Paola Coccetti

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. ncbi Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 346:786-93. 2006
  2. ncbi The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1 to S transition in Saccharomyces cerevisiae
    Paola Coccetti
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Cell Cycle 7:1391-401. 2008
  3. ncbi Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita Milano Bicocca, P zza della Scienza, 2, 20126 Milano, Italy
    Bioorg Med Chem Lett 20:2780-4. 2010
  4. ncbi A surface-activated chemical ionization approach allows quantitative phosphorylation analysis of the cyclin-dependent kinase inhibitor Sic1 phosphorylated on Ser201
    Claudia Cirulli
    Universita degli Studi di Milano Bicocca, Dipartimento di Biotecnologie e Bioscienze, Piazza della Scienza 2, 20126 Milano, Italy
    Rapid Commun Mass Spectrom 26:1527-32. 2012
  5. ncbi Mutations of the CK2 phosphorylation site of Sic1 affect cell size and S-Cdk kinase activity in Saccharomyces cerevisiae
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Mol Microbiol 51:447-60. 2004
  6. ncbi Nutritional modulation of CK2 in Saccharomyces cerevisiae: regulating the activity of a constitutive enzyme
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Mol Cell Biochem 356:269-75. 2011
  7. ncbi In CK2 inactivated cells the cyclin dependent kinase inhibitor Sic1 is involved in cell-cycle arrest before the onset of S phase
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 359:921-7. 2007
  8. ncbi Snf1/AMPK promotes S-phase entrance by controlling CLB5 transcription in budding yeast
    Stefania Pessina
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Cell Cycle 9:2189-200. 2010
  9. ncbi An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in Cdc34-like enzymes
    Elena Papaleo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    PLoS Comput Biol 7:e1002056. 2011
  10. ncbi CK2 activity is modulated by growth rate in Saccharomyces cerevisiae
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 398:44-50. 2010

Collaborators

Detail Information

Publications16

  1. ncbi Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 346:786-93. 2006
    ..These data strongly support the notion that CK2 phosphorylates Sic1 in vivo...
  2. ncbi The CK2 phosphorylation of catalytic domain of Cdc34 modulates its activity at the G1 to S transition in Saccharomyces cerevisiae
    Paola Coccetti
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Cell Cycle 7:1391-401. 2008
    ....
  3. ncbi Synthesis and biological evaluation of combretastatin analogs as cell cycle inhibitors of the G1 to S transition in Saccharomyces cerevisiae
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita Milano Bicocca, P zza della Scienza, 2, 20126 Milano, Italy
    Bioorg Med Chem Lett 20:2780-4. 2010
    ..Moreover, combretatstatin A-4 (2b) and compound 2c induced a G1 arrest by affecting the synthesis of Clb5 protein, the principal S-phase cyclin. The G1 arrest is coincident with the activation of the stress activated kinase Snf1...
  4. ncbi A surface-activated chemical ionization approach allows quantitative phosphorylation analysis of the cyclin-dependent kinase inhibitor Sic1 phosphorylated on Ser201
    Claudia Cirulli
    Universita degli Studi di Milano Bicocca, Dipartimento di Biotecnologie e Bioscienze, Piazza della Scienza 2, 20126 Milano, Italy
    Rapid Commun Mass Spectrom 26:1527-32. 2012
    ..The main advantages of SACI-MS technology are high sensitivity, quantitative accuracy and matrix effect reduction, which allow quantitative estimations...
  5. ncbi Mutations of the CK2 phosphorylation site of Sic1 affect cell size and S-Cdk kinase activity in Saccharomyces cerevisiae
    Paola Coccetti
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Mol Microbiol 51:447-60. 2004
    ..A strong reduction of the same parameters is observed in cells harbouring Sic1S201E. The deregulated coordination between cell size and cell cycle is also apparent at the level of S-Cdk activity...
  6. ncbi Nutritional modulation of CK2 in Saccharomyces cerevisiae: regulating the activity of a constitutive enzyme
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Mol Cell Biochem 356:269-75. 2011
    ..These findings newly indicate a regulatory role of β and β' subunits of CK2 in the nutrient response...
  7. ncbi In CK2 inactivated cells the cyclin dependent kinase inhibitor Sic1 is involved in cell-cycle arrest before the onset of S phase
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 359:921-7. 2007
    ..These findings indicate that Sic1 plays a major role during G1 arrest of CK2-inactivated cells...
  8. ncbi Snf1/AMPK promotes S-phase entrance by controlling CLB5 transcription in budding yeast
    Stefania Pessina
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Cell Cycle 9:2189-200. 2010
    ..In conclusion, this report describes a previously unrecognized role for Snf1 in transcriptional modulation of the G 1 to S transition, differing from the reported AMPK role in controlling the G 1/S transition in multicellular eukaryotes...
  9. ncbi An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in Cdc34-like enzymes
    Elena Papaleo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    PLoS Comput Biol 7:e1002056. 2011
    ....
  10. ncbi CK2 activity is modulated by growth rate in Saccharomyces cerevisiae
    Farida Tripodi
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Biochem Biophys Res Commun 398:44-50. 2010
    ..Also in chemostat cultures nuclear CK2 activity is higher in faster growing cells providing the first unequivocal demonstration that growth rate itself can affect CK2 activity in a eukaryotic organism...
  11. ncbi The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain
    Matteo Barberis
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Biochem J 387:639-47. 2005
    ..Taken together, these findings strongly indicate that budding yeast Sic1 and mammalian p27(Kip1) are functional homologues with a structurally conserved inhibitory domain...
  12. ncbi Loop 7 of E2 enzymes: an ancestral conserved functional motif involved in the E2-mediated steps of the ubiquitination cascade
    Elena Papaleo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    PLoS ONE 7:e40786. 2012
    ..Its different functions are exploited thank to its conserved hydrophobic and acidic residues in a finely orchestrate mechanism...
  13. ncbi Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network
    Lilia Alberghina
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Milano, Italy
    Biotechnol Adv 30:52-72. 2012
    ....
  14. ncbi Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae
    Stefano Busti
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza, 2 20126 Milano, Italy
    Sensors (Basel) 10:6195-240. 2010
    ..Many interconnections exist between the diverse glucose sensing systems, which enables yeast cells to fine tune cell growth, cell cycle and their coordination in response to nutritional changes...
  15. ncbi Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis
    Farida Tripodi
    Department of Biotechnology and Biosciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    J Med Chem 55:2112-24. 2012
    ..Additionally, the most potent compounds displayed antiproliferative activity against different colon cancer cell lines, opening the route to a new class of potential therapeutic agents against colon cancer...
  16. ncbi Systems biology of the cell cycle of Saccharomyces cerevisiae: From network mining to system-level properties
    Lilia Alberghina
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Biotechnol Adv 27:960-78. 2009
    ..The relevance of the insight coming from the cell cycle SB studies in developing a new framework for tackling very complex biological processes, such as cancer and aging, is discussed...