Arrigo F G Cicero

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint Treatment of massive hypertriglyceridemia resistant to PUFA and fibrates: a possible role for the coenzyme Q10?
    A F G Cicero
    GC Descovich Atherosclerosis Research Centre, D Campanacci Clinical Medicine and Applied Biotechonology Department, S Orsola Malpighi Hospital, University of Bologna, Italy
    Biofactors 23:7-14. 2005
  2. pmc Influence of metabolic syndrome superposition on familial combined hyperlipoproteinemia cardiovascular complication rate
    Arrigo F G Cicero
    Atherosclerosis and Metabolic disease Research Unit, Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Italy
    Arch Med Sci 9:238-42. 2013
  3. pmc Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from the brisighella heart study
    Arrigo F G Cicero
    Department of Internal Medicine, Aging and Kidney Disease Department, University of Bologna, 40138 Bologna, Italy
    Int J Endocrinol 2011:724816. 2011
  4. ncbi request reprint Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexin type 9: the available clinical evidence
    Arrigo F G Cicero
    S Orsola Malpighi University Hospital, Medical and Surgical Sciences Department, Internal Medicine Unit, Pad 2, Via Albertoni 15, 40138 Bologna, Italy 39 3498558017 39 0516826125
    Expert Opin Biol Ther 14:863-8. 2014
  5. pmc Preclinical and clinical evidence of nephro- and cardiovascular protective effects of glycosaminoglycans
    Arrigo F Cicero
    Hypertension Research Unit, Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Italy
    Arch Med Sci 6:469-77. 2010
  6. doi request reprint Population health needs assessment and healthcare services use in a 3 years follow-up on administrative and clinical data: results from the Brisighella Heart Study
    Arrigo F G Cicero
    Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
    High Blood Press Cardiovasc Prev 21:45-51. 2014
  7. doi request reprint Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects
    Arrigo F G Cicero
    Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy
    Nutr Res 33:622-8. 2013
  8. doi request reprint Combined nutraceutical approach to postmenopausal syndrome and vascular remodeling biomarkers
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    J Altern Complement Med 19:582-7. 2013
  9. ncbi request reprint Dietary determinants of oxidized-low-density lipoprotein antibodies in a sample of pharmacologically untreated non-smoker subjects: data from the Brisighella heart study
    Arrigo F G Cicero
    Medical and Surgical Sciences Dept, Sant Orsola Malpighi University Hospital, Bologna Italy
    Adv Clin Exp Med 22:69-76. 2013
  10. pmc Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    Am J Hypertens 26:442-9. 2013

Detail Information

Publications96

  1. ncbi request reprint Treatment of massive hypertriglyceridemia resistant to PUFA and fibrates: a possible role for the coenzyme Q10?
    A F G Cicero
    GC Descovich Atherosclerosis Research Centre, D Campanacci Clinical Medicine and Applied Biotechonology Department, S Orsola Malpighi Hospital, University of Bologna, Italy
    Biofactors 23:7-14. 2005
    ..To describe the effect of CoQ10 (added to either a fibrate, or PUFA or association of both) in patients affected by massive hypertriglyceridemia (MHTG) resistant to fibrates and PUFA...
  2. pmc Influence of metabolic syndrome superposition on familial combined hyperlipoproteinemia cardiovascular complication rate
    Arrigo F G Cicero
    Atherosclerosis and Metabolic disease Research Unit, Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Italy
    Arch Med Sci 9:238-42. 2013
    ..We aimed to evaluate whether the presence of the MS per se could account for a significant part of the elevated cardiovascular disease (CVD) risk associated with FCHL...
  3. pmc Adipokines and sexual hormones associated with the components of the metabolic syndrome in pharmacologically untreated subjects: data from the brisighella heart study
    Arrigo F G Cicero
    Department of Internal Medicine, Aging and Kidney Disease Department, University of Bologna, 40138 Bologna, Italy
    Int J Endocrinol 2011:724816. 2011
    ..87, 95% CI 0.79-0.95). In conclusion, in a sample of pharmacologically untreated subjects, leptin/adiponectin ratio seems to be the factor more strongly associated to MS and its components...
  4. ncbi request reprint Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexin type 9: the available clinical evidence
    Arrigo F G Cicero
    S Orsola Malpighi University Hospital, Medical and Surgical Sciences Department, Internal Medicine Unit, Pad 2, Via Albertoni 15, 40138 Bologna, Italy 39 3498558017 39 0516826125
    Expert Opin Biol Ther 14:863-8. 2014
    ..Moreover, a large number of subjects cannot tolerate statins or full doses of these drugs. Thus, there is a need for additional effective LDL-C reducing agents...
  5. pmc Preclinical and clinical evidence of nephro- and cardiovascular protective effects of glycosaminoglycans
    Arrigo F Cicero
    Hypertension Research Unit, Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Italy
    Arch Med Sci 6:469-77. 2010
    ..This review will discuss the evidence supporting the potential nephroprotective effects of sulodexide and other glycosaminoglycans...
  6. doi request reprint Population health needs assessment and healthcare services use in a 3 years follow-up on administrative and clinical data: results from the Brisighella Heart Study
    Arrigo F G Cicero
    Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
    High Blood Press Cardiovasc Prev 21:45-51. 2014
    ....
  7. doi request reprint Red yeast rice improves lipid pattern, high-sensitivity C-reactive protein, and vascular remodeling parameters in moderately hypercholesterolemic Italian subjects
    Arrigo F G Cicero
    Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy
    Nutr Res 33:622-8. 2013
    ..These results have to be confirmed in larger patient samples and longer studies. ..
  8. doi request reprint Combined nutraceutical approach to postmenopausal syndrome and vascular remodeling biomarkers
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    J Altern Complement Med 19:582-7. 2013
    ....
  9. ncbi request reprint Dietary determinants of oxidized-low-density lipoprotein antibodies in a sample of pharmacologically untreated non-smoker subjects: data from the Brisighella heart study
    Arrigo F G Cicero
    Medical and Surgical Sciences Dept, Sant Orsola Malpighi University Hospital, Bologna Italy
    Adv Clin Exp Med 22:69-76. 2013
    ..The demonstration of ox-LDL Ab presence in serum indicates the existence of a long-term lipid peroxidation in vivo...
  10. pmc Do the lactotripeptides isoleucine-proline-proline and valine-proline-proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    Am J Hypertens 26:442-9. 2013
    ..This decrease is convincingly shown in subjects of Asian origin, but less consistent results have been obtained in European populations...
  11. doi request reprint Predictors of the short-term effect of isoleucine-proline-proline/valine-proline-proline lactotripeptides from casein on office and ambulatory blood pressure in subjects with pharmacologically untreated high-normal blood pressure or first-degree hypertens
    A F G Cicero
    Hypertension Research Center, Department of Internal Medicine, Aging and Kidney Disease, University of Bologna, Bologna, Italy
    Clin Exp Hypertens 34:601-5. 2012
    ..A short-term supplementation with LTPs significantly improves the office SBP and DBP, especially in male subjects. The main predictor of LTP antihypertensive effect was the baseline BP...
  12. ncbi request reprint Leisure-time physical activity and cardiovascular disease mortality: the Brisighella Heart Study
    Arrigo F G Cicero
    Department of Internal Medicine, Aging and Kidney diseases, University of Bologna, Bologna, Italy
    J Cardiovasc Med (Hagerstown) 13:559-64. 2012
    ....
  13. doi request reprint Effect of a combined nutraceutical containing Orthosiphon stamineus effect on blood pressure and metabolic syndrome components in hypertensive dyslipidaemic patients: a randomized clinical trial
    A F G Cicero
    Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, Poliambulatorio Pad 2, Via Albertoni 15, 40138 Bologna, Italy
    Complement Ther Clin Pract 18:190-4. 2012
    ....
  14. doi request reprint Metabolic syndrome, adipokines and hormonal factors in pharmacologically untreated adult elderly subjects from the Brisighella Heart Study historical cohort
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    Obes Facts 5:319-26. 2012
    ..Our aim was to evaluate the relation of the sex hormone pattern and the serum level of the main adipokines with metabolic syndrome (MS) and its components in a cohort of pharmacologically untreated adult elderly subjects...
  15. doi request reprint Tolerability and safety of commonly used dietary supplements and nutraceuticals with lipid-lowering effects
    Arrigo F G Cicero
    Atherosclerosis and Metabolic disease Research Unit, Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, S Orsola Malpighi Hospital, Via Albertoni, 15, 40138 Bologna, Italy
    Expert Opin Drug Saf 11:753-66. 2012
    ..Lifestyle interventions, including dietary supplementation with natural compounds possessing known lipid-lowering effects, are strongly supported by the international guidelines for cardiovascular disease prevention...
  16. doi request reprint Antidiabetic properties of berberine: from cellular pharmacology to clinical effects
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, Bologna, Italy
    Hosp Pract (1995) 40:56-63. 2012
    ..The tolerability is high for low dosages, with some gastrointestinal complaints appearing to be associated with use of high dosages...
  17. pmc Tinnitus in elderly patients and prognosis of mild-to-moderate congestive heart failure: a cross-sectional study with a long-term extension of the clinical follow-up
    Claudio Borghi
    Department of Internal Medicine, Aging and Kidney diseases, Internal Medicine Unit, Bologna, Italy
    BMC Med 9:80. 2011
    ....
  18. doi request reprint Long-term effect of a dietary education program on postmenopausal cardiovascular risk and metabolic syndrome: the Brisighella Heart Study
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Italy
    J Womens Health (Larchmt) 19:133-7. 2010
    ..To evaluate whether a nutritional education intervention on a general population cohort is able to balance the metabolic effects of incident menopause in a large sample of perimenopausal women...
  19. doi request reprint Lactotripeptides effect on office and 24-h ambulatory blood pressure, blood pressure stress response, pulse wave velocity and cardiac output in patients with high-normal blood pressure or first-degree hypertension: a randomized double-blind clinical trial
    Arrigo F G Cicero
    Hypertension Research Center, Department of Internal Medicine, Aging and Kidney Disease, University of Bologna, Bologna, Italy
    Hypertens Res 34:1035-40. 2011
    ..No effect was observed on parameters related to fluid dynamics or vascular resistance. LTPs positively influenced the office SBP, PWV, SV, SV index, ACI and VI in patients with high-normal BP or first-degree hypertension...
  20. doi request reprint Gender-specific haemodynamic and metabolic effects of a sequential training programme on overweight-obese hypertensives
    Arrigo Francesco Giuseppe Cicero
    Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, Bologna, Italy
    Blood Press 18:111-6. 2009
    ..To evaluate the short-term cardiometabolic effect of a sequential physical activity programme on pharmacologically untreated hypertensive overweight women and on age-matched men...
  21. ncbi request reprint Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study
    Arrigo F G Cicero
    GC Descovich Atherosclerosis and Metabolic Disease Research Unit, Internal Medicine, Aging and Kidney Diseases Dept, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    J Am Coll Nutr 27:314-20. 2008
    ..The aim of our study was to assess the changes in the fatty acid composition of low density lipoproteins (LDL) after sustained consumption of olive oil at real-life doses (25 mL/day) and their relationship with lipid oxidative damage...
  22. doi request reprint Hemodynamic effects of lactotripeptides from casein hydrolysate in Mediterranean normotensive subjects and patients with high-normal blood pressure: a randomized, double-blind, crossover clinical trial
    Arrigo F G Cicero
    Hypertension Research Unit, Sant Orsola Malpighi University Hospital, Bologna, Italy
    J Med Food 13:1363-8. 2010
    ..In conclusion, diurnal diastolic BP is significantly reduced by lactrotripeptide supplementation in untreated Mediterranean subjects with normal or high-normal BP. Office systolic BP is reduced only in subjects with high-normal BP...
  23. ncbi request reprint Detection of familial combined hyperlipoproteinaemia patients in the Brisighella Heart Study historical cohort: an epidemiological approach
    A F G Cicero
    G Descovich Atherosclerosis and Metabolic Disease Research Unit, D Campanacci Clinical Medicine and Applied Biotechnologies Dept, University of Bologna, Bologna, Italy
    J Inherit Metab Dis 30:268. 2007
  24. ncbi request reprint Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease
    Arrigo F G Cicero
    GC Descovich Atherosclerosis and Metabolic Disease Research Unit, D Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Endothelium 14:193-8. 2007
    ..However, the superposition of MS on FCH further increases the plasma level of these parameters. The prognostic value of this observation has to be evaluated...
  25. doi request reprint Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials
    A F G Cicero
    Internal Medicine, Aging and Kidney Diseases Department, Sant Orsola Malpighi University Hospital, University of Bologna, Bologna, Italy
    J Hum Hypertens 25:425-36. 2011
    ..The relevance of this findings in other ethnicities or associated with different dietary pattern should to be further investigated...
  26. ncbi request reprint Different effect of psyllium and guar dietary supplementation on blood pressure control in hypertensive overweight patients: a six-month, randomized clinical trial
    Arrigo F G Cicero
    GC Descovich Atherosclerosis Research Centre, D Campanacci Clinical Medicine and Applied Biotechnology Dept, University of Bologna, Italy
    Clin Exp Hypertens 29:383-94. 2007
    ..In our study, six-month supplementation with psyllium fiber, but not with guar fiber nor standard diet, appears to significantly reduce both SBP and DBP in hypertensive overweight subjects...
  27. ncbi request reprint Omega-3 polyunsaturated fatty acids: their potential role in blood pressure prevention and management
    Arrigo F G Cicero
    Hypertension Research Unit, Internal Medicine, Aging and Kidney Diseases Department, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Curr Vasc Pharmacol 7:330-7. 2009
    ..Future research will clarify if PUFA supplementation could improve the antihypertensive action of specific BP lowering drug classes and of statins...
  28. pmc Activity and potential role of licofelone in the management of osteoarthritis
    Arrigo F G Cicero
    D Campanacci Clinical Medicine and Applied Biotechnology Department, Sant Orsola Malpighi Hospital, University of Bologna Via Massarenti, Bologna, Italy
    Clin Interv Aging 2:73-9. 2007
    ..Preliminary data with this drug seem promising, but further well-designed clinical trials of this agent in the elderly will be necessary before a final evaluation is possible...
  29. doi request reprint Effect of a sequential training programme on inflammatory, prothrombotic and vascular remodelling biomarkers in hypertensive overweight patients with or without metabolic syndrome
    Arrigo F G Cicero
    Department of Internal Medicine, Aging and Kidney diseases, University of Bologna, Bologna, Italy
    Eur J Cardiovasc Prev Rehabil 16:698-704. 2009
    ..It is not known whether serum level of vascular remodelling parameters, such as matrix metalloproteinases could be modulated by physical activity and whether the eventual change could be influenced by metabolic syndrome (MS) diagnosis...
  30. ncbi request reprint What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks
    A F G Cicero
    G Descovich Atherosclerosis Research Centre, University of Bologna, 1 40138 Bologna, Italy
    Acta Diabetol 41:91-8. 2004
    ....
  31. ncbi request reprint Antihyperlipidaemic effect of a Monascus purpureus brand dietary supplement on a large sample of subjects at low risk for cardiovascular disease: a pilot study
    Arrigo F G Cicero
    Department of Internal Medicine and Applied Biotechnology, Atherosclerosis and Metabolic Diseases Study Centre G Descovich, University of Bologna, S Orsola Malpighi University Hospital Via Massarenti, 9 40138 Bologna, Italy
    Complement Ther Med 13:273-8. 2005
    ....
  32. ncbi request reprint Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates
    A F G Cicero
    GC Descovich Atherosclerosis Research Centre, D Campanacci Clinical Medicine and Applied Biotechonology Department, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Biomed Pharmacother 59:312-7. 2005
    ..To describe the effect of Coenzyme Q10 (CoQ10) (added to either a fibrate, or polyunsaturated fatty acids (PUFA) or association of both) in patients affected by massive hypertriglyceridemia (MHTG) resistant to fibrates and PUFA...
  33. ncbi request reprint Relative role of major risk factors for Type 2 diabetes development in the historical cohort of the Brisighella Heart Study: an 8-year follow-up
    A F G Cicero
    Atherosclerosis Research Centre GC Descovich, Clinical Medicine and Applied Biotechonology, Department D Campanacci S Orsola Malpighi Hospital, University of Bologna, Italy
    Diabet Med 22:1263-6. 2005
    ..The aim of this study was to evaluate and quantify the role of different risk factors in the long-term development of Type 2 diabetes mellitus in a rural Italian population...
  34. doi request reprint Omega 3 polyunsaturated fatty acids supplementation and blood pressure levels in hypertriglyceridemic patients with untreated normal-high blood pressure and with or without metabolic syndrome: a retrospective study
    Arrigo F G Cicero
    Lipid Research Unit, Department of Internal Medicine, Aging and Kidney diseases, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Clin Exp Hypertens 32:137-44. 2010
    ..No significant difference was perceived in the metabolic syndrome subgroup. The main determinants of the PUFA anti-hypertensive effect appear to be the basal blood pressure level and age...
  35. doi request reprint Sex hormones and adipokines in healthy pre-menopausal, post-menopausal and elderly women, and in age-matched men: data from the Brisighella Heart study
    A F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, 40138 Bologna, Italy
    J Endocrinol Invest 34:e158-62. 2011
    ..Sex hormones and adipokines seem to differently interact in both genders at different ages...
  36. doi request reprint Effects of AT1 receptor and beta1 receptor blocking on blood pressure, peripheral hemodynamic and lipid profile in statin-treated hypertensive hypercholesterolemic patients
    Arrigo F G Cicero
    Hypertension Research Unit, Sant Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    Fundam Clin Pharmacol 23:583-8. 2009
    ....
  37. ncbi request reprint Gender difference in hepatic steatosis index and lipid accumulation product ability to predict incident metabolic syndrome in the historical cohort of the Brisighella Heart Study
    Arrigo F G Cicero
    1 Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
    Metab Syndr Relat Disord 11:412-6. 2013
    ..17, 95% CI 1.15-1.18). Conclusion: HSI and LAP differently predict the 4-year incidence of metabolic syndrome. In women, both indexes can be considered significant predictors, whereas in men only LAP can be considered predictive. ..
  38. pmc A prospective evaluation of persistence on antihypertensive treatment with different antihypertensive drugs in clinical practice
    Maddalena Veronesi
    D Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum University of Bologna, Italy
    Vasc Health Risk Manag 3:999-1005. 2007
    ..A trend toward a better BP control was observed in response to lercanidipine vs other CCBs (p = 0.059). The present results confirm the importance of persistence on treatment for the management of hypertension in clinical practice...
  39. doi request reprint Blood pressure and metabolic effect of a combination of lercanidipine with different antihypertensive drugs in clinical practice
    Arrigo F G Cicero
    Department of Internal Medicine, Aging and Kidney diseases, S Orsola Malpighi University Hospital, University of Bologna, Pad 2 Via Albertoni 15, Bologna, Italy
    Clin Exp Hypertens 34:113-7. 2012
    ..Moreover, the association of lercanidipine with renin-angiotensin system blockers is also associated with significant improvements in triglycerides and fasting plasma glucose...
  40. doi request reprint Serum cholesterol levels on admission and survival in patients with acute myocardial infarction treated with zofenopril: a post hoc analysis of the Survival of Myocardial Infarction Long-term Evaluation trial
    Claudio Borghi
    Department of Internal Medicine, Aging and Kidney diseases, University Hospital of Bologna, Bologna, Italy
    Fundam Clin Pharmacol 23:641-8. 2009
    ..The presence of hypercholesterolaemia in patients with anterior myocardial infarction could be associated with more favourable effects of early ACE-inhibition...
  41. doi request reprint Relationship between blood pressure, cholesterolemia and serum apolipoprotein B in a large population sample: the Brisighella Heart Study
    Arrigo F G Cicero
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna, Italy
    J Hypertens 30:492-6. 2012
    ..The objective is to evaluate the relationship between cholesterolemia, serum apolipoprotein B (apoB) level and blood pressure in a large sample of general population...
  42. doi request reprint Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril
    Claudio Borghi
    Hypertension Research Unit, Internal Medicine, Aging and Kidney Disease Department, Sant Orsola Malpighi University Hospital, Bologna, Italy
    Clin Drug Investig 30:843-54. 2010
    ..Further studies are required to evaluate the cardiovascular protective effects of lercanidipine/enalapril...
  43. ncbi request reprint Cerebrovascular disease in Italy and Europe: it is necessary to prevent a 'pandemia'
    Antonio Gaddi
    Atherosclerosis and Dysmetabolic Disease Study Centre G Descovich, University of Bologna, Bologna, Italy
    Gerontology 49:69-79. 2003
    ..The aim of this review is to resume the actual knowledge about the epidemiology of cerebrovascular disease in Italy and Europe, and about the means available to prevent this phenomenon...
  44. ncbi request reprint Persistence on treatment and blood pressure control with different first-line antihypertensive treatments: a prospective evaluation
    Maria Grazia Prandin
    D Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum, University of Bologna, Italy
    Clin Exp Hypertens 29:553-62. 2007
    ..46.6%). Systolic and diastolic BP decreased more in patients treated with ARBs (-11.2/-5.8 mmHg), ACE inhibitors (-10.5/-5.1 mmHg), and CCBs (-8.5/-4.6 mmHg) when compared to beta-blockers (-4.0/-2.3 mmHg) and diuretics (-2.3/-2.1 mmHg)...
  45. ncbi request reprint Effects of a new low dose soy protein/beta-sitosterol association on plasma lipid levels and oxidation
    Arrigo F G Cicero
    Atherosclerosis and Metabolic Diseases Study Centre G Descovich, Clinical Medicine and Applied Biotechnology, Dept D Campanacci, S Orsola Malpighi University Hospital, Via Massarenti, 9, 40138 Bologna, Italy
    Eur J Nutr 43:319-22. 2004
    ..High doses of soy protein are able to decrease plasma cholesterolemia significantly, but they unbalance daily protein intake and strongly modify nutritional habits in patients...
  46. ncbi request reprint Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study
    Claudio Borghi
    Unit of Internal Medicine, Policlinico S Orsola, University of Bologna, Bologna
    J Hypertens 31:1256-64. 2013
    ....
  47. pmc Fixed combination of zofenopril plus hydrochlorothiazide in the management of hypertension: a review of available data
    Claudio Borghi
    Hypertension Research Center, D Campanacci Clinical Medicine and Applied Biotechnology Department, Alma Mater Studiorum, University of Bologna, Italy
    Vasc Health Risk Manag 2:341-9. 2006
    ....
  48. ncbi request reprint Interaction between serum cholesterol levels and the renin-angiotensin system on the new onset of arterial hypertension in subjects with high-normal blood pressure
    Claudio Borghi
    Department of Internal Medicine, University of Bologna, Bologna, Italy
    J Hypertens 25:2051-7. 2007
    ..To investigate the possible interactions between serum cholesterol levels and the renin-angiotensin system on the development of stable hypertension in subjects with high-normal blood pressure (BP)...
  49. ncbi request reprint Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation
    Arrigo F G Cicero
    G Descovich Atherosclerosis and Dysmetabolic Disease Research Center, D Campanacci Clinical Medicine and Applied Biotechnology Department, University of Bologna, Bologna, Italy
    Arzneimittelforschung 57:26-30. 2007
    ....
  50. ncbi request reprint Combined lipoxygenase/cyclo-oxygenase inhibition in the elderly: the example of licofelone
    Arrigo F G Cicero
    Clinical Medicine and Applied Biotechnology Department D Campanacci, Atherosclerosis and Dysmetabolic Diseases Study Center G C Descovich, University of Bologna, Bologna, Italy
    Drugs Aging 22:393-403. 2005
    ..Preliminary data with this drug seem promising, but further well designed clinical trials of this agent in the elderly will be necessary before a final evaluation is possible...
  51. doi request reprint The role of irbesartan in the treatment of patients with hypertension: a comprehensive and practical review
    Claudio Borghi
    Department of Medicine, Aging and Clinical Nephrology, University of Bologna, Bologna, Italy
    High Blood Press Cardiovasc Prev 19:19-31. 2012
    ....
  52. pmc Psychosocial factors and metabolic parameters: is there any association in elderly people? The Massa Lombarda Project
    Marilisa Bove
    GC Descovich Atherosclerosis and Metabolic Diseases Research Unit, Internal Medicine, Department of Aging and Kidney Diseases, Sant Orsola Malpighi Hospital, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    Aging Ment Health 14:801-6. 2010
    ..The aim of our research is to discover and analyse a possible relationship between two psychosocial disorders (depression and perceived mental stress) and traditional cardiovascular risk markers...
  53. doi request reprint Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals
    Arrigo F G Cicero
    Medical and Surgical Science Department, University of Bologna, Via Albertoni 15 Pad 2, 40138, Bologna, Italy
    Curr Hypertens Rep 15:260-7. 2013
    ....
  54. ncbi request reprint Serum lipopotein (a) levels in a large sample of subjects affected by familial combined hyperlipoproteinaemia and in general population
    Arrigo F G Cicero
    Atherosclerosis Study Center G Descovich, Clinical Medicine and Applied Biotechnologies, Dept D Campanacci, University of Bologna, Italy
    J Cardiovasc Risk 10:149-51. 2003
    ..Serum lipoprotein (a) [Lp(a)] is a lipidic parameter, strictly under genetic control. Lp(a) levels vary in different dyslipidaemias according to the underlying disease...
  55. ncbi request reprint Cerebrovascular disease in Italy and Europe: it is necessary to prevent a 'pandemia'
    Antonio Gaddi
    Atherosclerosis and Dysmetabolic Disease Study Centre G Descovich, University of Bologna, Italy
    J Cardiovasc Risk 9:143-5. 2002
    ..It is plausible that the application of a suitable early prevention of the cerebrovascular pathology could bring to a more late slatentisation and less serious demonstrations of Alzheimer's disease, when this is destined to develop...
  56. ncbi request reprint Asymptomatic massive hypertriglyceridemia in an octogenarian
    Arrigo F G Cicero
    Atherosclerosis and Metabolism Diseases Study Centre GC Descovich, Clinical Medicine and Applied Biotechnology Department D Campanacci, University of Bologna, Italy
    Med Princ Pract 12:51-3. 2003
    ..To report the case of an 85-year-old man with asymptomatic massive hypertriglyceridemia (MHTG)...
  57. ncbi request reprint Factors associated with 2-year persistence in fully non reimbursed lipid-lowering treatments
    Arrigo F G Cicero
    Medicine and Surgery Sciences Department, University of Bologna, S Orsola Malpighi University Hospital, Via Albertoni, 15, 40138 Bologna, Italy Electronic address
    Atherosclerosis 235:81-3. 2014
    ..to evaluate the main factors associated with long-term persistence in fully paid lipid-lowering treatment...
  58. ncbi request reprint Panax notoginseng (Burk.) effects on fibrinogen and lipid plasma level in rats fed on a high-fat diet
    A F G Cicero
    Athensclensis Study Center, G Descovich, University of Bologna, Italy
    Phytother Res 17:174-8. 2003
    ..Besides a moderate, non dose-related decrease in the plasma lipid levels, P. notoginseng appeared to induce a significant reduction in the rat fibrinogenaemia...
  59. doi request reprint Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis: data from the Brisighella Heart Study
    Arrigo F G Cicero
    aInternal medicine, Aging and Kidney Disease Department, University of Bologna, Bologna bDepartment of Cardiology, Istituto Auxologico Italiano, Milan, Italy
    J Hypertens 32:57-64. 2014
    ..The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, hypertension, arterial stiffness and subclinical atherosclerosis...
  60. pmc Application of polyunsaturated fatty acids in internal medicine: beyond the established cardiovascular effects
    Arrigo F G Cicero
    Medical and Surgical Sciences Department, University of Bologna, Italy
    Arch Med Sci 8:784-93. 2012
    ....
  61. doi request reprint Hypertension: management perspectives
    Claudio Borghi
    University of Bologna, Internal Medicine, Aging and Kidney Diseases Department, Bologna, Italy
    Expert Opin Pharmacother 13:1999-2003. 2012
    ..So what are the possible future perspectives for high BP management?..
  62. ncbi request reprint Effects of a new soy/beta-sitosterol supplement on plasma lipids in moderately hypercholesterolemic subjects
    Arrigo F G Cicero
    Atherosclerosis and Dysmetabolic Disease Study Center G Descovich, Clinical Medicine and Applied Biotechnologies D Campanacci, University of Bologna, Italy
    J Am Diet Assoc 102:1807-11. 2002
    ..According to this recommends, low doses of soy protein added in b-sitosterol seems to be a practical and safe alternative for patients seeking modest reductions in LDL-C (< 15%)...
  63. pmc Metformin and its clinical use: new insights for an old drug in clinical practice
    Arrigo F G Cicero
    Medical and Surgical Sciences Department, Bologna University, Italy
    Arch Med Sci 8:907-17. 2012
    ....
  64. doi request reprint Global cardiovascular disease risk management in italian patients with metabolic syndrome in the clinical practice setting
    Ettore Ambrosioni
    Internal Medicine, Aging and Kidney Diseases Department, Sant Orsola Malpighi Hospital University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
    High Blood Press Cardiovasc Prev 15:37-45. 2008
    ....
  65. ncbi request reprint Clinical perspectives of anti-inflammatory therapy in the elderly: the lipoxigenase (LOX)/cycloxigenase (COX) inhibition concept
    Antonio Gaddi
    Medicine and Applied Biotechnology Department D Campanacci, Atherosclerosis and Dysmetabolic Diseases Study Center G Descovich, Bologna, Italy
    Arch Gerontol Geriatr 38:201-12. 2004
    ..Even if preliminary data seem to be very interesting, further clinical safety data on these drugs obtained from elderly oriented trials need to be available before to give a final evaluation...
  66. doi request reprint Rate of control of LDL cholesterol and incident hypertension requiring antihypertensive treatment in hypercholesterolemic subjects in daily clinical practice
    Claudio Borghi
    Internal Medicine, Aging and Kidney Disease Department, University of Bologna, Italy
    Ann Med 46:97-102. 2014
    ..We aimed at evaluating the association between low-density lipoprotein cholesterol (LDL-C) level and incidence of new onset of hypertension in a large population sample...
  67. pmc Practical guidelines for familial combined hyperlipidemia diagnosis: an up-date
    Antonio Gaddi
    Center for Metabolic Diseases and Atherosclerosis, University of Bologna, Italy
    Vasc Health Risk Manag 3:877-86. 2007
    ..The aim of this review is to define the main characteristics of the disease in order to simplify its detection and early treatment by all physicians by mean of practical guidelines...
  68. doi request reprint Prospective evaluation of the effect of statins on blood pressure control in hypertensive patients in clinical practice
    M G Prandin
    Hypertension Research Unit, Internal Medicine, Aging and Kidney Diseases Department, University of Bologna, Bologna, Italy
    Nutr Metab Cardiovasc Dis 20:512-8. 2010
    ....
  69. ncbi request reprint Comparison of the effects of telmisartan and nifedipine gastrointestinal therapeutic system on blood pressure control, glucose metabolism, and the lipid profile in patients with type 2 diabetes mellitus and mild hypertension: a 12-month, randomized, doubl
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 26:1228-36. 2004
    ..Angiotensin receptor blockers (ARBs) provide effective blood pressure control. Whereas none of the ARBs appear to affect glucose homeostasis, some ARBs have been associated with a decrease in cholesterolemia...
  70. ncbi request reprint Effects of doxazosin and irbesartan on blood pressure and metabolic control in patients with type 2 diabetes and hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol 45:599-604. 2005
    ..In conclusion, both doxazosin and irbesartan reduced BP during long-term treatment, but not to recommended levels, and doxazosin had the more beneficial effect on glucose metabolism and lipid profile...
  71. ncbi request reprint A randomized, double-blind, controlled, parallel-group comparison of perindopril and candesartan in hypertensive patients with type 2 diabetes mellitus
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, IRCCS Policlinico S Matteo, Pavia, Italy
    Clin Ther 25:2006-21. 2003
    ....
  72. ncbi request reprint The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 25:1429-39. 2003
    ..A previous study has demonstrated that L-carnitine reduces plasma lipoprotein(a) (Lp[a]) levels in patients with hypercholesterolemia...
  73. ncbi request reprint Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Endothelium 14:45-51. 2007
    ..MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event...
  74. ncbi request reprint Antithrombotic effects of rosiglitazone-metformin versus glimepiride-metformin combination therapy in patients with type 2 diabetes mellitus and metabolic syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Pharmacotherapy 25:637-45. 2005
    ....
  75. ncbi request reprint A comparison of the effects of pioglitazone and rosiglitazone combined with glimepiride on prothrombotic state in type 2 diabetic patients with the metabolic syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, P le C Golgi, 2 27100 Pavia, Italy
    Diabetes Res Clin Pract 69:5-13. 2005
    ..To compare the effects of glimepiride plus pioglitazone or plus rosiglitazone in diabetic patients with the metabolic syndrome on coagulation and fibrinolysis parameters...
  76. ncbi request reprint Comparison between metalloproteinases-2 and -9 in healthy subjects, diabetics, and subjects with acute coronary syndrome
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Heart Vessels 22:361-70. 2007
    ..In conclusion, MMP-2, MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic, ACS, and DACS patients, which may reflect abnormal extracellular matrix metabolism in diabetes and in acute coronary syndrome...
  77. ncbi request reprint Metalloproteinases in diabetics and nondiabetics during acute coronary syndromes and after 3 months
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endothelium 14:175-83. 2007
    ..MMPs and TIMP-1 and -2 plasma levels were alterated in nondiabetic and diabetic patients during ACS and after 3 months, which may reflect abnormal extracellular matrix metabolism in diabetes during and after acute event...
  78. ncbi request reprint Metabolic and antihypertensive effects of moxonidine and moxonidine plus irbesartan in patients with type 2 diabetes mellitus and mild hypertension: a sequential, randomized, double-blind clinical trial
    Giuseppe Derosa
    Department o f Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Clin Ther 29:602-10. 2007
    ..The autonomic nervous system plays an important part in the homeostasis of blood pressure (BP), and sympathetic overactivity may contribute to metabolic conditions such as glycemic intolerance or insulin resistance...
  79. ncbi request reprint Blood pressure control and inflammatory markers in type 2 diabetic patients treated with pioglitazone or rosiglitazone and metformin
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S Matteo, Pavia, Italy
    Hypertens Res 30:387-94. 2007
    ....
  80. ncbi request reprint Telmisartan and irbesartan therapy in type 2 diabetic patients treated with rosiglitazone: effects on insulin-resistance, leptin and tumor necrosis factor-alpha
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Hypertens Res 29:849-56. 2006
    ..These observed metabolic effects of different angiotensin type 1 receptor blockers could be relevant when choosing a therapy to correct metabolic derangement of patients affected by metabolic syndrome and diabetes...
  81. ncbi request reprint Synergistic effect of doxazosin and acarbose in improving metabolic control in patients with impaired glucose tolerance
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Drug Investig 26:529-39. 2006
    ..The aim of this study was to evaluate if the expected improvement in glucose and lipid metabolism obtainable with doxazosin is or is not synergistic with standard antihyperglycaemic treatment using the alpha-glucosidase inhibitor acarbose...
  82. ncbi request reprint Metabolic syndrome prevalence in Italy
    Arrigo F G Cicero
    Nutr Metab Cardiovasc Dis 16:e5-6. 2006
  83. ncbi request reprint Effects of 1 year of treatment with pioglitazone or rosiglitazone added to glimepiride on lipoprotein (a) and homocysteine concentrations in patients with type 2 diabetes mellitus and metabolic syndrome: a multicenter, randomized, double-blind, controlled
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 28:679-88. 2006
    ....
  84. ncbi request reprint Metabolic effects of pioglitazone and rosiglitazone in patients with diabetes and metabolic syndrome treated with glimepiride: a twelve-month, multicenter, double-blind, randomized, controlled, parallel-group trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Piazzale C Golgi 2, 27100 Pavia, Italy
    Clin Ther 26:744-54. 2004
    ..Glimepiride is approved as monotherapy and in combination with metformin or with insulin, whereas the combination of glimepiride with other antihyperglycemic drugs is under investigation...
  85. ncbi request reprint Long-term effects of glimepiride or rosiglitazone in combination with metformin on blood pressure control in type 2 diabetic patients affected by the metabolic syndrome: a 12-month, double-blind, randomized clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Clin Ther 27:1383-91. 2005
    ..Based on a literature search, few direct comparisons of different antihyperglycemic treatments on blood pressure have been reported...
  86. ncbi request reprint Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    J Cardiovasc Pharmacol 47:508-12. 2006
    ..05) in hypertensive patients after antihypertensive treatment. These results suggest that doxazosin treatment exerts anti-inflammatory effects in addition to its antihypertensive properties in hypertensive patients...
  87. pmc Effects of early treatment with zofenopril in patients with myocardial infarction and metabolic syndrome: the SMILE Study
    Claudio Borghi
    Department of Clinical Medicine, University of Bologna Bologna, Italy
    Vasc Health Risk Manag 4:665-71. 2008
    ....
  88. ncbi request reprint Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Endothelium 13:227-31. 2006
    ..0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism...
  89. ncbi request reprint Recommendations for the treatment of hypertension in patients with DM: critical evaluation based on clinical trials
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy
    Curr Clin Pharmacol 1:21-33. 2006
    ....
  90. ncbi request reprint Prospects for the development of novel anti-hyperlipidemic drugs
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Curr Opin Investig Drugs 7:826-33. 2006
    ....
  91. ncbi request reprint Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardio-vascular disease: response to Beishuizen et al
    Arrigo F G Cicero
    Diabetes Care 28:1262-3; author reply 1263-4. 2005
  92. ncbi request reprint It is necessary to prevent a cerebrovascular 'pandemia'
    Antonio Gaddi
    Cerebrovasc Dis 15:152-3. 2003
  93. ncbi request reprint Effect of oral chronic isoflavones supplementation on male rat sexual performances and sexual hormone plasma levels
    Arrigo F G Cicero
    Biomedical Sciences Department, Pharmacology Section, University of Modena and Reggio nell emilia, Modena, Italy
    Phytother Res 18:849-52. 2004
    ..No significant difference has been observed as regards FSH, progesterone, androstenedione plasma levels, either between groups or between baseline and study end. Slight differences were found regards LH and testosterone plasma level...
  94. ncbi request reprint Effects of nateglinide and glibenclamide on prothrombotic factors in naïve type 2 diabetic patients treated with metformin: a 1-year, double-blind, randomized clinical trial
    Giuseppe Derosa
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Intern Med 46:1837-46. 2007
    ..To evaluate the effect on coagulation and fibrinolysis parameters and on non-conventional cardiovascular risk factors of metformin plus nateglinide or glibenclamide in naïve type 2 diabetes patients...
  95. ncbi request reprint [Cardiovascular risk factors in severely ill psychiatric patients]
    Arrigo F G Cicero
    Centro per lo studio dell aterosclerosi e delle malattie dismetaboliche GC Descovichi, Ospedale Sant Orsola Malpighi Bologna
    Epidemiol Prev 27:40-3. 2003
    ..Thus, we find unethical do not treat hypertension, dyslipidemia and diabetes in severe psychiatric patients...
  96. ncbi request reprint Hypercholesterolemia underdiagnosis and undertreatment in psychiatric patients in Italy
    Arrigo F G Cicero
    Eur J Epidemiol 18:373-4. 2003