Research Topics
| A ContestabileSummaryAffiliation: University of Bologna Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic miceChristophe Crochemore
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Neurochem Int 46:357-68. 2005..Gestational supplementation of choline, while able to result in long-term enhancement of cholinergic activity, did not improve transgenic mice lifespan nor counteracted cholinergic impairment in brain regions and spinal cord...- Activation of the ornithine decarboxylase-polyamine system and induction of c-fos and p53 expression in relation to excitotoxic neuronal apoptosis in normal and microencephalic ratsA Contestabile
Department of Biology, University of Bologna, Italy
Exp Brain Res 120:519-26. 1998..In these rats, therefore, the cellular signalling pathways studied here and related to excitotoxic sensitivity and commitment to cell death are downregulated as a probable consequence of altered brain wiring... - Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitroAntonio Contestabile
Department of Biology, University of Bologna, Italy
Cerebellum 1:41-55. 2002.... - Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiationAntonio Contestabile
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Neurochem Int 45:903-14. 2004..To elucidate these complex, and possibly contrasting, effects of NO is indicated as an important task for future researches... - Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectivesA Contestabile
Department of Biology, University of Bologna, Italy
Curr Top Med Chem 1:553-68. 2001.... - Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approachesAntonio Contestabile
Department of Biology, University of Bologna, Italy
Curr Med Chem 10:2147-74. 2003..In the final sections, main classes of drugs able to interfere with NO physiopathology are examined, in order to try to devise possible directions for future NO-based therapeutical strategies... - Roles of NMDA receptor activity and nitric oxide production in brain developmentA Contestabile
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Brain Res Brain Res Rev 32:476-509. 2000..On the basis of the reviewed literature, some of the major controversial issues are addressed and, in some cases, suggestions for possible future experiments are proposed... - Nitric oxide regulates cGMP-dependent cAMP-responsive element binding protein phosphorylation and Bcl-2 expression in cerebellar neurons: implication for a survival role of nitric oxideElisabetta Ciani
Department of Biology, University of Bologna, Italy
J Neurochem 82:1282-9. 2002..These results not only confirm the role of CREB in neuronal survival but also provide circumstantial evidence for a novel link among NO, CREB activation and survival... - Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn ratElisabetta Ciani
Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40126 Bologna, Italy
J Cell Sci 119:3161-70. 2006..The finding that nitric oxide deprivation during early cerebellar neurogenesis, stimulates a brief increase in cell proliferation may contribute to a better understanding of the controversial role of nitric oxide in brain development... - Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injuryE Ciani
Department of Biology, University of Bologna, Bologna, Italy
Brain Res Bull 56:29-35. 2001..In view of the potential therapeutic use of NOS inhibitors, the effects of a too drastic alteration of the balance between neuroprotective and neurodegenerative actions of NO should be carefully considered... - Topography of neurochemical alterations in the CNS of aged ratsM Virgili
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Int J Dev Neurosci 19:109-16. 2001..The present results suggest that moderate and region-specific alterations of neurotransmitter-related parameters occur during normal aging and that glia-related markers are fundamentally stable in the absence of specific pathologies... - Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activationElisabetta Ciani
Department of Biology, Luigi Galvani Interdepartmental Center, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
J Biol Chem 277:49896-902. 2002..These experiments indicate that CREB activity is an important step for NO-mediated survival in neuronal cells... - NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro developmentBarbara Monti
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Eur J Neurosci 16:1490-8. 2002..These results provide good circumstantial evidence for a functional link between the NMDA receptor and CREB activity in promoting neuronal survival during development... - In vitro and in vivo toxicity of type 2 ribosome-inactivating proteins lanceolin and stenodactylin on glial and neuronal cellsBarbara Monti
Department of Experimental Evolutionary Biology, Alma Mater Studiorum University of Bologna, Via Selmi 3, I 40126 Bologna, Italy
Neurotoxicology 28:637-44. 2007..The retrograde transport of RIPs along neurons allows to perform experiments of target-selective lesioning, and can be exploited also to perform specific experiments of immunolesioning of selected neuronal populations... - Ricin toxicity to microglial and monocytic cellsM G Battelli
Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, I 40126, Bologna, Italy
Neurochem Int 39:83-93. 2001.... - Overactivation of LPS-stimulated microglial cells by co-cultured neurons or neuron-conditioned mediumElisabetta Polazzi
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
J Neuroimmunol 172:104-11. 2006.... - Postnatal neurogenesis in the dentate gyrus of the guinea pigSandra Guidi
Dipartimento di Fisiologia Umana e Generale, , Bologna, Italy
Hippocampus 15:285-301. 2005..This developmental pattern, resembling the human and nonhuman primate condition, may make the guinea pig a useful rodent model in developmental studies on dentate gyrus neurogenesis... - Neuron-conditioned media differentially affect the survival of activated or unstimulated microglia: evidence for neuronal control on apoptotic elimination of activated microgliaElisabetta Polazzi
Department of Biology, University of Bologna, Bologna, Italy
J Neuropathol Exp Neurol 62:351-62. 2003..They also suggest that immature neurons may, on the contrary, favor the survival of microglia during development... - Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulation in the spinal cord of aged ratsM Virgili
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Neurosci Lett 309:62-6. 2001..A possible role of protein polyamination by transglutaminase is discussed... - Sex differences in the hippocampal dentate gyrus of the guinea-pig before pubertyR Bartesaghi
Dipartimento di Fisiologia Umana e Generale, Universita di Bologna, Piazza di Porta San Donato 2, I 40127 Bologna, Italy
Neuroscience 121:327-39. 2003..These results demonstrate that sex differences are not ubiquitous in the dentate gyrus and suggest that the lower blade, unlike the upper blade, might be involved in non-sexually dimorphic behaviors... - Nitric oxide negatively regulates proliferation and promotes neuronal differentiation through N-Myc downregulationElisabetta Ciani
Department of Human and General Physiology, University of Bologna, Piazza di Porta San Donato 2, 40127, Bologna, Italy
J Cell Sci 117:4727-37. 2004.... - Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cellsElisabetta Ciani
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Brain Res Dev Brain Res 142:193-202. 2003..When cerebellar granule cells were exposed to different neurotoxic challenges, Lot1 appeared not affected by purely apoptotic cell death, while transitorily induced by mixed necrotic-apoptotic cell death... - Alpha-synuclein protects cerebellar granule neurons against 6-hydroxydopamine-induced deathBarbara Monti
Department of Biology, University of Bologna, Bologna, Italy
J Neurochem 103:518-30. 2007..These results are relevant to more precisely define the role of alpha-synuclein in neuronal cells and to better understand its putative involvement in neurodegeneration... - The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseasesAntonio Contestabile
Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
Neurochem Res 33:318-27. 2008.... 
Regulation of transcription factors by nitric oxide in neurons and in neural-derived tumor cellsAntonio Contestabile
Department of Biology and Interdepartmental Center for the Study of Complex Systems Luigi Galvani, University of Bologna, Via Selmi 3, Bologna, Italy
Prog Neurobiol 84:317-28. 2008....- Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cellsSimona Eleuteri
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Neurosci Lett 448:74-8. 2008.... - Benefits of caloric restriction on brain aging and related pathological States: understanding mechanisms to devise novel therapiesAntonio Contestabile
Department of Biology, University of Bologna, Italy
Curr Med Chem 16:350-61. 2009.... - Dysregulation of memory-related proteins in the hippocampus of aged rats and their relation with cognitive impairmentBarbara Monti
Department of Biology, University of Bologna, Bologna, Italy
Hippocampus 15:1041-9. 2005..However, while calcineurin expression decreases in the hippocampus of young adults after learning, no changes are observed in the hippocampus of aged, learning-impaired rats... - Alterations of markers related to synaptic function in aging rat brain, in normal conditions or under conditions of long-term dietary manipulationBarbara Monti
Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
Neurochem Int 44:579-84. 2004..Some age-related alterations in the expression of different subunits of the NMDA-type glutamate receptors in some CNS regions of aged rats were instead, at least in some cases, counteracted by long-term dietary manipulation... - Akt pathway mediates a cGMP-dependent survival role of nitric oxide in cerebellar granule neuronesElisabetta Ciani
Department of Biology, University of Bologna, Italy
J Neurochem 81:218-28. 2002..These results are the first evidence for a mechanism where endogenous nitric oxide promotes neuronal survival via Akt/GSK-3 pathway... - Microglial cells protect cerebellar granule neurons from apoptosis: evidence for reciprocal signalingE Polazzi
Department of Biology, University of Bologna, Bologna, Italy
Glia 36:271-80. 2001.... - Neurochemical correlates of nicotine neurotoxicity on rat habenulo-interpeduncular cholinergic neuronsElisabetta Ciani
Department of Human and General Physiology, University of Bologna, Italy
Neurotoxicology 26:467-74. 2005..Medical relevance of the data on unique vulnerability of the Hb-IPN connection to nicotine in relation to heavy smoking habits, is briefly discussed... - Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicitySimona Eleuteri
Department of Biology, University of Bologna, Via Selmi 3, Bologna 40126, Italy
Neurotox Res 15:127-32. 2009.... - Selective alteration of DNA fragmentation and caspase activity in the spinal cord of aged rats and effect of dietary restrictionBarbara Monti
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Brain Res 992:137-41. 2003..The increase in caspase-1 activation, but not the increased level of DNA fragmentation, was substantially reverted by long-lasting dietary restriction... - Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseasesAndrea Contestabile
Department of Human and General Physiology, University of Bologna, Italy
J Neurochem 97:515-26. 2006.... - Characterization of ceramide-induced apoptotic death in cerebellar granule cells in cultureB Monti
Department of Biology, University of Bologna, Via Selmi 3, 40126, Bologna, Italy
Neurochem Int 39:11-8. 2001.... - Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndromeA Contestabile
Department of Human and General Physiology, University of Bologna, Bologna, Italy
Cell Prolif 42:171-81. 2009.... - Dietary restriction differentially protects from neurodegeneration in animal models of excitotoxicityAndrea Contestabile
Department of Human and General Physiology, Bologna, Italy
Brain Res 1002:162-6. 2004..Analysis of alterations in the expression of relevant genes in different experimental conditions, could help in better understanding these differences... - Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural originAntonio Porro
Department of Biology, University of Bologna, Bologna, Italy
Curr Pharm Des 16:431-9. 2010..Overall, data reviewed here and novel results presented, unveil a NO-MYCN-ABC transporters axis with important implication on development and control of the chemoresistance phenotype in neuronal tumours... - Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotectionBarbara Monti
Department of Biology, University of Bologna, Bologna, Italy
Curr Mol Pharmacol 2:95-109. 2009..Perspective applications of the VPA neuroprotective potential in human neurodegenerative diseases are discussed, when relevant... - Valproic acid is neuroprotective in the rotenone rat model of Parkinson's disease: involvement of alpha-synucleinBarbara Monti
Department of Biology, University of Bologna, Bologna, Italy
Neurotox Res 17:130-41. 2010..Thus, the ability of VPA to increase histone acetylation is a novel candidate mechanism for its neuroprotective action... - Neuroprotection of microglial conditioned medium on 6-hydroxydopamine-induced neuronal death: role of transforming growth factor beta-2Elisabetta Polazzi
Department of Biology, University of Bologna, Italy
J Neurochem 110:545-56. 2009..Our results identify TGF-beta2 as an essential neuroprotective factor released by microglia in its culture medium that requires to be fully effective the concomitant presence of other factor(s) of low molecular weight... - Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosisCristophe Crochemore
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Muscle Nerve 39:548-52. 2009..We report that long-term dietary supplementation with RA has no effect on the decrease of the cholinergic marker in the spinal cord, but it significantly shortens lifespan of G93A mice... - Reciprocal interactions between microglia and neurons: from survival to neuropathologyElisabetta Polazzi
Department of Biology, University of Bologna, Italy
Rev Neurosci 13:221-42. 2002..This network shares similar features with some fundamental principles governing the activity of brain circuits: it is provided with memory and it continuously evolves in relation to the flow of time and information... - Nitric oxide control of proliferation in nerve cells and in tumor cells of nervous originEmiliano Peña-Altamira
Department of Biology, University of Bologna, Bologna, Italy
Curr Pharm Des 16:440-50. 2010.... - Subchronic rolipram delivery activates hippocampal CREB and arc, enhances retention and slows down extinction of conditioned fearBarbara Monti
Department of Biology, University of Bologna, Italy
Neuropsychopharmacology 31:278-86. 2006.... - Memory-enhancing drugs: a molecular perspectiveBarbara Monti
Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
Mini Rev Med Chem 9:769-81. 2009..We survey here the state of the art of research and clinical trials on these drugs from cholinesterase inhibitors and drugs acting on neurotransmitter receptors to drugs acting on gene expression... - Regional alterations of the NO/NOS system in the aging brain: a biochemical, histochemical and immunochemical study in the ratDaniela Necchi
Department of Animal Biology, University of Pavia, Pavia, Italy
Brain Res 933:31-41. 2002..Therefore, hypotheses implicating nitric oxide increase in brain aging should be reconsidered on the basis of a clear-cut distinction between the physiological and the pathological aspects of the aging process...