Maria Carmela Cerra

Summary

Affiliation: University of Calabria
Country: Italy

Publications

  1. pmc GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts
    Ernestina Marianna De Francesco
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy
    PLoS ONE 8:e69322. 2013
  2. doi request reprint Phospholamban and cardiac function: a comparative perspective in vertebrates
    M C Cerra
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
    Acta Physiol (Oxf) 205:9-25. 2012
  3. doi request reprint Nitrite modulates contractility of teleost (Anguilla anguilla and Chionodraco hamatus, i.e. the Antarctic hemoglobinless icefish) and frog (Rana esculenta) hearts
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    Biochim Biophys Acta 1787:849-55. 2009
  4. ncbi request reprint Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart
    Maria Carmela Cerra
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende CS, Italy
    Basic Res Cardiol 101:43-52. 2006
  5. ncbi request reprint Cardiovascular cGMP-generating systems in physiological and pathological conditions
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Curr Med Chem 14:585-99. 2007
  6. ncbi request reprint Cardiac morphodynamic remodelling in the growing eel (Anguilla anguilla L.)
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    J Exp Biol 207:2867-75. 2004
  7. ncbi request reprint Cardiac role of frog ANF: negative inotropism and binding sites in Rana esculenta
    Maria Carmela Cerra
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    Regul Pept 114:91-9. 2003
  8. ncbi request reprint Pericardium of the frog, Rana esculenta, is morphologically designed as a lymphatic space
    Maria Carmela Cerra
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
    J Morphol 257:72-7. 2003
  9. doi request reprint Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts
    Teresa Pasqua
    Department of Biology, Ecology, and Earth Sciences, University of Calabria, 87036 Arcavacata di Rende CS, Italy
    Endocrinology 154:3353-65. 2013
  10. doi request reprint Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin
    Tommaso Angelone
    Department of Cell Biology, Laboratory of Cardiovascular Pathophysiology, University of Calabria, Arcavacata di Rende CS, Italy
    Am J Physiol Heart Circ Physiol 302:H431-42. 2012

Collaborators

Detail Information

Publications35

  1. pmc GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts
    Ernestina Marianna De Francesco
    Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Cosenza, Italy
    PLoS ONE 8:e69322. 2013
    ..Hence, GPER may be considered as a useful target in the treatment of some cardiac dysfunctions associated with stressful conditions like the essential hypertension. ..
  2. doi request reprint Phospholamban and cardiac function: a comparative perspective in vertebrates
    M C Cerra
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
    Acta Physiol (Oxf) 205:9-25. 2012
    ..e. haemoglobinless and myoglobinless species)...
  3. doi request reprint Nitrite modulates contractility of teleost (Anguilla anguilla and Chionodraco hamatus, i.e. the Antarctic hemoglobinless icefish) and frog (Rana esculenta) hearts
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    Biochim Biophys Acta 1787:849-55. 2009
    ..Results suggest that nitrite is an integral physiological source of NO and acts as a signalling molecule in lower vertebrate hearts, exerting relevant inotropic actions through different species-specific mechanisms...
  4. ncbi request reprint Recombinant N-terminal fragments of chromogranin-A modulate cardiac function of the Langendorff-perfused rat heart
    Maria Carmela Cerra
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende CS, Italy
    Basic Res Cardiol 101:43-52. 2006
    ..15, r2 = 0.97; -7.7 +/- 0.15, r2 = 0.97; -7.8 +/- 0.78, r2 = 0.55, respectively) revealed a non-competitive type of antagonism of STA-CGA1-78. Taken together, these data suggest vasostatins as novel cardioregulatory peptides in mammals...
  5. ncbi request reprint Cardiovascular cGMP-generating systems in physiological and pathological conditions
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Curr Med Chem 14:585-99. 2007
    ..Here we will review recent concepts on NO/NPs dependent control of heart function in vertebrates, also focusing on cGMP-activated downstream signaling and its role in health and disease conditions...
  6. ncbi request reprint Cardiac morphodynamic remodelling in the growing eel (Anguilla anguilla L.)
    M C Cerra
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    J Exp Biol 207:2867-75. 2004
    ..The compacta also shows an increased mitochondrial compartment. Our results document a cardiac morphodynamic remodelling in the growing eel...
  7. ncbi request reprint Cardiac role of frog ANF: negative inotropism and binding sites in Rana esculenta
    Maria Carmela Cerra
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    Regul Pept 114:91-9. 2003
    ....
  8. ncbi request reprint Pericardium of the frog, Rana esculenta, is morphologically designed as a lymphatic space
    Maria Carmela Cerra
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, Cosenza 87030, Italy
    J Morphol 257:72-7. 2003
    ....
  9. doi request reprint Full-length human chromogranin-A cardioactivity: myocardial, coronary, and stimulus-induced processing evidence in normotensive and hypertensive male rat hearts
    Teresa Pasqua
    Department of Biology, Ecology, and Earth Sciences, University of Calabria, 87036 Arcavacata di Rende CS, Italy
    Endocrinology 154:3353-65. 2013
    ....
  10. doi request reprint Phosphodiesterase type-2 and NO-dependent S-nitrosylation mediate the cardioinhibition of the antihypertensive catestatin
    Tommaso Angelone
    Department of Cell Biology, Laboratory of Cardiovascular Pathophysiology, University of Calabria, Arcavacata di Rende CS, Italy
    Am J Physiol Heart Circ Physiol 302:H431-42. 2012
    ..Our results are of importance in relation to the putative application of CST as a cardioprotective agent against stress, including excessive sympathochromaffin overactivation...
  11. pmc The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism
    Tommaso Angelone
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende, Italy
    Endocrinology 149:4780-93. 2008
    ..g. hypertensive cardiomyopathy...
  12. doi request reprint The catecholamine release-inhibitory peptide catestatin (chromogranin A344-363) modulates myocardial function in fish
    Sandra Imbrogno
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Exp Biol 213:3636-43. 2010
    ....
  13. doi request reprint Catecholamines, cardiac natriuretic peptides and chromogranin A: evolution and physiopathology of a 'whip-brake' system of the endocrine heart
    Bruno Tota
    Department of Cell Biology, University of Calabria, 87030, Arcavacata di Rende, Italy
    J Exp Biol 213:3081-103. 2010
    ..The latter can also be used as an intellectual tool to disentangle the experimental complexity of the mammalian and human endocrine hearts, suggesting future investigational avenues...
  14. doi request reprint Cytoskeleton mediates negative inotropism and lusitropism of chromogranin A-derived peptides (human vasostatin1-78 and rat CgA₁₋₆₄) in the rat heart
    Tommaso Angelone
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Regul Pept 165:78-85. 2010
    ..Taken together these data indicate that in the rat heart, the actin cytoskeletal network strongly contributes to the cardiotropic action of CgA-derived peptides...
  15. ncbi request reprint Differential NOS expression in freshwater and aestivating Protopterus dolloi (lungfish): heart vs kidney readjustments
    Daniela Amelio
    Department of Cellular Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    Nitric Oxide 18:1-10. 2008
    ..Our findings are of evolutionary interest, since they document for the first time the presence of a NOS system in a ancestral fish, indicative of deep phylogenetic roots of NO bio-synthesis...
  16. ncbi request reprint Angiotensin II-induced inotropism requires an endocardial endothelium-nitric oxide mechanism in the in-vitro heart of Anguilla anguilla
    Sandra Imbrogno
    Department of Cellular Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    J Exp Biol 206:2675-84. 2003
    ..e. the Frank-Starling response), which in the eel heart is modulated by NO. This EE-paracrine-mediated cardio-suppressive action of endoluminal ANG II suggests that the hormone plays an important intracardiac role in the fish heart...
  17. doi request reprint Endothelin-1 induces connective tissue growth factor expression in cardiomyocytes
    Anna Grazia Recchia
    Department of Pharmaco Biology, Cell Biology, University of Calabria, 87036 Rende CS, Italy
    J Mol Cell Cardiol 46:352-9. 2009
    ..CTGF inhibitors should be considered in setting a comprehensive pharmacological approach towards ET-1 induced cardiovascular diseases...
  18. doi request reprint Malvidin, a red wine polyphenol, modulates mammalian myocardial and coronary performance and protects the heart against ischemia/reperfusion injury
    Anna Maria Quintieri
    Department of Cell Biology, University of Calabria, Arcavacata di Rende, CS, Italy
    J Nutr Biochem 24:1221-31. 2013
    ..This is of relevance not only for a better clarification of the beneficial cardiovascular effects of food-derived polyphenols but also for nutraceutical research...
  19. ncbi request reprint The emerging cardioinhibitory role of the hippocampal cholinergic neurostimulating peptide
    Tommaso Angelone
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    J Pharmacol Exp Ther 318:336-44. 2006
    ....
  20. ncbi request reprint Cardiac morpho-dynamics in Rana esculenta: influence of sex and season
    Filippo Garofalo
    Department of Cell Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    Comp Biochem Physiol A Mol Integr Physiol 145:82-9. 2006
    ..This data indicate that sex and season-related factors influence cardiac morpho-dynamics in R. esculenta...
  21. pmc The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes
    Rosamaria Lappano
    Department of Pharmaco Biology, University of Calabria, Rende, Italy
    PLoS ONE 6:e16631. 2011
    ..In addition, the levels of oxysterols, including 25 HC, have been found to be elevated in hypercholesterolemic serum...
  22. doi request reprint Hypoxia and anoxia tolerance of vertebrate hearts: an evolutionary perspective
    Bruno Tota
    Laboratory of Cardiovascular Physiology, Department of Cell Biology, University of Calabria, Arcavacata di Rende, Italy
    Antioxid Redox Signal 14:851-62. 2011
    ..This evolutionary and comparative perspective may provide a useful and heuristic stimulus for medically oriented research aimed at elucidating the environmental and genetic risk factors underlying the vulnerability of the human heart...
  23. ncbi request reprint Cardiac expression and distribution of nitric oxide synthases in the ventricle of the cold-adapted Antarctic teleosts, the hemoglobinless Chionodraco hamatus and the red-blooded Trematomus bernacchii
    Daniela Amelio
    Department of Cellular Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy
    Nitric Oxide 15:190-8. 2006
    ..These results indicate a high phylogenetic conservation of the intracardiac NOS system, emphasizing its importance in the control of the vertebrate heart and its relevance as a general mechanism of defense against pathogens...
  24. ncbi request reprint The chromogranin A-derived vasostatins: new players in the endocrine heart
    B Tota
    Department of Pharmaco Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Curr Med Chem 15:1444-51. 2008
    ....
  25. ncbi request reprint Beta3-adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO-cGMP-dependent mechanism
    S Imbrogno
    Department of Pharmaco Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    J Exp Biol 209:4966-73. 2006
    ....
  26. ncbi request reprint NO modulation of myocardial performance in fish hearts
    B Tota
    Department of Cellular Biology, University of Calabria, 87030, Arcavacata di Rende, CS, Italy
    Comp Biochem Physiol A Mol Integr Physiol 142:164-77. 2005
    ....
  27. ncbi request reprint New biological aspects of chromogranin A-derived peptides: focus on vasostatins
    Bruno Tota
    Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Italy
    Comp Biochem Physiol A Mol Integr Physiol 147:11-8. 2007
    ..Particular attention has been given to the still elusive mechanism of action of these peptides...
  28. ncbi request reprint A new membrane G protein-coupled receptor (GPR30) is involved in the cardiac effects of 17beta-estradiol in the male rat
    E Filice
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende, Italy
    J Physiol Pharmacol 60:3-10. 2009
    ..Our results also point to a potential role of GPR30, however further evaluation is required in order to fully understand the contribution of the different estrogen receptors in mediating estrogen activity on cardiac performance...
  29. doi request reprint The homologous rat chromogranin A1-64 (rCGA1-64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via endothelium-derived nitric oxide
    M C Cerra
    B T, Department of Cell Biology, University of Calabria, 87030 Arcavacata di Rende Cs, Calabria, Italy
    FASEB J 22:3992-4004. 2008
    ..Taken together, our data strongly suggest that in the rat heart the homologous rCGA1-64 fragment exerts an autocrine/paracrine modulation of myocardial and coronary performance acting as stabilizer against intense excitatory stimuli...
  30. doi request reprint Beta3-adrenoceptors modulate left ventricular relaxation in the rat heart via the NO-cGMP-PKG pathway
    T Angelone
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS, Italy
    Acta Physiol (Oxf) 193:229-39. 2008
    ..We also focused on the NOS/NO/cGMP/PKG cascade as the signal transduction mechanism...
  31. ncbi request reprint Myocardial production of chromogranin A in human heart: a new regulatory peptide of cardiac function
    Maurizio Pieroni
    Cardiology Department, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Eur Heart J 28:1117-27. 2007
    ..High chromogranin-A (CgA) levels were observed in patients with heart failure but its source remained uncertain. We evaluated whether CgA is produced by myocardium and might affect myocardial function...
  32. ncbi request reprint Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism
    Sandra Cappello
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Torino, Corso Raffaello 30, 10125 Turin, Italy
    Am J Physiol Heart Circ Physiol 293:H719-27. 2007
    ..As with repeated brief preconditioning ischemia, hrSTA-CgA(1-78) may be considered a stimulus strong enough to trigger both pathways, which may converge on PKC...
  33. ncbi request reprint Structural and functional evolution of three cardiac natriuretic peptides
    Koji Inoue
    Ocean Research Institute, The University of Tokyo, Minamidai, Nakano, Tokyo, Japan
    Mol Biol Evol 22:2428-34. 2005
    ..If the duplication occurred before the divergence of tetrapods and teleosts, VNP may exist in the tetrapod lineage...
  34. ncbi request reprint Signal transduction pathways involved in the mechanical responses to protease-activated receptors in rat colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo, Italy
    J Pharmacol Exp Ther 303:1265-72. 2002
    ..Indeed, tyrosine kinase and L-type Ca2+ channels would act sequentially. The influx of Ca2+ in turn would cause release of Ca2+ from sarcoplasmic reticulum...
  35. pmc Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italy
    Br J Pharmacol 136:367-74. 2002
    ..PARs mediate changes of the mechanical activity of longitudinal and circular muscle which might explain the alterations of colonic motility observed during inflammatory conditions...