Franco Chiarelli

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi Increased Na+/Li+ countertransport activity may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabetes Care 22:1158-64. 1999
  2. ncbi Addendum. Early diabetes-related complications in children and adolescents with type 1 diabetes: implications for screening and intervention
    Franco Chiarelli
    Paediatrics and Paediatric Endocrinology, University of Chieti, Chieti, Italy
    Endocrinol Metab Clin North Am 34:1047. 2005
  3. ncbi Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Pediatr Nephrol 16:116-20. 2001
  4. ncbi Paroxysmal tonic upgaze of childhood: effect of age-of-onset on prognosis
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    Acta Paediatr 90:1343-5. 2001
  5. ncbi Serum angiogenin concentrations in young patients with diabetes mellitus
    F Chiarelli
    Department of Medicine, Division of Pediatrics, University of Chieti, Italy
    Eur J Clin Invest 32:110-4. 2002
  6. ncbi Screening for vascular complications in children and adolescents with type 1 diabetes mellitus
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Res 57:113-6. 2002
  7. ncbi New antiepileptic drugs in childhood
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Panminerva Med 44:221-5. 2002
  8. ncbi New trends in the treatment of diabetic nephropathy in children
    Alberto Verrotti
    Department of Pediatrics, Ospedale Policlinico, Via dei Vestini, Chieti, Italy
    Expert Opin Pharmacother 3:1169-76. 2002
  9. ncbi Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes
    Francesco Chiarelli
    Clinica Pediatrica, University of Chieti, Chieti, Italy Patologia Medica, University of Chieti, Chieti, Italy
    Diabetes Care 25:1829-34. 2002
  10. ncbi Role of growth factors in diabetic kidney disease
    F Chiarelli
    Department of Paediatrics, University of Chieti, 66100 Chieti, Italy
    Horm Metab Res 41:585-93. 2009

Detail Information

Publications121 found, 100 shown here

  1. ncbi Increased Na+/Li+ countertransport activity may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabetes Care 22:1158-64. 1999
    ....
  2. ncbi Addendum. Early diabetes-related complications in children and adolescents with type 1 diabetes: implications for screening and intervention
    Franco Chiarelli
    Paediatrics and Paediatric Endocrinology, University of Chieti, Chieti, Italy
    Endocrinol Metab Clin North Am 34:1047. 2005
  3. ncbi Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Pediatr Nephrol 16:116-20. 2001
    ....
  4. ncbi Paroxysmal tonic upgaze of childhood: effect of age-of-onset on prognosis
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    Acta Paediatr 90:1343-5. 2001
    ..CONCLUSION: From a long-term follow-up, we can confirm the good prognosis of PTU and suggest it is possible to define a distinct syndrome of childhood without any neurological abnormalities and with spontaneous resolution...
  5. ncbi Serum angiogenin concentrations in young patients with diabetes mellitus
    F Chiarelli
    Department of Medicine, Division of Pediatrics, University of Chieti, Italy
    Eur J Clin Invest 32:110-4. 2002
    ..Angiogenin serum levels were measured in a large group of type 1 diabetic young patients, looking at whether increased Angiogenin concentrations are associated with long-term glycemic control and microvascular complications...
  6. ncbi Screening for vascular complications in children and adolescents with type 1 diabetes mellitus
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Res 57:113-6. 2002
    ..Early detection of diabetic microangiopathy and timely treatment of early signs of these complications have a pivotal role in prevention of blindness and end-stage renal failure in children and adolescents with diabetes...
  7. ncbi New antiepileptic drugs in childhood
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Panminerva Med 44:221-5. 2002
    ..g. phenobarbital, valproate, etc.). We report their mechanisms of action, effectiveness, dosage and side effects; moreover, some practical advice for their use in pediatric patients is given...
  8. ncbi New trends in the treatment of diabetic nephropathy in children
    Alberto Verrotti
    Department of Pediatrics, Ospedale Policlinico, Via dei Vestini, Chieti, Italy
    Expert Opin Pharmacother 3:1169-76. 2002
    ..In this review controversial aspects of this issue are presented and discussed...
  9. ncbi Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetes
    Francesco Chiarelli
    Clinica Pediatrica, University of Chieti, Chieti, Italy Patologia Medica, University of Chieti, Chieti, Italy
    Diabetes Care 25:1829-34. 2002
    ..To investigate the possible role of hyperglycemia-dependent monocyte chemoattractant protein (MCP)-1 biosynthesis in the pathophysiology of early nephropathy in type 1 diabetes...
  10. ncbi Role of growth factors in diabetic kidney disease
    F Chiarelli
    Department of Paediatrics, University of Chieti, 66100 Chieti, Italy
    Horm Metab Res 41:585-93. 2009
    ....
  11. ncbi Magnetoencephalographic and electroencephalographic evaluation in patients with cryptogenetic partial epilepsy
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Neurophysiol Clin 33:174-9. 2003
    ..Magnetoencephalography (MEG) has been applied for more than 20 years to the localization of the epileptic focus in partial epilepsies, but correlation with electroencephalographic (EEG) data in homogeneous groups of patients is scarce...
  12. ncbi Insulin resistance and obesity in childhood
    Francesco Chiarelli
    Department of Paediatrics, University of Chieti, Via dei Vestini 5, I 66100 Chieti, Italy
    Eur J Endocrinol 159:S67-74. 2008
    ....
  13. ncbi Kidney involvement and disease in patients with diabetes
    F Chiarelli
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Panminerva Med 45:23-41. 2003
    ....
  14. ncbi Anticardiolipin, glutamic acid decarboxylase, and antinuclear antibodies in epileptic patients
    A Verrotti
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66013 Chieti, Italy
    Clin Exp Med 3:32-6. 2003
    ..There was no significant difference in serum glutamic acid decarboxylase antibodies between epileptic children and controls, and between patients who were seizure free and those with uncontrolled epilepsy...
  15. ncbi Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Metab Res Rev 24:570-6. 2008
    ..Soluble CD40 ligand (sCD40L) is supposed to be one of the most likely candidates for both retinopathy and nephropathy...
  16. ncbi Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Diabetes Care 28:1690-7. 2005
    ..The objective of this study was to evaluate the effects of irbesartan, an angiotensin II receptor antagonist, on IAP in adolescents and young adults with type 1 diabetes and early signs of retinopathy and nephropathy...
  17. ncbi Effects of vitamin E supplementation on intracellular antioxidant enzyme production in adolescents with type 1 diabetes and early microangiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Pediatr Res 56:720-5. 2004
    ..Adolescents with early signs of diabetic angiopathy have defective IAP and activity, which are not modified by vitamin E...
  18. ncbi Growth, growth factors and diabetes
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Eur J Endocrinol 151:U109-17. 2004
    ....
  19. ncbi Treating diabetic retinopathy by tackling growth factor pathways
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
    Curr Opin Investig Drugs 6:395-409. 2005
    ..As the effects of GFs become better understood, pharmacological manipulation of GF synthesis and action will be useful in the early stages of vascular change with the potential to prevent diabetes-related visual loss...
  20. ncbi Febrile convulsions after 5 years of age: long-term follow-up
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    J Child Neurol 15:811-3. 2000
    ..1% vs 7.4%, P < .05). Our data suggest that children with febrile convulsions after 5 years of age probably must be considered as a group of patients at risk of developing unprovoked seizures...
  21. ncbi Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabet Med 17:650-6. 2000
    ....
  22. ncbi Advanced glycation end products in adolescents and young adults with diabetic angiopathy
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Pediatr Nephrol 14:841-6. 2000
    ..43, P<0.01). S-AGE concentrations are markedly increased in type 1 diabetic adolescents and young adults with diabetic nephropathy and retinopathy. The severity of diabetic angiopathy is related to the serum levels of AGEs...
  23. ncbi Approaches to quality of control in diabetes care
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Res 50:41-7. 1998
    ....
  24. ncbi Epilepsy with myoclonic absences with early onset: a follow-up study
    A Verrotti
    Department of Medicine, Pediatrics Section, University of Chieti, Italy
    J Child Neurol 14:746-9. 1999
    ..Our data suggest that myoclonic absence seizures with early onset can have a good long-term prognosis. Valproate is a useful anticonvulsant drug in these patients. Mental retardation is present only in patients with poor seizure control...
  25. ncbi The importance of microalbuminuria as an indicator of incipient diabetic nephropathy: therapeutic implications
    F Chiarelli
    Department of Paediatrics, University of Chieti, Italy
    Ann Med 29:439-45. 1997
    ..Screening programmes for microalbuminuria and early intervention can substantially modify the natural history of diabetic renal involvement and disease and possibly reduce the incidence of end-stage renal failure...
  26. ncbi Visual evoked potentials in young persons with newly diagnosed diabetes: a long-term follow-up
    A Verrotti
    Department of Paediatrics Policlinico Colle Dell Ara, University of Chieti, Italy
    Dev Med Child Neurol 42:240-4. 2000
    ..These findings suggest that early functional abnormalities of the optic nerve can be detected at onset of diabetes, and that glycaemic control reverses these abnormalities...
  27. ncbi Detection and management of diabetic glomerulopathy in children and adolescents with insulin-dependent diabetes mellitus: need for improved knowledge and better care
    A Casani
    Clinica Pediatrica, University School of Medicine, Ospedale Policlinico, Chieti, Italy
    J Pediatr Endocrinol Metab 13:467-74. 2000
    ..e. angiotensin-converting enzyme inhibitors (ACE-Is), moderate dietary protein intake, and other drugs. ACE-Is may provide a second line intervention in a well selected, high-risk subgroup of microalbuminuric diabetic adolescents...
  28. ncbi Modern management of childhood diabetes: a role for computerized devices?
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Acta Paediatr Jpn 40:299-302. 1998
    ..Nonetheless, computers cannot substitute for the pediatric diabetes team, which remains the major determinant for better care of diabetes in children and adolescents...
  29. ncbi Role of growth factors in the development of diabetic complications
    F Chiarelli
    Department of Medicine, Division of Paediatrics, University of Chieti, Italy
    Horm Res 53:53-67. 2000
    ..Knowledge of the involvement of growth factors in diabetic microangiopathy opens the way to new therapeutic interventions aimed at blocking the deleterious actions of several growth factors...
  30. ncbi Thyroid function in children with perinatal human immunodeficiency virus type 1 infection
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Thyroid 10:499-505. 2000
    ..To study thyroid function in children with perinatal HIV-1 infection retrospectively and determine whether thyroid abnormalities are correlated with clinical condition, disease progression, immunological impairment, and viral load...
  31. ncbi Increased vascular endothelial growth factor serum concentrations may help to identify patients with onset of type 1 diabetes during childhood at risk for developing persistent microalbuminuria
    F Santilli
    Department of Medicine, Division of Pediatrics, University of Chieti, 66100 Chieti, Italy
    J Clin Endocrinol Metab 86:3871-6. 2001
    ..Persistently increased vascular endothelial growth factor serum levels may help to identify normotensive, normoalbuminuric patients with type 1 diabetes who are predisposed to develop persistent microalbuminuria later in life...
  32. ncbi Thyroid hormones in epileptic children receiving carbamazepine and valproic acid
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    Pediatr Neurol 25:43-6. 2001
    ..Thyroid-stimulating hormone and thyrotropin-releasing hormone levels do not seem to be affected by these drugs, suggesting that hypothalamic function is not affected in these children...
  33. ncbi Effects of high-dose vitamin E supplementation on oxidative stress and microalbuminuria in young adult patients with childhood onset type 1 diabetes mellitus
    C Giannini
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Metab Res Rev 23:539-46. 2007
    ..The aim of this study was to evaluate the effects of high-dose vitamin E supplementation (1200 mg/day) on reducing both microalbuminuria (MA) and oxidative stress in patients with type 1 diabetes mellitus (T1DM) and persistent MA...
  34. ncbi Nationwide cross-sectional survey of 3560 children and adolescents with diabetes in Italy
    M Vanelli
    Department of Pediatrics, University of Parma, Parma, Italy
    J Endocrinol Invest 28:692-9. 2005
    ..Two thirds of Italian children with T1DM have HbA1c>8% despite regionalized centers, multidisciplinary team approach, free access to appropriate diabetes care, education, frequent blood glucose monitoring and multiple insulin injections...
  35. ncbi Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid
    R Greco
    Department of Medicine, University of Chieti, Italy
    Neurology 65:1808-9. 2005
    ..5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight...
  36. ncbi Interleukin-6 release by cultured peripheral blood mononuclear cells inversely correlates with height velocity, bone age, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 serum levels in children with perinatal HIV-1 infectio
    M De Martino
    Department of Pediatrics, University of Florence, Florence, I 50132, Italy
    Clin Immunol 94:212-8. 2000
    ..Growth-promoting strategies, including targeted anticytokine treatments, could be devised for such children...
  37. ncbi Increased carotid intima-media thickness in pre-pubertal children with constitutional leanness and severe obesity: the speculative role of insulin sensitivity, oxidant status, and chronic inflammation
    C Giannini
    Departments of Pediatrics, Cardiology Clinical Pathology, University of Chieti, Via dei Vestini 5, I 66100 Chieti, Italy
    Eur J Endocrinol 161:73-80. 2009
    ....
  38. ncbi Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control
    F Cipollone
    Atherosclerosis Prevention Center, G D Annunzio University of Chieti, Chieti, Italy
    Diabetologia 48:1216-24. 2005
    ..We tested the hypothesis that sCD40L may be involved in the vascular complications in diabetes and exerts its effect by triggering inflammatory reactions on mononuclear and endothelial cells (ECs)...
  39. ncbi Effects of ketoacidosis and puberty on basal and TRH-stimulated thyroid hormones and TSH in children with diabetes mellitus
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Metab Res 21:494-7. 1989
    ..abstract truncated at 250 words)..
  40. ncbi A girl with persistent hyperferritinaemia
    A Mohn
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Lancet 365:1744. 2005
  41. ncbi Adolescents and epilepsy: hormonal aspects
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 60:417-28. 2008
    ..Changes in hormone serum levels that occur during pubertal period are probably related to modifications in seizure features and are involved in some types of epilepsy that begin typically in adolescence...
  42. ncbi Skin reactions due to anti-epileptic drugs: several case-reports with long-term follow-up
    C Feliciani
    Department of Dermatology, University G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 16:89-93. 2003
    ....
  43. ncbi Relationship between reduced BCL-2 expression in circulating mononuclear cells and early nephropathy in type 1 diabetes
    F Cipollone
    Atherosclerosis Prevention Center, University of Chieti G D Annunzio School of Medicine, Chieti, Italy
    Int J Immunopathol Pharmacol 18:625-35. 2005
    ..Vitamin E might provide a novel form of therapy for prevention of nephropathy in diabetic patients in which an acceptable glycemic control is difficult to achieve despite insulin therapy...
  44. ncbi Topiramate in frontal lobe epilepsy
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Acta Neurol Scand 115:132-5. 2007
    ..Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM)...
  45. ncbi Influence of sex hormones on brain excitability and epilepsy
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    J Endocrinol Invest 30:797-803. 2007
    ..This review provides an overview of the current knowledge in this field and highlights some of the prevailing hypotheses about the effects of sexual hormones on neuronal excitability analysing data from both animal and clinical studies...
  46. ncbi Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Neurol 13:736-41. 2006
    ..Further investigations are required to determine the pathophysiological alteration(s) that are at the basis of color perception defects...
  47. ncbi Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Obes Rev 12:e32-43. 2011
    ....
  48. ncbi Celiac disease in children and adolescents with type I diabetes: importance of hypoglycemia
    A Mohn
    Department of Paediatrics, University of Chieti, Italy
    J Pediatr Gastroenterol Nutr 32:37-40. 2001
    ..Symptomatic hypoglycemia is an unavoidable problem in the treatment of type I diabetes. Celiac disease is associated with malabsorption and may therefore represent an important risk factor...
  49. ncbi Levetiracetam monotherapy for children and adolescents with benign rolandic seizures
    A Verrotti
    Department of Pediatrics, University of Chieti, Policlinico Universitario, Via dei Vestini 5, 66100 Chieti, Italy
    Seizure 16:271-5. 2007
    ..5%) patients. Our results support findings that LEV monotherapy is effective and well tolerated in children with BECTS. Prospective, large, long-term double-blind studies are needed to confirm these findings...
  50. ncbi Autosomal malignant osteopetrosis. From diagnosis to therapy
    A Mohn
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 56:115-8. 2004
    ....
  51. ncbi Flicker perimetry in diabetic children without retinopathy
    L Lobefalo
    Institute of Ophthalmology, G D Annunzio University, Chieti, Italy
    Can J Ophthalmol 32:324-8. 1997
    ..To determine the flicker fusion frequency in children and adolescents with insulin-dependent diabetes mellitus (IDDM) who did not have fluorescein angiographic signs of retinopathy...
  52. ncbi Necrobiosis lipoidica diabeticorum in children and adolescents: a clue for underlying renal and retinal disease
    A Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Pediatr Dermatol 12:220-3. 1995
    ..001) than those without NLD. Our study suggests that children as well as adult diabetics with NLD can be at high risk for nephropathy and retinopathy; NLD can be a clue for diabetic nephropathy and retinopathy...
  53. ncbi Deletion of the SHOX gene in patients with short stature of unknown cause
    E Morizio
    Dipartimento di Scienze Biomediche, Universita G D Annunzio, Chieti, Italy
    Am J Med Genet A 119:293-6. 2003
    ..Present results indicate that SHOX plays an important role also in short stature of unknown cause, and FISH analysis appears as an easy, appropriate, and inexpensive method for the detection of SHOX deletion...
  54. ncbi Childhood epilepsy with occipital paroxysms and benign nocturnal childhood occipital epilepsy
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    J Child Neurol 15:218-21. 2000
    ..Therefore, although childhood epilepsy with occipital paroxysms and benign nocturnal childhood occipital epilepsy are two different types of epilepsy, the long-term prognosis seems to be similar...
  55. ncbi Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Via dei Vestini 5, I 66100, Chieti, Italy
    Epilepsy Res 41:253-7. 2000
    ....
  56. ncbi Levetiracetam monotherapy for childhood occipital epilepsy of gastaut
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Acta Neurol Scand 120:342-6. 2009
    ..The aim of this open label pilot study was to evaluate the efficacy and tolerability of levetiracetam (LEV) as 'de novo' monotherapy in children and adolescents with late onset childhood occipital epilepsy-Gastaut type (COE-G)...
  57. ncbi Angiopathy in children with diabetes
    F Chiarelli
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 54:187-201. 2002
    ....
  58. ncbi Photoparoxysmal responses in non-epileptic children in long-term follow-up
    A Verrotti
    Department of Medicine, Division of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
    Acta Neurol Scand 105:400-2. 2002
    ..To evaluate the photoparoxysmal responses (PPR) in non-epileptic children and adolescents in long-term follow-up...
  59. ncbi Short arm rearrangements of sex chromosomes with haploinsufficiency of the SHOX gene are associated with Leri-Weill dyschondrosteosis
    G Palka
    Dipartimento di Scienze Biomediche, Universita G D Annunzio, Chieti, Italy
    Clin Genet 57:449-53. 2000
    ..These clinical data indicated a genotype phenotype correlation between haploinsufficiency of SHOX, and short stature and skeletal abnormalities...
  60. ncbi The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitus
    A Mohn
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Diabet Med 19:70-3. 2002
    ..A retrospective case control study was performed in order to explore the effect of subclinical hypothyroidism on metabolic control in Type 1 diabetes mellitus...
  61. ncbi The potential role of insulin analogues in the treatment of children and adolescents with Type 1 diabetes mellitus
    A Mohn
    Department of Paediatrics, University of Chieti, Italy
    Diabetes Nutr Metab 14:349-57. 2001
    ..Safety issues should also be carefully monitored when introducting analogues in long-term therapy...
  62. ncbi Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1
    A Verrotti
    Department of Medicine, University of Chieti, Ospedale Policlinico, Italy
    Clin Exp Med 1:133-6. 2001
    ..In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs...
  63. ncbi Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy
    A Verrotti
    Department of Medicine, Division of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
    Epilepsy Res 48:71-5. 2002
    ..In conclusion our study demonstrates that epilepsy per se and treatment with VPA and CBZ do not affect levels of Cu, Zn, Se, GSH-PX and CuZn-SOD concentrations...
  64. ncbi Serum leptin changes during weight loss in obese diabetic subjects with and without microalbuminuria
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    Diabetes Nutr Metab 14:283-7. 2001
    ..The changes of leptin in diabetics seem to be similar to those observed in healthy obese subjects...
  65. ncbi New trends in the etiopathogenesis of diabetic peripheral neuropathy
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    J Child Neurol 16:389-94. 2001
    ..The role of other factors, such as possible direct neurotrophic effects of insulin and insulin-related growth factors, seems to be relevant...
  66. ncbi Euthyroid sick syndrome in children with Hodgkin disease
    A Mohn
    Clinica Pediatrica, Universita di Chieti, Chieti, Italy
    Pediatr Hematol Oncol 18:211-5. 2001
    ..Thyroid function testing should be performed routinely at diagnosis and thereafter in children with Hodgkin disease to detect subtle abnormalities...
  67. ncbi A 12-month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy
    A Verrotti
    Department of Pediatrics, Chieti University Hospital, Chieti, Italy
    Eur J Neurol 17:232-7. 2010
    ....
  68. ncbi Ictal cardiorespiratory arrest in Panayiotopoulos syndrome
    A Verrotti
    Department of Pediatrics, Pediatric Neurology Unit, University of Chieti, Chieti, Italy
    Neurology 64:1816-7. 2005
  69. ncbi Afebrile benign convulsions with mild gastroenteritis: a new entity?
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Ospedale Policlinico, Chieti, Italy
    Acta Neurol Scand 120:73-9. 2009
    ..In conclusion, this type of seizure seems to be a new entity, but it awaits a correct place in the large group of infantile convulsion disorders...
  70. ncbi Neonatal suppurative parotitis: a study of five cases
    G Sabatino
    Neonatal Intensive Care Unit, University of Chieti, Italy
    Eur J Pediatr 158:312-4. 1999
    ..Antimicrobial therapy was effective in all cases; surgery was not required. CONCLUSION: Although neonatal suppurative parotitis is now uncommon in the newborn, it cannot be considered a "vanishing disease"...
  71. ncbi Blue-on-yellow and achromatic perimetry in diabetic children without retinopathy
    L Lobefalo
    Institute of Ophthalmology, University G D Annunzio, Chieti, Italy
    Diabetes Care 21:2003-6. 1998
    ..We compared blue-on-yellow perimetry with achromatic perimetry to determine whether the first was more sensitive in detecting visual field defects...
  72. ncbi Update of the medical treatment of West syndrome
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 59:249-53. 2007
    ..This review outlines the usefulness of the different antiepileptic drugs for the treatment of West syndrome...
  73. ncbi Serum and urinary nitrites and nitrates and Doppler sonography in children with diabetes
    Alessandra Savino
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Care 29:2676-81. 2006
    ....
  74. ncbi Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes
    C Pfleger
    Institute for Clinical Diabetes Research at German Diabetes Centre, Leibniz Institute at Heinrich Heine University Duesseldorf, Auf m Hennekamp 65, 40225 Duesseldorf, Germany
    Clin Immunol 128:57-65. 2008
    ..Blockage of chemokines or antagonism of CCR5 by therapeutic agents such as maraviroc may provide a new therapeutic target to ameliorate disease progression in type 1 diabetes...
  75. ncbi Peroxisome proliferator-activated receptor-gamma agonists and diabetes: current evidence and future perspectives
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Vasc Health Risk Manag 4:297-304. 2008
    ..In this review, we summarise the experimental, preclinical and clinical data regarding the effects of the TZDs in conditions for which they are indicated and discuss their potential in the treatment of other conditions...
  76. ncbi Early changes in renal hemodynamics in children with diabetes: Doppler sonographic findings
    Piernicola Pelliccia
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, 66013 Chieti, Italy
    J Clin Ultrasound 36:335-40. 2008
    ..This study was designed to investigate the possible alteration of intrarenal Doppler RI in children with diabetes compared with healthy children...
  77. ncbi Precocious puberty in a girl with floating-harbor syndrome
    Stefano Stagi
    Paediatric Endocrinology Unit, University of Florence, Italy
    J Pediatr Endocrinol Metab 20:1333-7. 2007
    ..20 SDS). This report suggests that, in patients with FHS, precocious puberty should be taken into consideration; in these patients, a careful endocrinological followup for the possible presence of growth and pubertal disorders is needed...
  78. ncbi Liver steatosis in obese prepubertal children: a possible role of insulin resistance
    Ebe D'Adamo
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Obesity (Silver Spring) 16:677-83. 2008
    ..To determine whether in obese prepubertal children insulin resistance (IR) is associated with the development of liver steatosis...
  79. ncbi Increased oxidative stress in prepubertal children born small for gestational age
    Angelika Mohn
    Department of Pediatrics, University of Chieti, Via Dei Vestini 15, 66100 Chieti, Italy
    J Clin Endocrinol Metab 92:1372-8. 2007
    ..The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group...
  80. ncbi Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes
    Chiara Cuccurullo
    Atherosclerosis, Hypertension and Dyslipidemia Unit, G.d'Annunzio University of Chieti-Pescara, Italy
    Arterioscler Thromb Vasc Biol 26:2716-23. 2006
    ..This effect in turn might contribute to plaque stabilization by inhibiting the biosynthesis of PGE2-dependent MMPs, responsible for plaque rupture...
  81. ncbi Antiepileptic drugs and visual function
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Pediatr Neurol 36:353-60. 2007
    ....
  82. ncbi Survey on acute and chronic complications in children and adolescents with type 1 diabetes at Muhimbili National Hospital in Dar es Salaam, Tanzania
    Edna S Majaliwa
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Care 30:2187-92. 2007
    ..The purpose of this study was to assess glycemic control and complications of type 1 diabetes in children and adolescents in Tanzania...
  83. ncbi Extended-release formulations in epilepsy
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    J Child Neurol 22:419-26. 2007
    ..The results of these studies are encouraging and suggest a good tolerability and efficacy of these extended-release formulations, although larger studies are needed...
  84. ncbi Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
    Lotte B Nielsen
    Department of Paediatrics, Glostrup University Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Denmark
    Eur J Endocrinol 156:663-71. 2007
    ..2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes...
  85. ncbi Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal children
    Cosimo Giannini
    Department of Paediatrics, University of Chieti, Via dei Vestini 5, I 66100 Chieti, Italy
    Atherosclerosis 197:448-56. 2008
    ..In conclusion, early changes in glucose metabolism and an alteration of oxidant-antioxidant status may be present in obese pre-pubertal children; this could lead to increase IMT and early cardiovascular disease...
  86. ncbi Increased oxidative stress in epileptic children treated with valproic acid
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    Epilepsy Res 78:171-7. 2008
    ..To determine influence of Valproic Acid (VPA) treatment on oxidative status in non-obese and overweight epileptic children...
  87. ncbi Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes
    Sven Pörksen
    Department of Pediatrics, Forskerparken, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    J Clin Endocrinol Metab 92:2910-6. 2007
    ..The role of glucagon in hyperglycemia in type 1 diabetes is unresolved, and in vitro studies suggest that increasing blood glucose might stimulate glucagon secretion...
  88. ncbi C-reactive protein in relation to the development of microalbuminuria in type 1 diabetes: the Oxford Regional Prospective Study
    M Loredana Marcovecchio
    University Department of Paediatrics, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Care 31:974-6. 2008
    ..To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes in relation to the development of microalbuminuria (MA)...
  89. ncbi ISPAD clinical practice consensus guidelines 2006-2007. Microvascular and macrovascular complications
    Kim C Donaghue
    The Children's Hospital at Westmead, University of Sydney, Sydney, Australia
    Pediatr Diabetes 8:163-70. 2007
  90. ncbi Physical exercise and diabetes during childhood
    Cosimo Giannini
    Paediatrics Department, University of Chieti, Chieti, Italy
    Acta Biomed 77:18-25. 2006
    ..Thus, patients and health professionals have to know in details the physiological effect of physical exercise and its metabolic events in order sport to be healthy and enjoyable for all children, adolescents and young adults with T1DM...
  91. ncbi The treatment of juvenile myoclonic epilepsy
    Alberto Verrotti
    University of Chieti, Alberto Verrotti Dept of Pediatrics, University of Chieti Ospedale Policlinico, Via dei Vestini 5, Italy
    Expert Rev Neurother 6:847-54. 2006
    ..Currently, administration of new antiepileptic drugs, such as levetiracetam, lamotrigine and topiramate, seems to have beneficial effects in the patients with poor response to valproate...
  92. ncbi Discontinuation of anticonvulsant therapy and the electroencephalogram
    Alberto Verrotti
    J Child Neurol 19:81; author reply 81-2. 2004
  93. ncbi Persistence of impaired pancreatic beta-cell function in children treated for acute lymphoblastic leukaemia
    Angelika Mohn
    Department of Paediatrics, University of Chieti, Via Dei Vestini 15, 66100, Chieti, Italy
    Lancet 363:127-8. 2004
    ..1, 7.2-153; p=0.02) were reduced in the children with impaired insulin response. Chemotherapy for acute lymphoblastic leukaemia is associated with beta-cell function damage, which persists even after therapy has been stopped...
  94. ncbi Benign focal epilepsy with onset in infancy in a patient with 18q-syndrome
    Alberto Verrotti
    Section of Pediatrics, Department of Medicine, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100 Chieti, Italy
    Childs Nerv Syst 20:362-5. 2004
    ..The magnetic resonance imaging of the brain was normal. CONCLUSION: In conclusion, benign focal epilepsy with onset in infancy could be a condition associated with 18q-syndrome...
  95. ncbi Serum insulin and leptin levels and valproate-associated obesity
    Alberto Verrotti
    Epilepsia 44:1606. 2003
  96. ncbi The receptor RAGE as a progression factor amplifying arachidonate-dependent inflammatory and proteolytic response in human atherosclerotic plaques: role of glycemic control
    Francesco Cipollone
    University of Chieti G D'Annunzio School of Medicine, Chieti, Italy
    Circulation 108:1070-7. 2003
    ....
  97. ncbi Risk factors for recurrence of epilepsy and withdrawal of antiepileptic therapy: a practical approach
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti Ospedale Policlinico, Italy
    Ann Med 35:207-15. 2003
    ..In this review we analyse data from the literature and we suggest a practical approach for safe anticonvulsant withdrawal, although the decision should always be made individually, weighing risks and benefits...
  98. ncbi Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration
    Giovanni Davi
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    Circulation 107:3199-203. 2003
    ..We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting...
  99. ncbi Preventing microvascular diabetic complications in children and adolescents: looking beyond glycaemic control
    Alberto Verrotti
    Department of Pediatrics-Policlinico Colle Dell'Ara, University G. D'Annunzio, Via dei Vestini 5, I-66013 Chieti, Italy
    Expert Opin Pharmacother 4:525-32. 2003
    ..Therapeutic interventions, particularly excellent metabolic control, may be almost effective in preventing complication onset, or significantly retarding the rate of progression...
  100. ncbi Suppression of the functionally coupled cyclooxygenase-2/prostaglandin E synthase as a basis of simvastatin-dependent plaque stabilization in humans
    Francesco Cipollone
    Department of Medicine and Aging, School of Medicine, University of Chieti G. D'Annunzio, Chieti, Italy
    Circulation 107:1479-85. 2003
    ....
  101. ncbi Influence of growth hormone therapy on pituitary and lumbar spine astrocytomas. A clinical observation
    Angelika Mohn
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Horm Res 59:156-60. 2003
    ..Substitution therapy with rGH requires further and longer studies before it can be recommended with absolute reassurance in children with subtotal resection of a pituitary astrocytoma...