M Comporti

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi Oxidative stress, isoprostanes and hepatic fibrosis
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Italy
    Histol Histopathol 24:893-900. 2009
  2. ncbi Isoprostanes and hepatic fibrosis
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy
    Mol Aspects Med 29:43-9. 2008
  3. ncbi F2-isoprostanes are not just markers of oxidative stress
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine, and Public Health, University of Siena, 53100 Siena, Italy
    Free Radic Biol Med 44:247-56. 2008
  4. ncbi F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Lab Invest 85:1381-91. 2005
  5. ncbi Plasma F2-isoprostanes are elevated in newborns and inversely correlated to gestational age
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine, and Public Health, University of Siena, 53100 Siena, Italy
    Free Radic Biol Med 37:724-32. 2004
  6. ncbi Iron release, oxidative stress and erythrocyte ageing
    Mario Comporti
    Department of Pathophysiology and Experimental Medicine, University of Siena, Siena, Italy
    Free Radic Biol Med 32:568-76. 2002
  7. ncbi Introduction-serial review: iron and cellular redox status
    Mario Comporti
    Dept. of Pathophysiology and Experimental Medicine, University of Siena, Siena, Italy
    Free Radic Biol Med 32:565-7. 2002
  8. ncbi Plasma esterified F2-isoprostanes and oxidative stress in newborns: role of nonprotein-bound iron
    Cinzia Signorini
    Departments of Pathophysiology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy
    Pediatr Res 63:287-91. 2008
  9. ncbi Iron release, membrane protein oxidation and erythrocyte ageing
    C Signorini
    Institute of General Pathology, University of Siena, Italy
    FEBS Lett 362:165-70. 1995
  10. ncbi Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin
    Cinzia Signorini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    J Pineal Res 46:148-54. 2009

Collaborators

  • Concetta Gardi
  • G Buonocore
  • Cinzia Signorini
  • M Ferrali
  • W Balduini
  • Gianluca Giorgi
  • Luis A Videla
  • Ramón Rodrigo
  • Lucia Ciccoli
  • Silvia Leoncini
  • Viviana Rossi
  • Silvia Dominici
  • Lisa Pieri
  • Alfonso Pompella
  • Aldo Paolicchi
  • Alejandra Elizondo
  • Patrizia Paffetti
  • Emilia Maellaro
  • Italo Tanganelli
  • Attila Csendes
  • Fernando Maluenda
  • Jaime Poniachik
  • Cristiana Sgherri
  • Julia Araya
  • Juan C Diaz
  • Donatella Tanganelli
  • Julian Blanco-Garcia
  • Carlo Aldinucci
  • Evelina Lorenzini
  • Barbara Del Bello
  • Giorgio Minotti
  • Rodolfo Bracci
  • Marta A Valentini
  • Athanase Visvikis
  • G Lungarella
  • A Benedetti
  • M M de Santi

Detail Information

Publications22

  1. ncbi Oxidative stress, isoprostanes and hepatic fibrosis
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Italy
    Histol Histopathol 24:893-900. 2009
    ..Immunocytochemical studies showed the major localization of TxA2r in the perinuclear site and its colocalization with alpha-smooth muscle actin...
  2. ncbi Isoprostanes and hepatic fibrosis
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy
    Mol Aspects Med 29:43-9. 2008
    ..The data suggest the possibility that F(2)-isoprostanes generated by lipid peroxidation in hepatocytes mediate hepatic stellate cell proliferation and collagen hyperproduction seen in hepatic fibrosis...
  3. ncbi F2-isoprostanes are not just markers of oxidative stress
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine, and Public Health, University of Siena, 53100 Siena, Italy
    Free Radic Biol Med 44:247-56. 2008
    ..Therefore F(2)-IsoPs generated by lipid peroxidation in hepatocytes may mediate hepatic stellate cell proliferation and collagen hyperproduction seen in hepatic fibrosis...
  4. ncbi F2-isoprostanes stimulate collagen synthesis in activated hepatic stellate cells: a link with liver fibrosis?
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Lab Invest 85:1381-91. 2005
    ..The data provide evidence for the possibility that F2-isoprostanes generated by lipid peroxidation in hepatocytes mediate HSC proliferation and collagen production seen in hepatic fibrosis...
  5. ncbi Plasma F2-isoprostanes are elevated in newborns and inversely correlated to gestational age
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine, and Public Health, University of Siena, 53100 Siena, Italy
    Free Radic Biol Med 37:724-32. 2004
    ..The marked increase in plasma isoprostanes suggests that oxidative stress is a feature of the physiopathological changes seen in the perinatal period...
  6. ncbi Iron release, oxidative stress and erythrocyte ageing
    Mario Comporti
    Department of Pathophysiology and Experimental Medicine, University of Siena, Siena, Italy
    Free Radic Biol Med 32:568-76. 2002
    ..In newborns the release of iron in erythrocytes is correlated with plasma nonprotein-bound iron and may contribute to its appearance...
  7. ncbi Introduction-serial review: iron and cellular redox status
    Mario Comporti
    Dept. of Pathophysiology and Experimental Medicine, University of Siena, Siena, Italy
    Free Radic Biol Med 32:565-7. 2002
  8. ncbi Plasma esterified F2-isoprostanes and oxidative stress in newborns: role of nonprotein-bound iron
    Cinzia Signorini
    Departments of Pathophysiology, Experimental Medicine and Public Health, University of Siena, 53100 Siena, Italy
    Pediatr Res 63:287-91. 2008
    ..NPBI-induced oxidative stress may contribute to the morbidity in preterm infants that are particularly susceptible to free radical damage...
  9. ncbi Iron release, membrane protein oxidation and erythrocyte ageing
    C Signorini
    Institute of General Pathology, University of Siena, Italy
    FEBS Lett 362:165-70. 1995
    ..The addition of ferrozine during the aerobic incubation prevented both the IgG binding and the protein alterations seen in the IR spectra, suggesting an intracellular chelation of the released iron by ferrozine...
  10. ncbi Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin
    Cinzia Signorini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    J Pineal Res 46:148-54. 2009
    ..These data show the important neuroprotective role of melatonin in reducing oxidative damage resulting from HI. Melatonin could represent a potential safe approach to perinatal brain damage in humans...
  11. ncbi Oxidative stress, erythrocyte ageing and plasma non-protein-bound iron in diabetic patients
    Silvia Leoncini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Free Radic Res 42:716-24. 2008
    ....
  12. ncbi F2-isoprostane receptors on hepatic stellate cells
    Concetta Gardi
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Siena, Italy
    Lab Invest 88:124-31. 2008
    ..14+/-1.9 x 10(-6) M and K(i)=1.15+/-0.3 x 10(-9) M, respectively), suggesting the involvement of a modified form of isoprostane receptor, homologous to the classic thromboxane A2-binding site in F2-isoprostanes-evoked responses on HSC...
  13. ncbi Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells
    Concetta Gardi
    Department of Pathophysiology and Experimental Medicine, University of Siena, Via Aldo Moro, I 53100 Siena, Italy
    Biochem Pharmacol 64:1139-45. 2002
    ....
  14. ncbi Iron release in erythrocytes and plasma non protein-bound iron in hypoxic and non hypoxic newborns
    Lucia Ciccoli
    Department of Pathophysiology and Experimental Medicine, University of Siena, Siena, Italy
    Free Radic Res 37:51-8. 2003
    ..NPBI was correlated with iron release seen in all the newborns and a significant part of the released iron could be recovered into the incubation medium at the end of the incubation...
  15. ncbi Oxidative stress and autologous immunoglobulin G binding to band 3 dimers in newborn erythrocytes
    Viviana Rossi
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Italy
    Free Radic Biol Med 40:907-15. 2006
    ..In conclusion dimers of band 3 with autologous IgG are found under conditions in which OS can be detected in erythrocytes or in plasma: namely in newborns or in aged erythrocytes...
  16. ncbi Iron release, superoxide production and binding of autologous IgG to band 3 dimers in newborn and adult erythrocytes exposed to hypoxia and hypoxia-reoxygenation
    Lucia Ciccoli
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Biochim Biophys Acta 1672:203-13. 2004
    ....
  17. ncbi Bromotrichloromethane-induced damage to bronchiolar Clara cells
    G Lungarella
    Institute of General Pathology, University of Siena, Italy
    Res Commun Chem Pathol Pharmacol 57:213-28. 1987
    ..The data obtained strongly support that BrCCl3 is highly metabolized in bronchiolar Clara cells...
  18. ncbi Ion trap tandem mass spectrometric determination of F2-isoprostanes
    Cinzia Signorini
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Mass Spectrom 38:1067-74. 2003
    ..This method is highly selective and sensitive and it has been successfully applied to biological samples...
  19. ncbi Polyunsaturated fatty acid pattern in liver and erythrocyte phospholipids from obese patients
    Alejandra Elizondo
    Department of Nutrition, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 15:24-31. 2007
    ....
  20. ncbi Gamma-glutamyltransferase-dependent prooxidant reactions: a factor in multiple processes
    Silvia Dominici
    Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy
    Biofactors 17:187-98. 2003
  21. ncbi Redox modulation of NF-kappaB nuclear translocation and DNA binding in metastatic melanoma. The role of endogenous and gamma-glutamyl transferase-dependent oxidative stress
    Silvia Dominici
    Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy
    Tumori 89:426-33. 2003
    ....
  22. ncbi Redox modulation of protein kinase/phosphatase balance in melanoma cells: the role of endogenous and gamma-glutamyltransferase-dependent H2O2 production
    Lisa Pieri
    Dip. di Patologia Sperimentale and B.M.I.E, Sez Pathologia Generale and Clinica, Scuola Medica, , Via Roma 55, 56126, Pisa, Italy
    Biochim Biophys Acta 1621:76-83. 2003
    ....