Elena Chiappini

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Infect Dis 9:140. 2009
  2. doi request reprint Use of combination neonatal prophylaxis for the prevention of mother-to-child transmission of HIV infection in European high-risk infants
    Elena Chiappini
    Department of Science for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
    AIDS 27:991-1000. 2013
  3. pmc Potential role of M. tuberculosis specific IFN-γ and IL-2 ELISPOT assays in discriminating children with active or latent tuberculosis
    Elena Chiappini
    Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Italy
    PLoS ONE 7:e46041. 2012
  4. pmc Self-reported pediatricians' management of the well-appearing young child with fever without a source: first survey in an European country in the anti-pneumococcal vaccine era
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Public Health 9:300. 2009
  5. doi request reprint Update of the 2009 Italian Pediatric Society Guidelines about management of fever in children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Viale Pieraccini 24, Florence, Italy
    Clin Ther 34:1648-1653.e3. 2012
  6. ncbi request reprint Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Florence, Italy
    AIDS 20:207-15. 2006
  7. ncbi request reprint Changing patterns of clinical events in perinatally HIV-1-infected children during the era of HAART
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano 13, I 50132 Florence, Italy
    AIDS 21:1607-15. 2007
  8. ncbi request reprint Antiretroviral use in Italian children with perinatal HIV infection over a 14-year period
    Elena Chiappini
    Department of Science for Woman and Child Health, University of Florence, Italy
    Acta Paediatr 101:e287-95. 2012
  9. pmc Adherence among Italian paediatricians to the Italian guidelines for the management of fever in children: a cross sectional survey
    Elena Chiappini
    Department of Health Sciences, Paediatric Section, Anna Meyer Children s University Hospital, Florence, Italy
    BMC Pediatr 13:210. 2013
  10. ncbi request reprint Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    J Clin Oncol 25:97-101. 2007

Collaborators

Detail Information

Publications53

  1. pmc Five-year follow-up of children with perinatal HIV-1 infection receiving early highly active antiretroviral therapy
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Infect Dis 9:140. 2009
    ..Nevertheless, data about long-term follow-up of early treated children are lacking...
  2. doi request reprint Use of combination neonatal prophylaxis for the prevention of mother-to-child transmission of HIV infection in European high-risk infants
    Elena Chiappini
    Department of Science for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
    AIDS 27:991-1000. 2013
    ....
  3. pmc Potential role of M. tuberculosis specific IFN-γ and IL-2 ELISPOT assays in discriminating children with active or latent tuberculosis
    Elena Chiappini
    Anna Meyer University Hospital, Department of Science for Woman and Child Health, University of Florence, Italy
    PLoS ONE 7:e46041. 2012
    ..Although currently available IGRA have been reported to be promising markers for TB infection, they cannot distinguish active tuberculosis (TB) from latent infection (LTBI)...
  4. pmc Self-reported pediatricians' management of the well-appearing young child with fever without a source: first survey in an European country in the anti-pneumococcal vaccine era
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    BMC Public Health 9:300. 2009
    ..To investigate whether the introduction of PCV might affect clinical decision making, we conducted a cross-sectional survey aimed at Italian Pediatric physicians...
  5. doi request reprint Update of the 2009 Italian Pediatric Society Guidelines about management of fever in children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Viale Pieraccini 24, Florence, Italy
    Clin Ther 34:1648-1653.e3. 2012
    ..In 2009, the Italian Pediatric Society developed national guidelines for management of fever in children for health care providers and parents/caregivers; an update of these guidelines was scheduled after 2 years...
  6. ncbi request reprint Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Florence, Italy
    AIDS 20:207-15. 2006
    ....
  7. ncbi request reprint Changing patterns of clinical events in perinatally HIV-1-infected children during the era of HAART
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano 13, I 50132 Florence, Italy
    AIDS 21:1607-15. 2007
    ..The introduction of HAART has decreased mortality and progression to AIDS in perinatally HIV-1-infected children, but information on modification of the rate of specific clinical events is limited...
  8. ncbi request reprint Antiretroviral use in Italian children with perinatal HIV infection over a 14-year period
    Elena Chiappini
    Department of Science for Woman and Child Health, University of Florence, Italy
    Acta Paediatr 101:e287-95. 2012
    ..Information on the use of new antiretroviral drugs in children in the real setting of clinical fields is largely unknown...
  9. pmc Adherence among Italian paediatricians to the Italian guidelines for the management of fever in children: a cross sectional survey
    Elena Chiappini
    Department of Health Sciences, Paediatric Section, Anna Meyer Children s University Hospital, Florence, Italy
    BMC Pediatr 13:210. 2013
    ..A survey was conducted before their publication and three years later to investigate their impact on knowledge and behaviors of paediatricians...
  10. ncbi request reprint Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: a study by the Italian Register for HIV Infection in Children
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    J Clin Oncol 25:97-101. 2007
    ..To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period...
  11. pmc Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection
    Elena Chiappini
    Department of Paediatrics, University of Florence, Via Luca Giordano, 13, I 50132 Florence, Italy
    Clin Exp Immunol 140:320-4. 2005
    ..In conclusion, IgA serum level is a cheap and low-complexity marker of immunological or virological failure of combined-ART which might be adopted in poor-resource settings...
  12. doi request reprint Is the interruption of antiretroviral treatment during pregnancy an additional major risk factor for mother-to-child transmission of HIV type 1?
    Luisa Galli
    Department of Pediatrics, University of Florence, Italy
    Clin Infect Dis 48:1310-7. 2009
    ..However, this recommendation is poorly supported by data. We evaluated the effects of discontinuing ART during pregnancy on the rate of mother-to-child transmission...
  13. doi request reprint VP7 and VP4 sequence analyses of rotavirus strains from Italian children with viraemia and acute diarrhoea
    Elena Chiappini
    Department of Paediatrics, University of Florence, Florence, Italy
    J Pediatr Gastroenterol Nutr 50:114-6. 2010
    ..We speculate that during co-infection by multiple strains, a preferential extraintestinal dissemination of some variants may occur, possibly because of differential viral characteristics...
  14. pmc Survey assessment on pediatricians' attitudes on head lice management
    Claudia Fancelli
    Department of Health Sciences, Unit of Paediatrics, University of Florence, Anna Meyer Children s University Hospital, Viale Pieraccini, 24 I 50129 Florence, Italy
    Ital J Pediatr 39:62. 2013
    ..Our survey investigated the knowledge and practice among primary care Italian pediatricians regarding to the prevention and treatment of head lice...
  15. ncbi request reprint Increasing incidence of tuberculosis in Tuscan youth, 1997 to 2011
    Elena Chiappini
    From the Department of Health Sciences, Anna Meyer Children s University Hospital, Florence, Italy
    Pediatr Infect Dis J 32:1289-91. 2013
    ..4) per 100,000 (P=0.009). Increases were particularly profound in children<5 years of age, reaching 13.3 (95% confidence interval: 7.8-18.9; P<0.0001 for 2011 vs.1997) per 100,000. Pediatric tuberculosis is a major issue in Tuscany...
  16. ncbi request reprint Lower mother-to-child HIV-1 transmission in boys is independent of type of delivery and antiretroviral prophylaxis: the Italian Register for HIV Infection in Children
    Luisa Galli
    Department of Pediatrics, University of Florence, Florence, Italy
    J Acquir Immune Defic Syndr 40:479-85. 2005
    ..A possible explanation is that, among infected fetuses, more girls survive up to the end of pregnancy and may take advantage of the benefits of preventive strategies...
  17. ncbi request reprint Immunological recovery despite virological failure is independent of human immunodeficiency virus-type 1 resistant mutants in children receiving highly active antiretroviral therapy
    Elena Chiappini
    Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Florence, Italy
    J Med Virol 70:506-12. 2003
    ..The findings suggest, immunological recovery notwithstanding, virological failure is independent of drug-resistant mutations and consequent possible changes in viral fitness...
  18. doi request reprint Utility of interferon-γ release assay results to monitor anti-tubercular treatment in adults and children
    Elena Chiappini
    Department of Science for Woman and Child s Health, Meyer Children s Hospital, University of Florence, Italy
    Clin Ther 34:1041-8. 2012
    ..Studies of the potential role of serial IGRAs for assessment of response to anti-tubercular therapy are accumulating...
  19. ncbi request reprint Serial T-SPOT.TB and quantiFERON-TB-Gold In-Tube assays to monitor response to antitubercular treatment in Italian children with active or latent tuberculosis infection
    Elena Chiappini
    Department of Science for Woman and Child Health, Meyer University Hospital, Florence, Italy
    Pediatr Infect Dis J 31:974-7. 2012
    ..59-17.58) for T-SPOT.TB (P=0.921) in TB cases. Significant decline in quantitative response was observed exclusively in TB cases. Our results suggest that serial IGRA have limited use in children receiving antitubercular treatment...
  20. pmc Parental and medical knowledge and management of fever in Italian pre-school children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    BMC Pediatr 12:97. 2012
    ..To provide information which may sustain educational interventions tailored to our population we investigated the parental and medical knowledge and management of fever in preschool children...
  21. ncbi request reprint Management of fever in children: summary of the Italian Pediatric Society guidelines
    Elena Chiappini
    Department of Pediatrics, University of Florence, I 50139 Florence, Italy
    Clin Ther 31:1826-43. 2009
    ..This article summarizes the Italian Pediatric Society guideline on the management of the signs and symptoms of fever in children, prepared as part of the National Guideline Program (NGLP)...
  22. ncbi request reprint Interleukin-7 and immunologic failure despite treatment with highly active antiretroviral therapy in children perinatally infected with HIV-1
    Elena Chiappini
    Division of Pediatrics and Infectious Diseases, Department of Pediatrics, University of Florence, Florence, Italy
    J Acquir Immune Defic Syndr 33:601-4. 2003
    ....
  23. doi request reprint Analysis of different recommendations from international guidelines for the management of acute pharyngitis in adults and children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    Clin Ther 33:48-58. 2011
    ..Streptococcal pharyngitis is a frequently observed condition, but its optimal management continues to be debated...
  24. ncbi request reprint Antibiotic resistance among Salmonella enterica isolates in Southern European children hospitalized for acute diarrhea
    Marta Cellai Rustici
    Department of Pediatrics, Division of Pediatrics, Via Luca Giordano 13, Florence, 50132, Italy
    Eur J Pediatr 165:577-8. 2006
  25. ncbi request reprint Clinical usefulness of the semiquantitative procalcitonin test in the diagnosis of bacterial infections in a third level children's hospital
    Marta Cellai Rustici
    Department of Sciences for Woman and Child s Health, University of Florence, Italy
    Clin Lab 57:497-506. 2011
    ....
  26. ncbi request reprint Viraemia is a common finding in immunocompetent children with rotavirus infection
    Elena Chiappini
    Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Italy
    J Med Virol 76:265-7. 2005
    ..These data suggest that viraemia is common in children infected with rotavirus, which may be associated with extra-intestinal involvement...
  27. ncbi request reprint Pediatric human immunodeficiency virus infection and cancer in the highly active antiretroviral treatment (HAART) era
    Elena Chiappini
    Anna Meyer Children s University Hospital, Department of Health Sciences, Firenze, Italy
    Cancer Lett 347:38-45. 2014
    ..How HAART affects this condition is an open question. Lastly, there is no evidence that prenatal exposure to HAART increases the risk of cancer in childhood, but long-term studies are needed. ..
  28. ncbi request reprint Reduced frequency of wheezing respiratory illness in infants with perinatal human immunodeficiency virus-type 1 infection: a model for immunologic and inflammatory mechanisms of airway obstruction?
    Luisa Galli
    Department of Paediatrics, University of Florence, Florence, Italy
    Pediatr Allergy Immunol 14:42-9. 2003
    ..97; 95% CL: 4.87-20.40; p < 0.001). Understanding the reason why HIV-1 protects against wheezing respiratory illness could shed light on the immunologic and inflammatory mechanisms of airway obstruction...
  29. ncbi request reprint Rapid and sensitive LC-MS/MS method for the analysis of antibiotic linezolid on dried blood spot
    Giancarlo la Marca
    Mass Spectrometry Laboratory, Clinic of Pediatric Neurology, A Meyer Children s Hospital, Florence, Italy
    J Pharm Biomed Anal 67:86-91. 2012
    ..Correlation between DBS data and serum samples measured by HPLC-UV was satisfactory. The benefit for patients is the ability to monitor the treatment with a simple and convenient sample collection at home...
  30. doi request reprint Lymphocytopenia as a marker for pandemic influenza A/H1N1 2009 virus infection in children
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    J Med Virol 83:1-4. 2011
    ..Considering that the pandemic virus is highly likely to continue to circulate in the coming winter season, these findings provide direct and practical implications for the near future...
  31. ncbi request reprint Nitric oxide in HIV-1 perinatally infected children treated with highly active antiretroviral therapy
    Elena Chiappini
    Pediatric Clinic and Division of Infectious Diseases, University of Florence, Florence, Italy
    Lancet Infect Dis 3:128-9; author reply 129-30. 2003
  32. ncbi request reprint Interferon-gamma release assay improves the diagnosis of tuberculosis in children
    Leila Bianchi
    Department of Pediatrics, University of Florence, Florence, Italy
    Pediatr Infect Dis J 28:510-4. 2009
    ..The aim of the present study was to evaluate the performance of an enzyme-linked immunosorbent assay (ELISA)-based IGRA for detecting TB in children...
  33. doi request reprint Management of acute pharyngitis in children: summary of the Italian National Institute of Health guidelines
    Elena Chiappini
    Department of Science for Woman and Child s Health, University of Florence, Florence, Italy
    Clin Ther 34:1442-1458.e2. 2012
    ....
  34. doi request reprint Performance of non-contact infrared thermometer for detecting febrile children in hospital and ambulatory settings
    Elena Chiappini
    Department of Paediatrics, Florence University, Florence, Italy
    J Clin Nurs 20:1311-8. 2011
    ....
  35. pmc Update on the management of acute pharyngitis in children
    Marta Regoli
    Department of Sciences for Woman and Child s Health, University of Florence, Florence, Italy
    Ital J Pediatr 37:10. 2011
    ..Cephalosporins can be used in patients allergic to penicillin (with the exception of type I hypersensibility) and have been also proposed to treat the relapses...
  36. ncbi request reprint An increasing incidence of chickenpox central nervous system complications in children: what's happening in Tuscany?
    Stefano Frenos
    Department of Pediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano, 13, I 50132 Florence, Italy
    J Clin Virol 38:358-61. 2007
    ..The most frequent noncutaneous site of involvement of chickenpox is the central nervous system (CNS) and complications include cerebellar ataxia, encephalitis, and meningitis...
  37. ncbi request reprint International guidelines on tackling community-acquired pneumonia show major discrepancies between developed and developing countries
    Elettra Berti
    Department of Health Sciences, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
    Acta Paediatr Suppl 102:4-16. 2013
    ..The goal of this study was to compare the current guidelines on diagnosis and treatment of paediatric community-acquired pneumonia (CAP) in developing and developed countries...
  38. ncbi request reprint Diagnostic features of community-acquired pneumonia in children: what's new?
    Elena Chiappini
    Department of Health Sciences, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
    Acta Paediatr Suppl 102:17-24. 2013
    ..To critically summarise the available data on diagnosis of CAP in children, focusing on the newest findings and on the need for new studies...
  39. ncbi request reprint Pertussis is still common in a highly vaccinated infant population
    Elettra Berti
    Department of Sciences for Health Sciences, Anna Meyer Children s University Hospital, University of Florence, Florence, Italy
    Acta Paediatr 103:846-9. 2014
    ..To provide epidemiological data on pertussis in a highly vaccinated paediatric population, focusing on the age of the infected children...
  40. doi request reprint Serogroup C Neisseria meningitidis invasive infection: analysis of the possible vaccination strategies for a mass campaign
    Elena Chiappini
    Department of Sciences for Woman and Child s Health, University of Florence, Viale Pieraccini, Florence, Italy
    Acta Paediatr 99:1609-14. 2010
    ..In the absence of randomized controlled trials that support a specific schedule, each country has adopted different vaccination programmes. Hereby, we analyse positive and negative aspects of the different vaccination strategies...
  41. doi request reprint Malaria prophylaxis in African and Asiatic children traveling to their parents' home country: a Florentine Study
    Elisabetta Venturini
    Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer Children s University Hospital, Florence, Italy
    J Travel Med 18:161-4. 2011
    ..The majority of malaria cases in Europe occur in immigrated adults and children settled in nonendemic countries but who had traveled to their home country to visit friends and relatives...
  42. doi request reprint Clinical efficacy and tolerability of linezolid in pediatric patients: a systematic review
    Elena Chiappini
    Department of Pediatrics, University of Florence, Florence, Italy
    Clin Ther 32:66-88. 2010
    ..Most information regarding the pharmacokinetic profile, efficacy, and tolerability of linezolid is derived from adult studies...
  43. ncbi request reprint Valganciclovir for congenital CMV infection: a pilot study on plasma concentration in newborns and infants
    Luisa Galli
    Departments of Pediatrics, University of Florence, Florence, Italy
    Pediatr Infect Dis J 26:451-3. 2007
    ..The pharmacokinetics of valganciclovir were studied in 8 infants ranging in age from 4 to 90 days (mean 20 days). We suggest that doses of 15 mg/kg given twice daily may be suitable for neonates and young infants...
  44. ncbi request reprint Selective deficiency of naïve CD4+ T-lymphocytes in a child with congenital lymphoedema
    Elena Chiappini
    Division of Paediatrics and Infectious Diseases, Department of Paediatrics, University of Florence, Via Luca Giordano 13, 50132 Florence, Italy
    Eur J Pediatr 162:752-4. 2003
    ..A high proportion of naïve CD4+ T-lymphocytes was found in the ascitic fluid, supporting the hypothesis of extra-vascular sequestration of these cells into lymphoedematous tissue...
  45. ncbi request reprint Antibiotic induced liver injury: what about children?
    Daniele Serranti
    University of Florence, Florence, Italy
    J Chemother 25:255-72. 2013
    ..Children are an important class of antibiotic users, with specific metabolic characteristics, so more studies on them should be carried out. ..
  46. pmc Pertussis re-emergence in the post-vaccination era
    Elena Chiappini
    Anna Meyer University Hospital, Department of Health Sciences, University of Florence, Florence, Italy
    BMC Infect Dis 13:151. 2013
    ....
  47. doi request reprint Herpes simplex encephalitis with occipital localization in an infant: a different route of entry in the brain system?
    Elisabetta Venturini
    Department of Sciences for Woman and Child s Health, University of Florence, Anna Meyer, Children s University Hospital, Florence, Italy
    Pediatr Neurol 48:463-5. 2013
    ..This study presents a rare case of a previously healthy infant with herpes simplex encephalitis with occipital involvement and permanent visual impairment. Possible pathogenic mechanisms are discussed...
  48. doi request reprint Your diagnosis? A 12-year-old girl with latent tuberculosis presenting with nausea, vomiting and increasing frontal headache
    Marina De Gaudio
    Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Via Luca Giordano 13, 50132 Florence, Italy
    Eur J Pediatr 168:245-6. 2009
    ..Toxicity to the anti-tuberculosis drug was suspected, but her symptoms persisted after isoniazid withdrawal. A computed tomography (CT) scan showed a brain mass to be present...
  49. ncbi request reprint Crohn disease and mycobacterial infection in children: an intriguing relationship
    Elena Chiappini
    Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
    J Pediatr Gastroenterol Nutr 49:550-8. 2009
    ..In the present review, the most recent literature findings on these topics are reported, focusing particularly on the paediatric age group...
  50. doi request reprint Syphilis in pregnancy in Tuscany, description of a case series from a global health perspective
    Lorenzo Zammarchi
    Department of Critical Care Medicine and Surgery, Infectious Diseases Unit, University of Florence, Florence, Italy
    J Matern Fetal Neonatal Med 25:2601-5. 2012
    ..To estimate the epidemiological impact of syphilis in pregnancy and congenital syphilis in Tuscany and to better delineate their determinants in this region...
  51. ncbi request reprint Results of a 5-year prospective surveillance study of antibiotic resistance among Salmonella enterica isolates and ceftriaxone therapy among children hospitalized for acute diarrhea
    Elena Chiappini
    Division of Pediatrics and Infectious Diseases, Department of Pediatrics, University of Florence, Florence, Italy
    Clin Ther 24:1585-94. 2002
    ....
  52. ncbi request reprint Varicella-zoster virus acquired at 4 months of age reactivates at 24 months and causes encephalitis
    Elena Chiappini
    Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Florence, Italy
    J Pediatr 140:250-1. 2002
    ..VZV-DNA was detected in cerebrospinal fluid. Early acquisition of VZV may predispose to major neurologic complications that can occur years after the primary infection...
  53. ncbi request reprint Henoch Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature
    Sandra Trapani
    Department of Pediatrics, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
    Semin Arthritis Rheum 35:143-53. 2005
    ..To examine epidemiological, clinical, and outcome in Italian children affected with Henoch Schönlein purpura (HSP)...