Research Topics
| Carlo ColosimoSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Nonmotor presentations of multiple system atrophyCarlo Colosimo
Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell Universita 30, 00185 Rome, Italy
Nat Rev Neurol 7:295-8. 2011..The importance of recognizing such symptoms should not be underestimated, being crucial for understanding the disease prognosis, avoiding unnecessary tests and procedures, and planning any therapeutic intervention...
Efficacy and safety of long-term botulinum toxin treatment in craniocervical dystonia: a systematic reviewCarlo Colosimo
Dipartimento di Neurologia e Psichiatria, Sapienza Universita di Roma, Viale dell Universita 30, 00185 Rome, Italy
Neurotox Res 22:265-73. 2012..Longitudinal studies aimed at defining the risk factors for this abnormal pattern of response to botulinum toxin treatment are currently being conducted...- A further case of nicotine sensitivity in multiple system atrophyCarlo Colosimo
Dipartimento di Neurologia e Psichiatria, Sapienza Universita di Roma, Italy
Clin Neuropharmacol 35:51-2. 2012..Further studies are warranted to investigate the prevalence of nicotine sensitivity in MSA and shed light on its neurochemical substrate... - Lack of association between progressive supranuclear palsy and arterial hypertension: a clinicopathological studyCarlo Colosimo
Dipartimento di Scienze Neurologiche, Universita La Sapienza, Rome, Italy
Mov Disord 18:694-7. 2003..60; 95% confidence interval, 0.20-1.76). Therefore, HT does not represent an important clinical feature of this neurodegenerative disorder, although cerebrovascular disease can masquerade clinically as PSP... - Drug Insight: new drugs in development for Parkinson's diseaseCarlo Colosimo
University Department of Neurosciences University of Rome, La Sapienza, Italy
Nat Clin Pract Neurol 2:600-10. 2006..In this Review, we discuss the numerous drugs in development that target the primary motor disorder in Parkinson's disease... - Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO studyCarlo Colosimo
Dipartimento di Scienze Neurologiche, Sapienza Universita di Roma, Rome, Italy
J Neurol 257:5-14. 2010..Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL... 
Diffusion tensor imaging in primary cervical dystoniaC Colosimo
Department of Neurological Sciences, University La Sapienza, I 00185 Rome, Italy
J Neurol Neurosurg Psychiatry 76:1591-3. 2005..It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes...- An early image of hemifacial spasm: Edouard Brissaud contributionCarlo Colosimo
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 25:531-3. 2010..We also discuss the role of other early European authors (Schültze, Gowers, Babinski, and Negro) who contributed to the definition of hemifacial spasm in the late 19th and early 20th centuries... - Task force report on scales to assess dyskinesia in Parkinson's disease: critique and recommendationsCarlo Colosimo
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 25:1131-42. 2010..As further testing of these scales in PD is warranted, no new scales are needed until the available scales are fully tested clinimetrically... - Noradrenergic drugs for levodopa-induced dyskinesiaCarlo Colosimo
Department of Neurological Science University La Sapienza, Viale dell Universita 30, I 00185 Rome, Italy
Clin Neuropharmacol 26:299-305. 2003.... - The symptomatic treatment of multiple system atrophyC Colosimo
Dipartimento di Scienze Neurologiche, Universita La Sapienza, Rome, Italy
Eur J Neurol 9:195-9. 2002..The treatment of the very common genito-urinary symptoms (incontinence, retention, impotence) should also be considered in order to improve the quality of life of these patients... - Onset and spread of dyskinesias and motor symptoms in Parkinson's diseaseGiovanni Fabbrini
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 24:2091-6. 2009..In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns... - Abnormal cortical synaptic plasticity in primary motor area in progressive supranuclear palsyAntonella Conte
Department of Neurology and Psychiatry Sapienza, University of Rome, Viale dell Universita, 30, 00185 Rome, Italy
Cereb Cortex 22:693-700. 2012..The iTBS-induced abnormal MEP facilitation in PSP persisted at 1-year follow-up. In conclusion, patients with PSP have abnormal M1 LTP/LTD-like plasticity. The enhanced LTP-like cortical synaptic plasticity parallels disease progression... - Mirror movements in patients with Parkinson's diseaseDonatella Ottaviani
Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
Mov Disord 23:253-8. 2008..16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization... - Psychiatric disorders in adult-onset focal dystonia: a case-control studyGiovanni Fabbrini
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 25:459-65. 2010..The most common psychiatric features in patients with CD and BPS are depressive disorders... - Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's diseaseFrancesca Romana Pezzella
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Mov Disord 20:77-81. 2005..Of interest, our patients showed a somewhat different pattern of the disorder, suggesting that cultural and environmental factors may play a role in the phenomenology of HHD... - Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsyMatteo Bologna
Department of Neurological Sciences, Sapienza, University of Rome, Rome, Italy
Brain 132:502-10. 2009..Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease... - A comparative study of primary and secondary hemifacial spasmCarlo Colosimo
Department of Neurosciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
Arch Neurol 63:441-4. 2006..Signs of synkinesis were present in significant proportions of patients with primary or secondary HFS. The 2 forms differed in clinical presentation... - Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystoniaAlessandra Scontrini
Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy
Mov Disord 26:742-6. 2011..The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation... - Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's diseaseElisa Iacovelli
Department of Neurological Sciences, University of Rome Sapienza, Rome, Italy
Mov Disord 25:1203-9. 2010..Our study also suggests that the OAB-q is a simple, easily administered test that can objectively evaluate bladder function in patients with PD... - No association between essential tremor and migraine: a case-control studyPiero Barbanti
Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
Cephalalgia 30:686-9. 2010..Our study excludes a comorbid association between ET and migraine. When ET and migraine coexist their clinical phenotype and evolution remain almost unchanged... - Which model of stroke unit is better for stroke patient management?Svetlana Lorenzano
Neurovascular Treatment Unit, Department of Neurological Sciences, University of Rome, La Sapienza, Rome, Italy
Clin Exp Hypertens 28:377-82. 2006.... - The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian casesV Bonifati
Department of Neurosciences, La Sapienza University, Roma, Italy
Neurosci Lett 274:61-5. 1999..Although a pathogenic role cannot be entirely excluded, +39deltaG is likely to be a rare polymorphism that may be in linkage disequilibrium with a biologically relevant locus inside or near to the tau gene... - Multidisciplinary approach for diagnosing syncope: a retrospective study on 521 outpatientsS Strano
Cardiovascular Pathophysiology, University of Rome La Sapienza, 00161 Rome, Italy
J Neurol Neurosurg Psychiatry 76:1597-600. 2005..To describe causes of syncope in outpatients in whom structural heart disease was ruled out as a cause, and to analyse the role of a multidisciplinary approach in a syncope unit for the diagnosis of patients with syncope of unknown origin... - A transverse and longitudinal MR imaging voxel-based morphometry study in patients with primary cervical dystoniaP Pantano
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
AJNR Am J Neuroradiol 32:81-4. 2011..Our purpose was to evaluate GM volumes in patients with CD at baseline and 5 years later... - Sad and happy facial emotion recognition impairment in progressive supranuclear palsy in comparison with Parkinson's diseaseFrancesco E Pontieri
I R C C S Santa Lucia Foundation, Rome, Italy
Parkinsonism Relat Disord 18:871-5. 2012.... - Case-control study of multiple system atrophyNicola Vanacore
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Mov Disord 20:158-63. 2005..Our results suggest that occupational history of farming is a risk factor for MSA. Smoking and farming seem to influence MSA risk independently. Further epidemiological studies might provide clues on the etiopathogenesis of MSA... - Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophyFrancesca R Buttarelli
Department of Neurological Sciences, University Sapienza, Rome, Italy
J Neural Transm 116:161-5. 2009..The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells... - Cranial movement disorders: clinical features, pathophysiology, differential diagnosis and treatmentGiovanni Fabbrini
Movement Disorders Clinic, Department of Neurosciences and Neuromed Institute, Sapienza University of Rome, Rome
Nat Clin Pract Neurol 5:93-105. 2009..Here, we review the clinical features, pathophysiologies and therapies of the main movement disorders that affect the face, jaw, tongue and palate... - Clinical phenomenology of dystoniaCarlo Colosimo
Department of Neurology and Psychiatry and Neuromed Institute IRCSS, Sapienza University of Rome, Italy
Int Rev Neurobiol 98:509-24. 2011..The different subtypes of focal and segmental dystonias may have different clinical features. Neuropsychiatric disorders may be present in dystonia... - Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasmG Fabbrini
Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
Eur J Neurol 15:185-9. 2008..The abnormal DTI findings in patients with CD suggest the presence of brain ultrastructural changes in adult-onset primary CD... - Epidemiology of progressive supranuclear palsy. ESGAP Consortium. European Study Group on Atypical ParkinsonismsN Vanacore
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Neurol Sci 22:101-3. 2001..The significance of this association is still not clear. We have performed a case-control study on 58 PSP cases, 116 hospital controls and 58 population controls... - Cerebrospinal fluid analysis for Whipple's disease in patients with progressive supranuclear palsyFrancesca Romana Pezzella
Dipartimento di Scienze Neurologiche, , Rome, Italy
Mov Disord 19:220-2. 2004..We looked for WD pathogen DNA in the cerebrospinal fluid of 9 patients with a clinical diagnosis of PSP. The analysis was negative for all samples, showing that WD is not commonly involved in the aetiopathogenesis of PSP... - Donepezil in the treatment of progressive supranuclear palsyG Fabbrini
Department of Neurological Sciences, University La Sapienza, Rome
Acta Neurol Scand 103:123-5. 2001..To evaluate the effect of 3 month therapy with donepezil, a centrally acting cholinesterase inhibitor, on cognitive performances, motor function and daily living activities in progressive supranuclear palsy (PSP)... - Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical ParkinsonismsN Vanacore
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Neurol Sci 22:97-9. 2001..We have performed a case-control study on 73 MSA cases, 146 hospital controls and 73 population controls... - Fast voluntary neck movements in patients with cervical dystonia: a kinematic study before and after therapy with botulinum toxin type AB Gregori
Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
Clin Neurophysiol 119:273-80. 2008..To study fast voluntary neck movements in patients with cervical dystonia (CD) before and after therapy with botulinum toxin type-A (BTX-A)... - Apraxia of eyelid opening in a case of atypical corticobasal degenerationM Sepe-Monti
Dipartimento di Scienze Neurologiche, , Rome, Italy
J Neural Transm 110:1145-8. 2003..We suggest that the finding of AEO in patients with a frontotemporal syndrome could be a helpful expedient for the early diagnosis of atypical clinical findings of CBD, characterised by behavioural and cognitive aspects at first... - Craniocervical dystonia: clinical and pathophysiological featuresC Colosimo
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
Eur J Neurol 17:15-21. 2010..The best treatment for craniocervical dystonia is botulinum toxin injected into the overactive muscles... - Management of multiple system atrophy: state of the artC Colosimo
Department of Neurological Sciences, La Sapienza University, Rome, Italy
J Neural Transm 112:1695-704. 2005..The treatment of the very common genitourinary symptoms (incontinence, retention, impotence) should also be considered in order to improve the quality of life of these patients... - Multiple system atrophyGregor K Wenning
Department of Neurology, University Hospital, A-6020 Innsbruck, Austria
Lancet Neurol 3:93-103. 2004..Symptomatic therapeutic strategies are still limited; however, several candidate neuroprotective agents have entered phase II and phase III clinical trials... - Accuracy of clinical diagnosis of progressive supranuclear palsyYasushi Osaki
National Hospital for Neurology and Neurosurgery, London, United Kingdom
Mov Disord 19:181-9. 2004.... - Red flags for multiple system atrophyMartin Köllensperger
Section for Clinical Neurobiology, Department of Neurology, Innsbruck Medical University, Austria
Mov Disord 23:1093-9. 2008..9 (+/-7.0) months earlier than with the Consensus criteria alone. We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P... - The PRIAMO study: background, methods and recruitmentAngelo Antonini
Parkinson Institute, Milan, Italy
Neurol Sci 29:61-5. 2008..PRIAMO has analysed a total of 1307 patients (out of 1325 initially enrolled). We expect that PRIAMO will substantially help to quantify the burden of NMS in patients with parkinsonism... - Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS)Gregor K Wenning
Department of Neurology, University of Innsbruck, Austria
Mov Disord 19:1391-402. 2004..Based on our findings, the UMSARS appears to be a multidimensional, reliable, and valid scale for semiquantitative clinical assessments of MSA patients... - Reply: Lack of association between progressive supranuclear palsy and arterial hypertension: a clinicopathological studyCarlo Colosimo
Mov Disord 20:1086-7. 2005 - Health-related quality of life in multiple system atrophyAnette Schrag
Department of Clinical Neurosciences, Royal Free and University College Medical School, London, United Kingdom
Mov Disord 21:809-15. 2006....