M Cicardi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Diagnosing angioedema
    Marco Cicardi
    Department of Biological and Clinical Sciences Luigi Sacco, Ospedale Luigi Sacco, University of Milan, Milano, Italy Electronic address
    Immunol Allergy Clin North Am 33:449-56. 2013
  2. doi Review of recent guidelines and consensus statements on hereditary angioedema therapy with focus on self-administration
    M Cicardi
    Department of Biomedical and Clinical Sciences, University of Milan and Luigi Sacco Hospital, Milan, Italy
    Int Arch Allergy Immunol 161:3-9. 2013
  3. doi Hereditary and acquired complement component 1 esterase inhibitor deficiency: a review for the hematologist
    Marco Cicardi
    Dipartimento di Scienze Mediche L Sacco, Universita di Milano, Ospedale L Sacco Milano, Milan, Italy
    Acta Haematol 127:208-20. 2012
  4. doi Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Ospedale L Sacco, Milano, Italy
    Allergy 67:147-57. 2012
  5. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
  6. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
  7. doi Replacement therapy with C1 esterase inhibitors for hereditary angioedema
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco Università di Milano, Ospedale L Sacco, Milano, Italy
    Drugs Today (Barc) 46:867-74. 2010
  8. ncbi How do we treat patients with hereditary angioedema
    Marco Cicardi
    Department of Internal Medicine University of Milan, IRCCS Maggiore Hospital, Milan, Italy
    Transfus Apher Sci 29:221-7. 2003
  9. doi Ecallantide for the treatment of acute attacks in hereditary angioedema
    Marco Cicardi
    University of Milan, Dept of Internal Medicine, Ospedale Luigi Sacco, Via Giovanni Battista Grassi 74, 20157 Milan, Italy
    N Engl J Med 363:523-31. 2010
  10. ncbi Autoantibodies and lymphoproliferative diseases in acquired C1-inhibitor deficiencies
    Marco Cicardi
    Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
    Medicine (Baltimore) 82:274-81. 2003

Collaborators

Detail Information

Publications47

  1. ncbi Diagnosing angioedema
    Marco Cicardi
    Department of Biological and Clinical Sciences Luigi Sacco, Ospedale Luigi Sacco, University of Milan, Milano, Italy Electronic address
    Immunol Allergy Clin North Am 33:449-56. 2013
    ..Evaluation of patients for recurrent angioedema without wheals must take into account both specific clinical signs and symptoms and specialized laboratory testing. ..
  2. doi Review of recent guidelines and consensus statements on hereditary angioedema therapy with focus on self-administration
    M Cicardi
    Department of Biomedical and Clinical Sciences, University of Milan and Luigi Sacco Hospital, Milan, Italy
    Int Arch Allergy Immunol 161:3-9. 2013
    ....
  3. doi Hereditary and acquired complement component 1 esterase inhibitor deficiency: a review for the hematologist
    Marco Cicardi
    Dipartimento di Scienze Mediche L Sacco, Universita di Milano, Ospedale L Sacco Milano, Milan, Italy
    Acta Haematol 127:208-20. 2012
    ....
  4. doi Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Ospedale L Sacco, Milano, Italy
    Allergy 67:147-57. 2012
    ..Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients...
  5. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
    ..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...
  6. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
    ....
  7. doi Replacement therapy with C1 esterase inhibitors for hereditary angioedema
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco Università di Milano, Ospedale L Sacco, Milano, Italy
    Drugs Today (Barc) 46:867-74. 2010
    ..Two plasma-derived C1 inhibitors and a recombinant form, produced in transgenic rabbits, have successfully completed controlled trials that reinforced the evidence of the safety and efficacy of this treatment...
  8. ncbi How do we treat patients with hereditary angioedema
    Marco Cicardi
    Department of Internal Medicine University of Milan, IRCCS Maggiore Hospital, Milan, Italy
    Transfus Apher Sci 29:221-7. 2003
    ..Since that time, 441 such patients have been examined and treated at our department; 403 are still actively followed. Here we present our experience on the treatment of HAE...
  9. doi Ecallantide for the treatment of acute attacks in hereditary angioedema
    Marco Cicardi
    University of Milan, Dept of Internal Medicine, Ospedale Luigi Sacco, Via Giovanni Battista Grassi 74, 20157 Milan, Italy
    N Engl J Med 363:523-31. 2010
    ..We evaluated ecallantide, a newly developed recombinant plasma kallikrein inhibitor, for the treatment of acute attacks of angioedema...
  10. ncbi Autoantibodies and lymphoproliferative diseases in acquired C1-inhibitor deficiencies
    Marco Cicardi
    Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
    Medicine (Baltimore) 82:274-81. 2003
    ..Antifibrinolytic agents are more effective than attenuated androgens in long-term prophylaxis. Patients with acquired C1-INH deficiency may be resistant to replacement therapy with C1-INH plasma concentrate...
  11. ncbi Angioedema associated with angiotensin-converting enzyme inhibitor use: outcome after switching to a different treatment
    Marco Cicardi
    Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Via Pace 9, 20122 Milan, Italy
    Arch Intern Med 164:910-3. 2004
    ..We describe 64 consecutive patients with ACE inhibitor-related angioedema, the outcome after discontinuing this treatment, and the safety of using ARBs...
  12. ncbi The deficiency of C1 inhibitor and its treatment
    Marco Cicardi
    Department of Internal Medicine, University of Milan, San Giuseppe Hospital A Fa R, Milan, Italy
    Immunobiology 212:325-31. 2007
    ....
  13. ncbi Established and new treatments for hereditary angioedema: An update
    Marco Cicardi
    Department of Internal Medicine, University of Milan, L Sacco Hospital, Via G B Grassi 74, 20157 Milan, Italy
    Mol Immunol 44:3858-61. 2007
    ..Here we review the characteristics of these products and the current situation of the trials...
  14. ncbi The use of plasma-derived C1 inhibitor in the treatment of hereditary angioedema
    Marco Cicardi
    University of Milan, Department of Internal Medicine, Ospedale L Sacco, Via G B Grassi 74, 20157 Milano, Italy
    Expert Opin Pharmacother 8:3173-81. 2007
    ..C1-INH is licensed only in a limited number of countries. Clinical trials are ongoing at present to expand registration...
  15. pmc Acquired angioedema
    Marco Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco Università di Milano, Milano Italy, Ospedale L, Sacco Milano, Italy
    Allergy Asthma Clin Immunol 6:14. 2010
    ..Angioedema prophylaxis is performed using antifibrinolytic agents and attenuated androgens with antifibrinolytic agents providing somewhat better results. Treatment of the associated disease can resolve AAE in some patients...
  16. doi Angioedema due to C1 inhibitor deficiency in 2010
    Marco Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Ospedale L Sacco, Milan, Italy
    Intern Emerg Med 5:481-6. 2010
    ..Because of these advances, in patients properly diagnosed and treated, the mortality for the disease has dropped close to zero, and the quality of life for patients approaches that of normal subjects...
  17. ncbi The acquired deficiency of C1-inhibitor: lymphoproliferation and angioedema
    M Cicardi
    Dipartimento di Scienze Cliniche L Sacco, Universita di Milano, Ospedale Luigi Sacco, Milano, Italy
    Curr Mol Med 10:354-60. 2010
    ..Demonstration that monoclonal components correspond to anti-C1-INH autoantibodies and correlation between course of lymphoma and course of AAE provide strong support to consider the two diseases expression of the same pathologic process...
  18. ncbi Angioedema due to angiotensin-converting enzyme inhibitors
    A Agostoni
    Department of Internal Medicine, University of Milan, IRCCS Ospedale, Maggiore, Italy
    Immunopharmacology 44:21-5. 1999
    ..These observations indicate that in ACE-inhibitor-induced angioedema, contrary to hereditary angioedema, the reduction of bradykinin catabolic rate plays a predominant role...
  19. doi Icatibant treatment for acquired C1-inhibitor deficiency: a real-world observational study
    A Zanichelli
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita degli Studi di Milano, Milano, Italy
    Allergy 67:1074-7. 2012
    ..One peripheral attack responded less quickly than other treated attacks. Five patients reported transient injection site reactions. Icatibant appeared to provide effective symptom relief and was generally well tolerated...
  20. ncbi Dental experience and self-perceived dental care needs of patients with angioedema
    G Lodi
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Italy
    Spec Care Dentist 21:27-31. 2001
    ..More than half (58%) of the group perceived a need for dental care. We conclude that persons with angioedema may experience difficulty in obtaining dental treatment, a common cause of acute attacks...
  21. ncbi Bradykinin and the pathophysiology of angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace, 15, 20122 Milan, Italy
    Int Immunopharmacol 3:311-7. 2003
    ....
  22. pmc Angioedema without urticaria: a large clinical survey
    Lorenza C Zingale
    Department of Internal Medicine, San Giuseppe Hospital, University of Milan, Milan, Italy
    CMAJ 175:1065-70. 2006
    ..Its causes are diverse, and little is known about its pathogenic mechanisms. We report on our 11 years of experience with this condition and propose a classification of patients affected by angioedema unaccompanied by urticaria...
  23. ncbi C1 inhibitor: molecular and clinical aspects
    Marco Cicardi
    Department of Internal Medicine, San Giuseppe Hospital, University of Milan, Milan, Italy
    Springer Semin Immunopathol 27:286-98. 2005
    ..We can expect that the introduction of this new product, along with the existing plasma derivative, will renew interest in exploiting C1-INH as a therapeutic agent...
  24. doi Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Autoimmun Rev 8:156-9. 2008
    ....
  25. doi Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency
    M Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Allergy 64:254-7. 2009
    ..Although cutaneous swelling is evident, abdominal angioedema is still a diagnostic challenge and attacks can mimic surgical emergencies. There is currently no laboratory marker for identifying angioedema attacks...
  26. ncbi C1-inhibitor deficiency and angioedema
    A Carugati
    Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Via Pace 9, 20122 Milan, Italy
    Mol Immunol 38:161-73. 2001
    ..A special remark to this treatment should be made for autoantibody-mediated AAE where very high doses can be needed depending on the rate of C1-Inh consumption...
  27. doi Standard care impact on angioedema because of hereditary C1 inhibitor deficiency: a 21-month prospective study in a cohort of 103 patients
    A Zanichelli
    Dipartimento di Scienze Cliniche L Sacco, Universita degli Studi di Milano, Ospedale Luigi Sacco, Milan, Italy
    Allergy 66:192-6. 2011
    ..Hereditary angioedema (HAE) due to the deficiency of C1 inhibitor (C1-INH) causes chronically recurrent cutaneous, abdominal and laryngeal angioedema that are disabling and potentially life-threatening...
  28. ncbi Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group
    M Cicardi
    Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Luigi Sacco Hospital Milan, Milan, Italy
    Allergy 69:602-16. 2014
    ..Here, we summarize the analysis of the data and the resulting classification of angioedema. ..
  29. ncbi Drug-induced angioedema without urticaria
    A Agostoni
    Department of Internal Medicine, IRCCS Milan Maggiore Hospital, University of Milan, Italy
    Drug Saf 24:599-606. 2001
    ..If the acute airway obstruction leads to life-threatening respiratory compromise an emergency cricothyroidotomy must be performed...
  30. ncbi Increased expression of C1-inhibitor mRNA in patients with hereditary angioedema treated with Danazol
    Emanuela Pappalardo
    Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Via Pace 9, Milan 20122, Italy
    Immunol Lett 86:271-6. 2003
    ..Our data demonstrate that minimal effective doses of Danazol increase the expression of C1-INH mRNA in PBMC of HAE patients even in the absence of a significant increase of C1-INH plasma levels...
  31. ncbi Acquired deficiency of the inhibitor of the first complement component: presentation, diagnosis, course, and conventional management
    Lorenza Chiara Zingale
    Department of Internal Medicine, San Giuseppe Hospital AFaR Ospedale San Giuseppe, University of Milan, Via San Vittore 12, 20123 Milano, Italy
    Immunol Allergy Clin North Am 26:669-90. 2006
    ..Moreover, the authors give an overview of the outcome of the disease and the different therapies proposed to cure it...
  32. ncbi Angiotensin-converting enzyme inhibitor-related angioedema: how to deal with it
    Laura Beltrami
    San Giuseppe Hospital AFaR, University of Milan, Department of Internal Medicine, Via San Vittore 12, 20123, Milan, Italy
    Expert Opin Drug Saf 5:643-9. 2006
    ..In this review, the authors analyse the pathogenetic mechanism, the clinical presentation, the management and future perspectives of research on this condition...
  33. ncbi A dysfunctional C1 inhibitor protein with a new reactive center mutation (Arg-444-->Leu)
    D Frangi
    Clinica Medica V, Universita di Milano, Ospedale S Paolo, Italy
    FEBS Lett 301:34-6. 1992
    ..The mutation was defined at the level of the protein (by sequence analysis of the Pseudomonas aeruginosa elastase-derived reactive center peptide), and the mRNA (CGC-->CTC) (by sequence analysis of PCR-amplified DNA)...
  34. pmc Alterations of coagulation and fibrinolysis in patients with angioedema due to C1-inhibitor deficiency
    M van Geffen
    Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Exp Immunol 167:472-8. 2012
    ....
  35. pmc Consumption of C4b-binding protein (C4BP) during in vivo activation of the classical complement pathway
    L Bergamaschini
    Department of Internal Medicine, Maggiore Hospital IRCCS, University of Milan, Milan, Italy
    Clin Exp Immunol 116:220-4. 1999
    ..The results of this study indicate that C4BP is consumed in vivo during acute, and possibly during chronic activation of the C' classical pathway, and that this protein, after interaction with C4b, not longer circulates in plasma...
  36. ncbi Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond
    Angelo Agostoni
    University of Milan, Italy
    J Allergy Clin Immunol 114:S51-131. 2004
    ..This supplement seeks to raise awareness and aid diagnosis of HAE, optimize treatment for all patients, and provide a platform for further research in this rare, partially understood disorder...
  37. doi C1-inhibitor deficiency and angioedema: molecular mechanisms and clinical progress
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Mangiagalli e Regina Elena, Milan 20122, Italy
    Trends Mol Med 15:69-78. 2009
    ..Here, we review the molecular mechanisms underlying angioedema due to C1-inhibitor deficiency and clinical progress using molecular-targeted interventions...
  38. doi Successful resolution of bowel obstruction in a patient with hereditary angioedema
    Lorenza C Zingale
    Department of Clinical Science L Sacco, University of Milan, Ospedale L Sacco, Milan, Italy
    Eur J Gastroenterol Hepatol 20:583-7. 2008
    ..Furthermore, it illustrates the usefulness of videos obtained from capsule endoscopy in identifying the presence of bowel occlusion and demonstrating its subsequent rapid resolution upon administration of DX-88...
  39. ncbi C1 inhibitor gene expression in patients with hereditary angioedema: quantitative evaluation by means of real-time RT-PCR
    Emanuela Pappalardo
    Department of Internal Medicine, University of Milan, Ospedale S Giuseppe, 20123 Milan, Italy
    J Allergy Clin Immunol 114:638-44. 2004
    ..Most patients have antigenic and functional deficiency (type I HAE), and 15% have reduced C1-INH function but normal to increased antigen because of the presence of a dysfunctional protein (type II HAE)...
  40. ncbi Recent advances in the use of C1 inhibitor as a therapeutic agent
    Luigi Bergamaschini
    Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Via Pace 9, 20122 Milan, Italy
    Mol Immunol 40:155-8. 2003
  41. ncbi Research on complement: old issues revisited and a novel sphere of influence
    Liliana Clemenza
    Department of Biopathology and Biomedical Methodologies, University of Palermo, Italy, Corso Tukory 211, Italy
    Trends Immunol 24:292-6. 2003
    ..We cover papers selected from studies presented at the XIX International Complement Workshop, held in Palermo in September 2002, and published within the past six months...
  42. ncbi Bradykinin-mediated angioedema
    Juerg Nussberger
    N Engl J Med 347:621-2. 2002
  43. ncbi Mechanisms of C1-inhibitor deficiency
    Emanuela Pappalardo
    Immunobiology 205:542-51. 2002
    ..Such conditions, as extensively investigated in sepsis, are of great relevance because they open the possibility of using C1-Inh as therapeutic agent in several different diseases...
  44. ncbi Lymphoproliferative disease and acquired C1 inhibitor deficiency
    Roberto Castelli
    Haematologica 92:716-8. 2007
    ..Our series suggest that different forms of B cell disorders coexist and/or evolve into each other in acquired angioedema...
  45. ncbi Canadian 2003 International Consensus Algorithm For the Diagnosis, Therapy, and Management of Hereditary Angioedema
    Tom Bowen
    Department of Medicine and Paeditrics, University of Calgary, Calgary, Alberta T2N 2T8, Canada
    J Allergy Clin Immunol 114:629-37. 2004
    ..Hopefully evidence to support approaches to the management of HAE will approach the level of meta-analysis of randomized controlled trials in the near future...
  46. doi Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol Methods 338:14-20. 2008
    ..It can be concluded that the diagnosis of fC1-Inh deficiency was made correctly in most cases in this survey. We can recommend the chromogenic assay for the determination of fC1-Inh, while the complex ELISA needs further investigation...
  47. ncbi Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedema
    Beata Visy
    Madarász Street Hospital of the Heim Pál Pediatric Hospital, Budapest, Hungary
    Helicobacter 12:251-7. 2007
    ..The present study aimed to reinvestigate the relationship between H. pylori infection and the attack rate in the framework of an international collaborative study...