Giancarlo Colombo

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. ncbi The development of medications for alcohol-use disorders targeting the GABAB receptor system
    Roberta Agabio
    Bernard B Brodie Department of Neuroscience, University of Cagliari, I 09042 Monserrato, Italy
    Recent Pat CNS Drug Discov 7:113-28. 2012
  2. ncbi Gamma-hydroxybutyric acid in alcohol preference, dependence and withdrawal
    G Colombo
    CNR Center for Neuropharmacology, University of Cagliari, Cagliari, Italy
    Addict Biol 5:389-403. 2000
  3. ncbi Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats
    Giancarlo Colombo
    CNR Institute of Neurogenetics and Neuropharmacology, c o Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042, Monserrato CA, Italy
    Psychopharmacology (Berl) 159:181-7. 2002
  4. ncbi Baclofen suppresses motivation to consume alcohol in rats
    Giancarlo Colombo
    C N R Institute of Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Km 4 5, S S 554, 09042 Monserrato, Italy
    Psychopharmacology (Berl) 167:221-4. 2003
  5. ncbi Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C N R Institute for Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042, Monserrato, CA, Italy
    Drug Alcohol Depend 70:105-8. 2003
  6. ncbi Suppression by baclofen of the stimulation of alcohol intake induced by morphine and WIN 55,212-2 in alcohol-preferring rats
    Giancarlo Colombo
    Department of Neuroscience, C N R Institute of Neuroscience, c o Bernard B Brodie University of Cagliari, Viale Diaz 182, Cagliari I 09126, Italy
    Eur J Pharmacol 492:189-93. 2004
  7. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Eur J Pharmacol 498:119-23. 2004
  8. ncbi Endocannabinoid system and alcohol addiction: pharmacological studies
    Giancarlo Colombo
    C N R Institute of Neuroscience, Viale Diaz, 182 I 09126 Cagliari CA, Italy
    Pharmacol Biochem Behav 81:369-80. 2005
  9. ncbi Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics
    Giancarlo Colombo
    C N R Institute of Neuroscience, University of Cagliari, Viale Diaz, 182, I 09126 Cagliari, Italy
    Neurotox Res 6:403-14. 2004
  10. ncbi Effect of the combination of naltrexone and baclofen, on acquisition of alcohol drinking behavior in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, 1 09126 Cagliari, Italy
    Drug Alcohol Depend 77:87-91. 2005

Collaborators

Detail Information

Publications94

  1. ncbi The development of medications for alcohol-use disorders targeting the GABAB receptor system
    Roberta Agabio
    Bernard B Brodie Department of Neuroscience, University of Cagliari, I 09042 Monserrato, Italy
    Recent Pat CNS Drug Discov 7:113-28. 2012
    ..The present paper also summarizes the most relevant patents on GABAB receptor agonists and GABAB PAMs as possible pharmacotherapies for AUDs...
  2. ncbi Gamma-hydroxybutyric acid in alcohol preference, dependence and withdrawal
    G Colombo
    CNR Center for Neuropharmacology, University of Cagliari, Cagliari, Italy
    Addict Biol 5:389-403. 2000
    ....
  3. ncbi Stimulation of voluntary ethanol intake by cannabinoid receptor agonists in ethanol-preferring sP rats
    Giancarlo Colombo
    CNR Institute of Neurogenetics and Neuropharmacology, c o Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042, Monserrato CA, Italy
    Psychopharmacology (Berl) 159:181-7. 2002
    ....
  4. ncbi Baclofen suppresses motivation to consume alcohol in rats
    Giancarlo Colombo
    C N R Institute of Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Km 4 5, S S 554, 09042 Monserrato, Italy
    Psychopharmacology (Berl) 167:221-4. 2003
    ....
  5. ncbi Suppression by baclofen of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C N R Institute for Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042, Monserrato, CA, Italy
    Drug Alcohol Depend 70:105-8. 2003
    ..These results implicate the GABA(B) receptor in the neural substrate mediating ADE and suggest that baclofen may possess anti-relapse properties...
  6. ncbi Suppression by baclofen of the stimulation of alcohol intake induced by morphine and WIN 55,212-2 in alcohol-preferring rats
    Giancarlo Colombo
    Department of Neuroscience, C N R Institute of Neuroscience, c o Bernard B Brodie University of Cagliari, Viale Diaz 182, Cagliari I 09126, Italy
    Eur J Pharmacol 492:189-93. 2004
    ..These results suggest the involvement of the GABA(B) receptor in the neural circuitry mediating the stimulating effect of morphine and cannabinoids on alcohol consumption in sP rats...
  7. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR 141716, on alcohol's motivational properties in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Eur J Pharmacol 498:119-23. 2004
    ..The results also implicate the cannabinoid CB1 receptor in the neural substrate mediating alcohol's motivational properties in this rat line...
  8. ncbi Endocannabinoid system and alcohol addiction: pharmacological studies
    Giancarlo Colombo
    C N R Institute of Neuroscience, Viale Diaz, 182 I 09126 Cagliari CA, Italy
    Pharmacol Biochem Behav 81:369-80. 2005
    ....
  9. ncbi Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics
    Giancarlo Colombo
    C N R Institute of Neuroscience, University of Cagliari, Viale Diaz, 182, I 09126 Cagliari, Italy
    Neurotox Res 6:403-14. 2004
    ..In both clinical studies, baclofen was well tolerated with minimal side effects. These results suggest that baclofen may represent a potentially effective medication in the treatment of alcohol-dependent patients...
  10. ncbi Effect of the combination of naltrexone and baclofen, on acquisition of alcohol drinking behavior in alcohol-preferring rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, 1 09126 Cagliari, Italy
    Drug Alcohol Depend 77:87-91. 2005
    ..These results are discussed in terms of naltrexone and baclofen exerting a concomitant and reciprocally potentiating inhibitory action on alcohol-induced activation of mesolimbic dopamine transmission...
  11. ncbi Suppression of acquisition of alcohol-drinking behavior by the concurrent availability of saccharin in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Section of Cagliari, Italy
    Alcohol 35:27-33. 2005
    ....
  12. ncbi Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 30:754-62. 2006
    ..The present study was designed to evaluate whether miltirone, one of the possible active constituents of S. miltiorrhiza, might be responsible for the reducing effect of the extracts on alcohol intake...
  13. ncbi Baclofen-induced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, Italy
    Eur J Pharmacol 550:123-6. 2006
    ..These results suggest that the GABA(B) receptor is part of the neural substrate mediating alcohol deprivation in sP rats...
  14. ncbi The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence
    Giancarlo Colombo
    C N R Institute of Neuroscience, Viale Diaz 182, Cagliari CA, 182 I 09126, Italy
    Mol Neurobiol 36:102-12. 2007
    ....
  15. ncbi GABA(B) receptor inhibition causes locomotor stimulation in mice
    G Colombo
    C N R Institute of Neurogenetics and Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554, Km 4 5, I 09042 Monserrato Ca, Italy
    Eur J Pharmacol 433:101-4. 2001
    ..1 mg/kg, i.p.), suggesting that hyperactivity induced by blockade of the GABA(B) receptor is mediated by enhanced dopamine release. These results suggest the existence of a GABA(B) receptor-mediated tonic inhibition of dopamine neurons...
  16. ncbi Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Physiol Behav 64:293-302. 1998
    ....
  17. ncbi Different sensitivity to ethanol in alcohol-preferring sP and -nonpreferring sNP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Alcohol Clin Exp Res 24:1603-8. 2000
    ....
  18. ncbi Gamma-hydroxybutyric acid intake in ethanol-preferring sP and -nonpreferring sNP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Physiol Behav 64:197-202. 1998
    ..The results are also discussed in terms of differences in GHB receptors contributing to the predisposition to ethanol preference and avoidance, respectively...
  19. ncbi Reduction of blood ethanol levels by the gamma-hydroxybutyric acid receptor antagonist, NCS-382
    G Colombo
    Centro C N R per la Neurofarmacologia, Cagliari, Italy
    Alcohol 17:93-5. 1999
    ..The reducing effect of NCS-382 on BELs is likely due to a lessened absorption of ethanol from the gastrointestinal tract...
  20. ncbi Stimulation of locomotor activity by voluntarily consumed ethanol in Sardinian alcohol-preferring rats
    G Colombo
    C N R Center for Neuropharmacology, Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Eur J Pharmacol 357:109-13. 1998
    ..These results suggest that the euphorigenic effects of ethanol, supposedly represented by the stimulation of locomotor activity, are part of the reinforcing properties of ethanol in sP rats...
  21. ncbi Selective breeding of two rat lines differing in sensitivity to GHB and baclofen
    G Colombo
    C N R Center for Neuropharmacology, c o Bernard B Brodie Department of Neuroscience, University of Cagliari, SS 554, Km 4 5, I 09042, Monserrato CA, Italy
    Brain Res 902:127-30. 2001
    ....
  22. ncbi Characterization of the discriminative stimulus effects of gamma-hydroxybutyric acid as a means for unraveling the neurochemical basis of gamma-hydroxybutyric acid actions and its similarities to those of ethanol
    G Colombo
    C N R Center for Neuropharmacology, University of Cagliari, Via Porcell 4, I 09124, Cagliari, Italy
    Alcohol 20:237-45. 2000
    ....
  23. ncbi Phenotypic characterization of genetically selected Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats
    Giancarlo Colombo
    C N R Institute of Neuroscience, Cagliari, CA, Italy
    Addict Biol 11:324-38. 2006
    ....
  24. ncbi Ability of baclofen in reducing alcohol intake and withdrawal severity: I--Preclinical evidence
    G Colombo
    CNR Center for Neuropharmacology, Bernard B Brodie Department of Neuroscience, University of Cagliari, Italy
    Alcohol Clin Exp Res 24:58-66. 2000
    ....
  25. ncbi Salvia miltiorrhiza extract inhibits alcohol absorption, preference, and discrimination in sP rats
    G Colombo
    CNR Center for Neuropharmacology, Cagliari, Italy
    Alcohol 18:65-70. 1999
    ..Collectively, the results are discussed as being suggestive that drugs curbing ethanol absorption from the gastrointestinal tract may constitute a novel strategy for controlling excessive alcohol consumption in human alcoholics...
  26. ncbi Cannabinoid modulation of intestinal propulsion in mice
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Eur J Pharmacol 344:67-9. 1998
    ..The results of the present study suggest a role for cannabinoid CB1 receptors in the control of propulsive activity in the mouse small intestine...
  27. ncbi Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen
    Paola Maccioni
    C N R Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 32:1558-64. 2008
    ..The present study was conducted to assess and compare the effect of baclofen and GS39783 on the motivational properties of alcohol...
  28. ncbi Baclofen-induced reduction of alcohol reinforcement in alcohol-preferring rats
    Paola Maccioni
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Alcohol 36:161-8. 2005
    ..These data are also in agreement with the results of recent preliminary clinical studies suggesting that baclofen may have therapeutic efficacy in the treatment of alcohol dependence...
  29. ncbi Reducing effect of a Phaseolus vulgaris dry extract on operant self-administration of a chocolate-flavoured beverage in rats
    Paola Maccioni
    CNR Neuroscience Institute, Viale Diaz 182, I 09126 Cagliari, Italy
    Br J Nutr 104:624-8. 2010
    ..These results indicate the capacity of a P. vulgaris preparation to reduce the reinforcing properties of a highly palatable fluid in rats...
  30. ncbi Suppression by the cannabinoid CB1 receptor antagonist, rimonabant, of the reinforcing and motivational properties of a chocolate-flavoured beverage in rats
    Paola Maccioni
    CNR Institute of Neuroscience, Cagliari, Italy
    Behav Pharmacol 19:197-209. 2008
    ..These results also suggest that the cannabinoid CB1 receptor is a crucial component of the neural substrate mediating the reinforcing and motivational properties of a highly palatable food such as a chocolate-flavoured beverage...
  31. ncbi Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, DL-dithiothreitol (DTT)
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, 09126 Cagliari, Italy
    Psychopharmacology (Berl) 174:283-90. 2004
    ....
  32. ncbi Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats
    Paola Maccioni
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, 09126, Cagliari, Italy
    Psychopharmacology (Berl) 193:171-8. 2007
    ..The present study was designed to extend the characterization of the "anti-alcohol" effects of GS39,783 to oral self-administration of alcohol under an operant procedure...
  33. ncbi Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats
    Paola Maccioni
    CNR Institute of Neuroscience, Cagliari, Italy
    Alcohol Clin Exp Res 33:1749-56. 2009
    ....
  34. ncbi Gamma-aminobutyric acidB (GABAB)-receptor mediation of different in vivo effects of gamma-butyrolactone
    Mauro A M Carai
    CNR Institute of Neuroscience, Cagliari, Italy
    J Pharmacol Sci 106:199-207. 2008
    ..Vice versa, NCS-382 failed to exert any antagonistic or protective effect. These results suggest that the in vivo GBL effects tested in the present study are mediated by activation of the GABA(B) receptor...
  35. ncbi Reducing effect of a Phaseolus vulgaris dry extract on food intake, body weight, and glycemia in rats
    Noemi Fantini
    CNR Institute of Neuroscience, Cagliari, Italy
    J Agric Food Chem 57:9316-23. 2009
    ....
  36. ncbi IDN 5082, a standardized extract of Salvia miltiorrhiza, delays acquisition of alcohol drinking behavior in rats
    Giuliana Brunetti
    Neuroscienze S.c.a r.l, Cagliari, Italy
    J Ethnopharmacol 85:93-7. 2003
    ..These results add further support to the preclinical anti-alcohol profile of S. miltiorrhiza extracts...
  37. ncbi Reducing effect of Salvia miltiorrhiza extracts on alcohol intake: influence of vehicle
    Giovanni Vacca
    Neuroscienze Scarl, Cagliari, Italy
    Phytother Res 17:537-41. 2003
    ..They may also offer relevant information for pharmaceutical preparation of Salvia miltiorrhiza extract to be used in future clinical trials...
  38. ncbi Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats
    Salvatore Serra
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy
    J Ethnopharmacol 88:249-52. 2003
    ..These results suggest that IDN 5082 may possess anti-relapse properties...
  39. ncbi Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats
    Alessandro Orru
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 525:105-11. 2005
    ..These data also suggest that positive allosteric modulation of the GABA(B) receptor may constitute a potential strategy for developing new drugs for treating alcohol dependence...
  40. ncbi Suppressing effect of the cannabinoid CB1 receptor antagonist, SR147778, on alcohol intake and motivational properties of alcohol in alcohol-preferring sP rats
    Gian Luigi Gessa
    C N R Institute of Neuroscience, Section of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Alcohol Alcohol 40:46-53. 2005
    ..The present study investigated the effect of the newly synthesized cannabinoid CB(1) receptor antagonist, SR147778, on alcohol intake and the motivational properties of alcohol in selectively bred Sardinian alcohol-preferring (sP) rats...
  41. ncbi Cue-induced reinstatement of ethanol seeking in Sardinian alcohol-preferring rats
    Paola Maccioni
    C N R Institute of Neuroscience, Viale Diaz 182, I 09126, Cagliari, Italy
    Alcohol 41:31-9. 2007
    ..The latter finding concurs with clinical observations that odor and taste of alcoholic beverages elicit immediate craving responses in abstinent alcoholics...
  42. ncbi The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration
    Paola Maccioni
    CNR Neuroscience Institute, Viale Diaz 182, I 09126 Cagliari, Italy
    Drug Alcohol Depend 109:96-103. 2010
    ..The present data constitute a further piece of evidence on the capacity of positive allosteric modulators of the GABA(B) receptor to reduce alcohol's reinforcing properties in rats...
  43. ncbi The GABA(B) receptor agonists baclofen and CGP 44532 prevent acquisition of alcohol drinking behaviour in alcohol-preferring rats
    Giancarlo Colombo
    C.N.R. Institute of Neurogenetics and Neuropharmacology, Cagliari, Italy
    Alcohol Alcohol 37:499-503. 2002
    ....
  44. ncbi Different sensitivity to the motor incoordinating effects of gamma-hydroxybutyric acid (GHB) and baclofen in GHB-sensitive and GHB-resistant rats
    Carla Lobina
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Brain Res 1033:109-12. 2005
    ..These results are discussed in terms of the GABA(B) receptor being the likely neural substrate on which the differential sensitivity of GHB-S and GHB-R rats resides...
  45. ncbi Blockade by the cannabinoid CB(1) receptor antagonist, SR 141716, of alcohol deprivation effect in alcohol-preferring rats
    Salvatore Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 443:95-7. 2002
    ..These results suggest that the cannabinoid CB(1) receptor is part of the neural substrate mediating the alcohol deprivation effect and that SR 141716 may possess anti-relapse properties...
  46. ncbi Multiple cycles of repeated treatments with a Phaseolus vulgaris dry extract reduce food intake and body weight in obese rats
    Mauro A M Carai
    CNR Neuroscience Institute, Section of Cagliari, S S 554, Km 4500, I 09042 Monserrato Ca, Italy
    Br J Nutr 106:762-8. 2011
    ..vulgaris...
  47. ncbi Increase in alcohol intake, reduced flexibility of alcohol drinking, and evidence of signs of alcohol intoxication in Sardinian alcohol-preferring rats exposed to intermittent access to 20% alcohol
    Barbara Loi
    CNR Neuroscience Institute, Viale Diaz, Cagliari, Italy
    Alcohol Clin Exp Res 34:2147-54. 2010
    ....
  48. ncbi Baclofen attenuates cue-induced reinstatement of alcohol-seeking behavior in Sardinian alcohol-preferring (sP) rats
    Paola Maccioni
    C N R Institute of Neuroscience, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Drug Alcohol Depend 95:284-7. 2008
    ..These results indicate that baclofen reduced cue-induced reinstatement of alcohol-seeking behavior in sP rats...
  49. ncbi gamma-Hydroxybutyric acid (GHB) suppresses alcohol's motivational properties in alcohol-preferring rats
    Paola Maccioni
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Alcohol 42:107-13. 2008
    ..These results are consistent with the anticraving properties of GHB observed in clinical studies...
  50. ncbi Withdrawal syndrome from gamma-hydroxybutyric acid (GHB) and 1,4-butanediol (1,4-BD) in Sardinian alcohol-preferring rats
    Mauro A M Carai
    Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Brain Res Brain Res Protoc 15:75-8. 2005
    ..We propose that the inherent sensitivity of sP rats to different GHB-associated responses may have contributed to the unraveling of a phenomenon which was otherwise not recognizable in other rat strains...
  51. ncbi Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats
    Gian Luigi Gessa
    C.N.R. Institute of Neuroscience, Viale Diaz, 182, I-09126 Cagliari (CA, Italy
    Psychopharmacology (Berl) 185:248-54. 2006
    ..These results also suggest that rimonabant may be more active on the hedonic rather than nutritive properties of diets...
  52. ncbi Differences in ethanol-induced conditioned taste aversion in Sardinian alcohol-preferring and Sardinian alcohol-nonpreferring rats
    Giuliana Brunetti
    Neuroscienze S.c.a r.l, I-09123, Cagliari, Italy
    Alcohol 26:167-72. 2002
    ....
  53. ncbi Stable preference for high ethanol concentrations after ethanol deprivation in Sardinian alcohol-preferring (sP) rats
    Salvatore Serra
    Neuroscienze S.c.a r.l, I-09123, Cagliari, Italy
    Alcohol 29:101-8. 2003
    ..These results provide further evidence on the heterogeneity of ethanol-drinking behavior among rat lines selectively bred for high ethanol preference and consumption...
  54. ncbi Boosting effect of morphine on alcohol drinking is suppressed not only by naloxone but also by the cannabinoid CB1 receptor antagonist, SR 141716
    Giovanni Vacca
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 445:55-9. 2002
    ....
  55. ncbi Suppression of maintenance of alcohol-drinking behavior by the concurrent availability of saccharin in Sardinian alcohol-preferring (sP) rats
    Giancarlo Colombo
    C.N.R. Institute of Neuroscience, Section of Cagliari, Italy
    Alcohol 35:35-41. 2005
    ..We hypothesized that saccharin solutions may have functioned as a reinforcer, partially substituting for alcohol reinforcement and rendering alcohol drinking less urgent...
  56. ncbi Blockade of the cannabinoid CB1 receptor and alcohol dependence: preclinical evidence and preliminary clinical data
    Paola Maccioni
    C N R Neuroscience Institute, Viale Diaz, 182, I 09126 Cagliari CA, Italy
    CNS Neurol Disord Drug Targets 9:55-9. 2010
    ....
  57. ncbi Operant self-administration of ethanol in Sardinian alcohol-preferring rats
    Giovanni Vacca
    Neuroscience S.c.a r.l, Cagliari, Italy
    Alcohol Clin Exp Res 26:1678-85. 2002
    ....
  58. ncbi Role of the GABA(B) receptor in alcohol-seeking and drinking behavior
    Paola Maccioni
    C N R Institute of Neuroscience, I 09126 Cagliari, Italy
    Alcohol 43:555-8. 2009
    ....
  59. ncbi Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring and Sardinian non-preferring rats
    Alessandro Orru
    Bernard B Brodie, Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Alcohol Alcohol 42:513-24. 2007
    ....
  60. ncbi Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats
    M Paola Castelli
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato CA, Italy
    Eur J Pharmacol 523:67-70. 2005
    ....
  61. ncbi GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats
    Carla Lobina
    Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy
    Brain Res Brain Res Protoc 15:1-5. 2005
    ....
  62. ncbi GABA(B)-receptor mediation of the inhibitory effect of gamma-hydroxybutyric acid on intestinal motility in mice
    Mauro A M Carai
    Neuroscienze S c a r l, Via Palabanda 9, I 09123, Cagliari, Italy
    Life Sci 70:3059-67. 2002
    ..p.), resulted in the blockade of the inhibiting effect of both GHB and NCS-382. These results suggest that the constipating effect of GHB and NCS-382 are secondary to stimulation of the GABA(B) receptor...
  63. ncbi In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 504:213-6. 2004
    ..These results confirm that CGP7930 may constitute an interesting tool for pharmacological studies in the GABAB receptor field...
  64. ncbi Resuscitative treatments on 1,4-butanediol mortality in mice
    Mauro A M Carai
    Department of Neuroscience, School of Medicine, University of Cagliari, National Research Council, Institute of Neuroscience, Cagliari, Italy
    Ann Emerg Med 47:184-9. 2006
    ....
  65. ncbi Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data
    Mauro A M Carai
    C N R Institute of Neuroscience, University of Cagliari, Cagliari CA, Italy
    CNS Drug Rev 12:91-9. 2006
    ..The data reviewed in this paper suggest that cannabinoid CB(1) receptor antagonists may constitute a novel class of drugs potentially effective in the treatment of obesity-related disorders...
  66. ncbi Role of GABA(B) receptors in the sedative/hypnotic effect of gamma-hydroxybutyric acid
    M A Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, S S 554 Km 4 5, I 09042 Monserrato, CA, Italy
    Eur J Pharmacol 428:315-21. 2001
    ..These results indicate that the sedative/hypnotic effect of GHB is mediated by the stimulation of GABA(B) receptors and add further support to the hypothesis that the GABA(B) receptor constitutes a central site of action of GHB...
  67. ncbi The R100Q mutation of the GABA(A) alpha(6) receptor subunit may contribute to voluntary aversion to ethanol in the sNP rat line
    L Saba
    Neuroscienze S.c.a.r.l, Cagliari, Italy
    Brain Res Mol Brain Res 87:263-70. 2001
    ....
  68. ncbi Investigation on the relationship between cannabinoid CB1 and opioid receptors in gastrointestinal motility in mice
    Mauro A M Carai
    C N R Institute of Neuroscience, Cagliari, Viale Armando Diaz 182, I 09126 Cagliari, Italy
    Br J Pharmacol 148:1043-50. 2006
    ....
  69. ncbi Rapid tolerance to the intestinal prokinetic effect of cannabinoid CB1 receptor antagonist, SR 141716 (Rimonabant)
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari, Italy
    Eur J Pharmacol 494:221-4. 2004
    ..On day 1, SR 141716 markedly activated intestinal peristalsis, but complete tolerance to this effect developed within the third day of treatment. The results may have some relevance to the proposed future clinical use of SR 141716...
  70. ncbi Electrophysiological properties of dopamine neurons in the ventral tegmental area of Sardinian alcohol-preferring rats
    Miriam Melis
    B B Brodie Department of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042, Monserrato, Italy
    Psychopharmacology (Berl) 201:471-81. 2009
    ..However, the electrophysiological properties of these cells in sP and sNP rats remain unknown...
  71. ncbi Rimonabant: the first therapeutically relevant cannabinoid antagonist
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Life Sci 77:2339-50. 2005
    ..Taken together, the data reviewed here suggest that rimonabant may constitute a new and potentially effective medication for the treatment of drug addiction and obesity-related disorders...
  72. ncbi Sardinian alcohol-preferring and non-preferring rats show different reactivity to aversive stimuli and a similar response to a natural reward
    Benedetta Leggio
    Department of Neuroscience, University of Siena, Via A. Moro 4, 53100 Siena, Italy
    Brain Res 973:275-84. 2003
    ..Interestingly, they also showed similar behavioral and neurochemical responses to a natural rewarding stimulus and a similar ability to learn an appetitive behavior...
  73. ncbi Protection by the GABAB receptor antagonist, SCH 50911, of gamma-hydroxybutyric acid-induced mortality in mice
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I 09126 Cagliari CA, Italy
    Eur J Pharmacol 503:77-80. 2004
    ....
  74. ncbi Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice
    Mauro A M Carai
    Bernard B Brodie Department of Neuroscience, School of Medicine, University of Cagliari, and CNR Institute of Neuroscience, Section of Cagliari, Italy
    Ann Emerg Med 45:614-9. 2005
    ....
  75. ncbi Sardinian alcohol-preferring rats prefer chocolate and sucrose over ethanol
    G Colombo
    C N R Center for Neuropharmacology, Cagliari, Italy
    Alcohol 14:611-5. 1997
    ..g., response to the presentation of palatable fluids), which might parallel the different types of alcoholism observed in humans...
  76. ncbi The cannabinoid receptor antagonist SR 141716 prevents acquisition of drinking behavior in alcohol-preferring rats
    S Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123, Cagliari, Italy
    Eur J Pharmacol 430:369-71. 2001
    ..The results suggest that activation of cannabinoid CB(1) receptors is essential for the acquisition of alcohol drinking behavior in animals with a genetically determined alcohol preference...
  77. ncbi Differences in the opioid system in selected brain regions of alcohol-preferring and alcohol-nonpreferring rats
    P Fadda
    Department of Neuroscience, University of Cagliari, Italy
    Alcohol Clin Exp Res 23:1296-305. 1999
    ....
  78. ncbi Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines
    Maria Luisa Barbaccia
    Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, Italy
    Neuropharmacology 49:48-58. 2005
    ..These results suggest that the GHB-induced increases of brain 3alpha,5alpha-THP and 3alpha,5alpha-THDOC concentrations are implicated in the eliciting of the sedative/hypnotic action of GHB...
  79. ncbi GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid
    M L Barbaccia
    Department of Neuroscience, University of Rome Tor Vergata, Via Tor Vergata 135, 00133 Rome, Italy
    Neuropharmacology 42:782-91. 2002
    ....
  80. ncbi Alcohol stimulates motor activity in selectively bred Sardinian alcohol-preferring (sP), but not in Sardinian alcohol-nonpreferring (sNP), rats
    R Agabio
    Bernard B. Brodie Department of Neuroscience, University of Cagliari, I-09124, Cagliari, Italy
    Alcohol 23:123-6. 2001
    ..These results suggest to us that a positive relationship exists between ethanol preference and ethanol-induced motor stimulation in sP/sNP rat lines...
  81. ncbi Procedure of bidirectional selective outbreeding for production of two rat lines differing in sensitivity to the sedative/hypnotic effect of gamma-hydroxybutyric acid
    C Lobina
    Bernard B. Brodie' Department of Neuroscience, University of Cagliari, S.S. 554, Km. 4.5, I-09042 (CA, Monserrato, Italy
    Brain Res Brain Res Protoc 8:74-81. 2001
    ..The selective breeding of GHB-S and GHB-R rats: (a) suggests that sensitivity to GHB is under genetic control, and (b) may constitute a unique model for investigation of the physiological function of GHB...
  82. ncbi Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze
    F Nava
    Department of Neuroscience, Bernard B Brodie, University of Cagliari, Cittadella Universitaria Monserrato, S S 554 km 4 500, 09042, Cagliari, Italy
    Neuropharmacology 41:392-9. 2001
    ..However, the major outcome of this work is the demonstration that no tolerance to the two inhibitory effects develops after a chronic Delta(9)-THC treatment...
  83. ncbi Reduced TH-immunoreactive fibers in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze S c a r l, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 924:242-51. 2002
    ....
  84. ncbi Factors mediating alcohol craving and relapse: stress, compulsivity, and genetics
    Zachary A Rodd
    Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202-4887, USA
    Alcohol Clin Exp Res 29:1325-33. 2005
  85. ncbi Long-term exposure to a sweetened alcoholic solution does not alter genetic aversion to ethanol in Sardinian alcohol-nonpreferring (sNP) rats
    Giuliana Brunetti
    Neuroscienze S.c.a r.l, I-09123 Cagliari, Italy
    Alcohol 30:29-34. 2003
    ..These results support the suggestion that an environmental manipulation such as a long-term exposure to a sucrose-fading procedure did not overcome the genetically determined predisposition to avoid ethanol in sNP rats...
  86. ncbi Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam
    Giovanni Addolorato
    Institute of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Med 119:276.e13-8. 2006
    ..Accordingly, the present study was designed to compare efficacy, tolerability and safety of baclofen versus diazepam in the treatment of AWS...
  87. ncbi Rapid suppression of alcohol withdrawal syndrome by baclofen
    Giovanni Addolorato
    Institute of Internal Medicine, , Rome, Italy
    Am J Med 112:226-9. 2002
  88. ncbi Reduced DAT- and DBH-immunostaining in the limbic system of Sardinian alcohol-preferring rats
    Maria Antonietta Casu
    Neuroscienze Scarl, Via Palabanda 9, 09125 Cagliari, Italy
    Brain Res 948:192-202. 2002
    ..This genetically-determined difference may be involved in the opposite alcohol preference and consumption of sP and sNP rats...
  89. ncbi Gamma-hydroxybutyric acid versus alcohol preference in Sardinian alcohol-preferring rats
    Salvatore Serra
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123 Cagliari, Italy
    Alcohol Alcohol 37:128-31. 2002
    ..The results also provide a model of the low abuse liability of GHB observed in human alcoholics...
  90. ncbi Ethanol, endocannabinoids, and the cannabinoidergic signaling system
    Basalingappa L Hungund
    New York State Psychiatric Institute and the Nathan Kline Institute, Orangeburg, New York 10962, USA
    Alcohol Clin Exp Res 26:565-74. 2002
    ..voluntary ethanol intake by cannabinoid receptor agonists and antagonists in alcohol-preferring sP rats, by Giancarlo Colombo; (5) Role of endogenous cannabinoid system in alcoholism, by Fernado Rodriguez de Fonseca; and (6) ..
  91. ncbi Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines
    Lawrence S Quang
    Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children s Hospital, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 1074:545-58. 2006
    ....
  92. ncbi Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid
    Mauro A M Carai
    Neuroscienze S c a r l, Via Palabanda 9, I 09123 Cagliari, Italy
    Eur J Pharmacol 441:157-63. 2002
    ..Accordingly 1,4-butanediol, unlike GHB, failed to displace [(3)H]GHB and [(3)H]baclofen in brain membranes...
  93. ncbi Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study
    Giovanni Addolorato
    Institute of Internal Medicine and Institute of Psychiatry, Catholic University of Rome, Rome, Italy
    Alcohol Alcohol 37:504-8. 2002
    ....
  94. ncbi Proconvulsive effect of the GABA(B) receptor antagonist, SCH 50911, in rats undergoing ethanol withdrawal syndrome
    Mauro A M Carai
    Neuroscienze S.c.a r.l, Via Palabanda 9, I-09123 Cagliari (CA, Italy
    Eur J Pharmacol 445:195-9. 2002
    ....