Silvia Colucci

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts
    Graziana Colaianni
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Biochem Biophys Res Commun 411:512-5. 2011
  2. ncbi request reprint Human osteoclasts express oxytocin receptor
    Silvia Colucci
    Department of Human Anatomy and Histology, University of Bari, Policlinico P zza G Cesare 11, Bari 70 124, Italy
    Biochem Biophys Res Commun 297:442-5. 2002
  3. ncbi request reprint The role of OPG/TRAIL complex in multiple myeloma: the OPG/TRAIL complex in an in vitro osteoclastogenesis model derived from human multiple myeloma-bone disease
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Ann N Y Acad Sci 1068:334-40. 2006
  4. doi request reprint The formation of osteoclasts in multiple myeloma bone disease patients involves the secretion of soluble decoy receptor 3
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1192:298-302. 2010
  5. ncbi request reprint TRAIL effect on osteoclast formation in physiological and pathological conditions
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Front Biosci (Elite Ed) 3:1154-61. 2011
  6. ncbi request reprint TRAIL is involved in human osteoclast apoptosis
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Medical School, Bari, Italy
    Ann N Y Acad Sci 1116:316-22. 2007
  7. doi request reprint Sclerostin is overexpressed by plasma cells from multiple myeloma patients
    Giacomina Brunetti
    Department of Basic Medical Science, Section of Human Anatomy and Histology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1237:19-23. 2011
  8. pmc Oxytocin is an anabolic bone hormone
    Roberto Tamma
    Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 106:7149-54. 2009
  9. pmc Osteoclastogenic potential of peripheral blood mononuclear cells in cleidocranial dysplasia
    Maria Felicia Faienza
    1 Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University of Bari, Bari, Italy
    Int J Med Sci 11:356-64. 2014
  10. pmc Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
    Roberto Tamma
    Department of Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 110:18644-9. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts
    Graziana Colaianni
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Biochem Biophys Res Commun 411:512-5. 2011
    ..We surmise that there is a local feed-forward loop in bone marrow through which the OT so produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action...
  2. ncbi request reprint Human osteoclasts express oxytocin receptor
    Silvia Colucci
    Department of Human Anatomy and Histology, University of Bari, Policlinico P zza G Cesare 11, Bari 70 124, Italy
    Biochem Biophys Res Commun 297:442-5. 2002
    ..We also show that the receptor is functional, as OT treatment induces an increase of [Ca(2+)](i), and that the hormone may affect osteoclastogenesis, since it increases the number of pre-osteoclasts...
  3. ncbi request reprint The role of OPG/TRAIL complex in multiple myeloma: the OPG/TRAIL complex in an in vitro osteoclastogenesis model derived from human multiple myeloma-bone disease
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Ann N Y Acad Sci 1068:334-40. 2006
    ..Our results highlight that MM T cells support OC formation and survival, possibly involving OPG/TRAIL interaction...
  4. doi request reprint The formation of osteoclasts in multiple myeloma bone disease patients involves the secretion of soluble decoy receptor 3
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1192:298-302. 2010
    ..We also show that serum DcR3 levels in myeloma patients are significantly higher compared to controls...
  5. ncbi request reprint TRAIL effect on osteoclast formation in physiological and pathological conditions
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Front Biosci (Elite Ed) 3:1154-61. 2011
    ..Finally, we detect high TRAIL levels in the sera from the patients. In conclusion, our results indicate that TRAIL could exert a different role in modulating OC differentiation in physiological and pathological conditions...
  6. ncbi request reprint TRAIL is involved in human osteoclast apoptosis
    Giacomina Brunetti
    Department of Human Anatomy and Histology, University of Bari, Medical School, Bari, Italy
    Ann N Y Acad Sci 1116:316-22. 2007
    ..We also demonstrated that the death receptor DR5, upregulated by TRAIL, could be the mediator of TRAIL-induced OC apoptosis...
  7. doi request reprint Sclerostin is overexpressed by plasma cells from multiple myeloma patients
    Giacomina Brunetti
    Department of Basic Medical Science, Section of Human Anatomy and Histology, University of Bari, Bari, Italy
    Ann N Y Acad Sci 1237:19-23. 2011
    ..Thus, our data indicate that MM cells, as a sclerostin source in the BM, could create a microenvironment with high sclerostin concentration that could contribute toward inhibiting osteoblast differentiation...
  8. pmc Oxytocin is an anabolic bone hormone
    Roberto Tamma
    Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 106:7149-54. 2009
    ..Together, the complementary genetic and pharmacologic approaches reveal OT as a novel anabolic regulator of bone mass, with potential implications for osteoporosis therapy...
  9. pmc Osteoclastogenic potential of peripheral blood mononuclear cells in cleidocranial dysplasia
    Maria Felicia Faienza
    1 Department of Biomedical Sciences and Human Oncology, Section of Pediatrics, University of Bari, Bari, Italy
    Int J Med Sci 11:356-64. 2014
    ..09) in the patient. In conclusions, our findings suggest that the heterozygous deletion of RUNX2 in this CCD patient did not alter the osteoclastogenic potential of PBMCs in vitro. ..
  10. pmc Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
    Roberto Tamma
    Department of Histology, University of Bari, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 110:18644-9. 2013
    ..Collectively, the data not only establish a primary role for Avp signaling in bone mass regulation, but also call for further studies on the skeletal actions of Avpr inhibitors used commonly in hyponatremic patients. ..
  11. pmc Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency
    Annamaria Ventura
    Department of Biomedical Sciences and Human Oncology, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    Biomed Res Int 2013:250462. 2013
    ..In this paper, we focus on the physiology and biosynthesis of endogenous steroid hormones as well as on the effects of GCs on bone cells, highlighting the pathogenetic mechanism of GIO in children with 21-OHD...
  12. ncbi request reprint The death receptor DR5 is involved in TRAIL-mediated human osteoclast apoptosis
    Silvia Colucci
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Bari 70124, Italy
    Apoptosis 12:1623-32. 2007
    ..Furthermore, the intracellular pathway induced by TRAIL in OCs involves caspase-8 and Bid activation. In conclusion, our data highlight an important role for the TRAIL/TRAIL receptor system in the regulation of OC apoptosis...
  13. ncbi request reprint Genotype-phenotype correlation in juvenile Paget disease: role of molecular alterations of the TNFRSF11B gene
    Giacomina Brunetti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari, Bari, Italy
    Endocrine 42:266-71. 2012
    ..This review describes the different clinical features which are characteristic of JPD and the correspondence with the different molecular alterations of the TNFRSN11B gene...
  14. ncbi request reprint Microgravity during spaceflight directly affects in vitro osteoclastogenesis and bone resorption
    Roberto Tamma
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza G Cesare 11, I 70124 Bari, Italy
    FASEB J 23:2549-54. 2009
    ..These results indicate for the first time osteoclasts and their precursors as direct targets for microgravity and mechanical forces...
  15. doi request reprint Osteoclastogenesis in children with 21-hydroxylase deficiency on long-term glucocorticoid therapy: the role of receptor activator of nuclear factor-kappaB ligand/osteoprotegerin imbalance
    Maria Felicia Faienza
    Department of Biomedicine of Developmental Age, University of Bari, Bari, Italy, Piazza G Cesare, 11, 70100 Bari, Italy
    J Clin Endocrinol Metab 94:2269-76. 2009
    ..cGC therapy is the most frequent and severe form of drug-induced osteoporosis, and different mechanisms have been proposed to explain its pathogenesis...
  16. pmc Periodontal disease: linking the primary inflammation to bone loss
    Adriana Di Benedetto
    Department of Basic Medical Sciences, Neurosciences and Sense organs, Section of Human Anatomy and Histology R Amprino, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Clin Dev Immunol 2013:503754. 2013
    ..In the present review, we summarize host factors including cell populations, cytokines, and mechanisms involved in the destruction of the supporting tissues of the tooth and discuss treatment perspectives based on this knowledge...
  17. doi request reprint Osteoblasts display different responsiveness to TRAIL-induced apoptosis during their differentiation process
    Giacomina Brunetti
    Section of Human Anatomy and Histology R Amprino, Department of Basic Medical Sciences, Neuroscience and Sense Organs, Medical School, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
    Cell Biochem Biophys 67:1127-36. 2013
    ..This study suggests that apoptotic effect exerted by TRAIL/TRAIL-receptor system on normal human OB is strictly dependent upon cell differentiation status. ..
  18. pmc FSH and TSH in the regulation of bone mass: the pituitary/immune/bone axis
    Graziana Colaianni
    Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, University of Bari, Bari, Italy
    Clin Dev Immunol 2013:382698. 2013
    ....
  19. ncbi request reprint T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction
    Silvia Colucci
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Blood 104:3722-30. 2004
    ..Our results highlight that MM T cells support OC formation and survival, possibly involving OPG/TRAIL interaction and unbalanced OC expression of TRAIL death and decoy receptors...
  20. ncbi request reprint Gelatinase levels in male and female breast cancer
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, Medical School, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    Biochem Biophys Res Commun 292:161-6. 2002
    ..In conclusion, the increased expression of gelatinases in male breast cancer patients together with anatomical features might explain the high tendency toward metastasis and the worse prognosis...
  21. ncbi request reprint A new titanium biofunctionalized interface based on poly(pyrrole-3-acetic acid) coating: proliferation of osteoblast-like cells and future perspectives
    Elvira De Giglio
    Dipartimento di Chimica, Universita degli Studi di Bari, Via E Orabona 4, 70126, Bari, Italy
    J Mater Sci Mater Med 18:1781-9. 2007
    ..Successively, the availability and reactivity of surface carboxylic groups were tested through the grafting of an aminoacidic residue to PPy-3-acetic films...
  22. pmc Transforming growth factor-beta1 triggers hepatocellular carcinoma invasiveness via alpha3beta1 integrin
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Bari, Italy
    Am J Pathol 161:183-93. 2002
    ..In conclusion, TGF-beta1 may play an important role in HCC invasiveness by stimulating alpha3-integrin expression, and could therefore be an important target for new therapies...
  23. ncbi request reprint Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts
    Roberta Faccio
    Department of Human Anatomy and Histology, University of Bari, Italy
    J Cell Sci 115:2919-29. 2002
    ..The capacity of growth factors to alter the affinity of alpha(v)beta(3) toward its ligands offers a potential explanation for the diverse responses of osteoclasts to the same ligand...
  24. ncbi request reprint Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    Nicola Giuliani
    Laboratory of Hematology, Hematology and Bone Marrow Transplantation BMT Center, Department of Internal Medicine and Biomedical Science, University of Parma, Parma, Italy
    Blood 106:2472-83. 2005
    ....
  25. ncbi request reprint Gorham-Stout syndrome: a monocyte-mediated cytokine propelled disease
    Silvia Colucci
    Istituto di Anatomia Umana Normale, Universita di Bari, Bari, Italy
    J Bone Miner Res 21:207-18. 2006
    ..We found that these cells belonged to a monocytic lineage with some characteristics of immature osteoclasts and were able to release large amounts of osteoclastogenic and angiogenic molecules that may contribute to disease progression...
  26. ncbi request reprint Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects
    Addolorata Corrado
    Chair of Rheumatology, University of Foggia, D Avanzo Hospital, Via Ascoli, 71100, Foggia, Italy
    Clin Rheumatol 24:527-34. 2005
    ..These results confirm the validity of using neridronate at doses usually administered in treating osteoporosis, and they suggest using it to treat other diseases which show an altered osteoblast metabolism, such as osteoarthritis...
  27. ncbi request reprint Osteocalcin synthesis by human osteoblasts from normal and osteoarthritic bone after vitamin D3 stimulation
    Francesco Paolo Cantatore
    D Avanzo Hospital, Chair of Rheumatology, University of Foggia, Via Ascoli, 71100 Foggia, Italy
    Clin Rheumatol 23:490-5. 2004
    ....
  28. ncbi request reprint Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement
    Ilaria Roato
    Center for Experimental Research and Medical Studies, University and A S O San Giovanni Battista, Turin, Italy
    FASEB J 19:228-30. 2005
    ..A neutralizing anti-TNF-alpha antibody in unstimulated PBMC cultures of osteolytic cancer patients induces an inhibition of osteoclastogenesis. These data suggest that TNF-alpha may be responsible for osteoclastogenesis in these tumors...
  29. ncbi request reprint Increased osteoclast activity in the presence of increased homocysteine concentrations
    Markus Herrmann
    Abteilung für Klinische Chemie und Laboratoriumsmedizin Zentrallabor and Klinik für Innere Medizin I, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Clin Chem 51:2348-53. 2005
    ..Increased plasma homocysteine (HCY) may be an independent risk factor for osteoporotic fractures and therefore may also adversely affect bone metabolism. We analyzed the effect of HCY on human osteoclast (OC) activity...
  30. ncbi request reprint Synovial fluid fibroblasts and lymphocytes support the osteoclastogenesis in human psoriatic arthritis
    Giorgio Mori
    Department of Biomedical Science, University of Foggia, Italy
    Ann N Y Acad Sci 1117:159-64. 2007
    ..Thus, T cells and fibroblasts from synovial fluid through the production of osteoclastogenic cytokines could support the OC formation in PsA patients...