A Contestabile

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice
    Christophe Crochemore
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 46:357-68. 2005
  2. ncbi Activation of the ornithine decarboxylase-polyamine system and induction of c-fos and p53 expression in relation to excitotoxic neuronal apoptosis in normal and microencephalic rats
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Exp Brain Res 120:519-26. 1998
  3. ncbi Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Cerebellum 1:41-55. 2002
  4. ncbi Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 45:903-14. 2004
  5. ncbi Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Top Med Chem 1:553-68. 2001
  6. ncbi Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 10:2147-74. 2003
  7. ncbi Roles of NMDA receptor activity and nitric oxide production in brain development
    A Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res Brain Res Rev 32:476-509. 2000
  8. ncbi Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide
    Elisabetta Ciani
    Department of Biology, University of Bologna, Italy
    J Neurochem 82:1282-9. 2002
  9. ncbi Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy
    J Cell Sci 119:3161-70. 2006
  10. ncbi Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury
    E Ciani
    Department of Biology, University of Bologna, Bologna, Italy
    Brain Res Bull 56:29-35. 2001

Collaborators

  • E Scherini
  • Barbara Monti
  • D Necchi
  • R Bartesaghi
  • F Stirpe
  • Maria Giulia Battelli
  • Elisabetta Ciani
  • Elisabetta Polazzi
  • Simona Eleuteri
  • Emiliano Peña-Altamira
  • M Virgili
  • Antonio Porro
  • Cristophe Crochemore
  • Marco Virgili
  • E Polazzi
  • Sandra Guidi
  • Christophe Crochemore
  • Paolo Petazzi
  • Nunzio Iraci
  • Christophe Chrochemore
  • Giovanni Perini
  • Francesco Cambuli
  • Sara Brignani
  • Barbara Bonamassa
  • Moreno Paolini
  • Chiara Casadio
  • Luis Emiliano Peña Altamira
  • Raffaella Barbaro
  • Donatella Canistro
  • Sabina Severi
  • G Angiolini
  • T Gianni

Detail Information

Publications48

  1. ncbi Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice
    Christophe Crochemore
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 46:357-68. 2005
    ..Gestational supplementation of choline, while able to result in long-term enhancement of cholinergic activity, did not improve transgenic mice lifespan nor counteracted cholinergic impairment in brain regions and spinal cord...
  2. ncbi Activation of the ornithine decarboxylase-polyamine system and induction of c-fos and p53 expression in relation to excitotoxic neuronal apoptosis in normal and microencephalic rats
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Exp Brain Res 120:519-26. 1998
    ..In these rats, therefore, the cellular signalling pathways studied here and related to excitotoxic sensitivity and commitment to cell death are downregulated as a probable consequence of altered brain wiring...
  3. ncbi Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Cerebellum 1:41-55. 2002
    ....
  4. ncbi Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurochem Int 45:903-14. 2004
    ..To elucidate these complex, and possibly contrasting, effects of NO is indicated as an important task for future researches...
  5. ncbi Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives
    A Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Top Med Chem 1:553-68. 2001
    ....
  6. ncbi Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 10:2147-74. 2003
    ..In the final sections, main classes of drugs able to interfere with NO physiopathology are examined, in order to try to devise possible directions for future NO-based therapeutical strategies...
  7. ncbi Roles of NMDA receptor activity and nitric oxide production in brain development
    A Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res Brain Res Rev 32:476-509. 2000
    ..On the basis of the reviewed literature, some of the major controversial issues are addressed and, in some cases, suggestions for possible future experiments are proposed...
  8. ncbi Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxide
    Elisabetta Ciani
    Department of Biology, University of Bologna, Italy
    J Neurochem 82:1282-9. 2002
    ..These results not only confirm the role of CREB in neuronal survival but also provide circumstantial evidence for a novel link among NO, CREB activation and survival...
  9. ncbi Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy
    J Cell Sci 119:3161-70. 2006
    ..The finding that nitric oxide deprivation during early cerebellar neurogenesis, stimulates a brief increase in cell proliferation may contribute to a better understanding of the controversial role of nitric oxide in brain development...
  10. ncbi Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury
    E Ciani
    Department of Biology, University of Bologna, Bologna, Italy
    Brain Res Bull 56:29-35. 2001
    ..In view of the potential therapeutic use of NOS inhibitors, the effects of a too drastic alteration of the balance between neuroprotective and neurodegenerative actions of NO should be carefully considered...
  11. ncbi Topography of neurochemical alterations in the CNS of aged rats
    M Virgili
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Int J Dev Neurosci 19:109-16. 2001
    ..The present results suggest that moderate and region-specific alterations of neurotransmitter-related parameters occur during normal aging and that glia-related markers are fundamentally stable in the absence of specific pathologies...
  12. ncbi Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation
    Elisabetta Ciani
    Department of Biology, Luigi Galvani Interdepartmental Center, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    J Biol Chem 277:49896-902. 2002
    ..These experiments indicate that CREB activity is an important step for NO-mediated survival in neuronal cells...
  13. ncbi NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Eur J Neurosci 16:1490-8. 2002
    ..These results provide good circumstantial evidence for a functional link between the NMDA receptor and CREB activity in promoting neuronal survival during development...
  14. ncbi In vitro and in vivo toxicity of type 2 ribosome-inactivating proteins lanceolin and stenodactylin on glial and neuronal cells
    Barbara Monti
    Department of Experimental Evolutionary Biology, Alma Mater Studiorum University of Bologna, Via Selmi 3, I 40126 Bologna, Italy
    Neurotoxicology 28:637-44. 2007
    ..The retrograde transport of RIPs along neurons allows to perform experiments of target-selective lesioning, and can be exploited also to perform specific experiments of immunolesioning of selected neuronal populations...
  15. ncbi Ricin toxicity to microglial and monocytic cells
    M G Battelli
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, I 40126, Bologna, Italy
    Neurochem Int 39:83-93. 2001
    ....
  16. ncbi Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned medium
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    J Neuroimmunol 172:104-11. 2006
    ....
  17. ncbi Postnatal neurogenesis in the dentate gyrus of the guinea pig
    Sandra Guidi
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Bologna, Italy
    Hippocampus 15:285-301. 2005
    ..This developmental pattern, resembling the human and nonhuman primate condition, may make the guinea pig a useful rodent model in developmental studies on dentate gyrus neurogenesis...
  18. ncbi Neuron-conditioned media differentially affect the survival of activated or unstimulated microglia: evidence for neuronal control on apoptotic elimination of activated microglia
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Bologna, Italy
    J Neuropathol Exp Neurol 62:351-62. 2003
    ..They also suggest that immature neurons may, on the contrary, favor the survival of microglia during development...
  19. ncbi Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulation in the spinal cord of aged rats
    M Virgili
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Neurosci Lett 309:62-6. 2001
    ..A possible role of protein polyamination by transglutaminase is discussed...
  20. ncbi Sex differences in the hippocampal dentate gyrus of the guinea-pig before puberty
    R Bartesaghi
    Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Piazza di Porta San Donato 2, I 40127 Bologna, Italy
    Neuroscience 121:327-39. 2003
    ..These results demonstrate that sex differences are not ubiquitous in the dentate gyrus and suggest that the lower blade, unlike the upper blade, might be involved in non-sexually dimorphic behaviors...
  21. ncbi Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulation
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40127, Bologna, Italy
    J Cell Sci 117:4727-37. 2004
    ....
  22. ncbi Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells
    Elisabetta Ciani
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res Dev Brain Res 142:193-202. 2003
    ..When cerebellar granule cells were exposed to different neurotoxic challenges, Lot1 appeared not affected by purely apoptotic cell death, while transitorily induced by mixed necrotic-apoptotic cell death...
  23. ncbi Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced death
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    J Neurochem 103:518-30. 2007
    ..These results are relevant to more precisely define the role of alpha-synuclein in neuronal cells and to better understand its putative involvement in neurodegeneration...
  24. ncbi The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases
    Antonio Contestabile
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurochem Res 33:318-27. 2008
    ....
  25. doi Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cells
    Antonio Contestabile
    Department of Biology and Interdepartmental Center for the Study of Complex Systems Luigi Galvani, University of Bologna, Via Selmi 3, Bologna, Italy
    Prog Neurobiol 84:317-28. 2008
    ....
  26. doi Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells
    Simona Eleuteri
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Neurosci Lett 448:74-8. 2008
    ....
  27. ncbi Benefits of caloric restriction on brain aging and related pathological States: understanding mechanisms to devise novel therapies
    Antonio Contestabile
    Department of Biology, University of Bologna, Italy
    Curr Med Chem 16:350-61. 2009
    ....
  28. ncbi Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairment
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Hippocampus 15:1041-9. 2005
    ..However, while calcineurin expression decreases in the hippocampus of young adults after learning, no changes are observed in the hippocampus of aged, learning-impaired rats...
  29. ncbi Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulation
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurochem Int 44:579-84. 2004
    ..Some age-related alterations in the expression of different subunits of the NMDA-type glutamate receptors in some CNS regions of aged rats were instead, at least in some cases, counteracted by long-term dietary manipulation...
  30. ncbi Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neurones
    Elisabetta Ciani
    Department of Biology, University of Bologna, Italy
    J Neurochem 81:218-28. 2002
    ..These results are the first evidence for a mechanism where endogenous nitric oxide promotes neuronal survival via Akt/GSK-3 pathway...
  31. ncbi Microglial cells protect cerebellar granule neurons from apoptosis: evidence for reciprocal signaling
    E Polazzi
    Department of Biology, University of Bologna, Bologna, Italy
    Glia 36:271-80. 2001
    ....
  32. ncbi Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neurons
    Elisabetta Ciani
    Department of Human and General Physiology, University of Bologna, Italy
    Neurotoxicology 26:467-74. 2005
    ..Medical relevance of the data on unique vulnerability of the Hb-IPN connection to nicotine in relation to heavy smoking habits, is briefly discussed...
  33. doi Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity
    Simona Eleuteri
    Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
    Neurotox Res 15:127-32. 2009
    ....
  34. ncbi Selective alteration of DNA fragmentation and caspase activity in the spinal cord of aged rats and effect of dietary restriction
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Brain Res 992:137-41. 2003
    ..The increase in caspase-1 activation, but not the increased level of DNA fragmentation, was substantially reverted by long-lasting dietary restriction...
  35. ncbi Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    Andrea Contestabile
    Department of Human and General Physiology, University of Bologna, Italy
    J Neurochem 97:515-26. 2006
    ....
  36. ncbi Characterization of ceramide-induced apoptotic death in cerebellar granule cells in culture
    B Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
    Neurochem Int 39:11-8. 2001
    ....
  37. doi Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
    A Contestabile
    Department of Human and General Physiology, University of Bologna, Bologna, Italy
    Cell Prolif 42:171-81. 2009
    ....
  38. ncbi Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicity
    Andrea Contestabile
    Department of Human and General Physiology, Bologna, Italy
    Brain Res 1002:162-6. 2004
    ..Analysis of alterations in the expression of relevant genes in different experimental conditions, could help in better understanding these differences...
  39. ncbi Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin
    Antonio Porro
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Pharm Des 16:431-9. 2010
    ..Overall, data reviewed here and novel results presented, unveil a NO-MYCN-ABC transporters axis with important implication on development and control of the chemoresistance phenotype in neuronal tumours...
  40. ncbi Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Mol Pharmacol 2:95-109. 2009
    ..Perspective applications of the VPA neuroprotective potential in human neurodegenerative diseases are discussed, when relevant...
  41. doi Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synuclein
    Barbara Monti
    Department of Biology, University of Bologna, Bologna, Italy
    Neurotox Res 17:130-41. 2010
    ..Thus, the ability of VPA to increase histone acetylation is a novel candidate mechanism for its neuroprotective action...
  42. doi Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Italy
    J Neurochem 110:545-56. 2009
    ..Our results identify TGF-beta2 as an essential neuroprotective factor released by microglia in its culture medium that requires to be fully effective the concomitant presence of other factor(s) of low molecular weight...
  43. doi Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis
    Cristophe Crochemore
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Muscle Nerve 39:548-52. 2009
    ..We report that long-term dietary supplementation with RA has no effect on the decrease of the cholinergic marker in the spinal cord, but it significantly shortens lifespan of G93A mice...
  44. ncbi Reciprocal interactions between microglia and neurons: from survival to neuropathology
    Elisabetta Polazzi
    Department of Biology, University of Bologna, Italy
    Rev Neurosci 13:221-42. 2002
    ..This network shares similar features with some fundamental principles governing the activity of brain circuits: it is provided with memory and it continuously evolves in relation to the flow of time and information...
  45. ncbi Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous origin
    Emiliano Peña-Altamira
    Department of Biology, University of Bologna, Bologna, Italy
    Curr Pharm Des 16:440-50. 2010
    ....
  46. ncbi Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fear
    Barbara Monti
    Department of Biology, University of Bologna, Italy
    Neuropsychopharmacology 31:278-86. 2006
    ....
  47. ncbi Memory-enhancing drugs: a molecular perspective
    Barbara Monti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Mini Rev Med Chem 9:769-81. 2009
    ..We survey here the state of the art of research and clinical trials on these drugs from cholinesterase inhibitors and drugs acting on neurotransmitter receptors to drugs acting on gene expression...
  48. ncbi Regional alterations of the NO/NOS system in the aging brain: a biochemical, histochemical and immunochemical study in the rat
    Daniela Necchi
    Department of Animal Biology, University of Pavia, Pavia, Italy
    Brain Res 933:31-41. 2002
    ..Therefore, hypotheses implicating nitric oxide increase in brain aging should be reconsidered on the basis of a clear-cut distinction between the physiological and the pathological aspects of the aging process...