Roberto Ciccocioppo

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. ncbi request reprint Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032, Camerino, Italy
    Peptides 23:117-25. 2002
  2. pmc Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats
    Lydia O Ayanwuyi
    Pharmacology Unit, School of Pharmacy, University of Camerino Camerino, Italy
    Front Psychiatry 4:23. 2013
  3. doi request reprint Genetically selected alcohol preferring rats to model human alcoholism
    Roberto Ciccocioppo
    Pharmacology Unit, School of Pharmacy, University of Camerino, Madonna delle Carceri 9, 62032 Camerino, MC, Italy
    Curr Top Behav Neurosci 13:251-69. 2013
  4. pmc Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Macerata, Italy
    Alcohol 43:491-8. 2009
  5. pmc The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    J Neurosci 23:9445-51. 2003
  6. ncbi request reprint Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Calif, USA
    Psychopharmacology (Berl) 168:208-15. 2003
  7. ncbi request reprint Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
    Roberto Ciccocioppo
    Department of Pharmacological Science and Experimental Medicine, University of Camerino, 62032 Camerino MC, Italy
    Nat Neurosci 7:495-6. 2004
  8. ncbi request reprint Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 27:391-9. 2002
  9. pmc Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
  10. pmc Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Heath, University of Camerino, MC, Italy
    Addict Biol 11:339-55. 2006

Detail Information

Publications64

  1. ncbi request reprint Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032, Camerino, Italy
    Peptides 23:117-25. 2002
    ....
  2. pmc Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats
    Lydia O Ayanwuyi
    Pharmacology Unit, School of Pharmacy, University of Camerino Camerino, Italy
    Front Psychiatry 4:23. 2013
    ....
  3. doi request reprint Genetically selected alcohol preferring rats to model human alcoholism
    Roberto Ciccocioppo
    Pharmacology Unit, School of Pharmacy, University of Camerino, Madonna delle Carceri 9, 62032 Camerino, MC, Italy
    Curr Top Behav Neurosci 13:251-69. 2013
    ..The predictive, face and construct validity of these animal models and the translational significance of findings achieved through their use will be critically discussed...
  4. pmc Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Macerata, Italy
    Alcohol 43:491-8. 2009
    ..Chaired by Markus Heilig and Roberto Ciccocioppo, this symposium offered a forum for the presentation of recent data linking neuropetidergic ..
  5. pmc The bed nucleus is a neuroanatomical substrate for the anorectic effect of corticotropin-releasing factor and for its reversal by nociceptin/orphanin FQ
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    J Neurosci 23:9445-51. 2003
    ..These data demonstrate that the BNST is involved in the modulation of CRF-induced anorexia, which is prevented by activation of N/OFQ receptors...
  6. ncbi request reprint Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, Calif, USA
    Psychopharmacology (Berl) 168:208-15. 2003
    ..An important possibility is that withdrawal reactions also influence the motivation to obtain and consume ethanol...
  7. ncbi request reprint Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
    Roberto Ciccocioppo
    Department of Pharmacological Science and Experimental Medicine, University of Camerino, 62032 Camerino MC, Italy
    Nat Neurosci 7:495-6. 2004
    ..In contrast, conditioned stimuli that were associated with a highly palatable non-drug reinforcer elicited modest behavioral responses that extinguished within 3 months...
  8. ncbi request reprint Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats
    Roberto Ciccocioppo
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 27:391-9. 2002
    ..Moreover, the data suggest that drugs aimed at the delta opioid receptor may offer advantages in the treatment and prevention of relapse compared with agents that also block the mu(1) receptor...
  9. pmc Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Biol Psychiatry 61:4-12. 2007
    ..Here we evaluated whether buprenorphine, a partial agonist at micro-opioid and NOP receptors, would reduce ethanol consumption in msP rats via activation of NOP receptors...
  10. pmc Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism
    Roberto Ciccocioppo
    Department of Experimental Medicine and Public Heath, University of Camerino, MC, Italy
    Addict Biol 11:339-55. 2006
    ....
  11. ncbi request reprint Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Psychopharmacology (Berl) 161:113-9. 2002
    ..1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions...
  12. pmc Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Psychopharmacology (Berl) 172:170-8. 2004
    ....
  13. doi request reprint Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino MC, Italy
    Biol Psychiatry 64:211-8. 2008
    ....
  14. doi request reprint Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats
    Serena Stopponi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy
    Alcohol Clin Exp Res 37:1351-60. 2013
    ..Pioglitazone was not able to prevent relapse elicited by alcohol cues. Conversely, the nonselective opioid antagonist naltrexone has been shown to reduce alcohol drinking and cue- but not stress-induced relapse in rodents...
  15. ncbi request reprint Role of cannabinoidergic mechanisms in ethanol self-administration and ethanol seeking in rat adult offspring following perinatal exposure to Delta9-tetrahydrocannabinol
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Toxicol Appl Pharmacol 223:73-85. 2007
    ....
  16. doi request reprint The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S
    Amalia Fedeli
    Department of Experimental Medicine and Public Heath, University of Camerino, 62032, Camerino, Italy
    Eur J Neurosci 30:1594-602. 2009
    ..The present study demonstrates that NPS evokes a potent inhibition of palatable food consumption and that the PVN is an important site of action for its effect...
  17. pmc Activation of brain NOP receptors attenuates acute and protracted alcohol withdrawal symptoms in the rat
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Alcohol Clin Exp Res 35:747-55. 2011
    ..In this study, we evaluated whether activation of brain NOP receptors may also attenuate alcohol withdrawal signs in rats...
  18. doi request reprint Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat
    Giordano de Guglielmo
    Pharmacology Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Addict Biol 18:644-53. 2013
    ..Overall, these results demonstrate that pregabalin may have potential in the treatment of some aspects of cocaine addiction. ..
  19. doi request reprint Activation of nuclear PPARγ receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking
    Serena Stopponi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy
    Biol Psychiatry 69:642-9. 2011
    ..TZDs bind with high affinity and activate peroxisome proliferator-activated receptor-gamma (PPARγ) receptors, which in the brain are expressed both in neurons and in glia...
  20. pmc Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system
    Marsida Kallupi
    School of Pharmacy Pharmacology Unit, University of Camerino, 62032 Camerino, Italy
    Proc Natl Acad Sci U S A 107:19567-72. 2010
    ..Finally, results showed that intra-LH injection of the NPS antagonist [D-Cys(tBu) (5)]NPS blocked cue-induced cocaine seeking, indicating a role for this system in the pathophysiology of drug relapse...
  21. pmc Revisiting intragastric ethanol intubation as a dependence induction method for studies of ethanol reward and motivation in rats
    Simone Braconi
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino, Italy
    Alcohol Clin Exp Res 34:538-44. 2010
    ....
  22. ncbi request reprint Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 Camerino, MC, Italy
    Physiol Behav 82:63-8. 2004
    ..In comparison to CRF receptor antagonists, NOP receptor agonists may have the advantage of not inhibiting the hypothalamic-pituitary-adrenal (HPA) axis...
  23. pmc Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition
    Andrea Cippitelli
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy
    PLoS ONE 6:e28142. 2011
    ....
  24. doi request reprint A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam
    Carlo Cifani
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Psychopharmacology (Berl) 204:113-25. 2009
    ..Preclinical models are needed to investigate the neurobiology and psychobiology of binge eating and to identify innovative pharmacotherapeutic strategies...
  25. doi request reprint Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system
    Nazzareno Cannella
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Neuropsychopharmacology 34:2125-34. 2009
    ..Based on the present findings, we also predict that antagonism at NPS receptors could represent a novel pharmacological approach to alcohol relapse treatment...
  26. doi request reprint Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat
    Andrea Cippitelli
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Psychopharmacology (Berl) 198:449-60. 2008
    ..As an alternative approach, CB1-receptor-mediated activity can be facilitated by increasing anandamide levels with the use of hydrolase fatty acid amide hydrolase (FAAH) inhibitors...
  27. ncbi request reprint Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032, Camerino, Italy
    Psychopharmacology (Berl) 183:394-403. 2006
    ..It has been suggested that endocannabinoid mechanisms are involved in the control of ethanol consumption...
  28. doi request reprint Pregabalin reduces alcohol drinking and relapse to alcohol seeking in the rat
    Serena Stopponi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Psychopharmacology (Berl) 220:87-96. 2012
    ..While the exact cellular mechanism of action of pregabalin is still unclear, evidence from several studies suggests that it reduces excitatory neurotransmitter release and postsynaptic excitability...
  29. ncbi request reprint Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat
    Amalia Fedeli
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 3, 62032 Camerino MC, Italy
    Peptides 27:3284-91. 2006
    ..Conversely, injection of N/OFQ (0.25-2.0 nmol/rat) blocked the anorectic effect of CRF (0.1 nmol/rat). These findings suggest that N/OFQ selectively prevent the anorectic effect mediated by activation of the CRF(1) receptor system...
  30. ncbi request reprint Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Camerino Macerata, Italy
    Alcohol Clin Exp Res 27:1554-62. 2003
    ..This study evaluated the effect on ethanol intake of the combined administration of a CO2 H. perforatum extract and naloxone or naltrexone in genetically selected Marchigian Sardinian alcohol-preferring rats...
  31. ncbi request reprint Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, via Scalino 3, 62032 Camerino MC, Italy
    Alcohol Alcohol 40:291-6. 2005
    ....
  32. pmc Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors
    Roberto Ciccocioppo
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino 62032, Italy, Institute of Psychopharmacology at the Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Heidelberg 68159, Germany, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, and National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108
    J Neurosci 34:363-72. 2014
    ..These combined results demonstrate that acute stress increases N/OFQ systems in the CeA and that N/OFQ has antistress properties. ..
  33. pmc Modification of anxiety-like behaviors by nociceptin/orphanin FQ (N/OFQ) and time-dependent changes in N/OFQ-NOP gene expression following ethanol withdrawal
    Harinder Aujla
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA
    Addict Biol 18:467-79. 2013
    ....
  34. doi request reprint Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat
    Marsida Kallupi
    School of Pharmacy Pharmacology Unit, University of Camerino, Building of Experimental Medicine, Via Madonna delle Carceri, 62032 Camerino, Italy
    Psychopharmacology (Berl) 226:347-55. 2013
    ....
  35. doi request reprint Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat
    Carlo Cifani
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 9, 62032 Camerino MC, Italy
    Peptides 32:44-50. 2011
    ....
  36. doi request reprint Neuropeptide S receptor gene expression in alcohol withdrawal and protracted abstinence in postdependent rats
    Barbara Ruggeri
    Department of Experimental Medicine and Public Health, University of Camerino, Camerino, Italy
    Alcohol Clin Exp Res 34:90-7. 2010
    ..Given that a history of ethanol intoxication may increase vulnerability to alcohol addiction, we sought to determine whether NPS receptor (NPSR) gene expression is altered during withdrawal...
  37. ncbi request reprint The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, 62032 MC, Camerino, Italy
    Physiol Behav 79:121-8. 2003
    ..Together, these findings suggest that N/OFQ and its receptor may represent an interesting target for pharmacological treatment of alcohol abuse...
  38. doi request reprint Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats
    Carlo Cifani
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, 62032 Camerino
    Addict Biol 14:397-407. 2009
    ..In addition, the present findings confirm that topiramate may represent an important pharmacotherapeutic approach to binge-related eating...
  39. doi request reprint Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain
    Pasha Ghazal
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Peptides 46:6-12. 2013
    ..These results demonstrated that morphine dependence induction led to (i) changes in NPSR mRNA expression; (ii) increased anxiety; and (iii) more potent anxiolytic-like effect of NPS...
  40. pmc Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects
    Melissa A Herman
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, SP30 1150, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 67:337-48. 2013
    ..The elevated GABAergic transmission observed in naïve msP rats is consistent with the neuroadaptations reported in Sprague Dawley rats after the development of ethanol dependence...
  41. doi request reprint Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats
    Maria Vittoria Micioni Di Bonaventura
    School of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino, MC, Italy
    Psychopharmacology (Berl) 228:53-63. 2013
    ..Nociceptin/orphanin FQ (N/OFQ) is a functional antagonist of corticotrophin-releasing factor, the main mediator of the stress response. Stress represents a key determinant of binge eating (BE) for highly palatable food (HPF)...
  42. doi request reprint The role of the neuropeptide S system in addiction: focus on its interaction with the CRF and hypocretin/orexin neurotransmission
    Nazzareno Cannella
    School of Pharmacy Pharmacology Unit, University of Camerino, Camerino, Italy
    Prog Neurobiol 100:48-59. 2013
    ..Finally, existing findings are discussed within the framework of addiction theories, and the potential of the NPS system as a treatment target for addiction is analyzed...
  43. ncbi request reprint Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments
    Amalia Fedeli
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino, MC Italy
    Res Commun Mol Pathol Pharmacol 112:113-27. 2002
    ..These long-lasting changes in brain 5-HT2A binding sites observed in the present study might contribute to specific aspects of ethanol dependence, such as development of depression and alcohol craving...
  44. ncbi request reprint Effect of novel NOP receptor ligands on food intake in rats
    Daina Economidou
    Department of Experimental Medicine and Public Health, University of Camerino, 62032 Camerino, Italy
    Peptides 27:775-83. 2006
    ..Overall, the results indicate that these compounds may represent valuable pharmacological tools to investigate the role of the brain N/OFQ system...
  45. ncbi request reprint Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology
    George F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Recent Dev Alcohol 16:263-81. 2003
    ....
  46. doi request reprint Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating
    Carlo Cifani
    School of Pharmacy, Pharmacology Unit, University of Camerino, via Madonna delle Carceri 9, 62032 Camerino MC, Italy
    Physiol Behav 101:555-62. 2010
    ..In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect...
  47. ncbi request reprint Memory impairment following combined exposure to delta(9)-tetrahydrocannabinol and ethanol in rats
    Roberto Ciccocioppo
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Sealzino 5, 62032 Camerino MC, Italy
    Eur J Pharmacol 449:245-52. 2002
    ..The present findings are in keeping with the notion that Cannabis derivatives impair memory processes and provide evidence for a synergic action of THC and ethanol, thus emphasizing the risks consequent to their co-administration...
  48. pmc Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin
    Remi Martin-Fardon
    The Scripps Research Institute, Molecular and Integrative Neurosciences Department, SP30 2120, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 1314:145-61. 2010
    ....
  49. ncbi request reprint The dorsal subiculum mediates the acquisition of conditioned reinstatement of cocaine-seeking
    Remi Martin-Fardon
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:1827-34. 2008
    ....
  50. ncbi request reprint Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats
    Marina Perfumi
    Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, 62032 Camerino MC, Italy
    Alcohol Alcohol 37:540-6. 2002
    ....
  51. ncbi request reprint Chronic THC during adolescence increases the vulnerability to stress-induced relapse to heroin seeking in adult rats
    Serena Stopponi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, Italy
    Eur Neuropsychopharmacol 24:1037-45. 2014
    ..Altogether these findings demonstrate that chronic exposure to THC during adolescence is responsible for heightened anxiety and increased vulnerability to drug relapse in adulthood. ..
  52. pmc Translational approach to develop novel medications on alcohol addiction: focus on neuropeptides
    Massimo Ubaldi
    School of Pharmacy, Pharmacology Unit, University of Camerino, 62032, Camerino, Italy
    Curr Opin Neurobiol 23:684-91. 2013
    ..Moreover, significant examples of promising targets from neuropeptidergic systems, namely nociceptin/orphanin FQ and neuropeptide S are given. ..
  53. doi request reprint Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
    Cinzia Nasuti
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy
    Toxicology 303:162-8. 2013
    ..The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 μg/L and it was completely eliminated after 96 h...
  54. ncbi request reprint Microarrays--the challenge of preparing brain tissue samples
    Laura Soverchia
    Department of Pharmacological Science and Experimental Medicine, University of Camerino, 62032 Camerino, Italy
    Addict Biol 10:5-13. 2005
    ..This article tries to provide hints for some basic rules to be observed in preparation of samples for expression profiling studies...
  55. pmc A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats
    Annika Thorsell
    Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892, USA
    J Neurosci 33:10132-42. 2013
    ..Together, these data provide an initial validation of the NPSR as a therapeutic target in alcoholism...
  56. ncbi request reprint Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies
    Anna Rizzi
    Department of Experimental and Clinical Medicine, Section of Pharmacology and Neuroscience Center, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:450-6. 2002
    ..pF)Phe(4)]NC(1-13)NH(2) was more potent and its in vivo effects were longer lasting than those of NC(1-13)NH(2) and NC...
  57. ncbi request reprint The anandamide transport inhibitor AM404 reduces ethanol self-administration
    Andrea Cippitelli
    Fundación IMABIS The European TARGALC Consortium, Hospital Carlos Haya, Avenida Carlos Haya s n, 7 Planta, Pabellon A, 29010 Malaga, Spain
    Eur J Neurosci 26:476-86. 2007
    ..These results indicate that AM404 may be considered as an innovative approach to reduce alcohol consumption...
  58. ncbi request reprint Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol
    Anita C Hansson
    Laboratory of Clinical and Translational Studies, NIAAA NIH, Bethesda, MD 20892 1108, USA
    Addict Biol 12:30-4. 2007
    ....
  59. ncbi request reprint 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism
    Donald R Gehlert
    Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 27:2718-26. 2007
    ..Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence...
  60. ncbi request reprint Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies
    Anna Rizzi
    Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy
    J Pharmacol Exp Ther 321:968-74. 2007
    ..The use of SB-612111 in future pathophysiological studies will certainly contribute to define the therapeutic potential of selective NOP receptor antagonists in different disease areas...
  61. ncbi request reprint Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats
    Andrea Cippitelli
    Fundacion Hospital Carlos Haya, Avenida Carlos Haya 82, 7 Planta, Pabellon A, 29010 Malaga, Spain
    Eur J Neurosci 21:2243-51. 2005
    ..In addition, current pharmacological and neuroanatomical data suggest that an altered function of the CB1 receptor system exists between genetically selected alcohol-preferring msP rats and a heterogeneous animal population...
  62. ncbi request reprint The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat
    Daniel Bachteler
    Department of Psychopharmacology, University of Heidelberg, Central Institute of Mental Health, Mannheim, Germany
    Neuropsychopharmacology 30:1104-10. 2005
    ..Treatment with neramexane that shares part of the pharmacological effects of acamprosate on NMDA receptors, however, resulted in a nonselective reduction of lever responding...
  63. ncbi request reprint Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats
    Patrizia Campolongo
    Department of Human Physiology and Pharmacology, Sapienza, University of Rome, Italy
    Addict Biol 12:485-95. 2007
    ..Taken together, the present results highlight how exposure to cannabinoids during early stages of brain development can lead to irreversible, subtle dysfunctions in the offspring...
  64. ncbi request reprint The genetic of alcoholism: learning from 50 years of research
    Roberto Ciccocioppo
    Addict Biol 11:193-4. 2006