M Colucci

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi Prevention and therapy of experimental venous thrombosis in rabbits by desmin 370
    M Colucci
    Department of Biomedical Sciences and Human Oncology, University of Bari, Italy
    Thromb Haemost 80:338-41. 1998
  2. ncbi Skin extracts from 2 Italian table grapes (Italia and Palieri) inhibit tissue factor expression by human blood mononuclear cells
    Rosa Anna Milella
    Research Unit for Grape and Wine Growing in the Mediterranean Environment, CRA UTV Agricultural Research Council, Turi, Bari, Italy
    J Food Sci 77:H154-9. 2012
  3. ncbi Evidence that fibrinolytic changes in paediatric obesity translate into a hypofibrinolytic state: relative contribution of TAFI and PAI-1
    Fabrizio Semeraro
    Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione di Patologia Generale e Sperimentale, Bari, Italy
    Thromb Haemost 108:311-7. 2012
  4. ncbi Thrombin activatable fibrinolysis inhibitor: at the nexus of fibrinolysis and inflammation
    Mario Colucci
    Department of Biomedical Sciences and Human Oncology Section of General and Experimental Pathology, University Aldo Moro, Bari, Italy
    Thromb Res 129:314-9. 2012
  5. ncbi Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    Hepatology 38:230-7. 2003
  6. ncbi Changes in coagulation-fibrinolysis balance in blood mononuclear cells and in gastric mucosa from patients with Helicobacter pylori infection
    M Colucci
    Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari, Piazza G Cesare, 11 I 70124 Bari, Italy
    Thromb Res 116:471-7. 2005
  7. ncbi An antifibrinolytic effect associated with an anti-factor V antibody in a patient with severe thrombophilia
    Mario Colucci
    Department of Biomedical Sciences, University of Bari, Italy
    Haematologica 88:1383-9. 2003
  8. ncbi Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
    Blood 103:2157-61. 2004
  9. ncbi Mild hyperhomocysteinemia is associated with increased TAFI levels and reduced plasma fibrinolytic potential
    M Colucci
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Bari, Italy
    J Thromb Haemost 6:1571-7. 2008
  10. ncbi Effect of heparin on TAFI-dependent inhibition of fibrinolysis: relative importance of TAFIa generated by clot-bound and fluid phase thrombin
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    Thromb Haemost 88:282-7. 2002

Collaborators

Detail Information

Publications27

  1. ncbi Prevention and therapy of experimental venous thrombosis in rabbits by desmin 370
    M Colucci
    Department of Biomedical Sciences and Human Oncology, University of Bari, Italy
    Thromb Haemost 80:338-41. 1998
    ..Our present data extend previous results on the therapeutic efficacy of D370 and underscore its potential as an alternative antithrombotic drug...
  2. ncbi Skin extracts from 2 Italian table grapes (Italia and Palieri) inhibit tissue factor expression by human blood mononuclear cells
    Rosa Anna Milella
    Research Unit for Grape and Wine Growing in the Mediterranean Environment, CRA UTV Agricultural Research Council, Turi, Bari, Italy
    J Food Sci 77:H154-9. 2012
    ..The simplicity of the method makes it suitable also for screening purposes in large-scale studies...
  3. ncbi Evidence that fibrinolytic changes in paediatric obesity translate into a hypofibrinolytic state: relative contribution of TAFI and PAI-1
    Fabrizio Semeraro
    Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione di Patologia Generale e Sperimentale, Bari, Italy
    Thromb Haemost 108:311-7. 2012
    ..These data indicate that paediatric obesity is associated with a hypofibrinolytic state which might contribute to the increased thrombotic risk associated with this condition...
  4. ncbi Thrombin activatable fibrinolysis inhibitor: at the nexus of fibrinolysis and inflammation
    Mario Colucci
    Department of Biomedical Sciences and Human Oncology Section of General and Experimental Pathology, University Aldo Moro, Bari, Italy
    Thromb Res 129:314-9. 2012
    ..Finally, the numerous clinical studies in patients with thrombotic disease support the idea that increased levels of TAFI and/or the enhancement of TAFI activation may represent a new risk factor for venous and arterial thrombosis...
  5. ncbi Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    Hepatology 38:230-7. 2003
    ..Impairment of the antifibrinolytic TAFI pathway might contribute to bleeding associated with this disease...
  6. ncbi Changes in coagulation-fibrinolysis balance in blood mononuclear cells and in gastric mucosa from patients with Helicobacter pylori infection
    M Colucci
    Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari, Piazza G Cesare, 11 I 70124 Bari, Italy
    Thromb Res 116:471-7. 2005
    ..In this study we investigated the procoagulant-fibrinolytic potential of blood MNC in patients with H. pylori infection. In the same patients we also evaluated the coagulation-fibrinolysis profile in gastric tissue and in plasma...
  7. ncbi An antifibrinolytic effect associated with an anti-factor V antibody in a patient with severe thrombophilia
    Mario Colucci
    Department of Biomedical Sciences, University of Bari, Italy
    Haematologica 88:1383-9. 2003
    ..Since activated protein C (APC) is also profibrinolytic we wanted to determine whether the presence of antibodies interfering with the anticoagulant activity of APC also inhibits its profibrinolytic effect...
  8. ncbi Hyperprothrombinemia associated with prothrombin G20210A mutation inhibits plasma fibrinolysis through a TAFI-mediated mechanism
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
    Blood 103:2157-61. 2004
    ..These findings provide a new mechanism that might contribute to the thrombotic risk in prothrombin 20210A carriers...
  9. ncbi Mild hyperhomocysteinemia is associated with increased TAFI levels and reduced plasma fibrinolytic potential
    M Colucci
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Bari, Italy
    J Thromb Haemost 6:1571-7. 2008
    ..Mild hyperhomocysteinemia (HHcy) has been shown to be associated with impaired fibrinolysis, but some aspects of this association are unclear...
  10. ncbi Effect of heparin on TAFI-dependent inhibition of fibrinolysis: relative importance of TAFIa generated by clot-bound and fluid phase thrombin
    Mario Colucci
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    Thromb Haemost 88:282-7. 2002
    ..Moreover, they suggest that clot-bound thrombin plays a major role in TAFI-mediated inhibition of fibrinolysis through "localized" TAFIa generation...
  11. ncbi Monocytes, but not endothelial cells, downregulate the anticoagulant activity of activated protein C
    M Colucci
    Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari, Italy
    Br J Haematol 112:519-26. 2001
    ..These strengthen the importance of monocytes in fibrin deposition associated with pathological conditions characterized by monocyte recruitment and activation...
  12. ncbi The role of thrombin activatable fibrinolysis inhibitor and factor XI in platelet-mediated fibrinolysis resistance: a thromboelastographic study in whole blood
    C Carrieri
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, Aldo Moro University, Bari, Italy
    J Thromb Haemost 9:154-62. 2011
    ..The role of TAFI in platelet-mediated resistance to lysis is unclear. Objective: We investigated the contribution of TAFI to the antifibrinolytic effect of platelets in whole blood by thromboelastography...
  13. ncbi Dabigatran enhances clot susceptibility to fibrinolysis by mechanisms dependent on and independent of thrombin-activatable fibrinolysis inhibitor
    C T Ammollo
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Bari, Italy
    J Thromb Haemost 8:790-8. 2010
    ..However, the efficiency of anticoagulants may vary remarkably, and the ability of direct thrombin inhibitors to facilitate clot lysis remains controversial...
  14. ncbi Thrombin activatable fibrinolysis inhibitor (TAFI) does not inhibit in vitro thrombolysis by pharmacological concentrations of t-PA
    M Colucci
    Department of Biomedical Sciences, University of Bari, Italy
    Thromb Haemost 85:661-6. 2001
    ..Our data indicate that, under our experimental conditions, clot lysis by pharmacological concentrations of t-PA is not influenced by TAFIa even after maximal activation of this procarboxy-peptidase...
  15. ncbi Hyperprothrombinaemia-induced APC resistance: differential influence on fibrin formation and fibrinolysis
    Bianca M Binetti
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Italy
    Thromb Haemost 95:606-11. 2006
    ..These data might help to better understand the relationship between thrombin formation and fibrinolysis down-regulation...
  16. ncbi Profibrinolytic activity of the direct thrombin inhibitor melagatran and unfractionated heparin in platelet-poor and platelet-rich clots
    Fabrizio Semeraro
    Department of Biomedical Sciences and Human Oncology, Section of General, Experimental and Clinical Pathology, University of Bari, Policlinico Piazza G Cesare 11, 70124 Bari, Italy
    Thromb Haemost 98:1208-14. 2007
    ..Altogether these data indicate that melagatran is more efficient than heparin in promoting fibrinolysis, particularly in plateletrich clots, and may thus grant a greater antithrombotic activity by enhancing thrombus dissolution...
  17. ncbi Desmin 370, a low molecular weight dermatan sulfate, reduces the weight of preformed thrombi in rats made afibrinogenemic by ancrod
    M Barbanti
    Department of Biomedical Sciences and Human Oncology, University of Bari, Italy
    Thromb Haemost 73:287-90. 1995
    ..Enhancement of plasma fibrinolytic activity by ancrod had no influence on thrombus lysis and was not all affected by administration of D370.(ABSTRACT TRUNCATED AT 250 WORDS)..
  18. ncbi Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells
    P Montemurro
    Dipartimento di Scienze Biomediche e Oncologia Umana, Sezione di Patologia Generale, University of Bari, Bari, Italy
    J Infect Dis 183:1055-62. 2001
    ..HP-NAP, by inducing the coordinate expression of cell procoagulant and antifibrinolytic activities, might favor fibrin deposition and contribute to the inflammatory reaction of gastric mucosa elicited by H. pylori...
  19. ncbi Tissue factor-expressing monocytes inhibit fibrinolysis through a TAFI-mediated mechanism, and make clots resistant to heparins
    Fabrizio Semeraro
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Bari, Italy
    Haematologica 94:819-26. 2009
    ..The aim of this study was to evaluate the effect of tissue factor-expressing monocytes on plasma fibrinolysis in vitro...
  20. ncbi Effect of warfarin treatment on thrombin activatable fibrinolysis inhibitor (TAFI) activation and TAFI-mediated inhibition of fibrinolysis
    F Incampo
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, Aldo Moro University, Bari, Italy
    J Thromb Haemost 11:315-24. 2013
    ..Because oral anticoagulant therapy (OAT) with warfarin causes a partial deficiency of vitamin K-dependent factors, its effect on clot lysability remains unclear...
  21. ncbi Tissue factor in health and disease
    N Semeraro
    Department of Biomedical Sciences and Human Oncology, University of Bari, Italy
    Thromb Haemost 78:759-64. 1997
    ..In malignancy, in vivo expression of TF by tumor cells and/or by host cells has been implicated not only in intratumoral and systemic activation of blood coagulation but also in tumor growth and dissemination...
  22. ncbi Tissue factor and vascular endothelial growth factor expression in colorectal cancer: relation with cancer recurrence
    D F Altomare
    Department of Emergency and Organ Transplantation, General Surgery and Liver Transplantation Unit, University of Bari, Bari, Italy
    Colorectal Dis 9:133-8. 2007
    ..This study was undertaken to quantify tissue factor (TF) and vascular endothelial growth factor (VEGF) in colorectal cancer and to evaluate their possible relationship with recurrence...
  23. ncbi Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells
    L Gesualdo
    Dipartimento dell Emergenza e dei Trapianti di Organi, Sezione di Nefrologia, Policlinico, Bari, Italy
    Kidney Int 56:461-70. 1999
    ..PAI-1 induction by Ang II in endothelial cells seems to be mediated by Ang IV via a receptor that is different from Ang II type 1 and 2 receptors (AT1 and AT2)...
  24. ncbi Coagulation-fibrinolysis changes during off-pump bypass: effect of two heparin doses
    Domenico Paparella
    Department of Emergency and Organ Transplant, Division of Cardiac Surgery, University of Bari, Bari, Italy
    Ann Thorac Surg 89:421-7. 2010
    ..We tested the effect of two different heparin dosages on the activation of the hemostatic system in patients undergoing OPCABG procedures...
  25. ncbi A novel nitric oxide-releasing statin derivative exerts an antiplatelet/antithrombotic activity and inhibits tissue factor expression
    M R Rossiello
    Department of Biomedical Sciences, Section of General Pathology, University of Bari, Bari, Italy
    J Thromb Haemost 3:2554-62. 2005
    ..CONCLUSIONS: Our results show that nitropravastatin exerts strong antithrombotic effects in vitro and in vivo, and may represent an interesting antiatherothrombotic agent for testing in acute coronary syndromes...
  26. ncbi Ochratoxin A inhibits the production of tissue factor and plasminogen activator inhibitor-2 by human blood mononuclear cells: another potential mechanism of immune-suppression
    Maria R Rossiello
    Department of Biomedical Sciences and Human Oncology, Section of General and Experimental Pathology, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Toxicol Appl Pharmacol 229:227-31. 2008
    ..The inhibition of TF and PAI-2 induction might represent a hitherto unrecognized mechanism whereby OTA exerts immunosuppressant activity...
  27. ncbi TAFI deficiency in liver cirrhosis: relation with plasma fibrinolysis and survival
    Paolo Gresele
    Department of Internal Medicine, Division of Internal and Cardiovascular Medicine, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Thromb Res 121:763-8. 2008
    ..We evaluated the relationship of TAFI level with plasma fibrinolysis and survival in cirrhotic patients...