F Cipollone

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes
    Chiara Cuccurullo
    Atherosclerosis, Hypertension and Dyslipidemia Unit, G D Annunzio University of Chieti Pescara, Italy
    Arterioscler Thromb Vasc Biol 26:2716-23. 2006
  2. ncbi COX-2 and the vasculature: angel or evil?
    Chiara Cuccurullo
    Centro Regionale per la Prevenzione dell Aterosclerosi, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Hypertens Rep 9:73-80. 2007
  3. doi Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients
    Donato Santovito
    G D Annunzio University, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, and Clinical Research Center, Center of Excellence on Aging CeSI, Via dei Vestini, 66, 66100 Chieti, Italy
    Expert Opin Ther Targets 17:217-23. 2013
  4. doi Angiotensin II Blockade and Total Cardiovascular Risk : Beyond Blood Pressure Reduction
    Francesco Cipollone
    Italian Society for the Study of Atherosclerosis Abruzzo Section, Centro di Riferimento Regionale per l Aterosclerosi, l Ipertensione Arteriosa e le Dislipidemie, Policlinico Clinicizzato Santissima Annunziata, Via Colle dell Ara, 66013, Chieti, Italy
    High Blood Press Cardiovasc Prev 15:245-53. 2008
  5. ncbi Relationship between reduced BCL-2 expression in circulating mononuclear cells and early nephropathy in type 1 diabetes
    F Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Int J Immunopathol Pharmacol 18:625-35. 2005
  6. ncbi Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans
    Francesco Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio, School of Medicine, Chieti, Italy
    Arterioscler Thromb Vasc Biol 24:1259-65. 2004
  7. ncbi Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina
    Francesco Cipollone
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 107:55-61. 2003
  8. ncbi Increased expression of transforming growth factor-beta1 as a stabilizing factor in human atherosclerotic plaques
    Francesco Cipollone
    Department of Medicine and Aging, School of Medicine, and Aging Research Center, Ce S I Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    Stroke 35:2253-7. 2004
  9. ncbi Association between 5-lipoxygenase expression and plaque instability in humans
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1665-70. 2005
  10. ncbi Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1925-31. 2005

Collaborators

Detail Information

Publications52

  1. ncbi Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes
    Chiara Cuccurullo
    Atherosclerosis, Hypertension and Dyslipidemia Unit, G D Annunzio University of Chieti Pescara, Italy
    Arterioscler Thromb Vasc Biol 26:2716-23. 2006
    ..Thus, the aim of this study was to characterize the effect of simvastatin on the expression of RAGE and RAGE-dependent plaque-destabilizing genes in human atherosclerotic plaques...
  2. ncbi COX-2 and the vasculature: angel or evil?
    Chiara Cuccurullo
    Centro Regionale per la Prevenzione dell Aterosclerosi, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Hypertens Rep 9:73-80. 2007
    ..Thus, the role of COX-2 in atherothrombosis appears to be quite complex. In this article we summarize our recent papers investigating mechanisms regulating the expression and pharmacologic modulation of COX-2 in atherosclerotic plaques...
  3. doi Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients
    Donato Santovito
    G D Annunzio University, European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, and Clinical Research Center, Center of Excellence on Aging CeSI, Via dei Vestini, 66, 66100 Chieti, Italy
    Expert Opin Ther Targets 17:217-23. 2013
    ..However, no evidences are available at this time about modulation of miR-145 in the setting of hypertension. Thus, the aim of this study was to investigate the expression of miR-145 in complicated hypertension...
  4. doi Angiotensin II Blockade and Total Cardiovascular Risk : Beyond Blood Pressure Reduction
    Francesco Cipollone
    Italian Society for the Study of Atherosclerosis Abruzzo Section, Centro di Riferimento Regionale per l Aterosclerosi, l Ipertensione Arteriosa e le Dislipidemie, Policlinico Clinicizzato Santissima Annunziata, Via Colle dell Ara, 66013, Chieti, Italy
    High Blood Press Cardiovasc Prev 15:245-53. 2008
    ..ACE inhibitors and ARBs are very important drugs in the modern management of the total cardiovascular risk in hypertensive patients...
  5. ncbi Relationship between reduced BCL-2 expression in circulating mononuclear cells and early nephropathy in type 1 diabetes
    F Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Int J Immunopathol Pharmacol 18:625-35. 2005
    ..Vitamin E might provide a novel form of therapy for prevention of nephropathy in diabetic patients in which an acceptable glycemic control is difficult to achieve despite insulin therapy...
  6. ncbi Balance between PGD synthase and PGE synthase is a major determinant of atherosclerotic plaque instability in humans
    Francesco Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio, School of Medicine, Chieti, Italy
    Arterioscler Thromb Vasc Biol 24:1259-65. 2004
    ..Thus, in this study we investigated whether a shift from a PGDS-oriented to a PGES-oriented profile in arachidonate metabolism leads to inflammatory activation in rupture-prone plaque macrophages...
  7. ncbi Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina
    Francesco Cipollone
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 107:55-61. 2003
    ....
  8. ncbi Increased expression of transforming growth factor-beta1 as a stabilizing factor in human atherosclerotic plaques
    Francesco Cipollone
    Department of Medicine and Aging, School of Medicine, and Aging Research Center, Ce S I Gabriele D Annunzio University Foundation, Chieti Pescara, Italy
    Stroke 35:2253-7. 2004
    ..The aim of this study was to characterize the expression of TGF-beta1 in human carotid plaque and to correlate it with the extent of inflammatory infiltration and collagen content with the clinical signs of plaque instability...
  9. ncbi Association between 5-lipoxygenase expression and plaque instability in humans
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1665-70. 2005
    ..Thus, the aims of this study was to analyze the expression of 5-LO in human carotid plaques and to investigate the mechanism by which this enzyme could lead to plaque instability and rupture...
  10. ncbi Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Arterioscler Thromb Vasc Biol 25:1925-31. 2005
    ....
  11. ncbi Novel determinants of plaque instability
    F Cipollone
    Atherosclerosis Prevention Center and Clinical Research Center, G d Annunzio University Foundation, G D Annunzio University of Chieti, Chieti, Italy
    J Thromb Haemost 3:1962-75. 2005
    ....
  12. ncbi COX-2 and prostaglandins in atherosclerosis
    F Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Lupus 14:756-9. 2005
    ....
  13. doi Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives
    Francesco Cipollone
    Italian Society for the Study of Atherosclerosis, Abruzzo Division, Italy
    Pharmacol Ther 118:161-80. 2008
    ..Finally, we briefly review the controversial vascular effects on prostanoid inhibition by COX-2 inhibitors...
  14. ncbi Cyclooxygenase-2 inhibition: vascular inflammation and cardiovascular risk
    Francesco Cipollone
    Centro Regionale per la Prevenzione dell Aterosclerosi, Via Colle dell Ara, 66013 Chieti, Italy
    Curr Atheroscler Rep 8:245-51. 2006
    ..In this article, we review the pattern of expression of COX-2 in the cellular players of atherothrombosis, its role as a determinant of plaque vulnerability, and the vascular effects on prostanoid inhibition by COX-2 inhibitors...
  15. ncbi COX-2 and atherosclerosis
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    J Cardiovasc Pharmacol 47:S26-36. 2006
    ....
  16. ncbi Genetic and molecular determinants of atherosclerotic plaque instability
    Francesco Cipollone
    Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, University of Chieti G D Annunzio, Chieti, Italy
    Curr Vasc Pharmacol 8:545-52. 2010
    ....
  17. doi A unique microRNA signature associated with plaque instability in humans
    Francesco Cipollone
    Centro di Eccellenza Europeo e di Riferimento Regionale per l Aterosclerosi, l Ipertensione Arteriosa e le Dislipidemie, Nuovo Policlinico SS, Annunziata, Via dei Vestini 66, 66013 Chieti, Italy
    Stroke 42:2556-63. 2011
    ..Thus, the aim of this study was to investigate the expression level of miRNAs in human plaques and to correlate it with clinical features of plaque destabilization...
  18. ncbi Preprocedural level of soluble CD40L is predictive of enhanced inflammatory response and restenosis after coronary angioplasty
    Francesco Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 108:2776-82. 2003
    ..We tested the hypothesis that soluble CD40L (sCD40L) may be involved in the process of restenosis and that it exerts its effect by triggering a complex group of inflammatory reactions on endothelial and mononuclear cells...
  19. ncbi Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control
    F Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Diabetologia 48:1216-24. 2005
    ..We tested the hypothesis that sCD40L may be involved in the vascular complications in diabetes and exerts its effect by triggering inflammatory reactions on mononuclear and endothelial cells (ECs)...
  20. ncbi Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability
    F Cipollone
    University of Chieti, G. D'Annunzio School of Medicine, Chieti, Italy
    Circulation 104:921-7. 2001
    ....
  21. ncbi Blockade of the angiotensin II type 1 receptor stabilizes atherosclerotic plaques in humans by inhibiting prostaglandin E2-dependent matrix metalloproteinase activity
    Francesco Cipollone
    G d Annunzio University of Chieti and the G d Annunzio University Foundation, Chieti, Italy
    Circulation 109:1482-8. 2004
    ..Thus, the aim of this study was to characterize the effect of the angiotensin II type 1 (AT1) receptor antagonist irbesartan on the inflammatory infiltration and expression of COX-2/mPGES-1 and MMPs in human carotid plaques...
  22. ncbi Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans
    Francesco Cipollone
    Department of Medicine and Aging, School of Medicine, University of Chieti G D Annunzio, Chieti, Italy
    Circulation 107:1479-85. 2003
    ..The aim of this study was to characterize the effect of simvastatin on inflammatory infiltration and the expression of COX-2/mPGES and MMPs in human carotid plaques...
  23. ncbi The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control
    Francesco Cipollone
    University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 108:1070-7. 2003
    ..The aim of this study was to characterize RAGE expression in human plaques and to correlate it with the inflammatory infiltration, COX-2/mPGES-1 and MMP expression, and with clinical evidence of diabetes...
  24. ncbi Increased systemic oxidative stress after elective endarterectomy: relation to vascular healing and remodeling
    A Mezzetti
    Centro per lo Studio dell Ipertensione Arteriosa delle Dislipidemie e dell Aterosclerosi, University Gabriele D Annunzio, Chieti, Italy
    Arterioscler Thromb Vasc Biol 19:2659-65. 1999
    ..In conclusion, carotid endarterectomy with atherosclerotic plaque removal is associated with an acute and prolonged increase in systemic oxidative stress that influences vascular healing and late luminal loss...
  25. ncbi Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm
    A Mezzetti
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Cardiovasc Res 47:475-88. 2000
    ....
  26. ncbi Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty
    F Cipollone
    Department of Medicine and Aging, University of Chieti G D'Annunzio School of Medicine, Chieti, Italy
    Arterioscler Thromb Vasc Biol 21:327-34. 2001
    ..Further understanding of the mechanism(s) by which MCP-1 is produced and acts after arterial injury may provide insight into therapies to limit the progression of atherosclerosis and restenosis after balloon angioplasty...
  27. ncbi Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers
    P Patrignani
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 102:539-45. 2000
    ..We performed a randomized, double-blind, placebo-controlled study of the effects of vitamin E (300, 600, and 1200 mg/d, each dose for 3 consecutive weeks) on 8-iso-PGF(2alpha) and TXA(2) biosynthesis in 46 moderate cigarette smokers...
  28. ncbi Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus
    Francesca Santilli
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    J Am Coll Cardiol 47:391-7. 2006
    ....
  29. ncbi COX-2: friend or foe?
    Annalisa Iezzi
    University of Chieti G D Annunzio, and the G d Annunzio University Foundation, Chieti, Italy
    Curr Pharm Des 13:1715-21. 2007
    ..Our goal is to provide an overview of the relevant biology and pharmacology of this enzyme in atherosclerosis...
  30. ncbi A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke
    Francesco Cipollone
    G d Annunzio University of Chieti and G d Annunzio University Foundation, Chieti, Italy
    JAMA 291:2221-8. 2004
    ..Although COX-2 expression may be genetically determined, the relation between COX-2 polymorphisms and the risk of MI and stroke is unclear...
  31. pmc High preprocedural non-HDL cholesterol is associated with enhanced oxidative stress and monocyte activation after coronary angioplasty: possible implications in restenosis
    F Cipollone
    Department of Medicine and Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Heart 89:773-9. 2003
    ....
  32. ncbi COX-2 expression in atherosclerosis: the good, the bad or the ugly?
    C Cuccurullo
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, and the Clinical Research Center G d Annunzio University Foundation, Chieti, Italy
    Curr Med Chem 14:1595-605. 2007
    ....
  33. ncbi Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy
    Francesco Cipollone
    Center of Excellence on Aging, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Circulation 106:399-402. 2002
    ..The aim of this study was to characterize the in vivo expression of soluble CD40L (sCD40L) in hypercholesterolemia, to correlate it with the extent of the prothrombotic state, and to investigate whether it may be modified by statins...
  34. ncbi Advanced glycation end products in adolescents and young adults with diabetic angiopathy
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Pediatr Nephrol 14:841-6. 2000
    ..43, P<0.01). S-AGE concentrations are markedly increased in type 1 diabetic adolescents and young adults with diabetic nephropathy and retinopathy. The severity of diabetic angiopathy is related to the serum levels of AGEs...
  35. ncbi Serum angiogenin concentrations in young patients with diabetes mellitus
    F Chiarelli
    Department of Medicine, Division of Pediatrics, University of Chieti, Italy
    Eur J Clin Invest 32:110-4. 2002
    ..Angiogenin serum levels were measured in a large group of type 1 diabetic young patients, looking at whether increased Angiogenin concentrations are associated with long-term glycemic control and microvascular complications...
  36. ncbi Factors associated with apoptosis in symptomatic and asymptomatic carotid atherosclerotic plaques
    L Artese
    Medical and Dental Schools, University of Chieti Pescara, Italy
    Int J Immunopathol Pharmacol 18:645-53. 2005
    ....
  37. ncbi Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabet Med 17:650-6. 2000
    ....
  38. ncbi Effects of vitamin E supplementation on intracellular antioxidant enzyme production in adolescents with type 1 diabetes and early microangiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Pediatr Res 56:720-5. 2004
    ..Adolescents with early signs of diabetic angiopathy have defective IAP and activity, which are not modified by vitamin E...
  39. ncbi Role of angiotensin II receptor blockers in atherosclerotic plaque stability
    Francesco Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Via Colle dell Ara, 66013 Chieti, Italy
    Expert Opin Pharmacother 7:277-85. 2006
    ..This article reviews the results of this study and the most recent evidence that supports the possibility that angiotensin II receptor blockers represent a novel therapy for plaque stabilisation...
  40. ncbi Cyclooxygenase-2 expression and inhibition in atherothrombosis
    Francesco Cipollone
    Center of Excellence on Aging, G D Annunzio University of Chieti School of Medicine, Chieti, Italy
    Arterioscler Thromb Vasc Biol 24:246-55. 2004
    ....
  41. ncbi Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E
    Raffaele De Caterina
    Chair of Cardiology, G D Annunzio University, Chieti, Italy
    Circulation 106:2543-9. 2002
    ..Both statins and vitamin E, by reducing the rate of lipid peroxidation, may interfere with oxidative stress, but the impact of their combination is unknown...
  42. ncbi Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes
    Francesco Chiarelli
    Clinica Pediatrica, University of Chieti, Chieti, Italy Patologia Medica, University of Chieti, Chieti, Italy
    Diabetes Care 25:1829-34. 2002
    ..To investigate the possible role of hyperglycemia-dependent monocyte chemoattractant protein (MCP)-1 biosynthesis in the pathophysiology of early nephropathy in type 1 diabetes...
  43. ncbi Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Diabetes Care 28:1690-7. 2005
    ..The objective of this study was to evaluate the effects of irbesartan, an angiotensin II receptor antagonist, on IAP in adolescents and young adults with type 1 diabetes and early signs of retinopathy and nephropathy...
  44. ncbi Endothelial function in sustained and white coat hypertension
    Sante D Pierdomenico
    Centro per lo Studio dell Ipertensione Arteriosa, delle Dislipidemie e dell Arteriosclerosi, Dipartimento di Medicina e Scienze dell Invecchiamento, University Gabriele D Annunzio, Via dei Vestini, 66013 Chieti Scalo Chieti, Italy
    Am J Hypertens 15:946-52. 2002
    ....
  45. doi MicroRNAs and atherosclerosis: new actors for an old movie
    D Santovito
    European Center of Excellence on Atherosclerosis, Hypertension and Dyslipidemia, and Clinical Research Center Center of Excellence on Aging Ce S I, G D Annunzio University, Chieti Pescara, Italy
    Nutr Metab Cardiovasc Dis 22:937-43. 2012
    ..Thus, the aim of this review is to describe the role of miRNA in atherosclerosis development and evolution and to individuate their role as potential therapeutic target...
  46. doi Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans
    Donato Santovito
    Italian Society for the Study of Atherosclerosis, Abruzzo section, Chieti, Italy
    Curr Opin Lipidol 20:402-8. 2009
    ..In this review, we will analyze the role of COX and prostaglandin synthases in plaque stability...
  47. ncbi Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome
    Jacopo Vecchiet
    Department of Medicine and Science of Aging, G D Annunzio University of Chieti, Italy
    Neurosci Lett 335:151-4. 2003
    ..Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome...
  48. ncbi Platelets in atherothrombosis: new and evolving roles
    Andy Weyrich
    Eccles Institute of Human Genetics, Salt Lake City, Utah 84112, USA
    Curr Pharm Des 13:1685-91. 2007
    ....
  49. ncbi Enhanced plasma soluble CD40 ligand levels in essential hypertensive patients with blunted nocturnal blood pressure decrease
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, L Aquila, Italy
    Am J Hypertens 20:70-6; discussion 77. 2007
    ..Therefore, we evaluated the relationship between circulating sCD40L levels, circadian BP profile, and early carotid atherosclerosis in essential hypertensives...
  50. ncbi Cyclooxygenase-2 polymorphism: putting a brake on the inflammatory response to vascular injury?
    Francesco Cipollone
    Arterioscler Thromb Vasc Biol 22:1516-8. 2002
  51. ncbi [New insights on the molecular mechanisms of type-1 angiotensin II receptor blockers and their contribution to atherosclerotic plaque stabilization]
    Andrea Mezzetti
    Recenti Prog Med 95:586-90. 2004
    ..These findings suggest that AT1 receptor blockers could represent a novel form of therapy for plaque stabilization in patients with atherosclerotic disease...
  52. ncbi Enhanced soluble CD40 ligand and Alzheimer's disease: evidence of a possible pathogenetic role
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, L Aquila, Italy
    Neurobiol Aging 29:348-56. 2008
    ..These data might suggest a pathogenetic role for sCD40L in Alzheimer's disease...