Research Topics
Genomes and GenesSpecies | F CetaniSummaryAffiliation: University of Pisa Country: Italy Publications
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Detail Information
Publications
Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glandsElena Donadio
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonnanno 6, Pisa, 56126, Italy
Proteome Sci 9:29. 2011..abstract:..
Genetic analyses in familial isolated hyperparathyroidism: implication for clinical assessment and surgical managementFilomena Cetani
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Clin Endocrinol (Oxf) 64:146-52. 2006..Design Genetic analyses of MEN1, HRPT2 and CASR genes in FIHP...- Beta-catenin activation is not involved in sporadic parathyroid carcinomas and adenomasF Cetani
Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
Endocr Relat Cancer 17:1-6. 2010..Our results suggest that the Wnt/beta-catenin signaling pathway is not involved in the development of parathyroid carcinomas and adenomas... - Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumorsFilomena Cetani
Dipartimento di Endocrinologia e Metabolismo, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 89:5583-91. 2004..The finding that two of the seven patients with sporadic parathyroid cancer carried an HRPT2 germline mutation suggests that they might have occult HPT-JT. Our results also confirm the need for testing HRPT2 gene in FIHP families... - Spontaneous short-term remission of primary hyperparathyroidism from infarction of a parathyroid adenomaF Cetani
J Endocrinol Invest 27:687-90. 2004..0 x 1.2 cm parathyroid adenoma with areas of necrosis with hemosiderinladen macrophages. In conclusion, we describe a case of spontaneous short-term remission of PHPT due to infarction of parathyroid adenoma... - Should parafibromin staining replace HRTP2 gene analysis as an additional tool for histologic diagnosis of parathyroid carcinoma?Filomena Cetani
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Eur J Endocrinol 156:547-54. 2007..The aim of our study was to extend parafibromin studies in a series of benign and malignant parathyroid tumors and cross-validate the results of immunohistochemistry with those of HRPT2 analysis... - Molecular pathogenesis of primary hyperparathyroidismF Cetani
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
J Endocrinol Invest 34:35-9. 2011..FHH and NSHPT represent the mildest and severest variants of PHPT, caused by heterozygous and homozygous mutations in the calcium sensing receptor (CASR) gene, respectively... - Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutationF Cetani
Department of Endocrinology and Metabolism, University of Pise, Pise, Italy
Endocr Relat Cancer 14:493-9. 2007.... - MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidismF Cetani
Department of Endocrinology and Metabolism, Orthopedics and Traumatology, and Occupational Medicine, University of Pisa, Italy
J Endocrinol Invest 25:508-12. 2002..In conclusion, MEN1 gene alterations are rather common in sporadic PHPT and their presence does not correlate with the clinical manifestations of the disease... - Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidismF Cetani
Department of Endocrinology and Metabolism, University of Pisa, Italy
J Endocrinol Invest 25:614-9. 2002..The A986S polymorphism does not correlate with serum calcium levels in normal Italian subjects... - Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal womenF Cetani
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Universita di Pisa, Pisa, Italy
Eur J Endocrinol 148:603-7. 2003..We investigated whether the presence of 986S allele was associated with bone mineral density (BMD) and osteoporotic fractures... - Hyperparathyroidism 2 gene (HRPT2, CDC73) and parafibromin studies in two patients with primary hyperparathyroidism and uncertain pathological assessmentF Cetani
Department of Endocrinology, University of Pisa, Pisa, Italy
J Endocrinol Invest 31:900-4. 2008..A lung 1.5-cm nodule detected by computed tomography was excised. Histology showed a metastasis of parathyroid carcinoma. HRPT2 gene studies improved the diagnostic accuracy in 2 parathyroid tumors that are of uncertain type... - The impact of thyroidectomy on parathyroid glands: a biochemical and clinical profileP Miccoli
Department of Surgery, University of Pisa, Via Roma 67, 56100, Pisa, Italy
J Endocrinol Invest 30:666-71. 2007..This study aims to monitor the parathyroid function during total thyroidectomy through intra-operative serial samples for calcium and PTH... - High-intensity focused ultrasound as an alternative to the surgical approach in primary hyperparathyroidism: A preliminary experienceC E Ambrosini
Department of Surgery, University of Pisa, Via Paradisa, 2 56124 Pisa PI, Italy
J Endocrinol Invest 34:655-9. 2011..Recently, high-intensity focused ultrasound (HIFU), a totally non-invasive technique, has become available to cure solid tumors... - A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive casesE Vignali
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, , Via Paradisa 2, 56124 Pisa, Italy
Eur J Endocrinol 146:783-8. 2002..It indicates whether all hyperfunctioning parathyroid tissue has been removed, limiting the procedure to a unilateral neck exploration in most cases... - Cinacalcet efficacy in patients with moderately severe primary hyperparathyroidism according to the European Medicine Agency prescription labelingF Cetani
Department of Endocrinology and Metabolism, Section of Endocrinology and Bone Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Endocrinol Invest 35:655-60. 2012..Patients with primary hyperparathyroidism (PHPT) with contraindications to parathyroidectomy (PTx) or persistent PHPT have few non surgical options... - Familial parathyroid hyperplasia: is there a place for minimally invasive surgery? Description of the first treated caseP Miccoli
Department of Surgery, University of Pisa, Pisa, Italy
J Endocrinol Invest 28:942-3. 2005..Quick intraoperative PTH assay (QPTH) confirmed the surgical cure of the disease... - Genetic analysis of the MEN1 gene and HPRT2 locus in two Italian kindreds with familial isolated hyperparathyroidismFilomena Cetani
Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia e Medicina del Lavoro, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
Clin Endocrinol (Oxf) 56:457-64. 2002..Therefore, an extensive analysis of the genes involved in these diseases should be performed in families with familial isolated hyperparathyroidism to identify the subset linked to the MEN1 gene or to the HPRT2 locus... - A novel mutation of the autoimmune regulator gene in an Italian kindred with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, acting in a dominant fashion and strongly cosegregating with hypothyroid autoimmune thyroiditisF Cetani
Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 86:4747-52. 2001..The G228W mutation acts in a dominant fashion and may shed light on the structure-function relationship of the autoimmune regulator protein... - Microvessel density in human normal and neoplastic parathyroidsPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
Endocr Pathol 17:175-81. 2006..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size... - A proteomic approach to study parathyroid glandsLaura Giusti
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, Via, Bonanno 6, 56126 Pisa, Italy
Mol Biosyst 7:687-99. 2011..The functional role of these proteins in the network of intracellular pathways is discussed... - The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatmentAgostino Virdis
Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
J Clin Endocrinol Metab 95:920-7. 2010..A compensatory CYP 2C9-derived EDHF pathway is activated to sustain endothelium-dependent vasodilation. This PHPT-related endothelial dysfunction is reversed after PTx... - A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancerFilomena Cetani
Dipartimenti di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, , Pisa, Italy
Clin Endocrinol (Oxf) 60:99-106. 2004..Retention of heterozygosity seems to exclude parathyroid malignancy, which is suggested by the combined finding of LOH and lack of protein expression... - Somatostatin analogues do not affect calcium metabolism in patients with acromegaly and primary hyperparathyroidism [corrected] due to MEN 1-like syndromeF Bogazzi
Department of Endocrinology, University of Pisa, Pisa, Italy
Horm Metab Res 43:126-9. 2011..SSA therapy does not affect calcium-phosphorus metabolism in patients with MEN 1-like syndrome, suggesting that the drug has no role in controlling PHP in these subset of patients... - Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutationFilomena Cetani
Dipartimento di Endocrinologia e Metabolismo, , Pisa, Italy
Clin Endocrinol (Oxf) 58:199-206. 2003.... - Familial hypocalciuric hypercalcemia in a woman with metastatic breast cancer: a case report of mistaken identityClaudio Marcocci
Dipartimento di Endocrinologia e Metabolismo, Universita degli Studi di Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 88:5132-6. 2003..In conclusion, we describe a case of familial hypocalciuric hypercalcemia due to a novel CaR mutation, in a woman with breast cancer in whom hypercalcemia was initially attributed to hypercalcemia of malignancy... 
Genetic and clinical features of multiple endocrine neoplasia types 1 and 2C Romei
Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
J Oncol 2012:705036. 2012..MEN 2 prognosis is strictly dependent on the MTC aggressiveness and thus on the success of the initial treatment...- Update on the use of cinacalcet in the management of primary hyperparathyroidismC Marcocci
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
J Endocrinol Invest 35:90-5. 2012..Moreover, there are no data as to whether long-term treatment with cinacalcet can prevent the complications of PHPT. Finally, more data are needed on the long-term safety of cinacalcet, particularly at the renal level... - Undetectable inferior petrosal sinus levels of PTH-related peptide (PTHrP) in patients with ACTH-dependent Cushing's diseaseL Manetti
Department of Endocrinology, University of Pisa, Italy
J Endocrinol Invest 28:819-21. 2005..Our data, combined with others reported in literature, indicate that PTHrP release by ACTH-secreting tumors is not a common occurrence. Therefore, we conclude that IPS and peripheral PTHrP are of little clinical usefulness... - Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemiaFilomena Cetani
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Eur J Endocrinol 160:481-9. 2009..Identification and characterization of calcium-sensing receptor (CASR) mutations in four unrelated Italian kindreds with familial hypocalciuric hypercalcemia... - The reduction of bone mineral density in postmenopausal women with primary hyperparathyroidism is higher in the presence of concomitant GH secretion impairmentElisabetta Cecconi
Department of Endocrinology and Metabolism, University of Pisa, Ospedale, Cisanello, Via Paradisa 2, 56124 Pisa, Italy
Eur J Endocrinol 155:41-5. 2006..CONCLUSIONS: Concomitant impairment of GH secretion may play a pathogenetic role in the occurrence of changes in bone mass observed in PHP and contribute to make them more severe... - Surgery or surveillance for mild asymptomatic primary hyperparathyroidism: a prospective, randomized clinical trialElena Ambrogini
Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
J Clin Endocrinol Metab 92:3114-21. 2007..It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT) do better with parathyroidectomy (PTx) as compared with conservative medical management... - Parafibromin as a tool for the diagnosis of parathyroid tumorsClaudio Marcocci
Adv Anat Pathol 15:179; author reply 179-80. 2008 - High doses of intravenous calcitriol in the treatment of severe secondary hyperparathyroidismMassimo Morosetti
Nephrology and Dialysis Unit, GB Grassi Hospital, ASL RMD Ostia Rome, Italy
J Nephrol 17:95-100. 2004..In this prospective study, our aim was to determine the necessary calcitriol dose required to control severe HPTH preventing hypercalcemia or hyperphosphatemia and avoiding parathyroidectomy...