P M Comoglio

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth
    P M Comoglio
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Candiolo, 10060, Italy
    Exp Cell Res 253:88-99. 1999
  2. pmc Invasive growth: from development to metastasis
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo Torino, Italy
    J Clin Invest 109:857-62. 2002
  3. ncbi request reprint Scatter factors and invasive growth
    P M Comoglio
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, Str Provinciale 142, Km 3 95, Candiolo TO, 10060, Italy
    Semin Cancer Biol 11:153-65. 2001
  4. pmc Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
    A Bardelli
    Institute for Cancer Research and Treatment, University of Torino, School of Medicine 10060, Candiolo, Italy
    Proc Natl Acad Sci U S A 95:14379-83. 1998
  5. ncbi request reprint HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
    L Trusolino
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 14:1629-40. 2000
  6. ncbi request reprint Cross-talk between the proto-oncogenes Met and Ron
    A Follenzi
    Institute for Cancer Research and Treatment IRCC, University of Torino, School of Medicine 10060, Candiolo, Italy
    Oncogene 19:3041-9. 2000
  7. ncbi request reprint Interactions between scatter factors and their receptors: hints for therapeutic applications
    L Trusolino
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, University of Torino School of Medicine, 10060 Candiolo, Torino
    FASEB J 12:1267-80. 1998
  8. pmc A point mutation in the MET oncogene abrogates metastasis without affecting transformation
    S Giordano
    Institute for Cancer Research, University of Torino Medical School, Strada Provinciale 142, Km 3 95, 10060 Candiolo, Italy
    Proc Natl Acad Sci U S A 94:13868-72. 1997
  9. ncbi request reprint Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
    C Boccaccio
    Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
    Nature 391:285-8. 1998
  10. ncbi request reprint A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth
    P M Comoglio
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Candiolo, 10060, Italy
    Exp Cell Res 253:88-99. 1999
    ..Deregulated activation of PRGF or semaphorin ligands or receptors, by mutation or overexpression, confers to cancer cells invasive and metastatic properties...
  2. pmc Invasive growth: from development to metastasis
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo Torino, Italy
    J Clin Invest 109:857-62. 2002
  3. ncbi request reprint Scatter factors and invasive growth
    P M Comoglio
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, Str Provinciale 142, Km 3 95, Candiolo TO, 10060, Italy
    Semin Cancer Biol 11:153-65. 2001
    ..Here we discuss how alterations of these receptors or of their signal transduction pathways are responsible for cancer onset and progression towards metastasis...
  4. pmc Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth
    A Bardelli
    Institute for Cancer Research and Treatment, University of Torino, School of Medicine 10060, Candiolo, Italy
    Proc Natl Acad Sci U S A 95:14379-83. 1998
    ....
  5. ncbi request reprint HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
    L Trusolino
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 14:1629-40. 2000
    ..These data suggest that HGF/SF promotes cell adhesion and invasiveness by increasing the avidity of integrins for their specific ligands...
  6. ncbi request reprint Cross-talk between the proto-oncogenes Met and Ron
    A Follenzi
    Institute for Cancer Research and Treatment IRCC, University of Torino, School of Medicine 10060, Candiolo, Italy
    Oncogene 19:3041-9. 2000
    ..These data show that, while specific for their ligands, scatter factor receptors cross-talk and cooperate in intracellular signaling...
  7. ncbi request reprint Interactions between scatter factors and their receptors: hints for therapeutic applications
    L Trusolino
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, University of Torino School of Medicine, 10060 Candiolo, Torino
    FASEB J 12:1267-80. 1998
    ..This review is focused on how, and to what extent, scatter factors can behave 'well' or 'badly' according to their molecular structure, the way they are activated, and the way they interact with cell surface receptors and coreceptors...
  8. pmc A point mutation in the MET oncogene abrogates metastasis without affecting transformation
    S Giordano
    Institute for Cancer Research, University of Torino Medical School, Strada Provinciale 142, Km 3 95, 10060 Candiolo, Italy
    Proc Natl Acad Sci U S A 94:13868-72. 1997
    ....
  9. ncbi request reprint Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
    C Boccaccio
    Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
    Nature 391:285-8. 1998
    ..Activation of signal transducers that directly control transcription is therefore required for morphogenesis...
  10. ncbi request reprint A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001
    ..Such findings invoke an unexpected role for alpha6beta4 in cancer invasion as a functional amplifier of biochemical outputs rather than a mechanical adhesive device...
  11. ncbi request reprint Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility
    D Barberis
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    FASEB J 18:592-4. 2004
    ..We conclude that plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension...
  12. doi request reprint Met-driven invasive growth involves transcriptional regulation of Arhgap12
    A Gentile
    Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Turin Medical School, Turin, Italy
    Oncogene 27:5590-8. 2008
    ..Consistently, Arhgap12 silencing by RNA interference selectively increased the scatter and adhesion responses. These data show that HGF-driven invasive growth involves transcriptional regulation of a Rac1-specific GAP...
  13. ncbi request reprint Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor
    S Grisendi
    Institute for Cancer Research and Treatment, University of Turin 10060, Candiolo, Italy
    J Biol Chem 276:46632-8. 2001
    ..Significantly, nonphosphorylated HGF receptor prevents FAP68 from stimulating p70S6K. These data suggest a role for FAP68 in coupling HGF receptor signaling to the p70S6K pathway...
  14. pmc Macrophage stimulating protein is a novel neurotrophic factor
    M C Stella
    Institute for Cancer Research and Treatment, IRCC, University of Torino Medical School, 10060 Candiolo, Torino, Italy
    Mol Biol Cell 12:1341-52. 2001
    ..Together, these data suggest that MSP is a novel neurotrophic factor for cranial motoneurons and, by regulating the production of NO, may have a role in brain plasticity and regeneration...
  15. ncbi request reprint Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF
    M Prat
    Institute for Cancer Research IRCC, University of Torino, Medical School, Candiolo, Italy
    J Cell Sci 111:237-47. 1998
    ..Since simple receptor dimerization is not sufficient to trigger full biological responses, we propose that the region on the ss chain of the receptor recognized by the full agonist mAb is crucial for optimal receptor activation...
  16. ncbi request reprint Silencing the MET oncogene leads to regression of experimental tumors and metastases
    S Corso
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Oncogene 27:684-93. 2008
    ..Notably, silencing MET in already established metastases led to their almost complete regression. This indicates that persistent expression of the MET oncogene is mandatory until the advanced phases of cancer progression...
  17. ncbi request reprint A gene trap vector system for identifying transcriptionally responsive genes
    E Medico
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Italy
    Nat Biotechnol 19:579-82. 2001
    ..The flexibility and efficiency of the GFNR-based trap screening procedure make it suitable for wide surveys of transcriptionally regulated genes...
  18. ncbi request reprint Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth
    E Medico
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo To, Italy
    Cancer Res 61:5861-8. 2001
    ....
  19. doi request reprint Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer
    S Gastaldi
    Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Oncogene 32:1428-40. 2013
    ....
  20. ncbi request reprint HGF: a multifunctional growth factor controlling cell scattering
    M C Stella
    Institute for Cancer Research I R C C, University of Torino Medical School, Candiolo, Torino, Italy
    Int J Biochem Cell Biol 31:1357-62. 1999
    ..The role of HGF as putative therapeutical agent in pathologies characterized by massive cell loss or deregulated cell proliferation is under investigation...
  21. ncbi request reprint Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis
    P Gual
    Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, Str Prov 142, Km 3 95, 10060 Candiolo, Italy
    Oncogene 19:1509-18. 2000
    ..It is concluded that sustained recruitment of PLCgamma to Gab1 plays an important role in branching tubulogenesis...
  22. ncbi request reprint Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
    L Tamagnone
    Institute for Cancer Research and Treatment, University of Torino, Candiolo, Italy
    Cell 99:71-80. 1999
    ..We conclude that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion...
  23. pmc A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype
    C Collesi
    Institute for Cancer Research, University of Turin Medical School, Italy
    Mol Cell Biol 16:5518-26. 1996
    ..These data (i) provide a novel molecular mechanism for posttranscriptional activation of a tyrosine kinase receptor protein and (ii) suggest a role for the Ron receptor in progression toward malignancy...
  24. ncbi request reprint Staging of head and neck squamous cell carcinoma using the MET oncogene product as marker of tumor cells in lymph node metastases
    G Cortesina
    Department of Clinical Physiopathology, University of Torino School of Medicine, Torino, Italy
    Int J Cancer 89:286-92. 2000
    ..After RT-PCR analysis we were able to attribute a more advanced stage to 10 out of 20 HNSCC cases, including 5 cases classified as tumor-free after routine histopathology...
  25. ncbi request reprint Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene
    P Longati
    Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
    Curr Drug Targets 2:41-55. 2001
    ..By using the MET oncogene as a model this review focuses on the strategies that can be applied to therapeutically target RTKs...
  26. ncbi request reprint "Invasive-growth" signaling by the Met/HGF receptor: the hereditary renal carcinoma connection
    A Bardelli
    Institute for Cancer Research IRCC, University of Torino Medical School, Candiolo, Turin, Italy
    Biochim Biophys Acta 1333:M41-51. 1997
  27. ncbi request reprint Apoptosis enhancement by the HIV-1 Nef protein
    A Rasola
    Division of Molecular Oncology, Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
    J Immunol 166:81-8. 2001
    ..These data show that Nef enhances programmed cell death in different cell types by affecting multiple critical components of the apoptotic machinery independently from the Fas pathway...
  28. pmc HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death
    A Bardelli
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    EMBO J 15:6205-12. 1996
    ..The finding of a link between growth factor receptors and the anti-apoptotic machinery fills a gap in the understanding of the molecular events regulating programmed cell death...
  29. ncbi request reprint The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues
    G Gaudino
    Institute for Cancer Research I R C C, University of Torino School of Medicine, Italy
    Oncogene 11:2627-37. 1995
    ..These findings show that the Ron receptor and its ligand are involved in the development of epithelial tissues, bones, and neuroendocrine derivatives driving cells towards the proliferation program...
  30. ncbi request reprint A functional role for hemostasis in early cancer development
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
    Cancer Res 65:8579-82. 2005
    ..These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis...
  31. ncbi request reprint p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling
    Davide Barberis
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino 10060, Italy
    J Cell Sci 118:4689-700. 2005
    ..We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins...
  32. ncbi request reprint Cancer therapy: can the challenge be MET?
    Simona Corso
    IRCC, Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, 10060 Candiolo, Turin, Italy
    Trends Mol Med 11:284-92. 2005
    ..Interfering with Met activation is thus a new and challenging approach to hamper tumorigenic and metastatic processes...
  33. pmc Negative feedback regulation of Met-dependent invasive growth by Notch
    M Cristina Stella
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, IV Floor, Str Prov 142, km 3, 95, 10060 Candiolo, Torino, Italy
    Mol Cell Biol 25:3982-96. 2005
    ..These results unravel an in-built mechanism of negative feedback regulation in which Met activation leads to transcriptional induction of Notch function, which in turn limits HGF activity through repression of the Met oncogene...
  34. ncbi request reprint The MET oncogene drives a genetic programme linking cancer to haemostasis
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str Prov 142, I 10060 Candiolo, Torino, Italy
    Nature 434:396-400. 2005
    ..In vivo analysis showed that both proteins support the thrombohaemorrhagic phenotype, thus providing direct genetic evidence for the long-sought-after link between oncogene activation and haemostasis...
  35. ncbi request reprint Invasive growth: a two-way street for semaphorin signalling
    Paolo M Comoglio
    Nat Cell Biol 6:1155-7. 2004
  36. ncbi request reprint Invasive growth: a genetic program
    Alessandra Gentile
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    Int J Dev Biol 48:451-6. 2004
    ..Here we discuss the different biological facets of invasive growth and analyze the intracellular signals which lead to its execution...
  37. pmc An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
    Massimiliano Mazzone
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    J Clin Invest 114:1418-32. 2004
    ..These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions...
  38. pmc Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    Annalisa Petrelli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, 10060 Candiolo, Italy
    Proc Natl Acad Sci U S A 103:5090-5. 2006
    ..Interestingly, the "decoy effect" generated by the shed ectodomain, acting as a dominant negative molecule, enhanced the inhibitory effect of the Ab...
  39. ncbi request reprint Invasive growth: a MET-driven genetic programme for cancer and stem cells
    Carla Boccaccio
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Nat Rev Cancer 6:637-45. 2006
    ....
  40. ncbi request reprint The Met pathway: master switch and drug target in cancer progression
    Massimiliano Mazzone
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, Strada Provinciale 142, Km 3 95, I 10060 Candiolo Torino, Italy
    FASEB J 20:1611-21. 2006
    ..As we suggest possible directions for drug development, we propose the receptor for the hepatocyte growth factor, Met, as an ideal target for tackling cancer progression...
  41. ncbi request reprint The MET receptor tyrosine kinase in invasion and metastasis
    Silvia Benvenuti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo Torino, Italy
    J Cell Physiol 213:316-25. 2007
    ..Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON...
  42. doi request reprint The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
    ..Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met...
  43. pmc The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment
    Charlotte Rolny
    Institute for Cancer Research and Treatment IRCC, University of Turin, School of Medicine, 10060 Candiolo, Italy
    J Exp Med 205:1155-71. 2008
    ..In conclusion, we report that SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion and recruitment of macrophages coupled to the suppression of tumor growth...
  44. pmc A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
    Cristina Basilico
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, I 10060 Candiolo, Turin, Italy
    J Biol Chem 283:21267-77. 2008
    ..Although the IPT-HGF-alpha interaction provides binding strength, the Sema-HGF-beta contact confers selective sensitivity to the active form of the ligand...
  45. doi request reprint Metron factor-1 prevents liver injury without promoting tumor growth and metastasis
    Terumi Takahara
    Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Hepatology 47:2010-25. 2008
    ....
  46. doi request reprint Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008
    ..Here we discuss recent progress in the development of molecules that inhibit MET function and consider their application in a subset of human tumours that are potentially responsive to MET-targeted therapies...
  47. ncbi request reprint Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression
    Chiara Bardella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo, Turin, Italy
    Cancer Res 64:5154-61. 2004
    ..Altogether, these data show that expression of a naturally occurring, constitutively active truncated RON kinase results in loss of epithelial phenotype and aggressive behavior and, thus, it might contribute to tumor progression...
  48. ncbi request reprint Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion
    Annalisa Lorenzato
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, Torino, Italy
    Cancer Res 62:7025-30. 2002
    ..These data suggest that MET might be one of the long sought oncogenes controlling progression of primary cancers to metastasis...
  49. ncbi request reprint Functional regulation of semaphorin receptors by proprotein convertases
    Stefania Artigiani
    Institute for Cancer Research and Treatment IRCC, University of Torino School of Medicine, 10060 Candiolo, Italy
    J Biol Chem 278:10094-101. 2003
    ..Thus, we conclude that cleavage by proprotein convertases is a novel regulatory step for semaphorin receptors localized at the cell surface...
  50. ncbi request reprint Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    Livio Trusolino
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    Nat Rev Cancer 2:289-300. 2002
    ..What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?..
  51. ncbi request reprint Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
    ..These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer...
  52. ncbi request reprint Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity
    Federica Chiara
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    J Biol Chem 278:29352-8. 2003
    ..This explains why mutant met provides an oncogenic predisposition but needs a second activating "hit," provided by sustained ligand stimulation or receptor overexpression, to achieve a fully transformed phenotype...
  53. ncbi request reprint An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
    Paolo Michieli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    Nat Biotechnol 20:488-95. 2002
    ..In an in vivo murine model of drug-induced nephrotoxicity, intravenous injection of recombinant Metron factor 1 prevented renal damage and preserved tubular integrity...
  54. ncbi request reprint The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
    Piera Maggiora
    Laboratory of Cancer Genetics of the Institute for Cancer Research and Treatment, University of Torino School of Medicine, SP 142, Km 3 95, 10060 Candiolo Torino, Italy
    Exp Cell Res 288:382-9. 2003
    ..These data suggest that coexpression of the MET and RON receptors confer a selective advantage to ovarian cancer cells and might promote ovarian cancer progression...
  55. ncbi request reprint The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
    Annalisa Petrelli
    CNR CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy
    Nature 416:187-90. 2002
    ..These data provide further evidence of a relationship between receptor-mediated signalling and endocytosis, and disclose a novel functional role for Cbl in HGF receptor signalling...
  56. ncbi request reprint Interactions between growth factor receptors and adhesion molecules: breaking the rules
    Paolo M Comoglio
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
    Curr Opin Cell Biol 15:565-71. 2003
    ....
  57. ncbi request reprint Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
    Paolo Michieli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo Torino, Italy
    Cancer Cell 6:61-73. 2004
    ....
  58. pmc Plexin-B3 is a functional receptor for semaphorin 5A
    Stefania Artigiani
    Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo To, Italy
    EMBO Rep 5:710-4. 2004
    ..We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3...
  59. ncbi request reprint Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
    Oliver M Fischer
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 279:28970-8. 2004
    ....
  60. pmc To move or not to move? Semaphorin signalling in cell migration
    Luca Tamagnone
    Institute for Cancer Research and Treatment, University of Turin Medical School IRCC, SP 142, 10060 Candiolo, Turin, Italy
    EMBO Rep 5:356-61. 2004
    ..This review focuses on the mechanisms whereby semaphorins are thought to regulate cell migration...
  61. ncbi request reprint A differentiation switch for genetically modified hepatocytes
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 16:120-2. 2002
    ....
  62. ncbi request reprint Tyrosine kinase signal specificity: lessons from the HGF receptor
    Andrea Bertotti
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060, Candiolo Torino, Italy
    Trends Biochem Sci 28:527-33. 2003
    ..This suggests that integration of cell-restricted expression of receptor partners that modulate kinase outputs with the intrinsic signalling features of receptors is required for specification of biological responses...
  63. ncbi request reprint Hepatocyte growth factor and its receptor are required for malaria infection
    Margarida Carrolo
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Nat Med 9:1363-9. 2003
    ..Our findings identify HGF and MET as potential targets for new approaches to malaria prevention...
  64. ncbi request reprint The semaphorin 4D receptor controls invasive growth by coupling with Met
    Silvia Giordano
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    Nat Cell Biol 4:720-4. 2002
    ..This work identifies a novel biological function of semaphorins and suggests the involvement of an unexpected signalling mechanism, namely, the coupling of a plexin to a tyrosine kinase receptor...
  65. ncbi request reprint Feline STK gene expression in mammary carcinomas
    Raffaella De Maria
    Comparative Oncology Center, Institute for Cancer Research and Treatment, University of Torino, SP 142, Km 3 95, 10060 Candiolo Torino Italy
    Oncogene 21:1785-90. 2002
    ....
  66. pmc Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    J Cell Biol 175:993-1003. 2006
    ..These results unravel a novel pathway whereby beta4 directs tyrosine kinase-based signals toward adhesion-unrelated outcomes...
  67. ncbi request reprint MET overexpression turns human primary osteoblasts into osteosarcomas
    Salvatore Patanè
    Laboratory of Cancer Genetics, University of Turin School of Medicine, Candiolo Turin, Italy
    Cancer Res 66:4750-7. 2006
    ..These data show that MET overexpression is oncogenic and that it is essential for the maintenance of the cancer phenotype...
  68. ncbi request reprint p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis
    Nadia Coltella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Italy
    Int J Cancer 118:2981-90. 2006
    ..Therefore, the p38 MAPK pathway might be a suitable target to improve response to conventional chemotherapy in human ovarian cancer...
  69. ncbi request reprint Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino School of Medicine, Candiolo Torino, Italy
    Cancer Res 65:10674-9. 2005
    ....
  70. ncbi request reprint Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin
    Andrea Rasola
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Res 64:1744-50. 2004
    ..This suggests that HGF may be used to improve response to chemotherapy in a set of human ovarian carcinomas molecularly classified based on the MET oncogene expression...
  71. ncbi request reprint Cancer: the matrix is now in control
    Paolo M Comoglio
    Nat Med 11:1156-9. 2005