A Cherubini

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Role of antioxidants in atherosclerosis: epidemiological and clinical update
    A Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Policlinico Monteluce, Padiglione E, Via Brunamonti, 06122, Perugia Italy
    Curr Pharm Des 11:2017-32. 2005
  2. doi request reprint Predictors of hospitalization in Italian nursing home residents: the U.L.I.S.S.E. project
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    J Am Med Dir Assoc 13:84.e5-10. 2012
  3. ncbi request reprint Dietary antioxidants as potential pharmacological agents for ischemic stroke
    A Cherubini
    Department of Clinical and Experimental Medicine, Institute of Gerontology and Geriatrics, Policlinico Monteluce, Pad E, Via Brunamonti, 51, 06100, Perugia, Italy
    Curr Med Chem 15:1236-48. 2008
  4. ncbi request reprint Potential markers of oxidative stress in stroke
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
    Free Radic Biol Med 39:841-52. 2005
  5. ncbi request reprint The prevention of adverse drug reactions in older subjects
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    Curr Drug Metab 12:652-7. 2011
  6. pmc Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Gerontol A Biol Sci Med Sci 62:1120-6. 2007
  7. ncbi request reprint Comparative effects of lercanidipine, lacidipine, and nifedipine gastrointestinal therapeutic system on blood pressure and heart rate in elderly hypertensive patients: the ELderly and LErcanidipine (ELLE) study
    Antonio Cherubini
    Sezione di Gerontologia e Geriatria, Perugia University Medical School, Via Brunamonti, Policlino Monteluce, I 06122, Perugia, Italy
    Arch Gerontol Geriatr 37:203-12. 2003
  8. doi request reprint The persistent exclusion of older patients from ongoing clinical trials regarding heart failure
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, Policlinico Santa Maria della Misericordia, University of Perugia Medical School, Piazzale Menghini 1, 06156 Perugia PG, Italy
    Arch Intern Med 171:550-6. 2011
  9. ncbi request reprint Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Department of Clinical and Experimental Medicine, Via Brunamonti, Policlinico Monteluce, Padiglione E, Perugia 06122, Italy
    Neurobiol Aging 26:987-94. 2005
  10. ncbi request reprint Antioxidant profile and early outcome in stroke patients
    A Cherubini
    Institute of Gerontology and Geriatrics, Perugia University Hospital and Medical School, Italy
    Stroke 31:2295-300. 2000

Detail Information

Publications74

  1. ncbi request reprint Role of antioxidants in atherosclerosis: epidemiological and clinical update
    A Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Policlinico Monteluce, Padiglione E, Via Brunamonti, 06122, Perugia Italy
    Curr Pharm Des 11:2017-32. 2005
    ..Future studies should probably select patients in a context of high-oxidative stress / low-antioxidant defence, to verify if antioxidants may really prove useful as therapeutic anti-atherosclerotic agents...
  2. doi request reprint Predictors of hospitalization in Italian nursing home residents: the U.L.I.S.S.E. project
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    J Am Med Dir Assoc 13:84.e5-10. 2012
    ..To examine resident and facility characteristics associated with hospitalization in a cohort of Italian older nursing home residents...
  3. ncbi request reprint Dietary antioxidants as potential pharmacological agents for ischemic stroke
    A Cherubini
    Department of Clinical and Experimental Medicine, Institute of Gerontology and Geriatrics, Policlinico Monteluce, Pad E, Via Brunamonti, 51, 06100, Perugia, Italy
    Curr Med Chem 15:1236-48. 2008
    ....
  4. ncbi request reprint Potential markers of oxidative stress in stroke
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Policlinico Monteluce Pad E, Via Brunamonti 51, 06122 Perugia, Italy
    Free Radic Biol Med 39:841-52. 2005
    ....
  5. ncbi request reprint The prevention of adverse drug reactions in older subjects
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    Curr Drug Metab 12:652-7. 2011
    ....
  6. pmc Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Gerontol A Biol Sci Med Sci 62:1120-6. 2007
    ..N-3 fatty acids (FA) have an important role in brain development and function. However, there is conflicting evidence concerning the relationship between n-3 FA and dementia in older persons...
  7. ncbi request reprint Comparative effects of lercanidipine, lacidipine, and nifedipine gastrointestinal therapeutic system on blood pressure and heart rate in elderly hypertensive patients: the ELderly and LErcanidipine (ELLE) study
    Antonio Cherubini
    Sezione di Gerontologia e Geriatria, Perugia University Medical School, Via Brunamonti, Policlino Monteluce, I 06122, Perugia, Italy
    Arch Gerontol Geriatr 37:203-12. 2003
    ..5%) and the nifedipine group (10.1%). These data demonstrate that lercanidipine is effective in lowering blood pressure in older adult hypertensive patients while maintaining a superior tolerability and safety profile...
  8. doi request reprint The persistent exclusion of older patients from ongoing clinical trials regarding heart failure
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, Policlinico Santa Maria della Misericordia, University of Perugia Medical School, Piazzale Menghini 1, 06156 Perugia PG, Italy
    Arch Intern Med 171:550-6. 2011
    ..A good example is heart failure. Therefore, we investigated the extent of exclusion of older individuals in ongoing clinical trials regarding heart failure...
  9. ncbi request reprint Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, University of Perugia Medical School, Department of Clinical and Experimental Medicine, Via Brunamonti, Policlinico Monteluce, Padiglione E, Perugia 06122, Italy
    Neurobiol Aging 26:987-94. 2005
    ..This study supports the notion that higher vitamin E plasma levels might provide significant protection against cognitive impairment and dementia in elderly subjects...
  10. ncbi request reprint Antioxidant profile and early outcome in stroke patients
    A Cherubini
    Institute of Gerontology and Geriatrics, Perugia University Hospital and Medical School, Italy
    Stroke 31:2295-300. 2000
    ..The purpose of this study was to investigate the time course of plasma antioxidant changes in ischemic stroke patients...
  11. ncbi request reprint Plasma antioxidants and longevity: a study on healthy centenarians
    P Mecocci
    Sezione di Gerontologia e Geriatria, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
    Free Radic Biol Med 28:1243-8. 2000
    ..From these results, it is evident that healthy centenarians show a particular profile in which high levels of vitamin A and vitamin E seem to be important in guaranteeing their extreme longevity...
  12. pmc Relationship between low levels of high-density lipoprotein cholesterol and dementia in the elderly. The InChianti study
    G Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    J Gerontol A Biol Sci Med Sci 65:559-64. 2010
    ..To evaluate the association between plasma lipid fractions and the prevalence of dementia in a large sample of Italian older individuals...
  13. ncbi request reprint Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Perugia, Italy
    Diabetes Metab Res Rev 16:15-9. 2000
    ..This evidence is limited in elderly patients with non-insulin dependent diabetes, in which age- and disease-related production of reactive oxygen species might exert synergistic damaging effects on tissues and organs...
  14. ncbi request reprint Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease
    P Rinaldi
    Department of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce Pad E, Via Brunamonti 51, 06126 Perugia, Italy
    Neurobiol Aging 24:915-9. 2003
    ....
  15. ncbi request reprint High vitamin E plasma levels and low low-density lipoprotein oxidation are associated with the absence of atherosclerosis in octogenarians
    A Cherubini
    Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Am Geriatr Soc 49:651-4. 2001
    ..31-0.91) were independently associated with VASA. CONCLUSIONS: These results suggest that an appropriate level of vitamin E and a low level of LDL oxidation might be important for reaching advanced age without developing atherosclerosis...
  16. ncbi request reprint Impact of the earthquake of September 26, 1997 in Umbria, Italy on the socioenvironmental and psychophysical conditions of an elderly population
    P Mecocci
    Department of Gerontology and Geriatrics, University of Perugia, Italy
    Aging (Milano) 12:281-6. 2000
    ..These observations suggest that, after natural disasters, emergency programs should be more adapted to elderly people, whose needs and expectations are often different from those of young adults...
  17. ncbi request reprint Physical activity and oxidative stress during aging
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Italy
    Int J Sports Med 21:154-7. 2000
    ....
  18. ncbi request reprint Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview
    E Mariani
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce Padiglione E, Via Brunamonti 51, 06122 Perugia Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 827:65-75. 2005
    ..Particular attention will be given to the current knowledge about the biomarkers of oxidative stress that can be possibly used to monitor their severity and outcome...
  19. ncbi request reprint Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study
    Dario Maggio
    Gerontology and Geriatrics, University of Perugia, 06122 Perugia, Italy
    J Clin Endocrinol Metab 88:1523-7. 2003
    ..Our results reveal that antioxidant defenses are markedly decreased in osteoporotic women. The mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporosis deserve further investigation...
  20. ncbi request reprint Predictors of high level of burden and distress in caregivers of demented patients: results of an Italian multicenter study
    P Rinaldi
    Department of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    Int J Geriatr Psychiatry 20:168-74. 2005
    ..Considerable suffering is experienced by carers of patients with dementia. Most existing studies do not consider the coexistence of subjective and objective aspects that cause, interacting to each other, this suffering...
  21. ncbi request reprint (1)H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging
    M Catani
    1Institute of Gerontology and Geriatrics, University of Perugia, Italy
    Neuroreport 12:2315-7. 2001
    ..The choline/creatine ratio was not significantly different among the three groups. These data suggest that MCI is different from normal brain aging, having a white matter biochemical pattern similar to AD...
  22. ncbi request reprint Physical activity and cardiovascular health in the elderly
    A Cherubini
    Department of Clinical Medicine, Pharmacology and Pathology, University of Perugia, Italy
    Aging (Milano) 10:13-25. 1998
    ..Physicians should recommend moderate-intensity physical activity to sedentary older subjects, who are still the majority within the elderly population...
  23. pmc Uric acid and dementia in community-dwelling older persons
    Carmelinda Ruggiero
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dement Geriatr Cogn Disord 27:382-9. 2009
    ..Epidemiological studies found that hyperuricemia is associated with conditions leading to dementia. Our aim is to investigate the relationship between UA levels and dementia in older persons...
  24. ncbi request reprint Omega-3 polyunsaturated fatty acids and immune-mediated diseases: inflammatory bowel disease and rheumatoid arthritis
    C Ruggiero
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Pharm Des 15:4135-48. 2009
    ..In both IBD and RA further clinical trials with large sample size are needed to clarify the efficacy of omega-3 PUFA as a treatment...
  25. ncbi request reprint Peripheral non-enzymatic antioxidant changes with human aging: a selective status report
    M C Polidori
    Institute of Gerontology and Geriatrics, Perugia University Hospital, Italy
    Biogerontology 2:99-104. 2001
    ....
  26. ncbi request reprint Hip fracture in nursing homes: an Italian study on prevalence, latency, risk factors, and impact on mobility
    D Maggio
    Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Via Eugubina, Italy
    Calcif Tissue Int 68:337-41. 2001
    ..We also suggest that preserved mobility may represent an additional risk factor for hip fracture in nursing homes...
  27. ncbi request reprint Vascular dementia Italian sulodexide study (VA.D.I.S.S.). Clinical and biological results
    L Parnetti
    Section of Gerontology and Geriatrics, Perugia University, Italy
    Thromb Res 87:225-33. 1997
    ..A parallel improvement of G.B.S. Rating Scale for dementia scores was observed in Sdx group. These results seem to indicate that sulodexide treatment can have positive effects in vascular dementia...
  28. ncbi request reprint Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization: results from the GIFA study
    Patrizia Mecocci
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce Padiglione E, Via Brunamonti 51, IT 06122 Perugia, Italy
    Dement Geriatr Cogn Disord 20:262-9. 2005
    ..To detect the main factors associated with the occurrence of specific geriatric syndromes (namely pressure sores, fecal incontinence, urinary incontinence and falls) in elderly patients during hospitalization...
  29. ncbi request reprint [Impact of population aging on the social and the health care system: need for a new model of long-term care]
    Umberto Senin
    Sezione di Gerontologia e Geriatria, Dipartimento di Medicina Clinica e Sperimentale, Scuola di Specializzazione in Geriatria, Universita degli Studi di Perugia
    Ann Ital Med Int 18:6-15. 2003
    ....
  30. ncbi request reprint Use of artificial networks in clinical trials: a pilot study to predict responsiveness to donepezil in Alzheimer's disease
    Patrizia Mecocci
    Department of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    J Am Geriatr Soc 50:1857-60. 2002
    ..To evaluate the accuracy of artificial neural networks compared with discriminant analysis in classifying positive and negative response to the cholinesterase inhibitor donepezil in a group of Alzheimer's disease (AD) patients...
  31. ncbi request reprint Depression in the elderly: new concepts and therapeutic approaches
    Patrizia Mecocci
    Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Aging Clin Exp Res 16:176-89. 2004
    ....
  32. ncbi request reprint Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease
    Patrizia Mecocci
    Institute of Gerontology and Geriatrics, University of Perugia, Via Eugubina 42, 06122 Perugia, Italy
    Arch Neurol 59:794-8. 2002
    ..A large body of experimental evidence suggests that in Alzheimer disease (AD) pathogenesis an important role is played by oxidative stress, but there is still a lack of data on in vivo markers of free radical-induced damage...
  33. doi request reprint Validation of the Italian version of the falls efficacy scale international (FES-I) and the short FES-I in community-dwelling older persons
    C Ruggiero
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Policlinico Santa Maria della Misericordia, Perugia, Italy
    Arch Gerontol Geriatr 49:211-9. 2009
    ..The Short FES-I is highly comparable with the FES-I. We conclude that the FES-I and the Short FES-I are excellent instruments to asses FF in Italian older subjects and they may be used in future research projects and clinical trials...
  34. ncbi request reprint Antioxidants and bone turnover in involutional osteoporosis
    D Maggio
    University of Perugia, Perugia, Italy
    J Endocrinol Invest 25:101-2. 2002
  35. ncbi request reprint Hypertension and cognitive function in the elderly
    Antonio Cherubini
    Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    Am J Ther 14:533-54. 2007
    ..Furthermore, these are ten of the other essential cerebral or systematic pathologies present that would be able to produce a dementia syndrome...
  36. ncbi request reprint Risk factors for short-term mortality in older subjects with acute ischemic stroke
    Giovanni Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, Ferrara, Italy
    Gerontology 52:231-6. 2006
    ..The identification of predictors for mortality after stroke has a major importance for clinicians in order to allow the implementation of therapeutic and preventive strategies...
  37. ncbi request reprint Validation of the five-item geriatric depression scale in elderly subjects in three different settings
    Patrizia Rinaldi
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia Medical School, Italy
    J Am Geriatr Soc 51:694-8. 2003
    ..To test the effectiveness of a five-item version of the Geriatric Depression Scale (GDS) for the screening of depression in community-dwelling older subjects, hospitalized older patients, and nursing home residents...
  38. doi request reprint Hypertension and cognitive function in the elderly
    Antonio Cherubini
    Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    Dis Mon 56:106-47. 2010
    ..Furthermore, these are ten of the other essential cerebral or systematic pathologies present that would be able to produce a dementia syndrome...
  39. ncbi request reprint Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy
    Antonio Metastasio
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Via Brunamonti 51, 06122 Perugia, Italy
    Neurobiol Aging 27:926-32. 2006
    ..48+/-0.08) and sMCI (1.65+/-0.12) and between pMCI and controls (1.63+/-0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia...
  40. ncbi request reprint Treatment with angiotensin-converting enzyme inhibitors is associated with a reduction in short-term mortality in older patients with acute ischemic stroke
    Giovanni Zuliani
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, Gerontology and Geriatrics, University of Ferrara, 44100 Ferrara, Italy
    J Gerontol A Biol Sci Med Sci 60:463-5. 2005
    ..We tested the hypothesis that angiotensin-converting enzyme inhibitors (A-I) might affect short-term (30 day) mortality in older persons with severe acute ischemic stroke...
  41. ncbi request reprint Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease
    Elena Mariani
    Institute of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    J Neurol Sci 247:187-91. 2006
    ..Our data suggest that the CTSD-T allele of the CTSD-C/T polymorphism is associated with an increased relative risk for late-onset AD and, more interestingly, the combination of CTSD-T with the A2M-G allele seems to increase this risk...
  42. doi request reprint Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the ULISSE project
    Carmelinda Ruggiero
    Department of Clinical and Experimental Medicine, Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    Drugs Aging 27:747-58. 2010
    ..Little information is available about the prevalence of potentially inappropriate drug prescriptions (PIDPs) and the related health adverse outcomes among nursing home (NH) residents...
  43. ncbi request reprint Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease
    Tiziana Ingegni
    Department of Gerontology and Geriatrics, University of Perugia School of Medicine, Perugia, Italy
    Dement Geriatr Cogn Disord 16:151-5. 2003
    ..Our data indicate no significant association between this polymorphism and the risk of AD. Likewise there was no association between CTSD polymorphism and the apolipoprotein E genotype in the risk of developing AD...
  44. ncbi request reprint Low levels of carotenoids and retinol in involutional osteoporosis
    Dario Maggio
    Institute of Gerontology and Geriatrics, University of Perugia, Policlinico Monteluce, Via Brunamonti, 06124 Perugia, Italy
    Bone 38:244-8. 2006
    ..Our study suggests a bone sparing effect of retinol, to which the provitamin A activity of some carotenoids might have contributed...
  45. ncbi request reprint Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease
    Marco Catani
    Institute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy
    J Am Geriatr Soc 50:1707-10. 2002
    ..We evaluated the cerebral white matter biochemical pattern in healthy older subjects, older patients with chronic hypertension, and patients with Alzheimer's disease (AD) using proton magnetic resonance spectroscopy (1H-MRS)...
  46. doi request reprint Fighting against age discrimination in clinical trials
    Antonio Cherubini
    Institute of Gerontology and Geriatrics, Perugia University Medical School, Policlinico Santa Maria della Misericordia, Perugia, Italy
    J Am Geriatr Soc 58:1791-6. 2010
    ....
  47. doi request reprint Enhanced myocardial vitamin C accumulation in left ventricular hypertrophy in rats is not attenuated with transition to heart failure
    Susanne Rohrbach
    Institute of Pathophysiology, Martin Luther University Halle Wittenberg, Germany
    Eur J Heart Fail 10:226-32. 2008
    ..Therefore, the accumulation of vitamin C in compensated hypertrophy and in decompensated failure excludes cardiac vitamin C deficiency as a primary factor to oxidative stress in this model...
  48. pmc The interplay between uric acid and antioxidants in relation to physical function in older persons
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 55:1206-15. 2007
    ..To investigate the relationship between circulating uric acid (UA) levels and plasma antioxidants and whether antioxidant levels modulate the association between UA and physical function...
  49. pmc Usefulness of uric acid to predict changes in C-reactive protein and interleukin-6 in 3-year period in Italians aged 21 to 98 years
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Am J Cardiol 100:115-21. 2007
    ..In conclusion, our study suggests that in a population-based cohort, baseline UA and changes in circulating UA during 3 years of follow-up predict changes in circulating CRP independent of relevant confounders, including baseline IL-6...
  50. ncbi request reprint Elderly patients with cognitive impairment have a high risk for functional decline during hospitalization: The GIFA Study
    Claudio Pedone
    Centro Medicina dell Invecchiamento, Catholic University, Rome, Italy
    J Gerontol A Biol Sci Med Sci 60:1576-80. 2005
    ..We tested the hypothesis that cognitive impairment upon admission (CIA) and cognitive decline (CD) during hospitalization are associated with an increased risk for functional decline (FD) in older inpatients...
  51. ncbi request reprint Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    Biofactors 24:265-74. 2005
    ..Further studies are warranted to clarify whether the use of vitamin C may add clinical long-term beneficial effects in patients with stroke...
  52. ncbi request reprint Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 79:289-94. 2004
    ..Muscle strength and physical performance in old age might be related to the oxidative damage caused by free radicals...
  53. pmc Associations between vitamin D status and pain in older adults: the Invecchiare in Chianti study
    Gregory E Hicks
    Department of Physical Therapy, University of Delaware, Newark, Delaware 19716, USA
    J Am Geriatr Soc 56:785-91. 2008
    ..To examine cross-sectional associations between vitamin D status and musculoskeletal pain and whether they differ by sex...
  54. ncbi request reprint Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study
    Alessandro Ble
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 61:278-83. 2006
    ....
  55. ncbi request reprint Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  56. pmc Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study
    Angelo Di Iorio
    Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G D Annunzio, Via dei Vestini 5, 66013 Chieti Scalo, Italy
    Neurobiol Aging 27:1280-8. 2006
    ..The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity...
  57. ncbi request reprint Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome
    M Cristina Polidori
    Institute of Physiological Chemistry I, Heinrich Heine University, Dusseldorf, Germany
    Free Radic Res 36:265-8. 2002
    ..Among the carotenoids, only lutein plasma changes are associated with a poor early-outcome...
  58. pmc Serum micronutrient concentrations and decline in physical function among older persons
    Benedetta Bartali
    Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA
    JAMA 299:308-15. 2008
    ..The potential deleterious effect of poor nutrition on decline in physical function in older persons is unclear...
  59. ncbi request reprint Bone density and hemoglobin levels in older persons: results from the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina, NC 27157, USA
    Osteoporos Int 16:691-9. 2005
    ..The bone loss associated with hemoglobin levels mainly occurs in the cortical bone. Women with lower hemoglobin levels demonstrate a higher bone loss than male counterparts...
  60. ncbi request reprint Neurological examination findings to predict limitations in mobility and falls in older persons without a history of neurological disease
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Instituts on Aging, National Institute of Health, Baltimore, Maryland 21225, USA
    Am J Med 116:807-15. 2004
    ..To estimate the prevalence of neurological signs and their association with limitations in mobility and falls in a sample of older persons without known neurological disease...
  61. ncbi request reprint Prescription of anti-oedema agents and short-term mortality in older patients with acute ischaemic stroke
    Giovanni Zuliani
    2nd Department of Internal Medicine, University of Ferrara, Ferrara, Italy
    Drugs Aging 21:273-8. 2004
    ..The sample included patients aged over 65 years who were admitted to hospital for acute ischaemic stroke...
  62. ncbi request reprint Serum IL-1beta levels in health and disease: a population-based study. 'The InCHIANTI study'
    Angelo Di Iorio
    Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G D Annunzio, Chieti, Italy
    Cytokine 22:198-205. 2003
    ..Our data could lend support to the hypothesis that IL-1beta is mainly involved in the functional alterations of cardiomyocytes under conditions marked by mononuclear cell infiltration and by downregulation of calcium...
  63. pmc Low plasma selenium concentrations and mortality among older community-dwelling adults: the InCHIANTI Study
    Fulvio Lauretani
    Tuscany Regional Agency, Florence, Italy
    Aging Clin Exp Res 20:153-8. 2008
    ..We examined the relationship between plasma selenium levels at enrollment and all-cause mortality over a 6-year period among participants in the InCHIANTI study...
  64. ncbi request reprint Sertraline treatment for depression associated with acute coronary syndromes: a cost analysis from the viewpoint of the Italian Healthcare System
    Fabrizia Lattanzio
    Scientific Direction, Italian National Research Centre on Aging INRCA, 60124 Ancona, Italy
    Aging Clin Exp Res 20:76-80. 2008
    ..With the SADHART database, a cost analysis was carried out to determine the economic consequences of treating DD after ACS in the perspective of the Italian Healthcare System...
  65. ncbi request reprint Editorial comment--Elderly stroke patient at risk for dementia: in search of a profile
    Antonio Cherubini
    Stroke 34:2445. 2003
  66. ncbi request reprint The Caregiver Burden Inventory in evaluating the burden of caregivers of elderly demented patients: results from a multicenter study
    Martina Marvardi
    Dept of Gerontology and Geriatrics, University of Perugia
    Aging Clin Exp Res 17:46-53. 2005
    ....
  67. ncbi request reprint Low cholesterol levels are associated with short-term mortality in older patients with ischemic stroke
    Giovanni Zuliani
    2nd Department of Internal Medicine, University of Ferrara, Italy
    J Gerontol A Biol Sci Med Sci 59:293-7. 2004
    ..We evaluated the association between TC levels and 30-day mortality in a sample of older patients with acute ischemic stroke...
  68. pmc Uric acid and inflammatory markers
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA
    Eur Heart J 27:1174-81. 2006
    ..Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure...
  69. ncbi request reprint Urinary calcium is a determinant of bone mineral density in elderly men participating in the InCHIANTI study
    Giuseppe Vezzoli
    Division of Nephrology Dialysis and Hypertension, IRCCS San Raffaele Hospital, Postgraduate School of Nephrology, Vita Salute University, Milan, Italy
    Kidney Int 67:2006-14. 2005
    ....
  70. ncbi request reprint HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, CeRTA, Pharmacy School, University of Barcelona, Barcelona, Spain
    Clin Chem 53:292-9. 2007
    ..We sought to develop a method for nutritional analysis of resveratrol, a phenolic compound with purported health-promoting properties, and to determine all resveratrol metabolites...
  71. pmc Association between vitamin D status and physical performance: the InCHIANTI study
    Denise K Houston
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:440-6. 2007
    ..Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance...
  72. ncbi request reprint Rapidly progressive aphasic dementia with motor neuron disease: a distinctive clinical entity
    Marco Catani
    Institute of Psychiatry, London, UK
    Dement Geriatr Cogn Disord 17:21-8. 2004
    ..These findings support the conclusion that MND with rapidly progressive aphasic dementia is a distinctive clinical entity within the group of FTD-MND...
  73. pmc From chronic low back pain to disability, a multifactorial mediated pathway: the InCHIANTI study
    Angelo Di Iorio
    Department of Medicine and Sciences of Aging, Laboratory of Clinical Epidemiology, University G d Annunzio Chieti, Italy
    Spine (Phila Pa 1976) 32:E809-15. 2007
    ..Clinicoepidemiologic study in the Chianti area (Tuscany, Italy)...
  74. ncbi request reprint Axonal injury within language network in primary progressive aphasia
    Marco Catani
    Institute of Psychiatry, London, United Kingdom
    Ann Neurol 53:242-7. 2003
    ..The marked difference in the distribution of N-acetylaspartate to creatine between PPA and Alzheimer's disease suggests that proton magnetic resonance spectroscopy may help to differentiate between these two conditions...