C Colombo

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Liver involvement in cystic fibrosis: primary organ damage or innocent bystander?
    Carla Colombo
    J Hepatol 41:1041-4. 2004
  2. ncbi request reprint Liver disease in cystic fibrosis
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Curr Opin Pulm Med 13:529-36. 2007
  3. ncbi request reprint Liver disease in cystic fibrosis
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 43:S49-55. 2006
  4. doi request reprint Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study
    Carla Colombo
    CF Center of Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Milano, and University of Milan, Milan, Italy
    Pancreas 38:693-9. 2009
  5. ncbi request reprint Effects of liver transplantation on the nutritional status of patients with cystic fibrosis
    Carla Colombo
    Department of Pediatrics, University of Milan, Milan, Italy
    Transpl Int 18:246-55. 2005
  6. doi request reprint The implementation of standards of care in Europe: state of the art
    Carla Colombo
    Fondazione Cà Granda, Ospedale Maggiore Policlinico IRCCS, Universita degli Studi di Milano, Milan, Italy
    J Cyst Fibros 10:S7-15. 2011
  7. ncbi request reprint Dietary and circulating polyunsaturated fatty acids in cystic fibrosis: are they related to clinical outcomes?
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS Policlinico, Mangiagalli, Regina Elena, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 43:660-5. 2006
  8. doi request reprint Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations
    Carla Colombo
    Department of Pediatrics, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 52:73-83. 2011
  9. ncbi request reprint Seroprevalence of Helicobacter pylori in children with type 1 diabetes mellitus in Sardinia
    C Colombo
    Department of Paediatrics and Neonatology, University of Sassari, Italy
    Diabetes Nutr Metab 15:91-5. 2002
  10. ncbi request reprint Liver disease in cystic fibrosis: A prospective study on incidence, risk factors, and outcome
    Carla Colombo
    CF Center, Department of Pediatrics, University of Milan, Italy
    Hepatology 36:1374-82. 2002

Detail Information

Publications77

  1. ncbi request reprint Liver involvement in cystic fibrosis: primary organ damage or innocent bystander?
    Carla Colombo
    J Hepatol 41:1041-4. 2004
  2. ncbi request reprint Liver disease in cystic fibrosis
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Curr Opin Pulm Med 13:529-36. 2007
    ..This review highlights recent developments in liver disease associated with cystic fibrosis...
  3. ncbi request reprint Liver disease in cystic fibrosis
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 43:S49-55. 2006
    ..The 1-year survival rate after transplantation in CF patients is approximately 80%, with beneficial effects on lung function, nutritional status, body composition and quality of life in most cases...
  4. doi request reprint Efficacy and tolerability of Creon for Children in infants and toddlers with pancreatic exocrine insufficiency caused by cystic fibrosis: an open-label, single-arm, multicenter study
    Carla Colombo
    CF Center of Milano, Fondazione IRCCS Ospedale Policlinico, Mangiagalli, Regina Elena, Milano, and University of Milan, Milan, Italy
    Pancreas 38:693-9. 2009
    ..To evaluate the efficacy and safety of a pancreatic enzyme preparation specifically developed for infants and small children with cystic fibrosis (CF)...
  5. ncbi request reprint Effects of liver transplantation on the nutritional status of patients with cystic fibrosis
    Carla Colombo
    Department of Pediatrics, University of Milan, Milan, Italy
    Transpl Int 18:246-55. 2005
    ..Liver transplantation is associated with long-term beneficial effects on the nutritional status of CF patients and seems to favor bone mineralization...
  6. doi request reprint The implementation of standards of care in Europe: state of the art
    Carla Colombo
    Fondazione Cà Granda, Ospedale Maggiore Policlinico IRCCS, Universita degli Studi di Milano, Milan, Italy
    J Cyst Fibros 10:S7-15. 2011
    ..Suggestions for the future include at least one adequately staffed CF Centre in each country, improved funding, neonatal screening, national patient registries and the formation of national CF parent and patient organisations...
  7. ncbi request reprint Dietary and circulating polyunsaturated fatty acids in cystic fibrosis: are they related to clinical outcomes?
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione IRCCS Policlinico, Mangiagalli, Regina Elena, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 43:660-5. 2006
    ..To assess the relationship between dietary intakes, plasma phospholipid (PL) fatty acid profile and clinical parameters in children with cystic fibrosis (CF) in comparison to healthy controls...
  8. doi request reprint Clinical features and genotype-phenotype correlations in children with progressive familial intrahepatic cholestasis type 3 related to ABCB4 mutations
    Carla Colombo
    Department of Pediatrics, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 52:73-83. 2011
    ....
  9. ncbi request reprint Seroprevalence of Helicobacter pylori in children with type 1 diabetes mellitus in Sardinia
    C Colombo
    Department of Paediatrics and Neonatology, University of Sassari, Italy
    Diabetes Nutr Metab 15:91-5. 2002
    ....
  10. ncbi request reprint Liver disease in cystic fibrosis: A prospective study on incidence, risk factors, and outcome
    Carla Colombo
    CF Center, Department of Pediatrics, University of Milan, Italy
    Hepatology 36:1374-82. 2002
    ..Although LD does not condition a different clinical course of CF, in some patients it may progress rapidly and require liver transplantation...
  11. ncbi request reprint Influence of breast feeding, and adapted and hydrolyzed formulas on biliary bile acids in newborn guinea pigs
    Carla Colombo
    Institute of Pediatrics and Neonatology, School of Medicine, Ospedale San Paolo, University of Milan, Via Commenda 9, I 20122 Milan, Italy
    Biol Neonate 83:36-41. 2003
    ..The type of feeding can differently influence bile acid ontogeny during the period of physiologic cholestasis that characterizes early human development...
  12. ncbi request reprint Benefits of breastfeeding in cystic fibrosis: a single-centre follow-up survey
    Carla Colombo
    Department of Pediatrics, CF Center, Fondazione Ospedale Maggiore Policlinico IRCCS University of Milan, Milan, Italy
    Acta Paediatr 96:1228-32. 2007
    ..To study the effect of breastfeeding (BF) on growth, lung function and number of infections during the first 3 years of life in children with cystic fibrosis (CF)...
  13. doi request reprint Guidelines for the diagnosis and management of distal intestinal obstruction syndrome in cystic fibrosis patients
    Carla Colombo
    Cystic Fibrosis Center, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinica, University of Milan, Milan, Italy
    J Cyst Fibros 10:S24-8. 2011
    ..Avoiding dehydration and optimizing pancreatic enzyme dosage may reduce the chance of further episodes. Prophylactic laxative therapy is widely used, but is not evidence-based...
  14. ncbi request reprint Pancreatic development in newborn guinea pigs fed intact or low-hydrolyzed protein formulas
    Carla Colombo
    Institute of Pediatrics and Neonatology, University of Milan, Milan, Italy
    J Pediatr Gastroenterol Nutr 41:644-9. 2005
    ..To evaluate pancreatic development in newborn guinea pigs fed since birth intact or low-hydrolyzed protein formulas compared with breast milk...
  15. ncbi request reprint Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation
    A Serretti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, University of Milan School of Medicine, Milano, Italy
    Psychiatry Res 89:107-14. 1999
    ..Consideration of possible stratification effects such as gender, age at onset and duration of illness did not reveal any association either. DRD4 exon 3 variants are not a main factor influencing TSD outcome in bipolar disorder...
  16. doi request reprint A symptom-specific analysis of the effect of high-frequency left or low-frequency right transcranial magnetic stimulation over the dorsolateral prefrontal cortex in major depression
    D Rossini
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele, Milan, Italy
    Neuropsychobiology 62:91-7. 2010
    ....
  17. doi request reprint A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis
    G Alicandro
    Centro Fibrosi Cistica, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Italy
    Prostaglandins Leukot Essent Fatty Acids 88:163-9. 2013
    ..001). No differences were detected between groups for secondary outcomes. Despite a decrease of the AA/DHA ratio, DHA supplementation for one year did not induce any significant biochemical and clinical improvement in CF patients...
  18. doi request reprint Frontline extended surgery is associated with improved survival in retroperitoneal low- to intermediate-grade soft tissue sarcomas
    A Gronchi
    Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 23:1067-73. 2012
    ..The purpose of the study was to retrospectively reassess in our institutional series at a longer follow-up the value of a systematic attempt to carry out wide resections in retroperitoneal soft tissue sarcoma...
  19. ncbi request reprint Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    Am J Psychiatry 156:1450-2. 1999
    ..The authors tested the hypothesis that the allelic variation of the 5-HTT-linked polymorphic region (5-HTTLPR) could influence the response of depressed patients to total sleep deprivation...
  20. ncbi request reprint Changes in medial prefrontal cortex neural responses parallel successful antidepressant combination of venlafaxine and light therapy
    F Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Arch Ital Biol 147:83-93. 2009
    ..A significant interaction of treatment and valence of the stimuli was also detected in other areas that have been widely associated with the depressive illness...
  21. doi request reprint Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine
    F Benedetti
    Department of Clinical Neurosciences, Istituto Scientifico Ospedale San Raffaele, University Vita Salute San Raffaele, San Raffaele Turro, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 25:476-8. 2010
    ..Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but several other studies were negative. No study considered drug plasma levels as possible nuisance covariate...
  22. ncbi request reprint High prevalence of lactose absorbers in Northern Sardinian patients with type 1 and type 2 diabetes mellitus
    G F Meloni
    Department of Paediatrics and Neonatology and the Department of Internal Medicine, University of Sassari, Sassari, Italy
    Am J Clin Nutr 73:582-5. 2001
    ..Consequently, there is a greater exposure to glucose and galactose in diabetic patients with high lactose consumption. This may explain the association between diabetes and the risk of cataract...
  23. ncbi request reprint Worsening of delusional depression after sleep deprivation: case reports
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    J Psychiatr Res 33:69-72. 1999
    ....
  24. ncbi request reprint Analysis of inflammatory and immune response biomarkers in sputum and exhaled breath condensate by a multi-parametric biochip array in cystic fibrosis
    C Colombo
    Cystic Fibrosis Centre, Laboratory of Clinical Pathology, Fondazione IRCSS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Int J Immunopathol Pharmacol 24:423-32. 2011
    ..A panel of sputum cytokines and growth factors may better describe the response to intravenous antibiotic treatment of CF than one single systemic marker...
  25. doi request reprint Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients
    A Battezzati
    International Center for the Assessment of Nutritional Status DiSTAM, Universita degli Studi di Milano, Via Botticelli, 21, 20133 Milan, Italy
    Eur J Endocrinol 165:69-76. 2011
    ..Cystic fibrosis (CF)-related diabetes is a leading complication of CF and is associated with pulmonary and nutritional deterioration, years before an evident hyperglycemia, possibly because of insulin deficiency and resistance...
  26. doi request reprint Circadian clock gene Per3 variants influence the postpartum onset of bipolar disorder
    S Dallaspezia
    Department of Clinical Neurosciences, Scientific Institute and University Vita Salute San Raffaele, Via Stamira d Ancona 20, Milan, Italy
    Eur Psychiatry 26:138-40. 2011
    ..We showed a relationship between Per3 polymorphism and postpartum depressive onset in bipolar disorder...
  27. ncbi request reprint Ongoing lithium treatment prevents relapse after total sleep deprivation
    F Benedetti
    Department of Neuropsychiatric Sciences, Instituto Scientifico Ospedale San Raffaele, University of Milan, School of Medicine, Milano, Italy
    J Clin Psychopharmacol 19:240-5. 1999
    ....
  28. ncbi request reprint Morning sunlight reduces length of hospitalization in bipolar depression
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Via Prinetti 29, 20127 Milan, Italy
    J Affect Disord 62:221-3. 2001
    ..Bright artificial light improves non-seasonal depression. Preliminary observations suggest that sunlight could share this effect...
  29. ncbi request reprint Perceived mood and skin body temperature rhythm in depression
    B Barbini
    Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    Eur Arch Psychiatry Clin Neurosci 248:157-60. 1998
    ..A chi-square test confirmed a statistical significance of the discordance between the two rhythms. We discuss our findings hypothesizing a different degree of entrainment of the disease process to the main circadian pacemaker...
  30. ncbi request reprint Oxidation of individual fatty acids yields different profiles of oxidation markers
    F Visioli
    Institute of Pharmacological Sciences, University of Milan, Italy
    Biochem Biophys Res Commun 245:487-9. 1998
    ....
  31. pmc Lactose absorption in patients with glucose 6-phosphate dehydrogenase deficiency with and without favism
    T Meloni
    Department of Paediatrics and Neonatology, University of Sassari, Italy
    Gut 39:210-3. 1996
    ..It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as has been previously shown to occur for thalasaemia and glucose 6-phosphate dehydrogenase (G6PD) deficiency...
  32. ncbi request reprint Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?
    F Benedetti
    Universita Vita Salute San Raffaele, School of Medicine, Department of Neuropsychiatric Sciences, Via Stamira d Ancona 20 20127, Milano, Italy
    J Psychiatr Res 35:323-9. 2001
    ....
  33. doi request reprint Maternal smoking habits are associated with differences in infants' long-chain polyunsaturated fatty acids in whole blood: a case-control study
    C Agostoni
    Department of Pediatrics, San Paolo Hospital, 8 Via A di Rudini, I 20142 Milan, Italy
    Arch Dis Child 93:414-8. 2008
    ..To study the effects of maternal smoking on the status of long-chain polyunsaturated fatty acids (LCPUFA) in infants' whole-blood lipids...
  34. ncbi request reprint Influenza vaccine in healthy preschool children
    C Colombo
    Department of Pediatrics and Neonatology, University of Sassari, Viale San Petro 12, 07100 Sassari, Italy
    Rev Epidemiol Sante Publique 49:157-62. 2001
    ..Studies of influenza vaccination in healthy children have not definitely answered the question of their efficacy...
  35. doi request reprint Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation
    F Valenza
    Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore, Universita degli Studi di Milano, Milano, Italy
    Transplant Proc 44:1826-9. 2012
    ..Ex vivo lung perfusion (EVLP) has been validated as a valuable technique to increase the pool of organs available for lung transplantation...
  36. ncbi request reprint Effects of taurine and ursodeoxycholic acid on liver function tests in patients with cystic fibrosis
    C Colombo
    Department of Pediatrics, University of Milan, Italy
    Acta Univ Carol Med (Praha) 36:148-51. 1990
    ..The effects of longer period of treatment are currently investigated, with purpose of establishing their clinical impact and their relationship with changes in bile acid metabolism...
  37. ncbi request reprint Patterns of mood variation during antidepressant treatment
    F Benedetti
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, University of Milan, School of Medicine, Italy
    J Affect Disord 49:133-9. 1998
    ..We confirmed the existence and the predictability of cyclical mood patterns in a subgroup of patients. The absence of a linear improvement in perceived mood did not worsen the final response to antidepressant therapy...
  38. doi request reprint Growth assessment of paediatric patients with CF comparing different auxologic indicators: A multicentre Italian study
    Vincenzina Lucidi
    Fondazione IRCCS, Ospedale Pediatrico Bambino Gesu, Rome, Italy
    J Pediatr Gastroenterol Nutr 49:335-42. 2009
    ..To evaluate growth in Italian patients with cystic fibrosis (CF)...
  39. ncbi request reprint Spontaneous hypoglycemia in patients with cystic fibrosis
    A Battezzati
    Department of Pediatrics, CF Center, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Italy
    Eur J Endocrinol 156:369-76. 2007
    ..The relationship of CF genotype with insulin secretion control is also unclear...
  40. doi request reprint The in vitro effects of cigarette smoke on fatty acid metabolism are partially counteracted by simvastatin
    P Rise
    Department of Pharmacological Sciences, University of Milano via Balzaretti 9, 20133 Milano, Italy
    Prostaglandins Leukot Essent Fatty Acids 80:71-5. 2009
    ..On the contrary, cigarette smoke (CS) negatively and dose-dependently affects the LC-PUFA production...
  41. ncbi request reprint Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells
    P Rise
    Department of Pharmacological Sciences, University of Milan, 20133 Milano, Italy
    Lipids 38:841-6. 2003
    ..In fact, simvastatin decreased cholesterol synthesis and enhanced LA conversion (mainly delta5 desaturation), whereas curcumin and nicardipin decreased delta5 desaturation, with a limited effect on cholesterol synthesis...
  42. doi request reprint Clinical, pathological and surgical characteristics of duodenal gastrointestinal stromal tumor and their influence on survival: a multi-center study
    C Colombo
    Department of Surgery, Sarcoma Service, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Surg Oncol 19:3361-7. 2012
    ..The duodenum is a rare site of primary gastrointestinal stromal tumor (GIST). Overall (OS) and disease-free survival (DFS) after limited resection (LR) versus pancreaticoduodenectomy (PD) were studied...
  43. ncbi request reprint Increased 5-hydroxytryptamine-2 receptor binding in the frontal cortex of depressed patients responding to paroxetine treatment: a positron emission tomography scan study
    R Zanardi
    Istituto Scientifico Ospedale San Raffaele, Department of Neuropsychiatric Sciences, School of Medicine, University of Milan, Italy
    J Clin Psychopharmacol 21:53-8. 2001
    ..016). These data suggest that clinical improvement in patients treated with paroxetine is associated with an increase in the density of 5-HT2A receptors in the frontal cortex...
  44. ncbi request reprint Liver disease as risk factor for cystic fibrosis-related diabetes development
    L Minicucci
    Cystic Fibrosis Center, Pediatric Clinics University of Genova, G Gaslini Children Hospital, Genova, Italy
    Acta Paediatr 96:736-9. 2007
    ..To evaluate clinical and genetic factors, besides pancreatic insufficiency, associated with increased risk of cystic fibrosis-related diabetes...
  45. ncbi request reprint Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients
    F Benedetti
    Department of Neuropsychiatric Sciences, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    Genes Brain Behav 7:20-5. 2008
    ..Our results support the hypothesis that individual clock genotype may influence several variables linked with human behaviors in normal and psychopathological conditions...
  46. ncbi request reprint Ethanol enhances cholesterol synthesis and secretion in human hepatomal cells
    F Visioli
    University of Milan, Institute of Pharmacological Sciences, Italy
    Alcohol 15:299-303. 1998
    ..The observed modifications of lipid metabolism in HepG2 may partially explain the enhanced incidence of cardiovascular disorders that has been associated with alcoholism...
  47. ncbi request reprint Sleep deprivation hastens the antidepressant action of fluoxetine
    F Benedetti
    Department of Neuropsychiatric Sciences, Istituto Scientifico Ospedale San Raffaele, School of Medicine, University of Milan, Italy
    Eur Arch Psychiatry Clin Neurosci 247:100-3. 1997
    ..We discuss our findings hypothesizing an enhancement in dopaminergic and possibly in serotonergic transmission due to repeated TSD adding to the increase in serotonergic transmission due to fluoxetine medication...
  48. doi request reprint Molecular and clinical features associated with CFTR gene rearrangements in Italian population: identification of a new duplication and recurrent deletions
    V Paracchini
    Medical Genetics Laboratory, Fondazione IRCCS Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Clin Genet 73:346-52. 2008
    ..The search for deletion/duplications of the CFTR gene has made it possible to reach a 94.1% detection rate, with an improvement (1.6%) of the carrier detection rate in the Italian population...
  49. ncbi request reprint Carbohydrate 19-9 antigen is not a marker of liver disease in patients with cystic fibrosis
    Nora Bettinardi
    Analysis Laboratory, Sesto San Giovanni Hospital, Milan, Italy
    Clin Chem Lab Med 41:311-6. 2003
    ..2% (predictive value 33%). Our study indicates that measurement of the serum CA 19-9 concentration alone cannot be proposed as a reliable test of early hepatic involvement in CF...
  50. doi request reprint Sporadic desmoid-type fibromatosis: a stepwise approach to a non-metastasising neoplasm--a position paper from the Italian and the French Sarcoma Group
    A Gronchi
    Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Oncol 25:578-83. 2014
    ..A careful counseling at a referral center is mandatory and should be offered to all patients affected by sporadic DF from the time of their diagnosis. ..
  51. doi request reprint Neuropathological study of skeletal muscle, heart, liver, and brain in a neonatal form of glycogen storage disease type IV associated with a new mutation in GBE1 gene
    C Lamperti
    Fondazione Ospedale Maggiore Policlinico, Maniagalli and Regina Elena, IRCCS, Milan, Italy
    J Inherit Metab Dis 32:S161-8. 2009
    ..E152X, in exon 4, correlating with the lack of enzyme activity and with the severe neonatal involvement. Our findings contribute to increasing the spectrum of mutation associated with congenital GSD IV...
  52. doi request reprint Bridge to lung transplantation by venovenous extracorporeal membrane oxygenation: a lesson learned on the first four cases
    M Nosotti
    Thoracic Surgery and Lung Transplantation Unit, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
    Transplant Proc 42:1259-61. 2010
    ..We concluded that ECMO is an adequate bridge to lung transplantation but, especially in formerly healthy patients, an awake procedure is advisable for a successful outcome...
  53. ncbi request reprint The fatty acid profiles in a drop of blood from a fingertip correlate with physiological, dietary and lifestyle parameters in volunteers
    F Marangoni
    Department of Pharmacological Sciences, Via Balzaretti 9 20133, Milan, Italy
    Prostaglandins Leukot Essent Fatty Acids 76:87-92. 2007
    ....
  54. ncbi request reprint Are Italian medical societies bridging the distance from citizen and patients' associations? Results of a survey
    P Mosconi
    Laboratory for medical research and consumer involvement, Mario Negri Institute, Milan, Italy
    J Prev Med Hyg 49:112-5. 2008
    ..The aims of the survey were to know medical societies attitude vs. patients involvement in research activities and healthcare setting and to find out possible projects conducted in partnership with patients associations...
  55. ncbi request reprint Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial
    C Colombo
    Hormone Research Laboratory, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Int J Biol Markers 20:169-76. 2005
    ..The results indicated that a plant-based diet can improve the serum fatty acid profile and decrease ROMs production. These results suggest that a plant-based diet may reduce the body's exposure to oxidative stress...
  56. ncbi request reprint Olive phenol hydroxytyrosol prevents passive smoking-induced oxidative stress
    F Visioli
    University of Milan, Institute of Pharmacological Sciences, Milan, Italy
    Circulation 102:2169-71. 2000
    ..We tested the effects of a low dose of an OMWW extract in a model of sidestream smoke-induced oxidative stress in rats by evaluating the urinary excretion of 8-iso-prostaglandin (PG) F(2alpha) (iPF(2alpha)-III)...
  57. ncbi request reprint BMD and body composition in children and young patients affected by cystic fibrosis
    Maria Luisa Bianchi
    Centro Malattie Metaboliche Ossee, Istituto Auxologico Italiano IRCCS, Milano, Italy
    J Bone Miner Res 21:388-96. 2006
    ..One hundred thirty-six young patients were studied for 12-24 months. Low BMD was found in 66%. Fat mass and lean mass were also reduced. Impaired pulmonary function and total steroid dose had the greatest negative influence on bone...
  58. pmc Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births
    D Iafusco
    Department of Pediatrics, Second University of Naples, Italy
    Acta Diabetol 49:405-8. 2012
    ..Incidence of NDM was calculated at 1:90,000 (CI: 1:63,000-1:132,000) live births. Thus, with the definition currently in use, about 6 new cases with NDM are expected to be born in Italy each year...
  59. doi request reprint Primary extremity soft tissue sarcomas: outcome improvement over time at a single institution
    A Gronchi
    Department of Surgery, Istituto Nazionale Tumori, Milan, Italy
    Ann Oncol 22:1675-81. 2011
    ..To assess changes in survival over time of extremity soft tissue sarcoma (ESTS) patients treated at a single reference institution...
  60. ncbi request reprint Response to SSRIs and role of the hormonal therapy in post-menopausal depression
    R Zanardi
    Department of Psychiatry, School of Medicine, Vita Salute University San Raffaele Hospital, Via Stamira d Ancona 20, Milan 20127, Italy
    Eur Neuropsychopharmacol 17:400-5. 2007
    ..001) in the group without HT. In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response...
  61. ncbi request reprint Early treatment with ursodeoxycholic acid for cholestasis in children on parenteral nutrition because of primary intestinal failure
    G De Marco
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    Aliment Pharmacol Ther 24:387-94. 2006
    ..There is conflicting evidence as to whether ursodeoxycholic acid (UDCA) reduces the incidence of parenteral nutrition-associated cholestasis...
  62. ncbi request reprint The carbochromene derivative AD6 reduces the TxB2/6-keto-PGF1 alpha ratio in cerebral cortex during hypoxia and recovery and leukotriene synthesis in brain tissue, in the rat
    A Bertazzo
    Institute of Pharmacological Sciences, University of Milan, Italy
    Prostaglandins 35:15-29. 1988
    ..In addition it reduced the formation of compounds, the leukotrienes, which may exert pro-inflammatory activities on the cerebral microcirculation...
  63. ncbi request reprint An innovative approach to research and development: the CEFRIEL experience
    A Castelli
    Information and Communication Technology for Medicine Area--CEFRIEL, Milan, Italy
    Stud Health Technol Inform 84:1125-9. 2001
    ..These activities represent a natural outlet for the expertise and skills collected and enrich the contents of the training courses through continuous reference to the realities of the Industry and the Service sector...
  64. ncbi request reprint Cytokine levels in sputum of cystic fibrosis patients before and after antibiotic therapy
    Carla Colombo
    Department of Pediatrics, Cystic Fibrosis Center, University of Milan, Milan, Italy
    Pediatr Pulmonol 40:15-21. 2005
    ..In conclusion, TNF-alpha and IL-8 levels in sputum of young CF patients with pulmonary exacerbation were always detectable and may be useful, noninvasive outcome measures to assess response to therapy in CF patients...
  65. doi request reprint Borderline sweat test: Utility and limits of genetic analysis for the diagnosis of cystic fibrosis
    Manuela Seia
    Medical Genetics Laboratory, Fondazione IRCCS Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Clin Biochem 42:611-6. 2009
    ..We investigated the relationship between CFTR mutation analysis and sweat chloride concentration in a cohort of subjects with borderline sweat test values, in order to identify misdiagnosis of CF...
  66. ncbi request reprint Paranasal mucoceles in children with cystic fibrosis
    Maurizio Di Cicco
    ENT Department, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, MD Cystic Fibrosis Centre via Commenda 9, University of Milan, 20122 Milan, Italy
    Int J Pediatr Otorhinolaryngol 69:1407-13. 2005
    ..Endoscopic sinus surgery seems to be a safe and efficient treatment of this complication also in a paediatric population at a high risk as for the CF patients...
  67. doi request reprint Fetal cell microchimerism in papillary thyroid cancer: studies in peripheral blood and tissues
    Valentina Cirello
    Department of Medical Sciences, University of Milan and Endocrine Unit, Fondazione Policlinico IRCCS, Via F Sforza 35, Milan, Italy
    Int J Cancer 126:2874-8. 2010
    ....
  68. doi request reprint Role of biophysical parameters on ex vivo and in vivo gene transfer to the airway epithelium by polyethylenimine/albumin complexes
    Sante Di Gioia
    Institute for Experimental Treatment of Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy
    Biomacromolecules 9:859-66. 2008
    ....
  69. doi request reprint Oseltamivir-induced resistant pandemic A/H1N1 influenza virus in a child with cystic fibrosis and Pseudomonas aeruginosa infection
    Susanna Esposito
    Department of Maternal and Pediatric Sciences, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milan, Italy
    J Clin Virol 48:62-5. 2010
    ....
  70. ncbi request reprint Molecular characterization and structural implications of 25 new ABCB4 mutations in progressive familial intrahepatic cholestasis type 3 (PFIC3)
    Dario Degiorgio
    Laboratorio di Genetica Medica, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
    Eur J Hum Genet 15:1230-8. 2007
    ....
  71. doi request reprint Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis
    Andrea Crosignani
    San Paolo Hospital Medical School, University of Milan, Italy
    Clin Chim Acta 395:84-8. 2008
    ..No information is available on the hepatic and extrahepatic pathways of bile acid synthesis in normal children and in pediatric cholestatic liver diseases...
  72. ncbi request reprint Validation of an automated sensitive immunoassay for quantitation of cytokines in the sputum of cystic fibrosis patients
    Amedea Silvia Tirelli
    Laboratory of Clinical Chemistry and Microbiology, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Chem Lab Med 45:108-11. 2007
    ..Our aim was to investigate whether assay of cytokine levels in CF sputum is reproducible or is hampered by proteolytic degradation...
  73. pmc Engraftment of bone marrow-derived stem cells to the lung in a model of acute respiratory infection by Pseudomonas aeruginosa
    Joanna Rejman
    Institute for the Experimental Treatment of Cystic Fibrosis, H S Raffaele Scientific Institute, Milan, Italy
    Mol Ther 17:1257-65. 2009
    ..12%, respectively. Our results show for the first time that tissue damage inflicted by bacteria like P. aeruginosa facilitates the airway engraftment of heterologous bone marrow-derived stem cells and their epithelial transformation...
  74. ncbi request reprint Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis
    Virginia De Rose
    Respiratory Disease Division, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Eur J Hum Genet 13:96-101. 2005
    ..The observation that CF patients carrying the R allele of FcgammaRIIA are at higher risk of acquiring chronic P. aeruginosa infection suggests that the FcgammaRII loci genetic variation is contributing to this infection susceptibility...
  75. ncbi request reprint Growth failure in cystic fibrosis: a true need for anabolic agents?
    Carla Colombo
    J Pediatr 146:303-5. 2005
  76. ncbi request reprint Liver transplant in cystic fibrosis: a poll among European centers. A study from the European Liver Transplant Registry
    Maria L Melzi
    Liver Transplant Unit, Ospedali Riuniti, Bergamo, Italy
    Transpl Int 19:726-31. 2006
    ..This poll reveals that most European liver centers perform LTx prior to the development of end-stage liver disease or overt pulmonary or other clinical decompensation...
  77. ncbi request reprint Dysregulated interleukin-8 secretion and NF-kappaB activity in human cystic fibrosis nasal epithelial cells
    Salvatore Carrabino
    Institute for Experimental Treatment of Cystic Fibrosis, H S Raffaele, Via Olgettina 58, 20132 Milano, Italy
    J Cyst Fibros 5:113-9. 2006
    ..The aim of this study was to investigate IL-8 secretion and NF-kappaB activity in primary respiratory epithelial cells cultured from nasal polyps obtained from CF and non-CF subjects...