Roberto Chiarle

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    Alberto Zamo
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Oncogene 21:1038-47. 2002
  2. ncbi request reprint The anaplastic lymphoma kinase in the pathogenesis of cancer
    Roberto Chiarle
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 7, 10126, Italy
    Nat Rev Cancer 8:11-23. 2008
  3. doi request reprint The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
    Roberto Chiarle
    Center for Experimental Research and Medical Studies, University of Torino, Via Santena 7, 10126 Torino, Italy
    Nat Med 14:676-80. 2008
  4. pmc NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, University of Torino, Center for Experimental Research and Medical Studies, ASO San Giovanni Battista, Torino, Italy
    Cancer Res 69:8611-9. 2009
  5. pmc The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy
    Cancer Res 68:8899-907. 2008
  6. doi request reprint Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin
    Laura Barberis
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Eur J Immunol 39:1136-46. 2009
  7. doi request reprint An in vivo model of Met-driven lymphoma as a tool to explore the therapeutic potential of Met inhibitors
    Paolo Accornero
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Torino, Torino, Italy
    Clin Cancer Res 14:2220-6. 2008
  8. pmc Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth
    Ludovica Riera
    Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy
    J Biol Chem 285:26441-50. 2010
  9. doi request reprint Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer
    Paola Cappello
    Center for Experimental Research and Medical Studies, Città della Salute e della Scienza di Torino, Italy
    Gastroenterology 144:1098-106. 2013
  10. doi request reprint An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen
    Paola Cappello
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Torino, Italy
    Int J Cancer 125:639-48. 2009

Detail Information

Publications39

  1. ncbi request reprint Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
    Alberto Zamo
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Oncogene 21:1038-47. 2002
    ..These studies support a pathogenic mechanism whereby stimulation of anti-apoptotic signals through activation of Stat3 contributes to the successful outgrowth of ALK positive tumor cells...
  2. ncbi request reprint The anaplastic lymphoma kinase in the pathogenesis of cancer
    Roberto Chiarle
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 7, 10126, Italy
    Nat Rev Cancer 8:11-23. 2008
    ....
  3. doi request reprint The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
    Roberto Chiarle
    Center for Experimental Research and Medical Studies, University of Torino, Via Santena 7, 10126 Torino, Italy
    Nat Med 14:676-80. 2008
    ..These findings indicate that ALK represents an ideal tumor antigen for vaccination-based therapies of ALCL and possibly other ALK+ human tumors...
  4. pmc NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, University of Torino, Center for Experimental Research and Medical Studies, ASO San Giovanni Battista, Torino, Italy
    Cancer Res 69:8611-9. 2009
    ..Thus, our data reveal that oncogene-deregulated tyrosine kinase activity controls the expression of molecules that determine T-cell identity and signaling...
  5. pmc The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation
    Chiara Ambrogio
    Department of Biomedical Sciences and Human Oncology, Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy
    Cancer Res 68:8899-907. 2008
    ..Thus, our data open perspectives for new therapeutic strategies by revealing a mechanism of regulation of ALCL cell growth through Cdc42...
  6. doi request reprint Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin
    Laura Barberis
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino, Italy
    Eur J Immunol 39:1136-46. 2009
    ..These results define vimentin N-terminal phosphorylation and fiber reorganization as a target of chemokine-dependent PI3Kgamma signaling in leukocytes...
  7. doi request reprint An in vivo model of Met-driven lymphoma as a tool to explore the therapeutic potential of Met inhibitors
    Paolo Accornero
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Torino, Torino, Italy
    Clin Cancer Res 14:2220-6. 2008
    ..A far superior model would be a transgenic line developing spontaneous Met-driven tumors with high penetrance and short latency...
  8. pmc Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth
    Ludovica Riera
    Center for Experimental Research and Medical Studies, University of Torino, Torino, Italy
    J Biol Chem 285:26441-50. 2010
    ..Finally, shRNA knockdown experiments showed that Grb2 regulates primarily the NPM-ALK-mediated phosphorylation of SHP2 and plays a key role in ALCL cell growth...
  9. doi request reprint Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer
    Paola Cappello
    Center for Experimental Research and Medical Studies, Città della Salute e della Scienza di Torino, Italy
    Gastroenterology 144:1098-106. 2013
    ..We investigated whether an ENO1 DNA vaccine elicits antitumor immune responses and prolongs survival of mice that spontaneously develop autochthonous, lethal pancreatic carcinomas...
  10. doi request reprint An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen
    Paola Cappello
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Torino, Italy
    Int J Cancer 125:639-48. 2009
    ..It is thus a promising and clinically relevant molecular target candidate for immunotherapeutic approaches as new adjuvants to conventional treatments in pancreatic cancer...
  11. doi request reprint Anaplastic lymphoma kinase in human cancer
    Antonella Barreca
    Department of Pathology and Center for Experimental Research and Medical Studies CeRMS, University of Torino, Via Santena 7, Torino 10126, Italy
    J Mol Endocrinol 47:R11-23. 2011
    ..In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms...
  12. ncbi request reprint Anaplastic large-cell lymphoma
    Giorgio Inghirami
    Department of Pathology and Center for Experimental Research and Medical Studies, University of Torino, Turin, Italy
    Semin Diagn Pathol 28:190-201. 2011
    ..A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated...
  13. doi request reprint Anaplastic lymphoma kinase: an oncogene for tumor vaccination
    Cristina Mastini
    Center for Experimental Research and Medical Studies CERMS, University of Turin, Via Santena 7, 10126, Turin, Italy
    J Mol Med (Berl) 87:669-77. 2009
    ....
  14. doi request reprint Expression of IFNγR2 mutated in a dileucine internalization motif reinstates IFNγ signaling and apoptosis in human T lymphocytes
    Daniela Boselli
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, University of Turin, 10126 Turin, Italy
    Immunol Lett 134:17-25. 2010
    ..As a whole, these data indicate that perturbation of IFN-γR2 internalization by mutating the LI(255-256) motif induces a timely coordinated activation of IFN-γ/STAT1 signaling pathways that leads to the apoptosis of T cells...
  15. doi request reprint Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects
    Ludovica Riera
    Center for Experimental Research and Medical Studies, University of Turin, Turin, Italy
    Leuk Lymphoma 52:1742-50. 2011
    ..The discovery of these substitutions in normal donors encourages future studies to define new risk factors among patients with MPDs...
  16. pmc The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
    Francesco E Boccalatte
    Center for Experimental Research and Medical Studies CERMS, University of Torino, Via Santena 5, 10126 Torino, Italy
    Blood 113:2776-90. 2009
    ..Prediction of tumor responses to methotrexate may justify specific molecular-based chemotherapy...
  17. pmc Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas
    Roberto Piva
    Department of Pathology, Center for Experimental Research and Medical Studies, University of Turin, Italy
    Blood 107:689-97. 2006
    ..Therefore, ALK is a viable target for therapeutic intervention and its inactivation might represent a pivotal approach for the treatment of ALK lymphomas and other ALK-dependent human tumors...
  18. pmc Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
    Roberto Piva
    Department of Pathology and Center for Experimental Research and Medical Studies CeRMS, University of Turin, Turin, Italy
    J Clin Invest 116:3171-82. 2006
    ..Thus, we proved that an experimentally controlled and functionally validated GEP analysis represents a powerful tool to identify novel pathogenetic networks and validate biologically suitable target genes for therapeutic interventions...
  19. ncbi request reprint Incestuous paternity detected by STR-typing of chorionic villi isolated from archival formalin-fixed paraffin-embedded abortion material using laser microdissection
    Carlo Robino
    Laboratory of Criminalistic Sciences, Department of Anatomy, Pharmacology and Legal Medicine, University of Turin, Turin, Italy
    J Forensic Sci 51:90-2. 2006
    ..99999%)...
  20. ncbi request reprint New and old functions of STAT3: a pivotal target for individualized treatment of cancer
    Giorgio Inghirami
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Cell Cycle 4:1131-3. 2005
    ..The discovery and dissection of non-canonical modes of STAT3 action will open new avenues for the design of effective therapeutics capable of neutralizing the tumorigenic properties of this molecule...
  21. pmc Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Turin Medical School, Turin, Italy
    Am J Pathol 163:1313-20. 2003
    ..Taken together, these results open new perspectives on the effects of sex steroids and their antagonists on the human response in cancer and inflammation...
  22. pmc Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma
    Carlotta Costa
    Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Proc Natl Acad Sci U S A 104:14354-9. 2007
    ....
  23. ncbi request reprint Conditional activation of MET in differentiated skeletal muscle induces atrophy
    Tiziana Crepaldi
    Center for Experimental Research and Medical Studies, University of Turin, 10126 Turin, Italy
    J Biol Chem 282:6812-22. 2007
    ....
  24. doi request reprint Anaplastic large cell lymphoma: one or more entities among T-cell lymphoma?
    Alessandro Fornari
    Department of Pathology and Center for Experimental Research and Medical Studies CeRMS, University of Torino, Italy
    Hematol Oncol 27:161-70. 2009
    ..The aim of this review is to illustrate clinical features, histology, immunophenotype, genetics and biology of ALCL and discuss possible relationship(s) among different T-non-Hodgkin lymphoma (T-NHL)...
  25. doi request reprint The battle against ALK resistance: successes and setbacks
    Claudia Voena
    University of Torino, Center for Experimental Research and Medical Studies CERMS, Torino, Italy
    Expert Opin Investig Drugs 21:1751-4. 2012
    ..Thus, the identification of the molecular mechanisms of crizotinib resistance will be strictly required in order to pursue the appropriate therapeutic options for patients with ALK-rearranged tumors...
  26. ncbi request reprint CALming Down T Cell Acute Leukemia
    Emilio Hirsch
    Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    Cancer Cell 21:449-50. 2012
    ..In this issue of Cancer Cell, Subramaniam et al. show that T-ALL can be tamed by inhibiting γ and δ PI3K isoforms...
  27. doi request reprint Heat shock protein expression in diabetic nephropathy
    Federica Barutta
    Dept of Internal Medicine, Univ of Turin, Corso AM Dogliotti 14 Turin, 10126, Italy
    Am J Physiol Renal Physiol 295:F1817-24. 2008
    ....
  28. ncbi request reprint High energy shock waves (HESW) increase paclitaxel efficacy in a syngeneic model of breast cancer
    Roberto Canaparo
    Department of Clinical Pathophysiology, University of Torino, Via Genova 3, Torino, Italy
    Technol Cancer Res Treat 7:117-24. 2008
    ..5 mg/kg on days 7 and 11) and HESW (0.50 mJ/mm2, 500 shots on day 11) in comparison with paclitaxel alone. In conclusion, these data suggest that HESW enhance paclitaxel cytotoxicity in the Mat B-III syngeneic model of breast cancer...
  29. ncbi request reprint In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth
    Laura Conti
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    Blood 109:2496-504. 2007
    ..These data indicate that the inhibition of IGF-1 signaling combined with IFN-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own...
  30. pmc S-phase kinase-associated protein 2 expression in non-Hodgkin's lymphoma inversely correlates with p27 expression and defines cells in S phase
    Roberto Chiarle
    Department of Pathology and Kaplan Comprehensive CancerCenter, New York University School of Medicine, New York, New York
    Am J Pathol 160:1457-66. 2002
    ..The detection of Skp2 protein either by flow cytometry or by immunohistochemistry represents a simple method to precisely assess the S phase of lymphomas. The potential diagnostic and prognostic value of Skp2 is discussed...
  31. pmc In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation
    Roberto Piva
    Department of Pathology and NYU Cancer Institute Division of Hematopathology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 22:8375-87. 2002
    ..Our findings support a crucial role for Skp1 in proper chromosomal segregation, which is required for the maintenance of euploidy and suppression of transformation...
  32. ncbi request reprint NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors
    Roberto Chiarle
    Department of Pathology and Kaplan Comprehensive Cancer Center, and Department of Pediatric Oncology, New York University School of Medicine, New York, NY 10016, USA
    Blood 101:1919-27. 2003
    ..Our NPM-ALK Tg mice are a suitable model to dissect the molecular mechanisms of ALK-mediated transformation and to investigate the efficacy of new therapeutic approaches for the treatment of human ALCL in vivo...
  33. ncbi request reprint RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis
    Riccardo Taulli
    Center for Experimental Research and Medical Studies CERMS, Molinette Hospital, Turin, Italy
    Cancer Gene Ther 12:456-63. 2005
    ..Our results suggest that lentiviral-mediated delivery of anti-TM2 siRNA may be developed into a powerful tool to treat Tpr-Met-positive cancers...
  34. ncbi request reprint Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target
    Roberto Chiarle
    Department of Pathology and NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Nat Med 11:623-9. 2005
    ..0001) impaired the growth of human and mouse NPM-ALK tumors in vivo. Pharmacological ablation of Stat3 represents a new candidate approach for the treatment of human lymphoma..
  35. pmc p130Cas mediates the transforming properties of the anaplastic lymphoma kinase
    Chiara Ambrogio
    Center for Experimental Research and Medical Studies and Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Blood 106:3907-16. 2005
    ....
  36. ncbi request reprint Role of Pax2 in apoptosis resistance and proinvasive phenotype of Kaposi's sarcoma cells
    Stefano Buttiglieri
    Cattedra di Nefrologia, Dipartimento di Medicina Interna and Centro Ricerca Medicina Sperimentale, Universita di Torino, Torino 10126, Italy
    J Biol Chem 279:4136-43. 2004
    ..Moreover, PAX2-transfected endothelial cells acquired a phenotype resembling that of Kaposi's lesional cells, suggesting a role of this embryonic gene in tumorigenesis...
  37. ncbi request reprint Autoantibody signature in human ductal pancreatic adenocarcinoma
    Barbara Tomaino
    Center for Experimental Research and Medical Studies and University of Turin, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 6:4025-31. 2007
    ..The results of further studies of these serological-defined antigens could be of diagnostic and therapeutic significance in PDAC...
  38. ncbi request reprint The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration
    Claudia Voena
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Cancer Res 67:4278-86. 2007
    ..Finally, migration of ALCL cells was reduced by Shp2 shRNA. These findings show a direct involvement of Shp2 in NPM-ALK lymphomagenesis, highlighting its critical role in lymphoma cell proliferation and migration...
  39. ncbi request reprint Follicular origin of a subset of CD5+ diffuse large B-cell lymphomas
    Andrea D Manazza
    Center for Experimental Research and Medical Studies and Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Am J Clin Pathol 124:182-90. 2005
    ..Four of five patients died of disease within 42 months, consistent with the proposed prognostic value of CD5 expression in DLBCL. Our data describe an aggressive variant of CD5+ FL suggesting the follicular origin of some CD5+ DLBCLs...