Affiliation: University of Milan
- Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptorsMarta Busnelli
CNR, Institute of Neuroscience, Milan, Italy
J Pharmacol Exp Ther 346:318-27. 2013..These highly selective pharmacological tools will contribute to the investigation of the specific physiologic and pathologic roles of mOTR for the development of selective OT-based therapeutics. ..
- G-protein-coupled receptors, cholesterol and palmitoylation: facts about fatsBice Chini
CNR Institute of Neuroscience, Milan, Italy
J Mol Endocrinol 42:371-9. 2009..This review briefly highlights how lipids of the membrane and the receptor themselves can influence GPCR organisation and functioning...
- Agonist selectivity in the oxytocin/vasopressin receptor family: new insights and challengesB Chini
CNR Institute of Neuroscience, Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
Biochem Soc Trans 35:737-41. 2007..The pharmacological properties and selectivity profiles of these bivalent ligands, which remain to be investigated, could lead to highly novel research tools and potential therapeutic agents...
- G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there?B Chini
CNR Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Milan, Italy
J Mol Endocrinol 32:325-38. 2004..Finally, we review the growing evidence that lipid rafts and caveolae participate in the regulation of GPCR signalling by affecting both signalling selectivity and coupling efficacy...
- Molecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor familyB Chini
CNR Cellular and Molecular Pharmacology Center, Department of Pharmacology, University of Milan, Italy
Exp Physiol 85:59S-66S. 2000....
- Oxytocin stimulates migration and invasion in human endothelial cellsM G Cattaneo
Department of Pharmacology, University of Milano, Via Vanvitelli 32, Milano, Italy
Br J Pharmacol 153:728-36. 2008..Among these, human umbilical vein endothelial cells (HUVECs) respond to oxytocin with an increased proliferation, suggesting a possible role for the hormone in the regulation of angiogenesis...
- Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogueB Chini
CNR Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Via Vanvitelli 32, 20129 Milano, Italy
Br J Cancer 89:930-6. 2003..These features makes radiolabelled DOTA-dLVT a very good candidate for the radiotargeting of OTR-expressing tumours...
- Thioacylation is required for targeting G-protein subunit G(o1alpha) to detergent-insoluble caveolin-containing membrane domainsF Guzzi
Department of Experimental and Environmental Medicine and Medical Biotechnologies, University of Milano-Bicocca, Via Cadore 48, 20052 Monza, Italy
Biochem J 355:323-31. 2001....
- Oxytocin and oxytocin receptors in cancer cells and proliferationP Cassoni
Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
J Neuroendocrinol 16:362-4. 2004....
- Tyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptorB Chini
Unité INSERM 401, CCIPE rue de la Cardionille, Montpellier, France
EMBO J 14:2176-82. 1995..Our results indicate that the interaction between peptide residue 8 and the receptor residue at position 115 is not only crucial for agonist high affinity binding but also for receptor selectivity...
- Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunitsE Raimondi
Dipartimento di Genetica e Microbiologia A Buzzati Traverso, Pavia, Italy
Genomics 12:849-50. 1992