F Cetani

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association?
    Enrico Erdas
    General Surgery Unit, Department of Surgical Sciences, San Giovanni di Dio Hospital, University of Cagliari, Cagliari, Italy
    BMC Cancer 12:614. 2012
  2. pmc Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands
    Elena Donadio
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
    Proteome Sci 9:29. 2011
  3. ncbi request reprint Molecular pathogenesis of primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:35-9. 2011
  4. doi request reprint Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
  5. ncbi request reprint Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
  6. ncbi request reprint Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 156:547-54. 2007
  7. ncbi request reprint Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical management
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 64:146-52. 2006
  8. ncbi request reprint Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
  9. ncbi request reprint Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenoma
    F Cetani
    J Endocrinol Invest 27:687-90. 2004
  10. ncbi request reprint MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002

Collaborators

Detail Information

Publications35

  1. pmc Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association?
    Enrico Erdas
    General Surgery Unit, Department of Surgical Sciences, San Giovanni di Dio Hospital, University of Cagliari, Cagliari, Italy
    BMC Cancer 12:614. 2012
    ..We describe a very uncommon case of functioning glucagonoma associated with primary hyperparathyroidism (pHPT) in which genetic testing failed to detect germline mutations of MEN-1 and other known genes responsible for MEN1...
  2. pmc Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands
    Elena Donadio
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
    Proteome Sci 9:29. 2011
    ..abstract:..
  3. ncbi request reprint Molecular pathogenesis of primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 34:35-9. 2011
    ..FHH and NSHPT represent the mildest and severest variants of PHPT, caused by heterozygous and homozygous mutations in the calcium sensing receptor (CASR) gene, respectively...
  4. doi request reprint Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomas
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 17:1-6. 2010
    ..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas...
  5. ncbi request reprint Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation
    F Cetani
    Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
    Endocr Relat Cancer 14:493-9. 2007
    ....
  6. ncbi request reprint Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 156:547-54. 2007
    ..The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis...
  7. ncbi request reprint Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical management
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 64:146-52. 2006
    ..Design Genetic analyses of MEN1, HRPT2 and CASR genes in FIHP...
  8. ncbi request reprint Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5583-91. 2004
    ..The finding that two of the seven patients with sporadic parathyroid cancer carried an HRPT2 germline mutation suggests that they might have occult HPT-JT. Our results also confirm the need for testing HRPT2 gene in FIHP families...
  9. ncbi request reprint Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenoma
    F Cetani
    J Endocrinol Invest 27:687-90. 2004
    ..0 x 1.2 cm parathyroid adenoma with areas of necrosis with hemosiderinladen macrophages. In conclusion, we describe a case of spontaneous short-term remission of PHPT due to infarction of parathyroid adenoma...
  10. ncbi request reprint MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
    J Endocrinol Invest 25:508-12. 2002
    ..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease...
  11. ncbi request reprint Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    F Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Endocrinol Invest 25:614-9. 2002
    ..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects...
  12. ncbi request reprint Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Eur J Endocrinol 148:603-7. 2003
    ..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures...
  13. ncbi request reprint Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessment
    F Cetani
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 31:900-4. 2008
    ..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type...
  14. doi request reprint Cinacalcet efficacy in patients with moderately severe primary hyperparathyroidism according to the European Medicine Agency prescription labeling
    F Cetani
    Department of Endocrinology and Metabolism, Section of Endocrinology and Bone Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 35:655-60. 2012
    ..Patients with primary hyperparathyroidism (PHPT) with contraindications to parathyroidectomy (PTx) or persistent PHPT have few non surgical options...
  15. ncbi request reprint The impact of thyroidectomy on parathyroid glands: a biochemical and clinical profile
    P Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    J Endocrinol Invest 30:666-71. 2007
    ..This study aims to monitor the parathyroid function during total thyroidectomy through intra-operative serial samples for calcium and PTH...
  16. ncbi request reprint High-intensity focused ultrasound as an alternative to the surgical approach in primary hyperparathyroidism: a preliminary experience
    C E Ambrosini
    Department of Surgery, University of Pisa, Via Paradisa, Pisa, Italy
    J Endocrinol Invest 34:655-9. 2011
    ..Recently, high-intensity focused ultrasound (HIFU), a totally non-invasive technique, has become available to cure solid tumors...
  17. ncbi request reprint A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive cases
    E Vignali
    Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 146:783-8. 2002
    ..The traditional surgical approach for patients with primary hyperparathyroidism (PHPT) consists of the identification of at least four glands and in the removal of all hyperfunctioning parathyroid tissue...
  18. ncbi request reprint Familial parathyroid hyperplasia: is there a place for minimally invasive surgery? Description of the first treated case
    P Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    J Endocrinol Invest 28:942-3. 2005
    ..Quick intraoperative PTH assay (QPTH) confirmed the surgical cure of the disease...
  19. ncbi request reprint Genetic analysis of the MEN1 gene and HPRT2 locus in two Italian kindreds with familial isolated hyperparathyroidism
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Clin Endocrinol (Oxf) 56:457-64. 2002
    ....
  20. ncbi request reprint A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditis
    F Cetani
    Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:4747-52. 2001
    ..The G228W mutation acts in a dominant fashion and may shed light on the structure-function relationship of the autoimmune regulator protein...
  21. doi request reprint A proteomic approach to study parathyroid glands
    Laura Giusti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
    Mol Biosyst 7:687-99. 2011
    ..The functional role of these proteins in the network of intracellular pathways is discussed...
  22. doi request reprint The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Clin Endocrinol Metab 95:920-7. 2010
    ..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx...
  23. ncbi request reprint Microvessel density in human normal and neoplastic parathyroids
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Endocr Pathol 17:175-81. 2006
    ..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size...
  24. ncbi request reprint A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer
    Filomena Cetani
    Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 60:99-106. 2004
    ..Some histological features may suggest the malignant nature of a parathyroid tumour. However, the diagnosis of parathyroid cancer can only be definitively established in the presence of local invasion or metastases...
  25. doi request reprint Somatostatin analogues do not affect calcium metabolism in patients with acromegaly and primary hyperparathyroidism [corrected] due to MEN 1-like syndrome
    F Bogazzi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Horm Metab Res 43:126-9. 2011
    ..SSA therapy does not affect calcium-phosphorus metabolism in patients with MEN 1-like syndrome, suggesting that the drug has no role in controlling PHP in these subset of patients...
  26. ncbi request reprint Familial hypocalciuric hypercalcemia in a woman with metastatic breast cancer: a case report of mistaken identity
    Claudio Marcocci
    Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:5132-6. 2003
    ..In conclusion, we describe a case of familial hypocalciuric hypercalcemia due to a novel CaR mutation, in a woman with breast cancer in whom hypercalcemia was initially attributed to hypercalcemia of malignancy...
  27. ncbi request reprint Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation
    Filomena Cetani
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 58:199-206. 2003
    ..Description of two unrelated Italian kindreds with familial hypocalciuric hypercalcaemia (FHH), an autosomal dominant disease mostly caused by heterozygous inactivating mutations of the Ca2+ sensing receptor (CaR)...
  28. pmc Genetic and clinical features of multiple endocrine neoplasia types 1 and 2
    C Romei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Oncol 2012:705036. 2012
    ..MEN 2 prognosis is strictly dependent on the MTC aggressiveness and thus on the success of the initial treatment...
  29. doi request reprint Update on the use of cinacalcet in the management of primary hyperparathyroidism
    C Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Endocrinol Invest 35:90-5. 2012
    ..Moreover, there are no data as to whether long-term treatment with cinacalcet can prevent the complications of PHPT. Finally, more data are needed on the long-term safety of cinacalcet, particularly at the renal level...
  30. ncbi request reprint Undetectable inferior petrosal sinus levels of PTH-related peptide (PTHrP) in patients with ACTH-dependent Cushing's disease
    L Manetti
    Department of Endocrinology, University of Pisa, Italy
    J Endocrinol Invest 28:819-21. 2005
    ..Our data, combined with others reported in literature, indicate that PTHrP release by ACTH-secreting tumors is not a common occurrence. Therefore, we conclude that IPS and peripheral PTHrP are of little clinical usefulness...
  31. doi request reprint Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia
    Filomena Cetani
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 160:481-9. 2009
    ..Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia...
  32. ncbi request reprint Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trial
    Elena Ambrogini
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 92:3114-21. 2007
    ..It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management...
  33. ncbi request reprint The reduction of bone mineral density in postmenopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH secretion impairment
    Elisabetta Cecconi
    Department of Endocrinology and Metabolism, University of Pisa, Ospedale, Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 155:41-5. 2006
    ..To investigate, in a large group of postmenopausal primary hyperparathyroidism (PHP) women, whether the concomitance of GH deficiency (GHD) may contribute to the development of changes in bone mineral density (BMD)...
  34. doi request reprint Parafibromin as a tool for the diagnosis of parathyroid tumors
    Claudio Marcocci
    Adv Anat Pathol 15:179; author reply 179-80. 2008
  35. ncbi request reprint High doses of intravenous calcitriol in the treatment of severe secondary hyperparathyroidism
    Massimo Morosetti
    Nephrology and Dialysis Unit, GB Grassi Hospital, ASL RMD Ostia Rome, Italy
    J Nephrol 17:95-100. 2004
    ..In this prospective study, our aim was to determine the necessary calcitriol dose required to control severe HPTH preventing hypercalcemia or hyperphosphatemia and avoiding parathyroidectomy...