Mario Clerici

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection
    Eleonora Castelletti
    Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate Vialba, University of Milano, Milano, Italy
    PLoS ONE 2:e969. 2007
  2. pmc A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis
    Maira Gironi
    Semeion Research Center, Via Sersale 117, Rome, 00128, Italy
    Immun Ageing 10:1. 2013
  3. pmc Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, King Abdullah road, Riyadh 11451, Kingdom of Saudi Arabia
    BMC Med 10:140. 2012
  4. doi request reprint Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn's disease
    Mario Clerici
    Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milano, Milano, Italy
    Dig Liver Dis 43:946-52. 2011
  5. pmc Activating KIR/HLA complexes in classic Kaposi's Sarcoma
    Franca R Guerini
    Don C, Gnocchi Foundation ONLUS, P, le Morandi 6, 20121 Milan, Italy
    Infect Agent Cancer 7:9. 2012
  6. pmc Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, 23842 Bosisio Parini, LC, Italy
    BMC Evol Biol 11:171. 2011
  7. pmc The landscape of human genes involved in the immune response to parasitic worms
    Matteo Fumagalli
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Via don L, Monza 20, 23842 Bosisio, Parini, LC, Italy
    BMC Evol Biol 10:264. 2010
  8. ncbi request reprint Beyond IL-17: new cytokines in the pathogenesis of HIV infection
    Mario Clerici
    Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milan, Via Fratelli Cervi 93, Segrate, Milan, Italy
    Curr Opin HIV AIDS 5:184-8. 2010
  9. ncbi request reprint Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals
    Daria Trabattoni
    Department of Immunology, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    AIDS 18:859-69. 2004
  10. ncbi request reprint Distinct patterns of HIV-specific memory T lymphocytes in HIV-exposed uninfected individuals and in HIV-infected patients
    Monica Schenal
    Immunology DISP LITA Vialba, University of Milano, Milano, Italy
    AIDS 19:653-61. 2005

Detail Information

Publications90

  1. pmc The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection
    Eleonora Castelletti
    Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate Vialba, University of Milano, Milano, Italy
    PLoS ONE 2:e969. 2007
    ..The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model...
  2. pmc A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis
    Maira Gironi
    Semeion Research Center, Via Sersale 117, Rome, 00128, Italy
    Immun Ageing 10:1. 2013
    ..abstract:..
  3. pmc Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, King Abdullah road, Riyadh 11451, Kingdom of Saudi Arabia
    BMC Med 10:140. 2012
    ....
  4. doi request reprint Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn's disease
    Mario Clerici
    Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milano, Milano, Italy
    Dig Liver Dis 43:946-52. 2011
    ..Autologous haematopoietic stem cells transplantation (HSCT) has been shown to be effective in refractory Crohn's disease...
  5. pmc Activating KIR/HLA complexes in classic Kaposi's Sarcoma
    Franca R Guerini
    Don C, Gnocchi Foundation ONLUS, P, le Morandi 6, 20121 Milan, Italy
    Infect Agent Cancer 7:9. 2012
    ..abstract:..
  6. pmc Balancing selection is common in the extended MHC region but most alleles with opposite risk profile for autoimmune diseases are neutrally evolving
    Rachele Cagliani
    Scientific Institute IRCCS E, Medea, 23842 Bosisio Parini, LC, Italy
    BMC Evol Biol 11:171. 2011
    ..We aimed at testing the hypothesis whereby balancing selection has shaped the frequency of opposite risk alleles...
  7. pmc The landscape of human genes involved in the immune response to parasitic worms
    Matteo Fumagalli
    Scientific Institute IRCCS E, Medea, Bioinformatic Lab, Via don L, Monza 20, 23842 Bosisio, Parini, LC, Italy
    BMC Evol Biol 10:264. 2010
    ..The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight. Therefore, helminth infections can be regarded as a strong selective pressure...
  8. ncbi request reprint Beyond IL-17: new cytokines in the pathogenesis of HIV infection
    Mario Clerici
    Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milan, Via Fratelli Cervi 93, Segrate, Milan, Italy
    Curr Opin HIV AIDS 5:184-8. 2010
    ..Thus, new cytokines are being investigated within the context of HIV pathogenesis. This review describes novel functions of 'old' cytokines and summarizes the potential role of 'new' cytokines in this disease...
  9. ncbi request reprint Granule-dependent mechanisms of lysis are defective in CD8 T cells of HIV-infected, antiretroviral therapy-treated individuals
    Daria Trabattoni
    Department of Immunology, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    AIDS 18:859-69. 2004
    ..CTL are stimulated by type 1 cytokines and can kill targets via granule-dependent (perforin and granzymes) and -independent (tumour necrosis factor-alpha, CD95) mechanisms...
  10. ncbi request reprint Distinct patterns of HIV-specific memory T lymphocytes in HIV-exposed uninfected individuals and in HIV-infected patients
    Monica Schenal
    Immunology DISP LITA Vialba, University of Milano, Milano, Italy
    AIDS 19:653-61. 2005
    ....
  11. doi request reprint TLR activation pathways in HIV-1-exposed seronegative individuals
    Mara Biasin
    Cattedra di Immunologia, Universita degli Studi di Milano, Milan, Italy
    J Immunol 184:2710-7. 2010
    ....
  12. pmc HHV8 a subtype is associated with rapidly evolving classic Kaposi's sarcoma
    Roberta Mancuso
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation, IRCCS S Maria Nascente, Milan, Italy
    J Med Virol 80:2153-60. 2008
    ..Infection supported by KSHV A subtype is associated with more rapid progressive disease. Careful monitoring and aggressive therapeutic protocols should be considered in patients with KSHV A-supported infection...
  13. doi request reprint The MCP-1 gene (SCYA2) and mood disorders: preliminary results of a case-control association study
    A Carlo Altamura
    Department of Psychiatry, Geriatric Medicine Unit, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neuroimmunomodulation 17:126-31. 2010
    ....
  14. ncbi request reprint Early initiation of highly active antiretroviral therapy fails to reverse immunovirological abnormalities in gut-associated lymphoid tissue induced by acute HIV infection
    Camilla Tincati
    Department of Internal Medicine, Clinic of Infectious Diseases and Tropical Medicine, San Paolo Hospital, University of Milan, Milan, Italy
    Antivir Ther 14:321-30. 2009
    ..During the acute phase of HIV infection, large CD4+ T-cell depletion occurs in the gastrointestinal tract. The kinetics of CD4+ T-cell decrease and highly active antiretroviral therapy (HAART)-mediated immune reconstitution were evaluated...
  15. ncbi request reprint Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART
    Giulia Marchetti
    Department of Clinical Sciences, Chair of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    AIDS 20:1727-36. 2006
    ..A better understanding of the relationship between T-cell dynamics and the HIV intracellular reservoir in HIV-infected patients failing to recover CD4 cell count following long-term HAART, is required...
  16. doi request reprint Costimulatory pathways in multiple sclerosis: distinctive expression of PD-1 and PD-L1 in patients with different patterns of disease
    Daria Trabattoni
    Department of Immunology, University of Milano, Milan, Italy
    J Immunol 183:4984-93. 2009
    ..The PD-1/PD-L1 pathway plays an important role in modulating immune functions in MS patients; monitoring and targeting these proteins could offer diagnostic and therapeutic advantages...
  17. pmc Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation ONLUS, IRCCS S Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy
    Clin Immunol 129:509-17. 2008
    ..Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases...
  18. pmc JC virus detection and JC virus-specific immunity in natalizumab-treated multiple sclerosis patients
    Roberta Mancuso
    Don C, Gnocchi Foundation, ONLUS, Milan, Italy
    J Transl Med 10:248. 2012
    ..The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML)...
  19. ncbi request reprint IL-7/IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:447-52. 2004
    ..Our data confirm the pivotal role of IL-2 and IL-7 in the regulation of T-lymphocyte homeostasis in HIV infection...
  20. ncbi request reprint Failure to eradicate HIV despite fully successful HAART initiated in the first days of life
    Alessandra Vigano
    Department of Paediatrics, University of Milan, Italy
    J Pediatr 148:389-91. 2006
    ..Discontinuation of HAART 2 years after apparent HIV eradication, however, was followed by virus replication, CD4 decline, and destruction of HIV-specific lymphocytes, epitomizing the impossibility of HIV eradication...
  21. ncbi request reprint Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation
    Stefania Piconi
    Allergy and Clinical Immunology Unit, Luigi Sacco Hospital, Milan, Italy
    J Immunol 178:1931-7. 2007
    ..B7-H1 could be an optimal target for IT of allergic diseases using mAbs...
  22. doi request reprint Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders
    Stefania Piconi
    I Divisione Malattie Infettive, H L Sacco, Milan, Italy
    Blood 118:3263-72. 2011
    ..HCQ reduces lipopolysaccharide/TLR-mediated immune activation; this compound could be a useful immunomodulant in HIV-infected patients. This study is registered at EutraCT as 2009-012499-28 with study number HLS01/2009-1-16-03-2009...
  23. ncbi request reprint Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men
    Sergio Lo Caputo
    Unita Operativa Malattie Infettive, Ospedale SM Annunziata, Firenze, Milano, Italy
    AIDS 17:531-9. 2003
    ..Mucosal and systemic immune correlates of this condition have been analysed in HIV-1-exposed women but no data are available concerning mucosal immunity and HIV-1-specific immune responses in exposed but uninfected men...
  24. ncbi request reprint A complex proinflammatory role for peripheral monocytes in Alzheimer's disease
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi ONLUS Foundation IRCCS, Milano, Italy
    J Alzheimers Dis 38:403-13. 2014
    ..Therapeutic approaches designed to interrupt these mechanism might prove beneficial. ..
  25. ncbi request reprint Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Italy
    AIDS 18:211-6. 2004
    ..The hallmark of interleukin-2 (IL-2)-induced immune reconstitution is the selective outgrowth of CD4 through undefined mechanisms...
  26. doi request reprint In vivo imaging of lymph node migration of MNP- and (111)In-labeled dendritic cells in a transgenic mouse model of breast cancer (MMTV-Ras)
    Cristina Martelli
    Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Mol Imaging Biol 14:183-96. 2012
    ..The authors present a protocol for the in vivo evaluation, using different imaging techniques, of lymph node (LN) homing of tumor-specific dendritic cells (DCs) in a murine breast cancer model...
  27. ncbi request reprint Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals
    Mara Biasin
    Department of Immunology, Dipartimento di Scienze Precliniche Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milano University Medical School, Milano, Italy
    J Infect Dis 195:960-4. 2007
    ..Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection...
  28. doi request reprint Humoral and cellular response to influenza vaccine in HIV-infected children with full viroimmunologic response to antiretroviral therapy
    Alessandra Vigano
    Clinic of Pediatrics, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Acquir Immune Defic Syndr 48:289-96. 2008
    ..We evaluated the influenza-specific immune responses elicited by a virosomal vaccine in HIV-infected children on long-term successful highly active antiretroviral therapy (HAART)...
  29. doi request reprint Endoplasmic reticulum aminopeptidase 2 haplotypes play a role in modulating susceptibility to HIV infection
    Mara Biasin
    Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy
    AIDS 27:1697-706. 2013
    ..As ERAP2 trims peptides loaded on major histocompatibility complex (MHC) class I and CD8 T lymphocytes protect against viral infections, we analysed its role in resistance to HIV-1 infection...
  30. doi request reprint T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)
    Laura Guazzarotti
    Luigi Sacco Hospital, Milan, Italy
    Am J Intellect Dev Disabil 114:100-9. 2009
    ....
  31. ncbi request reprint Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trial
    Andrea Gori
    Institute of Infectious Diseases and Tropical Medicine, L Sacco Hospital, University of Milan, Milan, Italy
    Antivir Ther 9:603-14. 2004
    ..In a Phase I/II clinical trial performed on HIV-positive patients we analysed the safety and immunomodulating effects of tucaresol, a novel compound that has previously been described tn enhance cell-mediated immune responses...
  32. doi request reprint Vitamin D receptor (VDR) gene SNPs influence VDR expression and modulate protection from multiple sclerosis in HLA-DRB1*15-positive individuals
    Cristina Agliardi
    Don C Gnocchi Foundation ONLUS, P le Morandi 6, 20121 Milan, Italy
    Brain Behav Immun 25:1460-7. 2011
    ..Results herein offer a model justifying the interaction between the major genetic (HLA-DRB*15) and environmental (vitamin D) factors associated with MS onset...
  33. doi request reprint Not just sheer luck! Immune correlates of protection against HIV-1 infection
    Luca Piacentini
    DISP LITA Vialba, Milano, University Medical School, Milano, Italy
    Vaccine 26:3002-7. 2008
    ..In this review, we will summarize the body of knowledge that stemmed from that first observation...
  34. ncbi request reprint Human alpha defensin in HIV-exposed but uninfected individuals
    Daria Trabattoni
    Cattedra di Immunologia, Universita di Milano, Milano, Italy
    J Acquir Immune Defic Syndr 35:455-63. 2004
    ..A robust constitutive production of alpha defensin is seen in HIV-exposed uninfected individuals; these peptides could have a role in the potentially protective immune response that characterizes ESNs...
  35. doi request reprint CD4+CD25+FoxP3+PD1- regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi ONLUS Foundation, IRCCS, Milan, Italy
    FASEB J 22:3500-8. 2008
    ..The data herein suggest that PD1- T(reg) cells play a pivotal role in MS and offer a biological explanation for disease relapse and for the mechanism associated with response to COPA and IFNbeta...
  36. doi request reprint Atherosclerosis is associated with multiple pathogenic mechanisms in HIV-infected antiretroviral-naive or treated individuals
    Stefania Piconi
    Infectious Diseases Unit, University of Milano, Milan, Italy
    AIDS 27:381-9. 2013
    ....
  37. pmc CCL28 induces mucosal homing of HIV-1-specific IgA-secreting plasma cells in mice immunized with HIV-1 virus-like particles
    Veronica Rainone
    Department of Clinical Sciences, University of Milan, Milan, Italy
    PLoS ONE 6:e26979. 2011
    ..These data suggest that CCL28 could be useful in enhancing the IgA immune response that will likely play a pivotal role in prophylactic HIV vaccines...
  38. ncbi request reprint Early and late effects of highly active antiretroviral therapy: a 2 year follow-up of antiviral-treated and antiviral-naive chronically HIV-infected patients
    Mario Clerici
    Cattedra di Immunologia, Universita degli Studi di Milano, DISP LITA Vialba, Milano, Italy
    AIDS 16:1767-73. 2002
    ..Control of HIV replication can be observed in highly active antiretroviral therapy (HAART)-treated and, occasionally, in HAART-naive patients. The immunological correlates of these situations were examined in a longitudinal study...
  39. ncbi request reprint Cytokine polymorphisms in the pathophysiology of mood disorders
    Mario Clerici
    Department of Biomedical Sciences and Technologies, University of Milan, Italy
    CNS Spectr 14:419-25. 2009
    ..The aim of this study was to define the genetic immunologic scenario associated with major depressive disorder (MDD) and bipolar disorder...
  40. ncbi request reprint Immune activation and normal levels of endogenous antivirals are seen in healthy adolescents born of HIV-infected mothers
    Alessandra Vigano
    Department of Pediatrics, Luigi Sacco Hospital, Milan, Italy
    AIDS 21:245-8. 2007
    ..Endogenous antivirals (APOBEC, TRIM5alpha) were comparable in seroreverters and HC, and might not play a role in resistance to vertical HIV infection...
  41. doi request reprint T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis
    Marina Saresella
    Don C Gnocchi Foundation, ONLUS, Milano, 20148, Italy
    Clin Immunol 148:79-88. 2013
    ..Results herein clarify the pathogenic similarities between ALS and PP-MS and could be helpful for the design of novel diagnostic and therapeutic approaches to ALS...
  42. doi request reprint Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness
    Stefania Piconi
    Infectious Diseases Unit, Hospital Luigi Sacco, Milan, Italy
    FASEB J 23:1196-204. 2009
    ..These results shed light on the pathogenesis of atherosclerosis and could have practical implications for public health...
  43. ncbi request reprint Growth hormone in T-lymphocyte thymic and postthymic development: a study in HIV-infected children
    Alessandra Vigano
    Pediatrics and Immunology, Milano University, Milan, Italy
    J Pediatr 145:542-8. 2004
    ....
  44. ncbi request reprint Functional repertoire of dendritic cells generated in granulocyte macrophage-colony stimulating factor and interferon-alpha
    Silvia Della Bella
    Dipartmento di Scienze e Technologie Biomediche, Cattedra di Immunologia, Universita degli Studi di Milano, L I T A, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
    J Leukoc Biol 75:106-16. 2004
    ....
  45. doi request reprint Detection of viral DNA sequences in the cerebrospinal fluid of patients with multiple sclerosis
    Roberta Mancuso
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation, IRCCS S Maria Nascente, Milan, Italy
    J Med Virol 82:1051-7. 2010
    ....
  46. doi request reprint Intrafamiliar transmission of Kaposi's sarcoma-associated herpesvirus and seronegative infection in family members of classic Kaposi's sarcoma patients
    Roberta Mancuso
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation, ONLUS, IRCCS, Milan, Italy
    J Gen Virol 92:744-51. 2011
    ..Thus, the risk of KSHV infection is greatly enhanced within families of cKS patients, where close contacts (horizontal and/or sexual) can contribute to the spread of KSHV...
  47. doi request reprint Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy
    Stefania Piconi
    Department of Infectious Diseases of the Luigi Sacco Hospital, Milano, Italy
    AIDS 24:1991-2000. 2010
    ..Persistently reduced CD4(+) T-lymphocyte counts in the face of undetectable HIV viremia are seen in a sizable percentage of HIV-infected patients undergoing antiretroviral therapy (ART). We analyzed the immune correlates of this phenomenon...
  48. ncbi request reprint Selective granulocyte/monocyte apheresis in the treatment of HIV-infected patients: short-term and long-term effects on immunological and virological parameters
    Alberto Beretta
    Infectious Diseases Clinic, St Raffaele Hospital, Milan, Italy
    Perfusion 17:47-51. 2002
    ..Taken together, the results indicate that G1 apheresis could be used to improve the immunological and virological response to HAART...
  49. ncbi request reprint Torque teno virus (TTV) in multiple sclerosis patients with different patterns of disease
    Roberta Mancuso
    Don C Gnocchi Foundation, ONLUS, Milan, Italy
    J Med Virol 85:2176-83. 2013
    ..Overall these findings suggest that, although TTV infects the same proportion of MS patients and healthy controls, the levels of replication of the virus differ among patients, being correlated with the clinical phenotype of disease...
  50. ncbi request reprint Low interleukin-10 production is associated with diabetes in HIV-infected patients undergoing antiviral therapy
    Daria Trabattoni
    Chair of Immunology, Milano University, DISP LITA Vialba, Via GB Grassi 74, 20157 Milan, Italy
    Med Microbiol Immunol 195:125-32. 2006
    ..Further studies will be necessary to clarify whether low IL-10 is a risk factor for, or a consequence of, diabetes...
  51. pmc Modulation of human immunodeficiency virus (HIV)-specific immune response by using efavirenz, nelfinavir, and stavudine in a rescue therapy regimen for HIV-infected, drug-experienced patients
    Daria Trabattoni
    Cattedra di Immunologia, Universita di Milano, DISP, LITA Vialba, Milan, Italy
    Clin Diagn Lab Immunol 9:1114-8. 2002
    ..Therapy with EFV, NFV, and d4T increases HIV-specific type 1 cytokine production as well as CD4 counts and reduces plasma viremia. This therapeutic regimen may be considered for use in cases of advanced HIV infection...
  52. doi request reprint Neuroinflammation and brain functional disconnection in Alzheimer's disease
    Francesca Baglio
    IRCCS, Don Gnocchi Foundation, Milan, Italy
    Front Aging Neurosci 5:81. 2013
    ..Monitoring of immune cells in peripheral blood could have a prognostic value in AD...
  53. ncbi request reprint Thalidomide in the treatment of chronic hepatitis C unresponsive to alfa-interferon and ribavirin
    Laura Milazzo
    Institute of Infectious and Tropical Diseases, University of Milan, Milan, Italy
    Am J Gastroenterol 101:399-402. 2006
    ....
  54. doi request reprint Immunological effects of sublingual immunotherapy: clinical efficacy is associated with modulation of programmed cell death ligand 1, IL-10, and IgG4
    Stefania Piconi
    Department of Allergic Diseases and Clinical Immunology, L Sacco Hospital, Milan, Italy
    J Immunol 185:7723-30. 2010
    ..A more detailed understanding of the interaction of allergen and APCs within the oral mucosa will allow improved targeting of allergy vaccine...
  55. doi request reprint FDG-PET imaging in HIV-infected subjects: relation with therapy and immunovirological variables
    Giovanni Lucignani
    Institute of Radiological Sciences, University of Milan, San Paolo Hospital, Milan, Italy
    Eur J Nucl Med Mol Imaging 36:640-7. 2009
    ....
  56. ncbi request reprint Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, IRCCS S Maria Nascente, Don C Gnocchi Foundation, 66, Milan, Italy
    J Neuroimmunol 166:173-9. 2005
    ..A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients...
  57. ncbi request reprint Probiotics reduce gut microbial translocation and improve adult atopic dermatitis
    Enrico Iemoli
    Allergy and Clinical Immunology Unit, L Sacco Hospital, Milan, Italy
    J Clin Gastroenterol 46:S33-40. 2012
    ..It has been suggested that probiotics modulate atopic dermatitis (AD) progression, but no data are actually available on their mechanisms of action and on their ability to act as immunomodulators in this pathology...
  58. ncbi request reprint Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment
    Giulia Marchetti
    Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Milan, Italy
    J Infect Dis 186:606-16. 2002
    ..Thus, adjuvant IL-2 therapy in immunologic nonresponders resulted in a clinical benefit, suggesting that the quantitative cell recovery involves functionally competent immune cells...
  59. ncbi request reprint Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease
    Beatrice Arosio
    Department of Geriatrics, Ospedale Maggiore IRCCS, University of Milano, Milan, Italy
    Neurobiol Aging 25:1009-15. 2004
    ..023). These results raise questions regarding the inflammatory theory in AD, pointing to a pivotal role of IL-10 and IL-6 and a selective alteration in this network...
  60. doi request reprint A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation IRCCS, S Maria Nascente, Milan, Italy
    Neurobiol Aging 33:624.e11-22. 2012
    ..Such alteration results in reduced IL-10 production and diminished apoptosis of Aβ-specific CD4(+) T lymphocytes; these phenomena could play a role in the neuroinflammation accompanying AD...
  61. ncbi request reprint Family-based transmission analysis of HLA genetic markers in Sardinian children with autistic spectrum disorders
    Franca R Guerini
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation IRCCS, S Maria Nascente, Milan, Italy
    Hum Immunol 70:184-90. 2009
    ..01). The results present novel gene markers, reinforcing the hypothesis that genetic factors play a pivotal role in the pathogenesis of ASD...
  62. ncbi request reprint Favorable outcome of ex-vivo purging of monocytes after the reintroduction of treatment after interruption in patients infected with multidrug resistant HIV-1
    Hamid Hasson
    San Raffaele Scientific Institute, Infectious Diseases Clinic, Milano, Italy
    J Med Virol 79:1640-9. 2007
    ..021). A consistent decrease of HIV DNA load in CD14+ purified cells was observed only in treatment interruption + MYP patients. These data suggest that MYP can improve the immunological and virological response to treatment interruption...
  63. ncbi request reprint B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression
    Daria Trabattoni
    Chair of Immunolgy, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate DISP LITA Vialba, University of Milano, Milano, Italy
    Blood 101:2514-20. 2003
    ..B7-H1 is a surrogate marker potentially involved in AIDS disease progression...
  64. ncbi request reprint Skewed T-cell maturation and function in HIV-infected patients failing CD4+ recovery upon long-term virologically suppressive HAART
    Giulia Marchetti
    Department of Medicine, Surgery and Dentistry, Clinic of Infectious Diseases, San Paolo Hospital, University of Milan, Milan, Italy
    AIDS 24:1455-60. 2010
    ..Analysis of functionally defined T-cell differentiation in HIV-infected patients with low CD4(+) on virologically suppressive HAART is crucial to design clinically efficacious treatments...
  65. ncbi request reprint Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice
    Daria Trabattoni
    Chair of Immunology, DISP LITA Vialba, Via GB Grassi 74, 20157 Milano, Italy
    Vaccine 24:1470-7. 2006
    ..The immune enhancing effects of HYB2055 adjuvant were dose-dependent. These findings warrant clinical evaluation of the HIV-1 immunogen/HYB2055 candidate as a therapeutic vaccine for HIV-1 infected patients...
  66. pmc Peripheral blood endothelial progenitors as potential reservoirs of Kaposi's sarcoma-associated herpesvirus
    Silvia Della Bella
    Laboratory of Immunology, Dipartimento di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 3:e1520. 2008
    ....
  67. doi request reprint PD1 negative and PD1 positive CD4+ T regulatory cells in mild cognitive impairment and Alzheimer's disease
    Marina Saresella
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi ONLUS Foundation IRCCS, Milano, Italy
    J Alzheimers Dis 21:927-38. 2010
    ..The observation that PD1neg Treg, cells are increased in MCI patients reinforces the inflammatory origin of AD and supports a possible beneficial role of these cells in MCI that is lost in patients with full-blown AD...
  68. ncbi request reprint Modulation of innate and adaptive immunity by lactoferrin in human immunodeficiency virus (HIV)-infected, antiretroviral therapy-naïve children
    Gian Vincenzo Zuccotti
    Paediatrics, University of Milan, Milan, Italy
    Int J Antimicrob Agents 29:353-5. 2007
    ..009), Toll-like receptor 2 expression (P=0.01) and the interleukin-12/interleukin-10 ratio (P=0.001) were also improved by lactoferrin. Lactoferrin supplementation results in immune modulation and could be useful in HIV infection...
  69. doi request reprint HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study
    Franca R Guerini
    Laboratory of Molecular Medicine and Biotechnologies, Don C Gnocchi Foundation IRCCS, S Maria Nascente, Milan, Italy
    J Neuroimmunol 230:135-42. 2011
    ..MOGc and MIB loci are linked with ASD in Italian patients...
  70. pmc A functional variant in ERAP1 predisposes to multiple sclerosis
    Franca Rosa Guerini
    Don C Gnocchi Foundation ONLUS, Milano, Italy
    PLoS ONE 7:e29931. 2012
    ..Results herein support the emerging concept that a subset of master-regulatory genes underlay the pathogenesis of autoimmunity...
  71. doi request reprint In vivo imaging of immune cell trafficking in cancer
    Luisa Ottobrini
    Department of Biomedical Sciences and Technologies, University of Milan, Milan, Italy
    Eur J Nucl Med Mol Imaging 38:949-68. 2011
    ....
  72. doi request reprint Innate immunity in resistance to HIV infection
    Mara Biasin
    Department of Clinical Sciences, University of Milano, Milan, Italy
    J Infect Dis 202:S361-5. 2010
    ..The study of these factors will shed light on HIV pathogenesis and contribute to the development of new therapeutic approaches to this elusive disease...
  73. ncbi request reprint Research on psychoimmunology
    Carlo Lorenzo Cazzullo
    Legrenzi Cazzullo Foundation Association Research on Schizophrenia, Milan, Italy
    World J Biol Psychiatry 4:119-23. 2003
    ....
  74. doi request reprint Labeling protocols for in vivo tracking of human skeletal muscle cells (HSkMCs) by magnetic resonance and bioluminescence imaging
    Ilaria V Libani
    Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Mol Imaging Biol 14:47-59. 2012
    ....
  75. pmc Early impairment of gut function and gut flora supporting a role for alteration of gastrointestinal mucosa in human immunodeficiency virus pathogenesis
    Andrea Gori
    Division of Infectious Diseases, Department of Internal Medicine, San Gerardo Hospital, University of Milano Bicocca, Via Solferino 16 20052, Milan, Italy
    J Clin Microbiol 46:757-8. 2008
    ..This impairment is associated with alterations in gut microbiota and intestinal inflammatory parameters. These findings support the hypothesis that alterations at the gastrointestinal-tract level are a key factor in HIV pathogenesis...
  76. doi request reprint Distinct cytokine patterns associated with different forms of chronic dysimmune neuropathy
    Maira Gironi
    Department of Neurology, Don C Gnocchi Foundation IRCCS, Milan, Italy
    Muscle Nerve 42:864-70. 2010
    ..These distinctive immune alterations may represent a biological tool in differential diagnosis and future therapeutic approaches...
  77. doi request reprint Vitamin D and inflammatory bowel disease
    Sandro Ardizzone
    Department of Gastroenterology, L Sacco University Hospital, Milan, Italy
    Vitam Horm 86:367-77. 2011
    ..The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Future studies now need to focus on the potential of vitamin D and its derivatives as therapeutic adjuncts in the treatment of IBD...
  78. doi request reprint A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models
    Angela Berzi
    Department of Clinical Sciences L Sacco, University of Milan, Segrate, Italy
    AIDS 26:127-37. 2012
    ..Inhibition of HIV interaction with DC-SIGN thus represents a potential therapeutic approach for viral entry inhibition at the mucosal level...
  79. ncbi request reprint Cytokine production in women with antiretroviral treatment-associated breast fat accumulation and limb wasting
    Massimo Galli
    Institute of Infectious and Tropical Diseases, University of Milan, Sacco Hospital, Milan, Italy
    AIDS 17:S155-61. 2003
    ..To test the cytokine production of peripheral blood mononuclear cells in a group of HIV-infected women with breast enlargement and lower limb wasting while receiving antiretroviral therapy (ART) including a protease inhibitor...
  80. doi request reprint HLA and autoimmune digestive disease: a clinically oriented review for gastroenterologists
    Andrea Cassinotti
    Department of Clinical Science, Division of Gastroenterology, L Sacco University Hospital, Via G B Grassi 74, Milan, Italy
    Am J Gastroenterol 104:195-217; quiz 194, 218. 2009
    ..The aim of this article is to review the association between HLA alleles and autoimmune digestive disease and its current relationship with modern HLA nomenclature and clinical practice...
  81. ncbi request reprint Cytokine profiles in schizophrenic patients treated with risperidone: a 3-month follow-up study
    Carlo L Cazzullo
    Association for the Research on Schizophrenia, Fondazione Legrenzi, Milan, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 26:33-9. 2002
    ..This modification suggests that clinical improvement is associated with a reduction in the inflammatory-like situation present in not currently treated schizophrenic patients...
  82. ncbi request reprint Long-term pertussis-specific immune responses to a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine in pre-term infants
    Susanna Esposito
    Pediatric Department I, University of Milan, Via Commenda 9, 20122 Milan, Italy
    Vaccine 20:2928-32. 2002
    ..In order to maintain an adequate pertussis-specific immune response, in term children a booster at 5-6 years of age may be suggested, whereas in pre-term an earlier booster should be useful...
  83. pmc Assessing corpus callosum changes in Alzheimer's disease: comparison between tract-based spatial statistics and atlas-based tractography
    Maria Giulia Preti
    Magnetic Resonance Laboratory, Don Gnocchi Foundation, Milan, Italy
    PLoS ONE 7:e35856. 2012
    ..This finding indicates that an analysis including a higher number of voxels (with no restriction to tract skeletons) may detect characteristic pattern of FA in the CC of patients with preclinical AD, when brain atrophy is still modest...
  84. ncbi request reprint Serum concentration of gammaGT is a surrogate marker of hepatic TNF-alpha mRNA expression in chronic hepatitis C
    Gloria Taliani
    DISP LITA Vialba, University of Milan, 20157, Milan, Italy
    Clin Immunol 105:279-85. 2002
    ..79, P < 0.0001). These findings suggest that serum gammaGT levels may represent a surrogate marker of hepatic TNF-alpha expression, thus explaining the importance of serum gammaGT levels in predicting treatment outcome...
  85. ncbi request reprint Mucosal immune response to Human Papilloma Virus (HPV) infection in HIV positive women
    Alberto Agarossi
    Department of Obstetrics and Gynaecology, Clinical Science Institute, L Sacco Hospital, University of Milan, Via GB Grassi 74, 20157 Milan, Italy
    Med Wieku Rozwoj 7:495-502. 2003
    ..T cells type 1 (Th1) to the helper T cells type 2 (Th2) immune response, which determines the downregulation of the cell-mediated immunity, may explain the frequent loss of immunologic control of HPV and its oncological complications..
  86. ncbi request reprint Disarming dendritic cells: a tumor strategy to escape from immune control?
    Silvia Della Bella
    Universita degli Studi di Milano, Laboratorio di Immunologia, Dipartimento di Scienze e Tecnologie Biomediche, LITA, Via Fratelli Cervi 93, 20090 Segrate Mi, Italy
    Expert Rev Clin Immunol 3:411-22. 2007
    ..An improved understanding of how tumors interact with DCs to escape from immune control may enable the design of improved DC-based immunotherapeutic strategies for patients with cancer...
  87. ncbi request reprint Distinct immune profiles characterize patients with diffuse or limited systemic sclerosis
    Francesca Ingegnoli
    Department of Rheumatology, Istituto Gaetano Pini, University of Milan, Italy
    Clin Immunol 108:21-8. 2003
    ..Overexpression of Fas in dSSc could results from the attempt of the immune system to induce apoptosis of autoreactive T-cell clones...
  88. ncbi request reprint Serum IgA of HIV-exposed uninfected individuals inhibit HIV through recognition of a region within the alpha-helix of gp41
    Mario Clerici
    Immunology, DISP LITA Vialba, University of Milan, Milan, Italy
    AIDS 16:1731-41. 2002
    ..HIV-specific IgA is present in HIV-exposed uninfected individuals (EU) and neutralizes primary strains of HIV-1 in vitro...
  89. ncbi request reprint Molecular imaging of cell-mediated cancer immunotherapy
    Giovanni Lucignani
    Institute of Radiological Sciences, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Trends Biotechnol 24:410-8. 2006
    ..The general concepts of noninvasive imaging of targeted cells as well as the technology and probes applied to cell-mediated cancer immunotherapy imaging are outlined in this review...
  90. ncbi request reprint Immune profiles of patients with chronic idiopathic urticaria
    Stefania Piconi
    First Department of Infectious Disease and Allergy Unit, L Sacco Hospital, Milan, Italy
    Int Arch Allergy Immunol 128:59-66. 2002
    ..The immunologic characterization of chronic idiopathic urticaria (CIU) is still incomplete. In particular, it is not known if positivity to the intradermal autologous serum skin test (ASST) identifies an immunologic subset of CIU patients...