Affiliation: University of Florence
Ippolito L, Morandi A, Taddei M, Parri M, Comito G, Iscaro A, et al
. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer. Oncogene. 2019;: pubmed publisher
..Our work reveals a crucial function of tumor mitochondria as the energy sensors and transducers of CAF-dependent metabolic reprogramming and underscores the reliance of PCa cells on CAF catabolic activity and mitochondria trading. ..
Ippolito L, Morandi A, Giannoni E, Chiarugi P. Lactate: A Metabolic Driver in the Tumour Landscape. Trends Biochem Sci. 2019;44:153-166 pubmed publisher
Chiarugi P, Cirri P. Metabolic exchanges within tumor microenvironment. Cancer Lett. 2016;380:272-80 pubmed publisher
Chiarugi P, Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol. 2008;76:1352-64 pubmed publisher
Chiarugi P, Fiaschi T. Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration. Expert Opin Ther Targets. 2010;14:193-206 pubmed publisher
..Indeed, this adipokine behaves as a stem factor for several tissues, giving a new perspective for its use as a tool for cell-based therapy of diseased/injured tissues. ..
Chiarugi P, Paoli P, Cirri P. Tumor microenvironment and metabolism in prostate cancer. Semin Oncol. 2014;41:267-80 pubmed publisher
..The interruption of this two-compartment crosstalk, together with the idea that stromal cells are mostly vulnerable, being drug-sensitive, could lead to the development of anticancer therapies that target tumor stromal elements. ..
Morandi A, Giannoni E, Chiarugi P. Nutrient Exploitation within the Tumor-Stroma Metabolic Crosstalk. Trends Cancer. 2016;2:736-746 pubmed publisher
..This review discusses the current knowledge of metabolic reprogramming in cancer, the tumor-stroma metabolic crosstalk, and the available compounds that may be used to effectively target the tumor-stroma metabolic symbiosis. ..