropsychopharmacology 31:278-86. 2006
    ....
  36. ncbi request reprint Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 45:903-14. 2004
    ..To elucidate these complex, and possibly contrasting, effects of NO is indicated as an important task for future researches...
  37. ncbi request reprint Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity
    Andrea Contestabile
    Department of Human and General Physiology, Bologna, Italy
    Brain Res 1002:162-6. 2004
    ..Analysis of alterations in the expression of relevant genes in different experimental conditions, could help in better understanding these differences...
  38. ncbi request reprint Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones
    Elisabetta Ciani
    Department of Biology, University of Bologna, Italy
    J Neurochem 81:218-28. 2002
    ..These results are the first evidence for a mechanism where endogenous nitric oxide promotes neuronal survival via Akt/GSK-3 pathway...
  39. ncbi request reprint Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin
    Emiliano Peña-Altamira
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Pharm Des 16:440-50. 2010
    ....
  40. ncbi request reprint Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Cerebellum 1:41-55. 2002
    ....
  41. pmc Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes
    Antonio Contestabile
    Department of Pharmacy and Biotechnology, University of Bologna, Italy
    Curr Neuropharmacol 10:303-10. 2012
    ..Aim of the paper is mainly to underline the physiologic aspects of these interactions rather than the pathologic ones...
  42. ncbi request reprint Reciprocal interactions between microglia and neurons: from survival to neuropathology
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Italy
    Rev Neurosci 13:221-42. 2002
    ..This network shares similar features with some fundamental principles governing the activity of brain circuits: it is provided with memory and it continuously evolves in relation to the flow of time and information...
  43. ncbi request reprint Memory-enhancing drugs: a molecular perspective
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Mini Rev Med Chem 9:769-81. 2009
    ..We survey here the state of the art of research and clinical trials on these drugs from cholinesterase inhibitors and drugs acting on neurotransmitter receptors to drugs acting on gene expression...
  44. ncbi request reprint Regional alterations of the NO/NOS system in the aging brain: a biochemical, histochemical and immunochemical study in the rat
    Daniela Necchi
    Department of Animal Biology, University of Pavia, Pavia, Italy
    Brain Res 933:31-41. 2002
    ..Therefore, hypotheses implicating nitric oxide increase in brain aging should be reconsidered on the basis of a clear-cut distinction between the physiological and the pathological aspects of the aging process...