Affiliation: University of Turin
Collino M, Patel N, Thiemermann C. PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury. Ther Adv Cardiovasc Dis. 2008;2:179-97 pubmed publisher
..This paper reviews the evidence and recent developments relating to the potential therapeutic effects of PPAR-agonists in the treatment of cerebral I/R injury. ..
Mastrocola R, Ferrocino I, Liberto E, Chiazza F, Cento A, Collotta D, et al
. Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study. J Nutr Biochem. 2018;55:185-199 pubmed publisher
..These results suggest that consumption of fructose under different forms, liquid or solid, may differently affect gut microbiota, thus leading to impairment in intestinal mucosa integrity and liver homeostasis. ..
Collino M, Thiemermann C, Cerami A, Brines M. Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacol Ther. 2015;151:32-40 pubmed publisher
..This review summarizes pharmacokinetic and pharmacodynamic data and discusses the molecular mechanisms underlying the long-lasting effects of this short-lived peptide. ..
Collino M, Aragno M, Castiglia S, Miglio G, Tomasinelli C, Boccuzzi G, et al
. Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. Br J Pharmacol. 2010;160:1892-902 pubmed publisher
..These effects were associated with changes in hepatic expression of SOCS-3, which may be a crucial link between the reduced local inflammation and the improved insulin signalling. ..
Collino M, Thiemermann C, Mastrocola R, Gallicchio M, Benetti E, Miglio G, et al
. Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. Shock. 2008;30:299-307 pubmed publisher
..The present study demonstrates that TDZD-8 protects the brain against I/R injury by inhibiting GSK-3beta activity. Collectively, our data may contribute to focus the role of GSK-3beta in cerebral I/R. ..
Collino M, Aragno M, Castiglia S, Tomasinelli C, Thiemermann C, Boccuzzi G, et al
. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta. Diabetes. 2009;58:235-42 pubmed publisher
..We propose that the inhibitory effect on the activity of GSK-3beta contributes to the protective effect of insulin independently of any effects on blood glucose. ..
Collino M, Castiglia S, Manoni M, Salsini L, Chini J, Masini E, et al
. Effects of a semi-synthetic N-,O-sulfated glycosaminoglycan K5 polysaccharide derivative in a rat model of cerebral ischaemia/reperfusion injury. Thromb Haemost. 2009;102:837-45 pubmed publisher
Collino M, Benetti E, Rogazzo M, Mastrocola R, Yaqoob M, Aragno M, et al
. Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-? agonism correlates with impaired NLRP3 inflammasome activation. Biochem Pharmacol. 2013;85:257-64 pubmed publisher
Collino M, Pini A, Mugelli N, Mastroianni R, Bani D, Fantozzi R, et al
. Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure. Dis Model Mech. 2013;6:1012-20 pubmed publisher