Laura Ciapponi

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint An essential function of AP-1 heterodimers in Drosophila development
    Laura Ciapponi
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mech Dev 115:35-40. 2002
  2. doi request reprint Telomere capping and cellular checkpoints: clues from fruit flies
    L Ciapponi
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Roma, Italy
    Cytogenet Genome Res 122:365-73. 2008
  3. doi request reprint Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres
    Grazia D Raffa
    Istituto Pasteur Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Genetica e Biologia Molecolare, Sapienza, Universita di Roma, Ple A Moro 5, 00185 Roma, Italy
    Nucleus 2:383-91. 2011
  4. ncbi request reprint The mechanism of telomere protection: a comparison between Drosophila and humans
    Giovanni Cenci
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Piazzale A Moro, 5, 00185 Rome, Italy
    Chromosoma 114:135-45. 2005
  5. ncbi request reprint Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells
    Maria Teresa Petrucci
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Via Benevento 6, 00161 Roma, Italy
    Leuk Lymphoma 43:2369-75. 2002
  6. ncbi request reprint The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage
    Laura Ciapponi
    Dipartimento di Genetica e Biologia Molecolare and Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Universita di Roma La Sapienza, 00185 Rome, Italy
    Curr Biol 14:1360-6. 2004
  7. pmc Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference
    Maria Patrizia Somma
    Dipartimento di Genetica e Biologia Molecolare, Istituto di Biologia e Patologia Molecolari del CNR, Rome, Italy
    PLoS Genet 4:e1000126. 2008
  8. pmc The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability
    Laura Ciapponi
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita di Lecce, 73100 Lecce, Italy
    Genetics 173:1447-54. 2006
  9. doi request reprint Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint
    Mariarosaria Musarò
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali DiSTeBA, Universita del Salento, Lecce 73100, Italy
    Nat Genet 40:362-6. 2008

Collaborators

  • Giovanni Cenci
  • Roberto Piergentili
  • Francesca Ceprani
  • Maurizio Gatti
  • Grazia D Raffa
  • Maria Patrizia Somma
  • Mariarosaria Musarò
  • Barbara Fasulo
  • Maria Teresa Petrucci
  • Ferdinando Di Cunto
  • Romano Petrucci
  • Claudia Pellacani
  • Maria Grazia Giansanti
  • Valeria Naim
  • Valeria De Arcangelis
  • Michael L Goldberg
  • Antonella Palena
  • Fiammetta Vernì
  • Elisabetta Bucciarelli
  • Rocco Savino
  • Gennaro Ciliberto
  • Agostino Tafuri
  • Maria Rosaria Ricciardi
  • Chiara Gregorj

Detail Information

Publications9

  1. ncbi request reprint An essential function of AP-1 heterodimers in Drosophila development
    Laura Ciapponi
    Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Mech Dev 115:35-40. 2002
    ..We conclude that Jun and Fos play complementary roles that are both required for signal transduction and gene activation during dorsal closure...
  2. doi request reprint Telomere capping and cellular checkpoints: clues from fruit flies
    L Ciapponi
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Roma, Italy
    Cytogenet Genome Res 122:365-73. 2008
    ..These results indicate that the DNA repair systems play multiple roles at Drosophila telomeres, highlighting the importance of this model organism for investigations on the relationships between DNA repair and telomere maintenance...
  3. doi request reprint Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres
    Grazia D Raffa
    Istituto Pasteur Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Genetica e Biologia Molecolare, Sapienza, Universita di Roma, Ple A Moro 5, 00185 Roma, Italy
    Nucleus 2:383-91. 2011
    ..Based on these findings, we propose that concomitant with telomerase loss Drosophila rapidly evolved terminin to bind chromosome ends in a sequence-independent fashion, and that terminin is functionally analogous to shelterin...
  4. ncbi request reprint The mechanism of telomere protection: a comparison between Drosophila and humans
    Giovanni Cenci
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Piazzale A Moro, 5, 00185 Rome, Italy
    Chromosoma 114:135-45. 2005
    ..We believe that the molecular characterization of these genes will lead to identification of many novel human genes with roles in telomere maintenance...
  5. ncbi request reprint Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells
    Maria Teresa Petrucci
    Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita La Sapienza, Via Benevento 6, 00161 Roma, Italy
    Leuk Lymphoma 43:2369-75. 2002
    ..Such effects may depend on the availability of large amounts of soluble IL-6R. Further studies should aim at defining the conditions necessary for optimal antiproliferative activity...
  6. ncbi request reprint The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage
    Laura Ciapponi
    Dipartimento di Genetica e Biologia Molecolare and Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Universita di Roma La Sapienza, 00185 Rome, Italy
    Curr Biol 14:1360-6. 2004
    ..This suggests that the MRN complex protects Drosophila telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends...
  7. pmc Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference
    Maria Patrizia Somma
    Dipartimento di Genetica e Biologia Molecolare, Istituto di Biologia e Patologia Molecolari del CNR, Rome, Italy
    PLoS Genet 4:e1000126. 2008
    ..We can foresee that elaboration of co-expression lists using genes in the same phenocluster will provide many candidate genes for small-scale RNAi screens aimed at completing the inventory of mitotic proteins...
  8. pmc The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability
    Laura Ciapponi
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Universita di Lecce, 73100 Lecce, Italy
    Genetics 173:1447-54. 2006
    ..In contrast, analysis of chromosome breakage indicated that the three components of the MRN complex function in a single pathway for the repair of the DNA damage leading to chromosome aberrations...
  9. doi request reprint Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint
    Mariarosaria Musarò
    Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali DiSTeBA, Universita del Salento, Lecce 73100, Italy
    Nat Genet 40:362-6. 2008
    ..Our results collectively suggest that recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20-APC function, preventing the metaphase-to-anaphase transition...