Agostino Consoli

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi Thiazolidinediones and inflammation
    A Consoli
    Department of Medicine and Aging Sciences, University of Chieti, Italy
    Lupus 14:794-7. 2005
  2. ncbi [Intensive glucose control in type 2 diabetes: is it harmful, needless or maybe useful in reducing cardiovascular risk?]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti
    G Ital Cardiol (Rome) 11:7S-11S. 2010
  3. pmc Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects
    Gloria Formoso
    Department of Medicine and Aging, G D Annunzio University, Chieti Pescara, Italy
    PLoS ONE 7:e52774. 2012
  4. doi [Towards evidence-based medicine: large-scale intervention trials with glucagon-like peptide-1 receptor agonists]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti
    G Ital Cardiol (Rome) 13:17S-22S. 2012
  5. doi [Protective effects of glucagon-like peptide-1 on beta-cells: preclinical and clinical data]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universit√° egli Studi G d Annunzio, Chieti
    G Ital Cardiol (Rome) 12:5-9. 2011
  6. ncbi G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    Massimo Federici
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti, Italy
    Circulation 109:399-405. 2004
  7. doi The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells
    Gloria Formoso
    Department of Medicine and Aging Sciences, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti Pescara, Italy
    Cardiovasc Res 89:184-92. 2011
  8. ncbi Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells
    Assunta Pandolfi
    Department of Biomorphology, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Chieti Pescara, Italy
    J Cell Physiol 213:699-709. 2007
  9. ncbi TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells
    Francesco Andreozzi
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini 1, 66100 Chieti, Italy
    Arterioscler Thromb Vasc Biol 28:1355-60. 2008
  10. ncbi Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects
    Gloria Formoso
    Department of Medicine and Aging Sciences, University G D Annunzio, Chieti, Italy
    Diabetes Metab Res Rev 24:231-7. 2008

Collaborators

Detail Information

Publications28

  1. ncbi Thiazolidinediones and inflammation
    A Consoli
    Department of Medicine and Aging Sciences, University of Chieti, Italy
    Lupus 14:794-7. 2005
    ..TZDs might thus be considered for use in clinical trials targeting prevention of atherosclerosis and cardiovascular diseases and in pilot trials exploring the possibility that TZDs might help in the treatment of rheumatic diseases...
  2. ncbi [Intensive glucose control in type 2 diabetes: is it harmful, needless or maybe useful in reducing cardiovascular risk?]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti
    G Ital Cardiol (Rome) 11:7S-11S. 2010
    ..Such trials should entail the use of the newer anti-diabetes agents which are not exposing the patients to the risk of hypoglycemia and weight gain...
  3. pmc Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects
    Gloria Formoso
    Department of Medicine and Aging, G D Annunzio University, Chieti Pescara, Italy
    PLoS ONE 7:e52774. 2012
    ....
  4. doi [Towards evidence-based medicine: large-scale intervention trials with glucagon-like peptide-1 receptor agonists]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti
    G Ital Cardiol (Rome) 13:17S-22S. 2012
    ..The design of such ongoing trials is described in this article...
  5. doi [Protective effects of glucagon-like peptide-1 on beta-cells: preclinical and clinical data]
    Agostino Consoli
    Dipartimento di Medicina Interna e Scienze dell Invecchiamento, Universit√° egli Studi G d Annunzio, Chieti
    G Ital Cardiol (Rome) 12:5-9. 2011
    ....
  6. ncbi G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    Massimo Federici
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti, Italy
    Circulation 109:399-405. 2004
    ....
  7. doi The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells
    Gloria Formoso
    Department of Medicine and Aging Sciences, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti Pescara, Italy
    Cardiovasc Res 89:184-92. 2011
    ..We wanted to replicate this latter association and, if so, to get deeper insights about the molecular mechanisms underlying the role of the TRIB3 Q84R polymorphism in atherosclerosis...
  8. ncbi Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells
    Assunta Pandolfi
    Department of Biomorphology, University G D Annunzio, Aging Research Center, Ce S I, G d Annunzio University Foundation, Chieti Pescara, Italy
    J Cell Physiol 213:699-709. 2007
    ..Thus, intervention targeting ESRD-RBC increased adhesion to endothelium and/or MAPK and Akt/eNOS pathways may have the potential to prevent vascular lesions under uremic conditions...
  9. ncbi TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells
    Francesco Andreozzi
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini 1, 66100 Chieti, Italy
    Arterioscler Thromb Vasc Biol 28:1355-60. 2008
    ..We have recently described a Q84R gain-of-function polymorphism of TRIB3 with the R84 variant being associated with insulin resistance and an earlier age at myocardial infarction...
  10. ncbi Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects
    Gloria Formoso
    Department of Medicine and Aging Sciences, University G D Annunzio, Chieti, Italy
    Diabetes Metab Res Rev 24:231-7. 2008
    ..Since oxidative stress and the consequent enhanced platelet activation contribute to accelerated atherosclerosis in diabetes, we hypothesized that metformin could reduce oxidative stress in this condition...
  11. ncbi Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) regulates endothelial nitric oxide synthase (eNOS) activity and its localization within the human vein endothelial cells (HUVEC) in culture
    Roberta Di Pietro
    Department of Biomorphology, G D Annunzio University, Chieti Pescara, Italy
    J Cell Biochem 97:782-94. 2006
    ....
  12. ncbi Selective insulin resistance affecting nitric oxide release but not plasminogen activator inhibitor-1 synthesis in fibroblasts from insulin-resistant individuals
    Assunta Pandolfi
    Aging Research Center, Ce S I, Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    Arterioscler Thromb Vasc Biol 25:2392-7. 2005
    ..Aim of this study was to investigate whether insulin effects on potentially pro-atherogenic and anti-atherogenic processes were differently affected in cells from insulin-resistant individuals...
  13. ncbi Adherence of uremic erythrocytes to vascular endothelium decreases endothelial nitric oxide synthase expression
    Mario Bonomini
    Department of Medicine, Institute of Nephrology, University G D Annunzio, Chieti Pescara, Italy
    Kidney Int 67:1899-906. 2005
    ..Since nitric oxide (NO) is the principal endothelium-derived vasodilator, a reduction in the NO bioavailability may be envisaged in ESRD patients...
  14. doi Effect of an L-carnitine-containing peritoneal dialysate on insulin sensitivity in patients treated with CAPD: a 4-month, prospective, multicenter randomized trial
    Mario Bonomini
    Department of Medicine, Institute of Nephrology, G D Annunzio University, Chieti Pescara, Italy Electronic address
    Am J Kidney Dis 62:929-38. 2013
    ..We evaluate the efficacy of a peritoneal dialysis solution containing l-carnitine as an additive to improve insulin sensitivity...
  15. ncbi Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus
    Francesca Santilli
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    J Am Coll Cardiol 47:391-7. 2006
    ....
  16. doi Postprandial hyperglycemia is a determinant of platelet activation in early type 2 diabetes mellitus
    F Santilli
    Centre of Excellence on Aging, G d Annunzio University Foundation, Chieti, Italy
    J Thromb Haemost 8:828-37. 2010
    ..Chronic hyperglycemia is a major contributor to in vivo platelet activation in diabetes mellitus...
  17. ncbi Initiating oral glucose-lowering therapy with metformin in type 2 diabetic patients: an evidence-based strategy to reduce the burden of late-developing diabetes complications
    A Consoli
    Department of Internal Medicine and Science of Aging, University G D Annunzio, Chieti, Italy
    Diabetes Metab 30:509-16. 2004
    ..Other national and local guideline committees should consider updating their recommendations on diabetes management in line with these findings...
  18. ncbi Plasminogen activator inhibitor type 1 is increased in the arterial wall of type II diabetic subjects
    A Pandolfi
    Dipartimento di Medicina e Scienze dell' Invecchiamento, , Chieti, Italy
    Arterioscler Thromb Vasc Biol 21:1378-82. 2001
    ..These data provide evidence that diabetes is associated with increased PAI-1 in the arterial wall. This might be an important factor for increased cardiovascular risk and unfavorable plaque evolution in diabetes...
  19. ncbi Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat
    A Pandolfi
    Department of Medicine and Aging Science, University of Chieti, Italy
    Acta Diabetol 38:71-6. 2001
    ..001) clamps. These data show that in vivo both acute hyperglycemia and acute hyperinsulinemia can decrease plasma fibrinolytic potential and that this is due to increased plasma PAI-1 and decreased free t-PA activities...
  20. doi Insulin resistance affects gene expression in endothelium
    Claudia Consoli
    Arterioscler Thromb Vasc Biol 28:e7-9. 2008
  21. ncbi Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus
    Elena De Filippis
    Center for Metabolic Biology, Arizona State University, 350 East Orange Street, P O Box 873704, Tempe, Arizona 85287 3704, USA
    J Clin Endocrinol Metab 91:4903-10. 2006
    ....
  22. ncbi Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium
    Gloria Formoso
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Building 10, Room 6C 205, 10 Center Drive MSC 1632, Bethesda, Maryland 20892 1632, USA
    Mol Endocrinol 20:1153-63. 2006
    ..Altering the balance between PI 3-kinase- and MAPK-dependent signaling in vascular endothelium may determine whether DHEA has beneficial or harmful effects relevant to the pathophysiology of diabetes...
  23. ncbi Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals
    Masafumi Matsuda
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 78229, USA
    Metabolism 51:1111-9. 2002
    ..The late (120 to 240 minutes) stimulation of hepatic glucose output (which primarily reflects gluconeogenesis) by glucagon tends to be increased, especially at supraphysiologic plasma glucagon concentrations...
  24. ncbi Phenotype modulation in cultures of vascular smooth muscle cells from diabetic rats: association with increased nitric oxide synthase expression and superoxide anion generation
    Assunta Pandolfi
    Dipartimento di Biomorfologia, Universita di Chieti, Italy
    J Cell Physiol 196:378-85. 2003
    ....
  25. ncbi Effects of multiple daily injection therapy with Humalog mixtures versus separately injected insulin lispro and NPH insulin in adults with type I diabetes mellitus
    Paris Roach
    Department of Medicine, Indiana University School of Medicine, 545 Barnhill Drive, EH 421, Indianapolis, IN 46202, USA
    Clin Ther 26:502-10. 2004
    ..When used in a similar fashion, premixed, fixed-ratio insulin preparations containing LP and NPL (an LP-based intermediate-acting insulin) may provide the basis for an optimized basal-bolus insulin regimen...
  26. ncbi Soluble RAGE in type 2 diabetes: association with oxidative stress
    Eleonora Devangelio
    Center of Excellence on Aging and Departments of Medicine and Drug Sciences, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, 66013 Chieti, Italy
    Free Radic Biol Med 43:511-8. 2007
    ..0001). Thus, poor glycemic control reduces sRAGE levels, in association with enhanced oxidative stress and endothelial dysfunction in diabetes. These abnormalities are susceptible to modulation by improvement in metabolic control...
  27. doi The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis
    Augusto Di Castelnuovo
    Laboratory of Genetic and Environmental Epidemiology, Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Thromb Haemost 99:594-601. 2008
    ....
  28. pmc An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction
    Paola Secchiero
    Department of Morphology and Embryology, University of Ferrara, Italy
    Am J Pathol 169:2236-44. 2006
    ..Altogether, these findings suggest that increased OPG production represents an early event in the natural history of diabetes mellitus, possibly contributing to disease-associated endothelial cell dysfunction...